Perioperative antibiotic prophylaxis. Evidence based guidelines by an expert panel of the Paul Ehrlich Gesellschaft;Perioperative antibiotika-prophylaxe. Empfehlungen einer expertenkommission der Paul-Ehrlich-Gesellschaft für chemotherapie e.V

Chemotherapie Journal

Volumn 19, Issue 3, 2010, Pages 70-84

  Wacha, Hannes ^a   Hoyme, Udo ^b   Isenmann, Rainer ^c   Kujath, Peter ^d   Lebert, Cordula ^e   Naber, Kurt ^a   Salzberger, Bernd ^f  

^a HELIOS Klinikum ^*  (Germany)

^b HELIOS KLINIKUM ERFURT   (Germany)

^c St Anna Virngrund Klinik   (Germany)

^d Klinik fur Chirurgie   (Germany)

^e KLINIKUM NÜRNBERG   (Germany)

^f Klinik und Poliklinik I fur Innere Medizin   (Germany)

Author keywords

Gynaecologic surgery; Heart and vascular surgery; Indication for antibiotic prophylaxis; Key risk factors; Neurosurgery; Orthopaedic surgery; Surgery of the abdomen; Trauma surgery; Urologic surgery

Indexed keywords

ANTIBIOTIC AGENT;

ABDOMINAL SURGERY; ANTIBIOTIC PROPHYLAXIS; COMORBIDITY; EVIDENCE BASED PRACTICE; FOREIGN BODY; HEART SURGERY; HUMAN; INFECTION RISK; MEDICAL EXPERT; MEDICAL SOCIETY; NEUROSURGERY; OPERATION DURATION; ORTHOPEDIC SURGERY; PEROPERATIVE CARE; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRACTICE GUIDELINE; REVIEW; TREATMENT INDICATION; UROLOGIC SURGERY; VASCULAR SURGERY; WOUND INFECTION;

EID: 77953550252     PISSN: 09406735     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (131)

1. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database of Systematic Reviews 2005;(3):CD001439.
2. Aufenacker TJ, van Geldere D, van Mesdag T, Bossers AN, et al. The role of antibiotic prophylaxis in prevention of wound infection after Lichtenstein openmesh repair of primary inguinal hernia: a multicenter double-blind randomized controlled trial. Ann Surg 2004;240:955-60; discussion 960-1.
3. Barie PS. Surgical site infections: epidemiology and prevention. Surg Infect (Larchmt) 2002;3(Suppl 1):9-21.
4. Barker FG. Efficacy of prophylactic antibiotic therapy against meningitis after craniotomy: a meta-analysis. Neurosurgery 2007;60:887-94.
5. Barker FG. Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysis. Neurosurgery 2002;51:391-400.
6. Bates T, Siller G, Crathern BC, Bradley SP, et aL Timing of prophylactic antibiotics in abdominal surgery: trial of a preoperative versus an intra-operative first dose. Br J Surg 1989;76:52-6. (Pubitemid 19027388)
7. Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery. Am J Obstet Gynecol 2005;193:1607-17.
8. Berry A, Barratt A. Prophylatic antibiotic use in transurethral prostatic resection: A meta-analysis. J Urol 2002;167:571-7. (Pubitemid 34074530)
9. Bert JM, Giannini D, Nace L. Antibiotic prophylaxis for arthroscopy of the knee: Is it necessary? Arthroscopy 2007;23:4-6.
10. Bratzler DW, Houck PM, Richards C, Steele L, et al. Baseline results from the National Surgical Infection Prevention Project Use of antimicrobial prophylaxis for major surgery. Arch Surg 2005;140:174-82. (Pubitemid 40229109)
11. Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project Clin Infect Dis 2004;38:1706-15.
12. Brunet F, et al. Risk factors for deep sternal wound infection after sternotomy: a prospective multicenter study. J Thorac Cardiovasc Surg 1996;111:1200-7.
13. Bucher P, Gervaz P, Morel P. Should preoperative mechanical bowel pre-paration be abandoned? Ann Surg 2007;245:662.
14. Burke JF. Preventing bacterial infection by coordinating antibiotic and host activity: a time-dependent relationship. South Med J 1977;70(Suppl 1):24-6.
15. Byrne AM, Morris S, McCarthy T, Quinlan W, et al. Outcome following deep wound contamination in cemented arthroplasty. Int Orthop 2007;31:27-31. (Pubitemid 46208220)
16. Caffarelli AD, Holden JP, Baron EJ, Lemmens HJM. et al. Plasma cefazolin levels during cardiovascular surgery: Effects of cardiopulmonary bypass and profound hypothermic circulatory arrest. J Thorac Cardiovasc Surg 2006;131:1338-43.
17. Carey JM, Korman HJ. Transrectal ultrasound guided biopsy of the prostate. Do enemas decrease clinically significant complications? J Urol 2001;166:82-5.
18. Carignan A. Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Clin Infect Dis 2008;46:1838.
19. Catarci M, Mancini S, Gentileschi P, Camplone C, et al. Antibiotic prophylaxis in elective laparoscopic cholecystectomy: lack of need or lack of evidence? Surg Endosc 2004;18:638-41.
20. Centofanti P, Savia F, La Torre M. Ceresa F, et al. A prospective study of prevalence of 60-days postoperative wound infections after cardiac surgery. An updated risk factor analysis. J Thorac Cardiovasc Surg 2007;48:641-6.
21. Chaberny IF, Gastmeier P. MRSA-Präventionsmaßnahmen und deren Umsetzung. Chemother J 2009;18:93.
22. Chen LF, Anderson DJ, Hartwig MD, Kaye KS, et al. Surgical site infections after laparoscopic and open cholecystectomies in community hospitals. Infect Control Hosp Epidemiol 2008;29:92-3.
23. Chuang SC, Lee KT, Chang WT, Wang SN, et al. Risk factors for wound infection after cholecystectomy. J Formos Med Assoc 2004;103:607-12.
24. Classen DC, Evans RS, Pestotnik SL, Horn SD, et al. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. NEJM 1992;326:281-6.
25. Colombo AZG, Negri L, Scalambrino S, Pasta F. A randomized comparison of one-dose versus two-dose antibiotic prophylaxis in gynecologic surgery lasting over two hours. J Gynaecol Obstet 1998;10:9-15.
26. Costantine MM, Rahman M, Ghulmiyah L, Byers BD, et al. Timing of perioperative antibiotics for cesarean delivery: a meta-analysis. Am J Obstet Gynecol 2008;199:301.e1-6.
27. Cruse PJE, Foord R. The epidemiology of wound infection: A 10-year old prospective study of 62,939 wounds. Surg Clin North Am 1980;60:27-40. (Pubitemid 10049641)
28. Culver DH, Horan TC, Gaynes RP, Martone WJ, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance System. Am J Med 1991;91:152S-7S.
29. Da Costa A, Kirkorian G, Cuchart M, et al. Antibiotic prophylaxis for permanent pacemakerimplantation. Circulation 1998;97:1796-801.
30. Dalley AJ, Lipman J, Venkatesh B, Rudd M, et al. Inadequate antimicrobial prophylaxis during surgery: a study of ß-lactam levels during bum debridement J Antimicrob Chemother 2007;60:166-9.
31. Davis KA, Stewart JJ, Crouch HK, Florez CE, et al. Methicillin-resistant Staphylococcus aureus (MRSA) nares colonization at hospital admission and its effect on subsequent MRSA infection. Clin Infect Dis 2004;39: 776-82.
32. Deng DM, Huang Z, Yuan WJ, Ding LZ, et al. Clinical study on coadministration of cefazolin sodium and metronidazole for infection prophylaxis in perioperative period of cesarean section. Pharmaceut Care Res 2007;7:278-80. (Pubitemid 47377225)
33. Dietrich ES, Bieser U, Frank U, Schwarzer G, et al. Ceftriaxone versus other cephalosporins for perioperative antibiotic prophylaxis: a meta-analysis of 43 randomized controlled trials. Chemother 2002;48:49-56. (Pubitemid 34233886)
34. El-Mufti M, Raka FS, Glessa A, Abdulhadi A. et al. Ceftriaxone versus clavulanate-potentiated amoxicillin for prophylaxis against post-operative sepsis in biliary surgery: A prospective randomized study in 200 patients. Curr Med Res Opin 1989;11:354-9. (Pubitemid 19086255)
35. Espehaug B, Engesaeter LB, Vollset SE, Havlin LI, et al. Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian Arthroplasty Register 1987 to 1995. J Bone Joint Surg 1997;79b:590-5.
36. Espin-Basany E, Sanchez-Garcia JL, Lopez-Cano M, Lozoya-Trujillo R, et al. Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics? Int J Colorectal Dis 2005;20:542-6.
37. Falagas ME, Afhanasiou S, Iavazzo C, Tokas T, et al. Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review. Int Urogynecol J 2008;19:1165-72.
38. Finkelstein R, Rabino G, Mashiah T, Bar-El Y, et al. Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections. J Thorac Cardiovasc Surg 2002;123:326-32. (Pubitemid 34127121)
39. Finlay-Jones JJ. Infection in surgery-basic and clinical aspects. Edinburgh: Churchill Livingstone, 1981.
40. Florek HJ. Prinzipien der Antibiotikaprophylaxe in der Gefäßchirurgie. Chirurg 1994;68:955-7.
41. Fonseca SNS, Kunzle SRM, Junqueira MJ, Nascimento RT, et al. Implementing 1-dose antibiotic prophylaxis for prevention of surgical site infection. Arch Surg 2006;141:1109-13.
42. Forbes SS, Stephen WJ, Harper WL, Loeb M, et al. Implementation of evidence-based practices for surgical site infection prophylaxis: Results of a pre- and postintervention study. J Am Coll Surg 2008;207:336-41.
43. Fry DE. Surgical site infections and the surgical care improvement project (SCIP): Evolution of national quality measures. Surg Infect 2008;9:579-84.
44. Fujita S, Saito N, Yamada T, Takii Y, et al. Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: Single dose vs. 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. Arch Surg 2007;142:657-61.
45. Garcia Prado ME. Matia EC, Ciuro FP, Diez-Canedo JS, et al. Surgical site infection in liver transplant recipients: Impact of the type of perioperative prophylaxis. Transplant 2008;85:1849-54.
46. Gastmeier P, Brandt C, Sohr D, Babikir R, et al. [Surgical site infections in hospitals and outpatient settings. Results of the German nosocomial infection surveillance system (KISS)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2004.
47. Geipel U, Herrmann M. The infected implant: Bacteriology. Unfallchir 2005;108:961-78.
48. Gislason H, Soreide O, Viste A. Wound complications after major gastrointestinal operations. The surgeon as a risk factor. Dig Surg 1999;16:512-4.
49. Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev 2004;1:CD003764.
50. Hall JC, Christiansen KJ, Goodman M, Lawrence-Brown M, et al. Duration of antimicrobial prophylaxis in vascular surgery. Am J Surg 1998:175:87-90. (Pubitemid 28132896)
51. Haynes AB, Weiser TG, Berry WR, Lipsitz SR, et al.; the Safe Surgery Saves Lives Study Group. A surgical safety checklist to reduce morbidity and mortality in a global population. NEJM 2009;360:491-9.
52. Hellbusch LC, Helzer-Julin M, Doran SE, Leibrock LG, et al. Single-dose vs. multiple-dose antibiotic prophylaxis in instrumented lumbar fusion - a prospective study. Surg Neurol 2008;70:622-7.
53. Higgins A, London J, Charland S, Ratzer E, et al. Prophylactic antibiotics for elective laparoscopic cholecystectomy: are they necessary? Arch Surg 1999;134:611-3, discussion 614.
54. Hutschala D. Skhirtladze K. Kinstner C, Mayer-Helm B. et al. In vivo microdialysis to measure antibiotic penetration into soft tissue during cardiac surgery. Ann Thorac Surg 2007;84:1605-10.
55. Illig KA, Schmidt E, Cavanaugh J, Krusch D, et al. Are prophylactic antibiotics required for elective laparoscopic cholecystectomy? J Am Coll Surg 1997;184:353-6.
56. Iribarren O, Araujo M. Effect of antimicrobial prophylaxis on the incidence of infections in clean surgical wounds in hospitals undergoing renovation. Infect Control Hosp Epidemiol 2006;27:1372-6.
57. Itani KMF, Jensen EH, Finn TS, Tomassini JE, et al. Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery. Surg Infect 2008;9:131-7.
58. Itani KMF, Wilson SE, Awad SS, Jensen EH, et al. Ertapenem versus cefotetan prophylaxis in elective colorectal surgery. NEJM 2006;355:2640-51.
59. Jamsen E, Huhtala H, Puolakka T, Moilanen T. Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am 2009;91:38-47.
60. Keighley MR, Winslet MC, Flinn R, Kmiot W. Multivariate analysis of factors influencing the results of restorative proctocolectomy. Z Gastroenterol Verh 1989;24:252-5.
61. Khan AA, Manan A, Qadir A. Comparison of etiology and rate of infection in different surgical wounds. Medical Forum Monthly 2006;17:10-6.
62. Knoop M, Schutze M, Piek J, Drewelow B, et al. Antibiotic prophylaxis in cerebrospinal fluid shunting: Reassessment of cefotiam penetration into human CSF. Zentralbl Neurochir 2007;68:14-8.
63. Koch A, Zippel R, Manisch F, Schmidt U, et al. Prospective multicenter study of antibiotic prophylaxis in operative treatment of appendicitis. Dig Surg 2000;17:370-8.
64. Koopman E, Nix DE, Erstad BL, Demeure MJ, et al. End-of-procedure cefazolin concentrations after administration for prevention of surgical-site infection. AJHP 2007;64:1927-34.
65. Kritchevsky SB, Braun BI, Bush AJ. Bozikis MR. et al., for the TRAPE Study Group. The effect of a quality improvement collaborative to improve antimicrobial prophylaxis in surgical patients: A randomized trial. Ann Intern Med 2008;49:472-80.
66. Lietard C, Thebaud V, Besson G, Lejeune B. Risk factors for neurosurgical site infections: An 18-month prospective survey - Clinical article. J Neurosurg 2008;109:729-34.
67. Lipp A, Lusardi G. Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy. Cochrane Database Syst Rev 2006;(4):CD005571.
68. Lizan-Garcia M, Garcia-Caballero J, Asensio-Vegas A. Risk factors for surgical-wound infection in general surgery: a prospective study. Infect Control Hosp Epidemiol 1997;18:310-5.
69. Lofgren M, Poromaa IS, Stjemdahl JH, Renstrom B. Postoperative infections and antibiotic prophylaxis for hysterectomy in Sweden: Study by the Swedish National Register for Gynecologic Surgery. Obstet Gynecol Survey 2005;60:168-9.
70. MacFie J, Reddy BS, Gatt M, Jain PK, et al. Bacterial translocation studied in 927 patients over 13 years. BJS 2006;93:87-93. (Pubitemid 43117311)
71. Mastoraki S, Michalopoulos A, Kriaras I, Geroulanos S. Cefuroxime as antibiotic prophylaxis in coronary artery bypass grafting surgery. ICVTS 2007;6:442-6.
72. May W, Gulmezoglu AM, Ba-Thike K. Antibiotics for incomplete abortion. Cochrane Database Syst Rev 2007;(4):CD001779.
73. Mc Ardle CS. Oral prophylaxis in biliary tract surgery. J Antimicrob Chemother 1994;33:200-2.
74. Medina M, Sillero M, Martinez-Gallego G, Delgado-Rodriguez M. Risk factors of surgical wound infection in patients undergoing herniorrhaphy. Eur J Surg 1997;163:191-8.
75. Meijer WS. Schmitz PIM, Jeekel J. Meta-analysis of randomized, controlled clinical trials of antibiotic prophylaxis in biliary tract surgery. BJS 1990;77:283-90. (Pubitemid 20103762)
76. Miller BS, Harper WP, Hughes JS, Sonnabend DH, et al. Regional antibiotic prophylaxis in elbow surgery. J Shoulder Elbow Surg 2004;13:57-9.
77. Mohri Y, Tonouchi H, Kobayashi M, Nakai K, et al. Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery. BJS 2007;94:683-8. (Pubitemid 46910059)
78. Nelson RL, Glenny AM, Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev 2009;21(1):CD001181.
79. Nichols RL, Condon RE, Barie PS. Antibiotic prophylaxis in surgery - 2005 and beyond. Surg Infect (Larchmt) 2005;6:349-61.
80. Novelli A. Antimicrobial prophylaxis in surgery: the role of pharmacokinetics. J Chemother 1999;11:565-72. (Pubitemid 30029557)
81. Owens SM, Brozanski BS, Meyn LA, Wiesenfeld HC. Timing is everything: Antibiotic prophylaxis for caesarean section prior to skin incision versus following umbilical cord clamping. Abstract 35th Annual Scientific Meeting Infectious Diseases Society for Obstetrics and Gynecology, Seattle, Washington, August 14-16, 2008.
82. Pan A, Ambrosini L, Patroni A, Soavi L, et al. Adherence to surgical site infection guidelines in Italian cardiac surgery units. Drugs Pharmacol Infect 2009;37:148-52.
83. Papaioannidou P, Vavilis D, Benoni GM, Cuzzolin L, et al. Quality of perioperative chemoprophylaxis in obstetrics and gynecology: Preliminary results of ASPPOC in Greece and Italy. Rev din Pharmacol Pharmacokinet 2008;22:282-4.
84. Perez AR. Roxas MF, Hilvano SS. A randomized, double-blind, placebo-controlled trial to determine effectiveness of antibiotic prophylaxis for tension-free mesh herniorrhaphy. J Am Coll Surg 2005;200:393-7; discussion 397-8.
85. Comment in: J Am Coll Surg 2006;203:138-9.
86. Perl TM, Roy MC. Postoperative wound infections: risk factors and role of Staphylococcus aureus nasal carriage. J Chemother 1995;7(Suppl 3):29-35.
87. Pessaux P, Atallah D, Lermite E, Msika S, et al.; French Associations for Surgical Research, Angers and Colombes, France. Risk factors for prediction of surgical site infections in "clean surgery". Am J Infect Control 2005;33:292-8.
88. Petignat C, Francioli P, Harbarth S, Regli L, et al. Cefuroxime prophylaxis is effective in non-instrumented spine surgery: A double-blind, placebo-controlled study. Spine 2008;33:1919-24.
89. Qiang W, Jianchen W, MacDonald R, Monga M, et al. Antibiotic prophylaxis for transurethral prostatic resection in men with preoperative urine containing less than 100,000 bacteria per ml: A systematic review. J Urol 2005;173:1175-81. (Pubitemid 40380529)
90. Ramos G, Resta M, Delgado EM, Durlach R, et al. Systemic perioperative antibiotic prophylaxis may improve skin autograft survival in patients with acute burns. J Burn Care Res 2008;29:917-23.
91. Rode H, Brown RA, Millar AJW. Surgical skin and soft tissue infections. Curr Opin Infect Dis 1993;5:683-90. (Pubitemid 23282802)
92. Rodrigo JP, Sǔrez C, Bernaldez R, Collado D. Efficacy of piperacillintazobactam in the treatment of surgical wound infection after clean-contaminated head and neck oncologic surgery. Head Neck 2004;26: 823-8.
93. Rosenberg AD, Wambold D, Kraemer L, Begley-Keyes M, et al. Ensuring appropriate timing of antimicrobial prophylaxis. JBJS 2008;90:226-32.
94. Rosmarakis ES, Prapas SN, Rellos K, Michalopoulos A. et al. Nosocomial infections after off-pump coronary artery bypass surgery: frequency, characteristics, and risk factors. ICVTS 2007;6:759.
95. Rovera F, Dionigi G, Boni L, Ferrari A, et al. Mechanical bowel preparation for colorectal surgery. Surg Infect 2006;7(Suppl 2):S61-3.
96. Rovera F, Diurni M, Dionigi G, Boni L. et al. Antibiotic prophylaxis in colorectal surgery. Expert Rev Antiinfect Ther 2005;3:787-95.
97. Rüden H, Gastmeier P, Daschner FD, Schumacher M. Nosocomial and community-acquired infections in Germany. Summary of the results of the First National Prevalence Study (NIDEP). Infection 1997;25:199-202.
98. Salehi OA, Karimi A. Ahmadi SH, Davoodi S, et al. Superficial and deep sternal wound infection after more than 9000 coronary artery bypass grafts (CABG): incidence, risk factors and mortality. BMC Infect Dis 2007:7:112. (Pubitemid 350111681)
99. Sanabria A, Dominguez LC, Valdivieso E, Gomez G. Prophylactic antibiotics for mesh inguinal hernioplasty: A meta-analysis. Ann Surg 2007;245:392-6. (Pubitemid 46673135)
100. Schussler O, Dermine H, Alifano M, Casetta A, et al. Should we change antibiotic prophylaxis for lung surgery? Postoperative pneumonia is the critical issue. Ann Thorac Surg 2008;86:1727-33.
101. Scott EM, Buckland R. A systematic review of intraoperative warming to prevent postoperative complications. AORN J 2006;83:1090-104, 1107-13.
102. Seenu V, Hafiz A. Routine antibiotic prophylaxis is not necessary for no scalpel vasectomy. Int Urol Nephrol 2005;37:763-5. (Pubitemid 43124243)
103. Shapiro M. Perioperative prophylactic use of antibiotics in surgery: principles and practice. Infect Control 1982;3:38.
104. Skitarelic N, Morovic M, Manestar D. Antibiotic prophylaxis in clean-contaminated head and neck oncological surgery. J Cranio-Maxillofacial Surg 2007;35:15-20.
105. Slobogean GP, Kennedy SA, Davidson D, O'Brien PJ. Single- versus multiple-dose antibiotic prophylaxis in the surgical treatment of closed fractures: A meta-analysis. J Orthopaedic Trauma 2008;22:264-9. (Pubitemid 351521604)
106. Song F, Glenny AM. Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomised controlled trials. Health Technology Assessment 1998;2:1-110.
107. Soriano A, Bori G, Garcia-Ramiro S, Martinez-Pastor JC, et al. Timing of antibiotic prophylaxis for primary total knee arthroplasty performed during ischemia. Clin Infect Dis 2008;46:1009-14. (Pubitemid 351589865)
108. Stewart AH, Eyers PS, Earnshaw JJ. Prevention of infection in peripheral arterial reconstruction: A systematic review and meta-analysis. J Vas Surg 2007;46:148-55.
109. Su HY, Ding DC, Chen DC, Lu MF, et al. Prospective randomized comparison of single-dose versus 1-day cefazolin for prophylaxis in gynecologic surgery. Acta Obstet Gynecol Scand 2005;84:384-9.
110. Suehiro T, Hirashata T, Araki S, Matsumata T, et al. Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective gastric and colorectal surgery. Hepatogastroenterology 2008;55:1636-9.
111. Suffoletta TJ, Jennings HR, Oh JJ, Stephens D, et al. Continuous versus intermittent infusion of prophylactic cefoxitin after colorectal surgery: a pilot study. Pharmacother 2008;28:1133-9.
112. Susman E. Amoxicillin/clavulanate superior to cefamandol for pneumonia prevention after lung surgery. 39th Annual Meeting of the Society of Thoracic Surgeons; 2003; San Diego.
113. Swoboda S, Oberdorfer K, Klee F, Hoppe-Tichy T, et al. Tissue and serum concentrations of levofloxacin 500 mg administered intravenously or orally for antibiotic prophylaxis in biliary surgery. J Antimicrob Chemother 2003;51:459-62.
114. Tamayo E, Gualis J, Florez S, Castrodeza J, et al. Comparative study of single-dose and 24-hour multiple-dose antibiotic prophylaxis for cardiac surgery. J Thor Cardiov Surg 2008;136:1522-7.
115. Tejirian T, DiFronzo LA, Haigh PI. Antibiotic prophylaxis for preventing wound infection after breast surgery: a systematic review and meta-analysis. J Am Coll Surg 2006;203:729-34. (Pubitemid 44648778)
116. Terai A. Ichioka K, Kohei N, Ueda N, et al. Antibiotic prophylaxis in radical prostatectomy: 1-day versus 4-day treatments. Int J Urol 2006;13:1488-93. (Pubitemid 44786335)
117. Tita ATN, Owen J, Stamm AM, Grimes A, et al. Impact of extended-spectrum antibiotic prophylaxis on incidence of post-cesarean surgical wound infection. Am J Obstet Gynecol 2008;199:303.e1-3.
118. Trautmann M, Stecher J, Hemmer W, Luz K, et al. Intranasal mupirocin prophylaxis in elective surgery: A review of published studies. Chemotherapy 2008;54:9-16. (Pubitemid 350308279)
119. Ulger N, Gulluoglu BM, Cakici O, Akin ML, et al. Do antimicrobial susceptibility patterns of colonic isolates of Bacteroides species change after antibiotic prophylaxis with cefoxitine during elective abdominal surgery? World J Surg 2005;29:1311-5.
120. Van Kasteren MEE. Mannien J, Ott A. Kullberg BJ, et al. Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: Timely administration is the most important factor. Clin Infect Dis 2007;44:921-7.
121. Wacha H. Perioperative Antibiotika zur Verhütung bakterieller Infektionen. Intensiv- u Notfallbehandlung 2002;1:3-15.
122. Wacha H. Wundinfektionen in der Viszeralchirurgie - Ätiologie, Risikofaktoren, Antibiotikaprophylaxe. Zentralbl Chir 2007;132:400-10.
123. Waltrip T, Lewis R, Young V, Farmer M, et al. A pilot study to determine the feasibility of continuous cefazolin infusion. Surg Infect (Larchmt) 2002;3:5-9.
124. Warters RD, Szmuk P, Pivalizza EG, Gebhard RE. et al. The role of anesthesiologists in the selection and administration of perioperative antibiotics: A survey of the American Association of Clinical Directors. Anesth Analg 2006;102:1177-82.
125. Wax DB, Beilin Y, Levin M, Chadha N, et al. The effect of an interactive visual reminder in an anesthesia information management system on timeless of prophylactic antibiotic administration. Anesth Analg 2007;104:1462-6.
126. Weber WP, Marti WR, Zwahlen M, Misteli H, et al. The timing of surgical antimicrobial prophylaxis. Ann Surg 2008;247:918-26.
127. Willemsen I, van den Broek R, Bijsterveldt T, van Hattum P, et al. A standard protocol for perioperative antibiotic prophylaxis is associated with improvement of timing and reduction of costs. J Hosp Infect 2007;67:156-60.
128. Wittmann DH, Welter J, Schassan HH. Antibiotic concentrations in the abdominal cavity as basis for antibacterial therapy of peritonitis: penetration of mezlocillin into the peritoneal exudate. Infection 1982;10(Suppl 3):204-8.
129. Zelenitsky SA, Ariano RE, Harding GKM. Silverman RE. Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 2002;46:3026-30.
130. Zelenitsky SA, Silverman RE. Duckworth H, Harding GK. A prospective, randomized, double-blind study of single high dose versus multiple standard dose gentamicin both in combination with metronidazole for colorectal surgical prophylaxis. J Hosp Infect 2000;46:135-40.
131. Zutt M, Zimmermann O, Krüger U, Kretschmer L. Operative Sanierung florider venöser Ulzera - Wundinfektionsrate unter Antibiogramm- orientierter perioperativer Prophylaxe. Phlebologie 2003;32:121-6.