Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: Timely administration is the most important factor

Clinical Infectious Diseases

Volumn 44, Issue 7, 2007, Pages 921-927

  Van Kasteren, Marjo E E ^a   Manniën, Judith ^b   Ott, Alewijn ^c   Kullberg, Bart Jan ^a   De Boer, Annette S ^b   Gyssens, Inge C ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CEFAMANDOLE; CEFAZOLIN; CEFUROXIME; CEMENT; CLINDAMYCIN; ERYTHROMYCIN; FLUCLOXACILLIN; GENTAMICIN; NETILMICIN;

ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; COST; FEMALE; HOSPITALIZATION; HUMAN; INFECTION; MALE; MORBIDITY; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NETHERLANDS; OPERATION DURATION; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; SURGICAL MORTALITY; SURGICAL SITE INFECTION; TOTAL HIP PROSTHESIS;

AGED; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; ARTHROPLASTY, REPLACEMENT, HIP; CONFIDENCE INTERVALS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERVENTION STUDIES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; POSTOPERATIVE CARE; PREOPERATIVE CARE; PROBABILITY; PROSPECTIVE STUDIES; RISK ASSESSMENT; SURGICAL WOUND INFECTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 33947396054     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/512192     Document Type: Article

References (40)

1. Whitehouse JD, Friedman ND, Kirkland KB, Richardson WJ, Sexton DJ. The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost. Infect Control Hosp Epidemiol 2002; 23:183-9.
2. Coello R, Charlett A, Wilson J, Ward V, Pearson A, Borriello P. Adverse impact of surgical site infections in English hospitals. J Hosp Infect 2005; 60:93-103.
3. Perencevich EN, Sands KE, Cosgrove SE, Guadagnoli E, Meara E, Platt R. Health and economic impact of surgical site infections diagnosed after hospital discharge. Emerg Infect Dis 2003; 9:196-203.
4. Ridgeway S, Wilson J, Charlet A, Kafatos G, Pearson A, Coello R. Infection of the surgical site after arthroplasty of the hip. J Bone Joint Surg Br 2005; 87:844-50.
5. Lentino JR. Prosthetic joint infections: bane of orthopedists, challenge for infectious disease specialists. Clin Infect Dis 2003; 36:1157-61.
6. Norwegian Total Hip Arthroplasty Register. 2006. Available at: http://www.haukeland.no/nrl/report2005.pdf. Accessed 20 June 2006.
7. Manniën J, Wille JC, Snoeren RL, Van den Hof S. Impact of postdischarge surveillance on surgical site infection rates for several surgical procedures: results from the nosocomial surveillance network in The Netherlands. Infect Control Hosp Epidemiol 2006; 27:809-16.
8. Gyssens IC. Preventing postoperative infections: current treatment recommendations. Drugs 1999; 57:175-85.
9. Sia IG, Berbari EF, Karchmer AW. Prosthetic joint infections. Infect Dis Clin North Am 2005; 19:885-914.
10. Dellinger EP, Gross PA, Barrett TL, et al. Quality standard for antimicrobial prophylaxis in surgical procedures. Infect Control Hosp Epidemiol 1994; 15:182-8.
11. Scottish Intercollegiate Network Guidelines. Antibiotic prophylaxis in surgery. 2001. Available at: http://www.sign.ac.uk/guidelines/fulltext/ 45/index.html. Accessed 20 June 2006.
12. Bratzler DW, Houck PM, Surgical Infection Prevention Guidelines Writers Workgroup. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 2004; 38:1706-15.
13. Van Kasteren ME, Gyssens IC, Kullberg BJ, Bruining HA, Stobberingh EE, Goris RJ. Optimizing antibiotics policy in the Netherlands. V. SWAB guidelines for perioperative antibiotic prophylaxis. Working Party on Antibiotic Policies (SWAB). Ned Tijdschr Geneeskd 2000; 144:2049-55.
14. de Boer AS, Geubbels EL, Wille J, Mintjes-de Groot AJ. Risk assessment for surgical site infections following total hip and total knee prostheses. J Chemother 2001; 13(Spec 1):42-7.
15. Geubbels EL, Wille JC, Nagelkerke NJ, Vandenbroucke-Grauls CM, Grobbee DE, de Boer AS. Hospital-related determinants for surgical-site infection following hip arthroplasty. Infect Control Hosp Epidemiol 2005; 26:435-41.
16. Berbari EF, Hanssen AD, Duffy MC, et al. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis 1998; 27:1247-54.
17. Van Kasteren ME, Kullberg BJ, de Boer AS, Mintjes-de Groot J, Gyssens IC. Adherence to local hospital guidelines for surgical antimicrobial prophylaxis: a multicentre audit in Dutch hospitals. J Antimicrob Chemother 2003; 51:1389-96.
18. Van Kasteren ME, Mannien J, Kullberg BJ, et al. Quality improvement of surgical prophylaxis in Dutch hospitals: evaluation of a multi-site intervention by time series analysis. J Antimicrob Chemother 2005; 56:1094-102.
19. Manniën J, van Kasteren ME, Nagelkerke NJ, et al. Effect of optimized antibiotic prophylaxis on the incidence of surgical site infections. Infect Control Hosp Epidemiol 2006; 27:1340-6.
20. Geubbels EL, Mintjes-de Groot AJ, van den Berg JM, de Boer AS. An operating surveillance system of surgical-site infections in The Netherlands: results of the PREZIES national surveillance network Preventie van Ziekenhuisinfecties door Surveillance. Infect Control Hosp Epidemiol 2000; 21:311-8.
21. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Am J Infect Control 1992; 20:271-3.
22. Society for Hospital Epidemiology of America, Association for Practitioners in Infection Control, Centers for Disease Control, Surgical Infection Society. Consensus paper on the surveillance of surgical wound infections. Am J Infect Control 1992; 20:263-70.
23. Owens WD, Felts JA, Spitznagel EL Jr. ASA physical status classifications: a study of consistency of ratings. Anesthesiology 1978; 49:239-43.
24. Culver DH, Horan TC, Gaynes RP, et al. Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance Systam. Am J Med 1991; 91:152S-7S.
25. Miettinen OS. Missing data representation. In: Miettinen OS, ed. Theoretical epidemiology: principles of occurrence research in medicine. New York: John Wiley and Sons, 1985:231-3.
26. de Boer AS, Mintjes-de Groot AJ, Severijnen AJ, van den Berg JM, van Pelt W. Risk assessment for surgical-site infections in orthopedic patients. Infect Control Hosp Epidemiol 1999; 20:402-7.
27. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004; 32:470-85.
28. Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med 1992; 326:281-6.
29. Lizan-Garcia M, Garcia-Caballero J, Asensio-Vegas A. Risk factors for surgical-wound infection in general surgery: a prospective study. Infect Control Hosp Epidemiol 1997; 18:310-5.
30. Burke JF. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery 1961; 50:161-8.
31. Stone HH, Hooper CA, Kolb LD, Geheber CE, Dawkins EJ. Antibiotic prophylaxis in gastric, biliary and colonic surgery. Ann Surg 1976; 184:443-50.
32. Wong-Beringer A, Corelli RL, Schrock TR, Guglielmo BJ. Influence of timing of antibiotic administration on tissue concentrations during surgery. Am J Surg 1995; 169:379-81.
33. Alvarez Ferrero MM, Vree TB, Baars AM, Slooff TJ. Plasma and bone concentrations of cefuroxime and flucloxacillin: oral versus parenteral administration in 20 arthroplasties. Acta Orthop Scand 1993; 64:525-9.
34. Polk R, Hume A, Kline BJ, Cardea J. Penetration of moxalactam and cefazolin into bone following simultaneous bolus or infusion. Clin Orthop Relat Res 1983; 177:216-21.
35. Zelenitsky SA, Ariano RE, Harding GK, Silverman RE. Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 2002; 46:3026-30.
36. Engesaeter LB, Lie SA, Espehaug B, Furnes O, Vollset SE, Havelin LI. Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic prophylaxis systemkally and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register. Acta Orthop Scand 2003; 74:644-51.
37. Polk HC Jr, Trachtenberg L, Finn MP. Antibiotic activity in surgical incisions: the basis of prophylaxis in selected operations. JAMA 1980; 244:1353-4.
38. Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med 1996; 334:1209-15.
39. Belda FJ, Aguilera L, Garcia de la Asuncion, et al. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA 2005; 294:2035-42.
40. Choban PS, Heckler R, Burge JC, Flancbaum L. Increased incidence of nosocomial infections in obese surgical patients. Am Surg 1995; 61:1001-5.