Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production

Molecules and Cells

Volumn 29, Issue 3, 2010, Pages 277-282

  Kim, Youn Young ^a   Kim, Song Hee ^a   Oh, Sora ^a   Sul, Ok Joo ^a   Lee, Hye Young ^a   Kim, Hyun Ju ^b   Kim, Shin Yoon ^b   Choi, Hye Seon ^a  

^a University of Ulsan   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

Bone loss; Fat; MCP 1; Osteoclast formation; Ovariectomy

Indexed keywords

ESTROGEN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE METABOLISM; CELL MATURATION; CONTROLLED STUDY; ESTROGEN DEFICIENCY; LIPID METABOLISM; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ADIPOSE TISSUE; ANIMALS; BONE DENSITY; BONE DISEASES, METABOLIC; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CCL2; ESTROGENS; FEMALE; FEMUR; INTRA-ABDOMINAL FAT; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; OSTEOCLASTS; OVARIECTOMY; RANK LIGAND; RECOMBINANT PROTEINS; SUBCUTANEOUS FAT; WEIGHT GAIN;

MUS;

EID: 77953542456     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0027-x     Document Type: Article

References (42)

1. Arci, A., Senturk, L.M., Seli, E., Bahtiyar, M.O., and Kim, G. (1999). Regulation of monocyte chemoattractant protein-1 expression in human endometrial stromal cells by estrogen and progesterone. Biol. Reprod. 61, 85-90. (Pubitemid 29295971)
2. Baggiolini, M. (1998). Chemokines and leukocyte traffic. Nature 392, 565-568.
3. Bays, H.E., Gonzalez-Compoy, J.M., Bray, G.A., Kitabchi, A.E., Bergman, D.A., Schorr, A.B., Rodbard, H.W., and Henry, R.R. (2008). Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev. Cardiovasc. Ther. 6, 343-368.
4. Binder, N.B., Niederreiter, B., Hoffmann, O., Strange, R., Pap, T., Stulnig, T.M., Mack, M., Erben, R.G., Smolen, J.S., and Redlich, K. (2009). Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med. 15, 417-424.
5. Broulik, P.D., and Kapitola, J. (1993). Interrelations between body weight, cigarette smoking and spine mineral density in osteoporotic Czech women. Endoc. Reg. 2, 57-60.
6. Cenci, S., Weitzmann, M.N., Roggia, C., Namba, N., Novack, D., Woodring, J., and Pacifici, R. (2000). Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J. Clin. Invest. 106, 1229-1237.
7. Ebeling, P.R., Atley, L.M., Guthrie, J.R., Burger, H.G., Dennerstein, L., Hopper, J.L., and Wark, J.D. (1996). Bone turnover markers and bone density across the menopausal transition. J. Clin. Endocrinol. Metab. 81, 3366-3371.
8. Gao, J.J., Gregoire, B.R., and Gao, H. (2009). High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in tibia in mice. Bone 44, 1097-1104.
9. Gui, Y., Silha, J.V., and Murphy, L.J. (2004). Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse. Obs. Res. 12, 1481-1491.
10. Gutierrez, G.E., Edwards, J.R., Garrett, I.R., Nyman, J.S., McCluskey, B., Rossini, G., Flores, A., Neidre, D.B., and Mundy, G.R. (2008). Transdermal lovastatin enhances fracture repair in rats. J. Bone Miner. Res. 23, 1722-1730.
11. Heine, P.A., Taylor, J.A., Iwamoto, G.A., Lubahn, D.B., and Cooke, P.S. (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 97, 12729-12734.
12. Hopwood, B., Tsykin, A., Findlay, D.M., and Fazzalari, N.L. (2009). Gene expression profile of the bone microenvironment in human fracture bone. Bone 44, 87-101.
13. Johnson, G.B., Riggs, B.L., and Platt, J.L. (2004). A genetic basis for the "Adonis" phenotype of low adiposity and strong bones. FASEB J. 18, 1282-1284.
14. Karelis, A.D., St-Pierre, D.H., Conus, F., Rabasa-Lhoret, R., and Poehlman, E.T. (2004). Metabolic and body composition factors in subgroups of obesity: what do we know? J. Clin. Endocrinol. Metab. 89, 2569-2675.
15. Kim, M.S., Days, C.J., and Morrison, N.A. (2005). MCP-1 is induced by receptor activator of NF-κB ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony stimulating factor suppression of osteoclast formation. J. Biol. Chem. 280, 16163-16169.
16. Kimble, R.B., Srivastava, S, Ross, F.P., Matayoshi, A., and Pacifici, R. (1996). Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin1and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J. Biol. Chem. 271, 28890-28897.
17. Kobayashi, K., Takahashi, N., Jimi, E., Udagawa, N., Takami, M., Kotake, S., Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., et al. (2000) Tumor necrosis factor stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J. Exp. Med. 191, 275-285.
18. Koh, K.K., Son, J.W., Ahn, J.Y., Lee, S.K., Hwang, H.Y., Kim, D.S., Jin, D.K., Ahn, T.H., and Shin, E.K. (2001). Effect of hormone replacement therapy on nitric oxide bioactivity and monocyte chemoattractant protein-1 levels. Int. J. Cardiol. 81, 43-50.
19. Kyung, T.W., Lee, J.E., Van Phan, T., Yu, R., and Choi, H.S. (2009). Osteoclastogenesis by bone marrow-derived macrophages is enhanced in obese mice. J. Nutr. 139, 502-506.
20. Lean, J.M., Davies, J.T., Fuller, K., Jagger, C.J., Kirstein, B., Partington, G.A., Urry, Z.L., and Chambers, T.J. (2003). A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J. Clin. Invest. 112, 915-923.
21. Lee, J.E., Shin, H.H., Lee, E.A., Phan, T.V., and Choi, H.S. (2007). Stimulation of osteoclastogenesis by enhanced level of MIP-1alpha in BALB/c mice. Exp. Hematol. 35, 1100-1108.
22. Lee, S.K., Choi, B.K., Kang, W.J., Kim, Y.H., Park, H.Y., Kim, K.H., and Kwon, B.S. (2008). MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4+ T cells in herpetic stromal keratitis Mol. Cells 26, 67-73
23. -ΔΔCt method. Methods 25, 402-408.
24. Lu, Y., Cai, Z., Xiao, G., Keller, E.T., Mizokami, A., Yao, Z., Roodman, G.D., and Zhang, J. (2007). Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption. Cancer Res. 67, 3646-3653.
25. Naaz, A., Yellayi, S., Zakroczymski, M.A., Bunick, D., Doerge, D.R., Lubahn, D.B., Helferich, W.G., and Cooke, P.S. (2003) The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology 144, 3315-3320.
26. Oh, S.R., Sul, O.J., Kim, Y.Y., Kim, H.J., Yu, R., Suh, J.H., and Choi, H.S. (Epub 2009). Saturated fatty acids enhance osteoclast survival. J. Lipid Res.
27. Pacifici, R. (1996). Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J. Bone Miner. Res. 11, 1043-1051.
28. Parfitt, AM., Villanueva, A.R., Folddes, J., and Rao, D.S. (1995). Relations between histologic indices of bone formation: implications for the pathogenesis of spinal osteoporosis. J. Bone Miner. Res. 10, 466-473.
29. Parhami, F., Tintut, Y, Beamer, W.G., Gharavi, N., Goodman, W., and Demer, L.L. (2001). Atherogenic high-fat diet reduces bone mineralization in mice. J. Bone Miner. Res. 16, 182-188.
30. Rollins, B.J. (1997). Chemokines. Blood 90, 909-928.
31. Sartipy, P., and Loskutoff, D.J. (2003). Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc. Natl. Acad. Sci. USA 100, 7265-7270.
32. Sheng, Z.F., Xu, K., Ma, Y.L., Liu, J.H., Dai, R.C., Zhang, Y.H., Jiang, Y.B., and Liao, E.Y. (2009). Zoledronate reverses mandibular bone loss in osteoprotegrin-deficient mice. Osteoporosis Int. 20, 151-159.
33. Shinoda, M., Latour, M.G., and Lavoie, J.M. (2002). Effects of physical training on body composition and organ weights in ovariectomized and hyperestrogenic rats. Int. J. Obes. 26, 335-345.
34. Srivastava, S, Toraldo, G, Weitzmann, M.N., Cenci, S., Ross, F.P., and Pacifici, R. (2001). Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J. Biol. Chem. 276, 8836-8840.
35. Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T., and Martin, T.J. (1999). Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20, 345-357. (Pubitemid 30649812)
36. Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., and Kotani, H. (2003). Adiposity elelvates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J. Biol. Chem. 278, 46654-46660.
37. Tan, G.D., Goossens, G.H., Humphreys, S.M., Vidal, H., and Karpe, F. (2004). Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans. Obes. Res. 12, 114-118.
38. Tintut, Y., Morony, S., and Demer, L.L. (2004). Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Thromb. Vasc. Biol. 24, e6-e10.
39. Uzzan, B., Cohen, R., Nicolas, P., Cucherat, M., and Perret, G.Y. (2007). Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone 40, 1581-1587.
40. van Royen, N., Hoefer, I., Buschmann, I., Kostin, S., Voskuil, M., Bode, C.H., Schaper, W., and Piek, J.J. (2003). Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits. Cardiovasc. Res. 57, 178-185.
41. Wade, G.N., and Gray, J.M. (1985). Gonadal influences on adiposity. Int. J. Obes. 9 (Suppl 1), 83-92.
42. Weizmann, M.N., and Pacifici, R. (2006). Estrogen deficiency and bone loss: an inflammatory tale. J. Clin. Invest. 116, 1186-1194.