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This is an informative review of degenerative aortic valve disease pathophysiology and therapeutic options
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This is a thorough review highlighting all experimental models of AS
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This is the only prospective study to demonstrate beneficial effect of statins on AS progression
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Moura LM, Ramos SF, Zamorano JL, et al.: Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007, 49:554-561. This is the only prospective study to demonstrate beneficial effect of statins on AS progression.
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Miller JD, Weiss RM, Serrano KM, et al.: Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 2009, 119:2693-2701.
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Nature
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This is an informative review highlighting genetic mutations that have been associated with AS
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Bosse Y, Mathieu P, Pibarot P: Genomics: The next step to elucidate the etiology of calcific aortic valve stenosis. J Am Coll Cardiol 2008, 51:1327-1336. This is an informative review highlighting genetic mutations that have been associated with AS.
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Zajarias A, Cribier AG: Outcomes and safety of percutaneous aortic valve replacement. J Am Coll Cardiol 2009, 53:1829-1836. This is a recent review summarizing patient outcomes and safety with percutaneous aortic valve replacement.
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