Association study of RGS2 gene polymorphisms with panic disorder in Japanese

Kobe Journal of Medical Sciences

Volumn 55, Issue 5, 2009, Pages

  Mouri, Kentaro ^a   Hishimoto, Akitoyo ^a   Fukutake, Masaaki ^a   Nishiguchi, Naoki ^b   Shirakawa, Osamu ^b   Maeda, Kiyoshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Case control study; Linkage disequilibrium; Panic disorder; Polymorphisms; RGS2

Indexed keywords

RGS2 PROTEIN;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA FLANKING REGION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PANIC; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PANIC DISORDER; POLYMORPHISM, SINGLE NUCLEOTIDE; RGS PROTEINS;

EID: 77953521836     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Barrett, JC., Fry, B., and Maller, J. 2005. Haploview: analysis and visualization ofLD and haplotype maps. Bioinformatics.21:263-265.
2. Cui, H., Nishiguchi, N., and Ivleva, E. 2008. Association of RGS2 genepolymorphisms with suicide and increased RGS2 immunoreactivity in the postmortembrain of suicide victims. Neuropsychopharmacology. 33:1537-1544.
3. Dupont, WD., and Plummer, WD Jr. 1998.Power and sample size calculations forstudies involving linear regression. Control Clin Trials. 19:589-601.
4. Ghavami, A., Hunt, RA., and Olsen, MA. 2004. Differential effects of regulator ofGprotein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2receptor-mediated signaling and adenylyl cyclase activity. Cell Signal.16:711-721.
5. Goodwin, RD., Faravelli, C., and Rosi, S. 2005. The epidemiology of panic disorderand agoraphobia in Europe. Eur Neuropsychopharmacol.15:435-443.
6. Gross, V., Tank, J., and Obst, M. 2005. Autonomic nervous system and bloodpressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol.288:R1134-R1142.
7. Hettema, JM., Neale, MC., and Kendler, KS. 2001. A review and meta-analysis ofthe genetic epidemiology of anxiety disorders. Am J Psychiatry. 158:1568-1578.
8. Ingi, T., and Aoki, Y. 2002.Expression of RGS2, RGS4 and RGS7 in the developingpostnatal brain. Eur J Neurosci. 15:929-936.
9. Ingi, T., Krumins, AM., and Chidiac, P. 1998. Dynamic regulation of RGS2 suggestsa novel mechanism in G-protein signaling and neuronal plasticity. JNeurosci.18:7178-7188.
10. Leygraf A., Hohoff C., Freitag C., 2006. Rgs 2 gene polymorphisms asmodulators of anxiety in humans? J Neural Transm. 113:1921-1925.
11. Neubig, RR., and Siderovski, DP. 2002.Regulators of G-protein signalling as newcentral nervous system drug targets. Nat Rev Drug Discov.1:187-197.
12. Oliveira-Dos-Santos, AJ., Matsumoto G., Snow B.E., 2000. Regulation of T cellactivation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U SA.97:12272-12277.
13. Semplicini, A., Lenzini L., Sartori M., 2006.Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilizationand ERK1/2 phosphorylation induced by angiotensin II. J Hypertens.24:1115-1124.
14. Smoller, JW., Acierno, JS., and Rosenbaum, JF. 2001. Targeted genome screen ofpanic disorder and anxiety disorder proneness using homology to murine QTL regions.Am J Med Genet. 105:195-206.
15. Weissmann, MM., Bland, RC., and Canino, GJ. 1997. The crossnationalepidemiology of panic disorder. Arch Gen Psychiatry.54:305-309.
16. Yalcin, B., Willis-Owen, SAG., and Fullerton, J. 2004.Genetic dissection ofabehavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. NatGenet. 36:1197-11202.