A quarter of a century of progress to prevent vitamin A deficiency through supplementation

Food Reviews International

Volumn 26, Issue 3, 2010, Pages 270-301

  Palmer, Amanda C ^a   West Jr , Keith P ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Child mortality; Supplementation; Vitamin A deficiency; Xerophthalmia

Indexed keywords

CHILD MORTALITY; FOOD FORTIFICATION; GLOBAL PUBLIC HEALTH; HEALTH IMPLICATIONS; PRESCHOOL CHILDREN; SUPPLEMENTATION; VITAMIN A DEFICIENCIES; XEROPHTHALMIA;

DEVELOPING COUNTRIES; PUBLIC HEALTH;

DIETARY SUPPLEMENTS;

EID: 77953521002     PISSN: 87559129     EISSN: 15256103     Source Type: Journal    
DOI: 10.1080/87559129.2010.484116     Document Type: Article

References (176)

1. West, K.P.; Sommer, A. Delivery of oral doses of vitamin A to prevent vitamin A deficiency and nutritional blindness. Food Reviews International 1985,1, 355-418.
2. Sommer, A.; Tarwotjo, I.; Hussaini, G.; Susanto, D.; Soegiharto, T. Incidence, prevalence, and scale of blinding malnutrition. Lancet 1981, 1, 1407-1408.
3. Sommer, A.; Katz, J.; Tarwotjo, I. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am. J. Clin. Nutr. 1984, 40, 1090-1095.
4. Sommer, A.; Tarwotjo, I.; Hussaini, G.; Susanto, D. Increased mortality in children with mild vitamin A deficiency. Lancet 1983, 2, 585-588.
5. Sommer, A.; Tarwotjo I.; Djunaedi E.; West, K.P., Jr.; Loeden, A.A.; Tilden, R.; Mele, L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. Lancet, 1986, 1, 1169-1173.
6. Muhilal, P.D.; Idjradinata, Y.R.; Muherdiyantiningsih, K.D. Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. Am. J. Clin. Nutr. 1988, 48, 1271-1276.
7. West, K.P., Jr.; Pokhrel, R.P.; Katz, J.; LeClerq, S.C.; Khatry, S.K.; Shrestha, S.R.; Pradhan, E.K.; Tielsch, J.M.; Pandey, M.R.; Sommer, A. Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet, 1991, 338, 67-71.
8. Daulaire, N.M.; Starbuck, E.S.; Houston, R.M.; Church, M.S.; Stukel, T.A.; Pandey, M.R. Child-hood mortality after a high dose of vitamin A in a high risk population. Bmj 1992, 304, 207-210.
9. Rahmathullah, L. Effect of receiving a weekly dose of vitamin A equivalent to the recommended dietary allowances among preschool children on mortality in south India. Indian J. Pediatr., 1991, 58, 837-847.
10. Ghana VAST Study Team. Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality. The Lancet 1993, 342: 7.
11. Beaton, G.H.; Martorell, R.; Aronson, K.J.; Edmonston, B.; McCabe, G.; Ross, A.C.; Harvey, B. In Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries, Nutrition Policy Discussion Paper No. 13; Administrative Committee on Coordination-Subcommittee on Nutrition (ACC/SCN)Geneva, Switzerland, 1993.
12. Tonascia, J.A. Meta-analysis of published community trials of the impact of vitamin A on mortality. Proceedings of the Bellagio Meeting on Vitamin A Deficiency and Childhood Mortality. Helen Keller International: New York, NY, 1993, 49-51.
13. Fawzi, W.W.; Chalmers, T.C.; Herrera, M.G.; Mosteller, F. Vitamin A supplementation and child mortality. A meta-analysis. Jama 1993, 269, 898-903.
14. Sommer, A.; West, K.P., Jr. Vitamin A deficiency: Health, survival and vision. New York: Oxford University Press, 1996; 456.
15. West, K.P., Jr.; Darnton-Hill, I. Vitamin A deficiency. In: Nutrition and Health in Developing Countries, 2nd ed.; Semba, R.D.; Bloem, M.; Eds. The Humana Press, Inc.: Totowa, NJ, 2008; 267-306.
16. Reddy, V. History of the International Vitamin A Consultative Group 1975-2000. J Nutr. 2002, 132, 2852S-2856S.
17. Helen Keller International. In Bellagio meeting on vitamin A deficiency and childhood mortality, Proceedings of "Public Health Significance of Vitamin A Deficiency and Its Control", Bellagio, Italy, February 3-7, 1992. Helen Keller International, New York, 1993, 76.
18. WHO; UNICEF; World Bank; CIDA; USAID; FAO; UNDP. In Ending hidden hunger: A policy conference on micronutrient malnutrition, Proceedings of "Ending Hidden Hunger,". Montreal, Canada, 10-12 October 1991; Micronutrient Initiative; Ottawa, 1992, 250.
19. IVACG. 25 Years of progress in controlling vitamin A deficiency: looking to the future. Proceedings and abstracts of the XX International Vitamin A Consultative Group Meeting. Hanoi, Vietnam, 12-15 February 2001. J Nutr 2002, 132, 2843S-2990S.
20. United Nations Children's Fund. Vitamin A Supplementation: A decade of progress. UNICEF: New York, NY, 2007, 32.
21. The Micronutrient Initiative. Food Fortification to End Micronutrient Malnutrition. State of the Art. The Micronutrient Initiative, International Development Research Center Ottawa, Canada: 1997, 116.
22. World Health Organization. The Global Prevalence of Vitamin A Deficiency. Micronutrient Deficiency Information System (MDIS) Working Paper no. 2 (WHO/NUT/95.3). World Health Organization: Geneva, Switzerland, 1995, 116.
23. The Micronutrient Initiative. Progress in Controlling Vitamin A Deficiency; The Micronutrient Initiative, UNICEF, Tulane University: Ottawa, Canada, 1998, 140.
24. Humphrey, J.H.; West, K.P., Jr.; Sommer, A. Vitamin A deficiency and attributable mortality among under-5-year-olds. Bull World Health Organ 1992, 70, 225-232.
25. West, K.P., Jr. Extent of Vitamin A Deficiency among Preschool Children and Women of Reproductive Age. J. Nutr. 2002, 132, 2857S-2866.
26. World Health Organization. Global prevalence of vitamin A deficiency in populations at risk 1995-2005. WHO Global Database on Vitamin A Deficiency. World Health Organization: Geneva, 2009, 116.
27. Rice, A.L.; West, K.P., Jr.; Black, R.E. Vitamin A deficiency. In: Comparative Quantification of Health Risks. Global and Regional Burden of Disease Attributable to Selected Major Risk Factors; Ezzati, M.; Lopez, A.D.; Rodgers, A.; Murray, C.J.L.; eds.; World Health Organization: Geneva, 2004; 211-256.
28. Sommer, A.; Davidson, F.R. Assessment and control of vitamin A deficiency: the Annecy Accords. J. Nutr. 2002, 132, 2845S-2850S.
29. Ross, D.A. Recommendations for vitamin A supplementation. J. Nutr. 2002, 132, 2902S-2906S.
30. West, K.P., Jr.; Katz, J.; Khatry, S.K; LeClerq, S.C.; Pradhan, E.K.; Shrestha, S.R.; Connor, P.B.; Dali, S.M.; Christian, P.; Pokhrel, R.P.; Sommer, A. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. Bmj 1999, 18, 570-575.
31. Christian, P.; West, K.P., Jr.; Khatry, S.K.; Katz, J.; Shrestra, S.R.; Pradhan, E.K.; LeClerq, S.C.; Pokhrel, R.P. Night blindness of pregnancy in rural Nepal-nutritional and health risks. Int. J. Epidemiol. 1998;27:231-237.
32. Christian, P.; West, K.P., Jr.; Khatry, S.K.; Kimbrough-Pradhan, E.; LeClerq, S.C.; Katz, J.; Shrestha, S.R.; Dali, S.M.; Sommer, A. Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and beta-carotene supplementation. Am. J. Epidemiol. 2000, 152, 542-547.
33. Humphrey, J.H.; Agoestina, T.; Wu, L.; Usman, A.; Nurachim, M.; Subardja, D.; Hidayat, S.; Tielsch, J.; West, K.P., Jr.; Sommer, A. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J. Pediatr. 1996, 128, 489-496.
34. Rahmathullah, L.; Tielsch, J.M.; Thulasiraj, R.D.; Katz, J.; Coles, C.; Devi, S.; John, R.; Prakash, K.; Sandanand, A.V.; Edwin, N.; Kamaraj, C. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 2003, 327, 254.
35. Klemm, R.D.; Labrique, A.B.; Christian, P.; Rashid, M.; Shamim, A.A.; Katz, J.; Sommer, A.; West, K.P., Jr. Newborn vitamin A supplementation reduced infant mortality in rural Bangladesh. Pediatrics 2008, 122, e242-250.
36. West, K.P., Jr. In Newborn Vitamin A Dosing: Policy Implications for Southern Asia and Africa, Proceedings of the First Meeting of the Micronutrient Forum: Istanbul, Turkey, 16-18 April 2007, Sight and Life, 2007, 40-42.
37. Sommer, A. Vitamin A deficiency and its consequences: a field guide to detection and control. World Health Organization: Geneva, Switzerland, 1995, 78.
38. Lamb, T.D.; Pugh, Jr., E.N. Dark adaptation and the retinoid cycle of vision. Prog. Retin. Eye Res. 2004, 23, 307-380.
39. Wittpenn, J.; Sommer, A. Clinical aspects of vitamin A deficiency. In: Vitamin A deficiency and its control; J.C. B, ed.; Academic Press: Orlando, FL, 1986, 177-206.
40. Christian, P. Recommendations for indicators: night blindness during pregnancy-a simple tool to assess vitamin A deficiency in a population. J. Nutr. 2002, 132, 2884S-2888S.
41. Saunders, C.; do Carmo Leal, M.; Gomes, M.M.; Campos, L.F.; dos Santos Silvia, B.A.; Thiapode Lima, A.P.; Ramalho, R.A. Gestational nightblindness among women attending a public maternity hospital in Rio de Janeiro, Brazil. J Health. Popul. Nutr. 2004, 22, 348-356.
42. Saunders, C.; Ramalho, R.A.; de Lima, A.P.; Gomes, M.M.; Campos, L.F.; dos Santos Silva, B.A.; Goncalves Soores, A.; do Carmo Leal, M. Association between gestational night blindness and serum retinol in mother/newborn pairs in the city of Rio de Janeiro, Brazil. Nutrition 2005, 21, 456-461.
43. Katz, J.; Zeger, S.L.; Tielsch, J.M. Village and household clustering of xerophthalmia and trachoma. Int. J. Epidemiol. 1988, 17, 865-869.
44. Gittelsohn, J.; Shankar, A.V.; West, K.P. Jr., Ram, R.; Dhungel, C.; Dahal, B.; Infant feeding practices reflect antecedent risk of xerophthalmia in Nepali children. Eur. J. Clin. Nutr. 1997, 51,484-490.
45. Semba, R.D.; de Pee, S.; Panagides, D.; Poly, O.; Bloem, M.W. Risk factors for xerophthalmia among mothers and their children and for mother-child pairs with xerophthalmia in Cambodia. Arch. Ophthalmol. 2004, 122, 517-523.
46. Katz, J.; Zeger, S.L.; West, K.P., Jr.; Tielsch, J.M.; Sommer, A. Clustering of xerophthalmia within households and villages. Int. J. Epidemiol. 1993, 22, 709-715.
47. de Pee, S.; Dary, O. Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. J. Nutr. 2002, 132, 2895-2901.
48. Beisel, W.R. Infection-induced depression of serum retinol--a component of the acute phase response or a consequence? Am. J. Clin. Nutr 1998, 68, 993-994.
49. Thurnham, D.I.; Mburu, A.S.; Mwaniki, D.L.; De Wagt, A. Micronutrients in childhood and the influence of subclinical inflammation. Proc. Nutr. Soc. 2005, 64,502-509.
50. Shankar, A.H.; Genton, B.; Semba, R.D.; Baisor, M.; Paino, J.; Tamja, S.; Adiguma, T.; Wu, L.; Rare, L.; Tielsch, J.M.; Alpers, M.P.; West, K.P., Jr. Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 1999, 354, 203-209.
51. Congdon, N.G.; West, K.P., Jr.; Physiologic indicators of vitamin A status. J. Nutr. 2002, 132, 2889S-2894S.
52. Rahmathullah, L.; Raj, M.S.; Chandravathi, T.S. Aetiology of severe vitamin A deficiency in children. Natl. Med. J. India 1997, 10, 62-65.
53. Khan, M.A.; Khan, M.D. Classification of 154 clinical cases of vitamin A deficiency in children (0-15 years) in a tertiary hospital in North West Frontier Province Pakistan. J. Pak. Med. Assoc. 2005;55, 77-78.
54. Aamoon, A.Z.; Sharif, K. Keratomalacia in northern Afghanistan. Community Eye Health 1998, 11, 32.
55. Semba, R.D.; Susatio, B.; Muhilal, N.G. The decline of admissions for xerophthalmia at Cicendo Eye Hospital, Indonesia, 1981-1992. Int Ophthalmol 1995, 19, 39-42.
56. Singh, V.; West, K.P., Jr. Vitamin A deficiency and xerophthalmia among school-aged children in Southeastern Asia. Eur. J. Clin. Nutr.2004, 58, 1342-1349.
57. Tielsch, J.M.; Rahmathullah, L.; Katz, J.; Thulasiraj, R.D.; Coles, C.; Sheeladevi, S.; Prakash, K. Maternal night blindness during pregnancy is associated with low birthweight, morbidity, and poor growth in South India. J. Nutr. 2008; 138, 787-792.
58. Humphrey, J.H.; Rice, A.L. Vitamin A supplementation of young infants. Lancet 2000, 356, 422-424.
59. West, K.P., Jr. Public health impact of preventing vitamin A deficiency in the first six months of life. In: Micronutrient Deficiencies in the First Months of Life, Nestle Nutrition Workshop Series Pediatric Program, Vol. 52; Delange, F.M.; West, K.P., Jr.; Eds.; Nestle Nutrition/Basel: Karger: Vevey, Switzerland:, 2003, 103-127.
60. Miller, M.; Humphrey, J.; Johnson, E.; Marinda, E.; Brookmeyer, R.; Katz, J. Why do children become vitamin A deficient? J. Nutr. 2002, 132, 2867S-2880S.
61. West, K.P., Jr. Vitamin A deficiency disorders in children and women. Food Nutr. Bull. 2003, 24, S78-90.
62. West, K.P., Jr.; McLaren, D.S. The epidemiology of vitamin A deficiency disorders. In: Epidemiology of Eye Disease, 2nd ed.; Johnson, G.J.; Minassian, D.C.; Weale, R.; West, S.; eds.; Medical & Health Sciences Publishing: London, 2003, 240-259.
63. Schmitz, J. Preschool Vitamin A Supplementation, Middle Ear Infection, and Young Adult Hearing Loss in Nepal. Department of International Health, Johns Hopkins University: Baltimore, MD, 2008, 229.
64. Stephensen, C.B., Vitamin A infection, and immune function. Annu. Rev. Nutr. 2001, 21, 167-192.
65. Semba, R.D. The role of vitamin A and related retinoids in immune function. Nutr. Rev. 1998, 56,S38-48.
66. Villamor, E.; Fawzi, W.W. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin. Microbiol. Rev. 2005, 18, 446-464.
67. Abdeljaber, M.H.; Monto, A.S.; Tilden, R.L.; Schork, M.A.; Tarwotjo, I. The impact of vitamin A supplementation on morbidity: a randomized community intervention trial. Am J Public Health 1991, 81, 1654-1656.
68. Rahmathullah, L.; Underwood, B.A.; Thulasiraj, R.D.; Milton, R.C. Diarrhea, respiratory infections, and growth are not affected by a weekly low-dose vitamin A supplement: a masked, controlled field trial in children in southern India. Am. J. Clin. Nutr. 1991, 54, 568-577.
69. Arthur, P.; Kirkwood, B.; Ross, D.; Morris, S.; Gyapong, J.; Tomkins, A.; Addy, H. Impact of vitamin A supplementation on childhood morbidity in northern Ghana. Lancet 1992, 339, 361-362.
70. Bhandari, N.M.K.; Sazawal, S. Impact of massive dose of vitamin A given to preschool children with acute diarrhoea on subsequent respiratory and diarrhoeal morbidity. Bmj 1994;, 309, 1404-1407.
71. Sommer, A.; West, K.P., Jr. Vitamin A and childhood morbidity. Lancet 1992, 339, 1302-1303.
72. Martorell, R.; Ho, T.J. Malnutrition, morbidity, and mortality. Popul. Dev. Rev. 1984, 10 (suppl), 49-68.
73. Sommer, A. Vitamin A, infectious disease, and childhood mortality: a 2 solution? J Infect Dis 1993, 167, 1003-1007.
74. Barreto, M.L.; Santos, L.M.; Assis, A.M.; Araujo, M.P.; Farenzena, G.G.; Santos, P.A.; Fiaccone, R.L. Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory-tract infections in young children in Brazil. Lancet 1994, 344, 228-231.
75. Biswas, R.; Biswas, A.B; Manna, B.; Bhattacharya, S.K.; Dey, R.; Sarkar S. Effect of vitamin A supplementation on diarrhoea and acute respiratory tract infection in children. A double blind placebo controlled trial in a Calcutta slum community. Eur. J. Epidemiol. 1994, 10, 57-61.
76. Coutsoudis, A.; Kiepiela, P.; Coovadia, H.M.; Broughton, M. Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles. Pediatr. Infect. Dis. J. 1992, 11, 203-209.
77. The Vitamin A and Pneumonia Working Group. Potential interventions for the prevention of childhood pneumonia in developing countries: a meta-analysis of data from field trials to assess the impact of vitamin A supplementation on pneumonia morbidity and mortality. Bull World Health Organ. 1995, 73, 609-619.
78. Coles, C.L.; Rahmathullah, L.; Kanungo, R.; Thulasiraj, R.D.; Katz, J.; Santhosham, M.; Tielsch, J.M. Vitamin A supplementation at birth delays pneumococcal colonization in South Indian infants. J. Nutr. 2001, 131, 255-261.
79. Ellison, J.B. Intensive vitamin therapy in measles. Br. Med. J. 1932, 2, 708-711.
80. Semba, R.D. Vitamin A as "anti-infective" therapy, 1920-1940. J. Nutr. 1999, 129, 783-791.
81. Glasziou, P.P.; Mackerras, D.E. Vitamin A supplementation in infectious diseases: a meta-analysis. Bmj 1993, 306, 366-370.
82. Ramakrishnan, U.; Latham, M.C.; Abel, R. Vitamin A supplementation does not improve growth of preschool children: a randomized, double-blind field trial in south India. J. Nutr. 1995, 125, 202-211.
83. Kirkwood, B.R.; Ross, D.A.; Arthur, P.; Morris, S.S.; Dollimore, N.; Binka, F.N.; Shier, R.P.; Gyapong, J.O.; Addy, H.A.; Smith, P.G. Effect of vitamin A supplementation on the growth of young children in northern Ghana. Am. J. Clin. Nutr. 1996, 63, 773-781.
84. Fawzi, W.W.; Herrera, M.G.; Willett, W.C.; Nestel, P.; el Amin, A.; Mohamed, K.A. The effect of vitamin A supplementation on the growth of preschool children in the Sudan. Am. J. Public Health 1997, 87, 1359-1362.
85. Bahl, R.; Bhandari, N.; Taneja, S.; Bhan, M.K. The impact of vitamin A supplementation on physical growth of children is dependent on season. Eur. J. Clin. Nutr. 1997, 51, 26-29.
86. West, K.P., Jr.; LeClerq, S.C.; Shrestha, S.R.; Wu, L.S.; Pradhan, E.K.; Khatry, S.K.; Katz, J.; Adhikari, R.; Sommer, A. Effects of vitamin A on growth of vitamin A-deficient children: field studies in Nepal. J. Nutr. 1997, 127, 1957-1965.
87. Hadi, H.; Stoltzfus, R.J.; Dibley, M.J.; Moulton, L.H.; West, K.P., Jr.; Kjolhede, C.L.; Sadjimin, T. Vitamin A supplementation selectively improves the linear growth of indonesian preschool children: results from a randomized controlled trial. Am. J. Clin. Nutr. 2000, 71, 507-513.
88. Hadi, H.; Dibley, M.J.; West, K.P., Jr. Complex interactions with infection and diet may explain seasonal growth responses to vitamin A in preschool aged Indonesian children. Eur. J. Clin. Nutr. 2004;, 58, 990-999.
89. Semba, R.D.; Bloem, M.W. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur. J. Clin. Nutr. 2002, 56, 271-281.
90. Fishman, S.M.; Christian, P.; West, K.P. The role of vitamins in the prevention and control of anaemia. Public Health Nutr. 2000,3, 125-150.
91. Bloem, M.W. Interdependence of vitamin A and iron: an important association for programmes of anaemia control. Proc. Nutr. Soc. 1995, 54, 501-508.
92. Ross, A.C. The relationship between innumocompetence and vitamin A status. In: Vitamin A deficiency: health, survival and vision; Sommer, A.; West, K.P., Jr.; Eds.; Oxford University Press: New York, 1996; 251-273.
93. Beisel, W.R.; Black, R.E.; West, K.P., Jr. Micronutrients in infection. In: Tropical infectious diseases: principles, pathogens & practice; Guerrant, R.L.; Walker, D.H.; Weller, P.F.; Eds.; Churchill Livingstone: Philadelphia, 1999; 76-87.
94. West, K.P., Jr.; Gernand, A.D.; Sommer, A. Vitamin A in nutritional anemia. In: Nutritional Anemia; Kraemer, K.; Zimmerman, M.B.; Eds.; Sight and Life: Basel, Switzerland, 2007; 133-154.
95. United Nations. World Declaration on the Survival, Protection and Development of Children; and Plan of Action for Implementing the World Declaration on the Survival, Protection and Development of Children in the 1990s, Proceedings of the World Summit for Children, New York, 30 September 1990; United Nations: New York, NY, 1990.
96. Food and Agriculture Organization, World Health Organization. In World Declaration and Plan of Action for Nutrition (ICN/92/2). International Conference on Nutrition, December 1992, Rome, Italy: FAO/WHO: Rome, 1992.
97. United Nations Children's Fund. Progress towards ensuring adequate vitamin A intakes; UNICEF: New York, NY, 1995, 28.
98. UNICEF, MI, WHO, CIDA, USAID. A Strategy for Acceleration of Progress in Combating Vitamin A Deficiency, Informal Technical Consultation or Vitamin A Deficiency Control 18-19 December 1997, New York; UNICEF. 99.
99. West, C.E.; Eilander, A.; van Lieshout, M. Consequences of revised estimates of carotenoid bioefficacy for dietary control of vitamin A deficiency in developing countries. J. Nutr. 2002, 132, 2920S-2926S.
100. Toenniessen, G.H. Crop genetic improvement for enhanced human nutrition. J. Nutr. 2002, 132, 2943S-2946S.
101. Sautter, C.; Poletti, S.; Zhang, P.; Gruissem, W. Biofortification of essential nutritional compounds and trace elements in rice and cassava. Proc. Nutr. Soc. 2006, 65, 153-159.
102. Hagenimana, V.; Oyunga, M.A.; Low, J.; Njoroge, S.M.; Gichuki, S.T.; Kabira, J. The Effects of Women Farmers' Adoption of Orange-Fleshed Sweet Potatoes: Raising Vitamin A Intake in Kenya. International Center for Research on Women: Washington, DC, 1999.
103. Low J, Arimond M, Osman N, et al. Towards sustainable nutrition improvement in rural Mozambique: addressing macro- and micronutrient malnutrition through new cultivars and new behaviors. 2005.
104. Beyer, P.; Al-Babili, S.; Ye, X.; et al. Golden Rice: Introducing the {beta}-Carotene Biosynthesis Pathway into Rice Endosperm by Genetic Engineering to Defeat Vitamin A Deficiency. J. Nutr. 2002, 132, 506S-510.
105. Mora, J.O.; Dary, O.; Chinchilla, D.; Arroyave G. Vitamin A Sugar Fortification in Central America: Experience and Lessons Learned; MOST/United States Agency for International Development: Arlington, VA, 2000, 69.
106. WHO/UNICEF/IVACG. Vitamin A supplements: a guide to their use in the treatment and prevention of vitamin A deficiency and xerophthalmia; WHO/UNICEF/IVACG: Geneva, 1997, 28.
107. Rahmathullah, L.; Underwood, B.A.; Thulasiraj, R.D.; Katz, J.; Coles, C.; Devi, S.; John, R.; Prakash, K.; Sandanand, A.V.; Edwin, N.; Kamaraj, C. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. N. Engl. J. Med. 1990, 323, 929-935.
108. Daulaire, N.M. Childhood mortality after high dose vitamin A. Bmj 1992, 304, 1381.
109. Vijayaraghavan, K.; Radhaiah, G.; Prakasam, B.S.; Sarma, K.V.; Reddy, V. Effect of massive dose vitamin A on morbidity and mortality in Indian children. Lancet 1990, 336, 1342-1345.
110. Herrera, M.G.; Nestel, P.; el Amin, A.; Fawzi, W.W.; Mohamed, K.A.; Weld, L. Vitamin A supplementation and child survival. Lancet 1992, 340, 267-271.
111. Binka, F.N.; Ross D.A.; Morris, S.S.; Kirkwood, B.R.; Arthur, P.; Dollimore, N.; Gyapong, J.O.; Smith, P.G. Vitamin A supplementation and childhood malaria in northern Ghana. Am. J. Clin. Nutr. 1995, 61, 853-859.
112. Stoltzfus, R.J.; Hakimi, M.; Miller, K.W.; Rasmussen, K.M.; Dawiesah, S.; Habicht, J.P.; Dibley, M.J. High dose vitamin A supplementation of breast-feeding. Indonesian mothers: effects on the vitamin A status of mother and infant. J. Nutr. 1993, 123, 666-675.
113. Roy, S.K.; Islam, A.; Molla, A.; Akramuzzaman, S.M.; Jahan, F.; Fuchs, G. Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants. Eur. J. Clin. Nutr. 1997, 51, 302-307.
114. Rice, A.L.; Stoltzfus, R.J.; de Francisco, A.; Chakraborty, J.; Kjolhede, C.L.; Wahed, M.A. Maternal vitamin A or beta-carotene supplementation in lactating Bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency. J. Nutr. 1999, 129, 356-365.
115. Bahl, R.; Bhandari, N.; Wahed, M.A.; Kumar, G.T.; Bhan, M.K. Vitamin A supplementation of women postpartum and of their infants at immunization alters breast milk retinol and infant vitamin A status. J. Nutr. 2002, 132, 3243-3248.
116. Malaba, L.C.; Iliff, P.J.; Nathoo, K.J.; Marinda, E.; Moulton, L.H.; Zijenah, L.S.; Zvandasara, P.; Ward, B.J.; Humphrey, J.H. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr 2005;81:454-460.
117. Benn, C.S.; Diness, B.R.; Roth, A.; Nante, E.; Fisker, A.B.; Lisse, I.M.; Yazdanbakhsh, M.; Whittle, H.; Rodrigues, A.; Aaby, P. Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial. BMJ 2008, 336, 1416-1420.
118. Tielsch, JM. Vitamin A supplements in newborns and child survival. Bmj 2008, 336, 1385-1386.
119. West, K.P. Jr.; Katz, J.; Shrestha, S.R.; LeClerq, S.C.; Khatry, S.K.; Pradhan, E.K.; Adhikari, R.; Wu, L.S.; Pokhrel, R.P.; Sommer, A. Mortality of infants < 6 mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal. Am. J Clin. Nutr. 1995, 62, 143-148.
120. Christian, P.; West, K.P., Jr.; Khatry, S.K.; LeClerq, S.C.; Khatry, S.K.; Pradhan, E.K.; Adhikari, R.; Wu, L.S.; Pokhrel, R.P.; Sommer, A. Maternal night blindness increases risk of mortality in the first 6 months of life among infants in Nepal. J. Nutr. 2001, 131, 1510-1512.
121. Christian, P.; West, K.P. Jr.; Khatry SK., Katz, J.; LeClerq, S.C.; Kimbrough-Pradhan, E.; Dali, S.M.; Shrestha, S.R. Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women. J. Nutr. 2000, 130, 2675-2682.
122. Faisel, H.; Pittrof, R. Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutr. 2000, 3, 321-327.
123. West, K.P., Jr. Personal communication, 2008.
124. Bloem, M.W.; De Pee, S.; Darnton-Hill, I. New issues in developing effective approaches for the prevention and control of vitamin A deficiency. Food and Nutrition Bulletin 1998, 19, 137-148.
125. Cohen, N.; Rahman, H.; Mitra, M.; Sprague, J.; Islam, S.; Leemhuis de Regt, E.; Jalil, M.A. Impact of massive doses of vitamin A on nutritional blindness in Bangladesh. Am. J. Clin. Nutr. 1987, 45, 970-976.
126. Bloem, M.W.; Hye, A.; Wijnroks, M; Ralte, A.; West, K.P., Jr.; Sommer, A. The role of universal distribution of vitamin A capsules in combatting vitamin A deficiency in Bangladesh. Am, J. Epidemiol. 1995, 142, 843-855.
127. Djunaedi, E.; Sommer, A.; Pandji, A.; Kusdiono, Taylor H.R. Impact of vitamin A supplementation on xerophthalmia. A randomized controlled community trial. Arch. Ophthalmol. 1988, 106, 218-222.
128. Thapa, S.; Choe, M.K.; Retherford, R.D. Effects of vitamin A supplementation on child mortality: evidence from Nepal's 2001 Demographic and Health Survey. Trop. Med. Int. Health 2005, 10, 782-789.
129. David, P. Evaluating the vitamin A supplementation programme in northern Ghana: has it contributed to child survival? Boston, Massachusetts: John Snow International, 2003, 56.
130. Banajeh, S.M. Is 12-monthly vitamin A supplementation of preschool children efffective? An observational study of mortality rates for severe dehydrating diarrhoea in Yemen. South African Journal of Clinical Nutrition 2003, 16, 137-142.
131. Bendich, A.; Olson, J.A. Biological actions of carotenoids. Faseb J. 1989, 3, 1927-1932.
132. Bauernfeind, J.C. The safe use of vitamin A: a report of the International Vitamin A Consultative Group; The Nutrition Foundation: Washington, DC, 1980, 44.
133. West, K.P., Jr.; Khatry, S.K.; LeClerq, S.C.; Adhikari, R.; See, L.; Katz, J.; Shrestha, S.R.; Pradhan, E.K.; Pokhrel, R.P.; Sommer, A. Tolerance of young infants to a single, large dose of vitamin A: a randomized community trial in Nepal. Bull World Health Organ 1992, 70, 733-739.
134. de Francisco, A.; Chakraborty, J.; Chowdhury, H.R.; Yunus, M.; Baqui, A.H.; Siddique, A.K.; Sack, R.B. Acute toxicity of vitamin A given with vaccines in infancy. Lancet 1993, 342, 526-527.
135. Baqui, A.H.; de Francisco, A.; Arifeen, S.E.; Siddique, A.K.; Sack R.B. Bulging fontanelle after supplementation with 25,000 IU of vitamin A in infancy using immunization contacts. Acta Paediatr. 1995, 84, 863-866.
136. Agoestina, T.; Humphrey, J.H.; Taylor, G.A.; Usman, A.; Subardja, D; Hidayat, S.; Nurachim, M.; Wu, L.; Friedman, D.S.; West, K.P., Jr. Safety of one 52-mumol (50,000 IU) oral dose of vitamin A administered to neonates. Bull. World Health Org. 1994, 72, 859-868.
137. Humphrey, J.H.; Agoestina, T.; Juliana, A.; Septiana, S.; Widjaja, H.; Cerreto, M.C.; Wu, L.S.; Ichord, R.N.; Katz, J.; West, K.P., Jr. Neonatal vitamin A supplementation: effect on development and growth at 3 y of age. Am J Clin Nutr 1998, 68, 109-117.
138. Semba, R.D.; Munasir, Z.; Beeler, J.; Akib, A.; Muhilal; Andet, S.; Sommer, A. Reduced seroconversion to measles in infants given vitamin A with measles vaccination. Lancet 1995 345, 1330-1332.
139. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. Lancet 1998, 352, 1257-1263.
140. Semba, R.D.; Akib, A.; Beeler, J.; Akib, A.; Muhilal; Andet, S.; Sommer, A. Effect of vitamin A supplementation on measles vaccination in nine-month-old infants. Public Health 1997, 111, 245-247.
141. Bahl, R.; Kumar, R.; Bhandari, N.; Kant, S.; Srivastava, R.; Bhan, M.K. Vitamin A administered with measles vaccine to nine-month-old infants does not reduce vaccine immunogenicity. J. Nutr. 1999, 129, 1569-1573.
142. Benn, C.S.; Aaby, P.; Bale, C.; Olsen, J.; Michaelsen, K.F.; George, E.; Whittle, H. Randomised trial of effect of vitamin A supplementation on antibody response to measles vaccine in Guinea-Bissau, west Africa. Lancet 1997, 350, 101-105.
143. de Francisco, A.; Ahmed, F. Measles vaccine failure not associated with vitamin A supplementation. Trans. R. Soc. Trop. Med. Hyg. 1996, 90, 441.
144. Benn, C.S.; Balde, A.; George, E.; Kidd, M.; Whittle, H.; Lisse, I.M.; Aaby, P. Effect of vitamin A supplementation on measles-specific antibody levels in Guinea-Bissau. Lancet 2002, 359, 1313-1314.
145. Benn, C.S.; Bale, C.; Sommerfelt, H.; Friis, H.; Aaby, P. Hypothesis: Vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines? Int. J. Epidemiol. 2003, 32, 822-828.
146. International Vitamin A Consultative Group. In Improving the Vitamin A Status of Populations, Report of the XXI International Vitamin A Consultative Group Meeting Marrakech, Morocco, February 3-5 2003; International Vitamin A Consultative Group: Washington, 2003, 84.
147. United Nations Children's Fund. Vitamin A Supplementation Programme Database; UNICEF: New York, NY, 2007.
148. International Vitamin A Consultative Group. Vitamin A and the Common Agenda for Micronutrients, Report of the XXII International Vitamin A Consultative Group Meeting, Lima, Peru, 15-17 November 2004, International Vitamin A Consultative Group: Washington, 2004, 102.
149. Helen Keller International-Indonesia. National vitamin A supplementation campaign activities. Indonesia Crisis Bulletin 2001, 3, 1-4.
150. Helen Keller International-Indonesia. Post partum vitamin A capsule distribution needs to be improved for the benefit of mothers and infants. Indonesia Health and Nutrition Bulletin 2004, 6, 1-4.
151. WHO/UNICEF. Integration of vitamin A supplementation with immunization: policy and programme implications; Report of a meeting, 12-13 January 1998, UNICEF, New York. World Health Organization: Geneva, 1998, 20.
152. Goodman, T.; Dalmiya, N.; de Benoist, B.; Schultink, W. Polio as a platform: using national immunization days to deliver vitamin A supplements. Bull. World Health Org. 2000, 78, 305-314.
153. Micronutrient Forum. Proceedings of the First Meeting of the Micronutrient Forum, Istanbul, Turkey, 16-18 April 2007. Sight and Life: Basel, 2007, 64.
154. Aguayo, V.M.; Baker, S.K.; Crespin, X.; Hamani, H.; MamadoulTaibou, A. Maintaining high vitamin A supplementation coverage in children: lessons from Niger. Food Nutr. Bull. 2005, 26, 26-31.
155. Bonu, S.; Rani, M.; Baker, T.D. The impact of the national polio immunization campaign on levels and equity in immunization coverage: evidence from rural North India. Social Science & Medicine 2003, 57, 1807.
156. Houston, R.M. Why They Work: An analysis of three successful public health interventions; MOST/USAID: Arlington, VA, 2003, 41.
157. UNICEF Regional Office for South Asia. Getting to the Roots: Mobilizing community volunteers to combat vitamin A deficiency disorders in Nepal; UNICEF Kathmandu, Nepal, 2003, 71.
158. Bloem, M.W.; Kiess, L.; Moench-Pfanner, R. Process Indicators for Monitoring and Evaluating Vitamin A Programs. J. Nutr. 2002, 132, 2934S-2939.
159. WHO/UNICEF. Child Survival Survey-based Indicators: report of a UNICEF/WHO Meeting. New York, 17-18 June, 2004, UNICEF: New York, 2004, 4.
160. Ag Bendech, M.; Baker, S.; Cusack, G.; Scott, S.; Tucker, M.; Bangura, M. Rapid vitamin A supplementation coverage surveys drive program improvement in Sierra Leone. Sight and Life Newsletter 2005, 3, 42-45.
161. Global Alliance for Vitamin A. Monitoring Vitamin A Supplementation, Proceedings of the Technical Advisory Group Meeting, 19-20 July 2006. UNICEF: New York, 2006, 32.
162. Cervinskas, J.; Houston, R.M. Monitoring vitamin A programs; Micronutrient Initiative: Ottawa, ON, 1998, 110.
163. World Health Organization. Indicators for assessing Vitamin A Deficiency and their application in monitoring and evaluating intervention programmes; World Health Organization: Geneva, Switzerland, 1996, 66.
164. Wasantwisut, E. Recommendations for monitoring and evaluating vitamin A programs: outcome indicators. J Nutr 2002, 132, 2940S-2942S
165. Austin, J.E.; Balding, T.K.; Pyle, D.; Solar, F.S.; Fernandes, T.L.; Latham, M.D.; Popkin, B.M. Fortification Study 3. Nutrition Intervention in Developing Countries; Oegeschlager, Gunn and Hain: Cambridge, MA, 1981, 225.
166. West K.P., Jr.; Sommer A. In Periodic Large, Oral Doses of Vitamin A for the Prevention of Vitamin A Deficiency and Xerophthlamia: A Summary of Experiences, Report of the International Vitamin A Consultative Group. The Nutrition Foundation: Washington, DC: 1984, 76.
167. World Bank. World Development Report 1993: Investing in health; Oxford University Press: Oxford, 1993, 329.
168. Edejer, T.T.; Aikins, M.; Black, R.; Wolfson, L.; Hutubessy, R.; Evans, D.B. Cost effectiveness analysis of strategies for child health in developing countries. Bmj 2005, 331, 1177.
169. MOST/USAID. Cost Analysis of the National Vitamin A Supplementation Program in Ghana.: MOST, USAID Micronutrient Program: Arlington, Virginia, 2004, 42.
170. MOST/USAID. Cost Analysis of the National Vitamin A Supplementation Program in Zambia; MOST, USAID Micronutrient Program: Arlington, Virginia, 2004, 23.
171. Fiedler, J.L. The Nepal National Vitamin A Program: prototype to emulate or donor enclave? Health Policy Plan 2000, 15, 145-156.
172. MOST/USAID. Cost Analysis of the National Twice-Yearly Vitamin A Supplementation Programme in Tanzania; MOST, USAID Micronutrient Program: Arlington, VA, 2005, 17.
173. Fiedler, J.L.; Chuko, T.; The cost of Child Health Days: a case study of Ethiopia's Enhanced Outreach Strategy (EOS). Health Policy Plan 2008, 23, 222-233.
174. Phillips, M.; Sanghvi, T.; Suarez, R.; McKigney, J.; Fiedler, J. The costs and effectiveness of three vitamin A interventions in Guatemala. Soc. Sci. Med. 1996, 42, 1661-1668.
175. Neidecker-Gonzales, O.; Nestel, P.; Bouis, H.; Meenakshi, J.V.; Pfeiffer, W. Estimating the global costs of vitamin A capsule supplementation: a review of the literature. Food Nutr. Bull 2007, 28, 307-316.
176. Dalmiya, N.; Palmer, A.; Darnton-Hill, I. Sustaining vitamin A supplementation requires a new vision. Lancet 2006, 368, 1052-1054.