Golden rice: Introducing the β-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin a deficiency

Journal of Nutrition

Volumn 132, Issue 3, 2002, Pages

  Beyer, Peter ^a   Al Babili, Salim ^a   Ye, Xudong ^a,b   Lucca, Paola ^b   Schaub, Patrick ^a   Welsch, Ralf ^a   Potrykus, Ingo ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Bioavailability; Golden Rice; Humanitarian project; Provitamin A; Transformation

Indexed keywords

BETA CAROTENE; ENZYME; LYCOPENE; PHYTOENE DESATURASE; PHYTOENE SYNTHASE; UNCLASSIFIED DRUG; XANTHOPHYLL;

BIOSYNTHESIS; CONFERENCE PAPER; ENDOSPERM; ERWINIA; FEEDBACK SYSTEM; GENETIC CODE; GENETIC ENGINEERING; RETINOL DEFICIENCY; RICE;

BACTERIA (MICROORGANISMS); ERWINIA; NARCISSUS; NARCISSUS PSEUDONARCISSUS; PANTOEA ANANATIS;

EID: 0036193776     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.3.506s     Document Type: Conference Paper

References (13)

1. Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm
2. New imperatives for an old vitamin (A)
3. Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis
4. Phytoene synthase from Narcissus pseudonarcissus: Functional expression, galactolipid requirement, topological distribution in chromoplasts and induction during flowering
5. Chloroplast import of four carotenoid biosynthetic enzymes in vitro reveals differential fates prior to membrane binding and oligomeric assembly
6. Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtl in transgenic plants showing an increase of β-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon
7. A cDNA encoding lycopene cyclase (accession no. X98796) from Narcissus pseudonarcissus L. (PGR 96-107)
8. A one-year study of the macular pigment: The effect of 140 days of a lutein supplement
9. Two Arabidopsis thaliana carotene desaturases, phytoene desaturase and β-carotene desaturase, expressed in E. coli catalyze a poly-cis pathway to yield pro-lycopene
10. On the mechanism of the lycopene isomerase/cyclase reactions in Narcissus pseudonarcissus L. chromoplasts
11. CPTA mudulates levels of carotenogenic proteins and their mRNAs and affects carotenoid and ABA content as well as chromoplast structure in Narcissus pseudonarcissus flowers
12. Effective selection and regeneration of transgenic rice plants with mannose as selective agent
13. The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms