Expression of NG2 proteoglycan during endochondral and intramembranous ossification

Developmental Dynamics

Volumn 228, Issue 1, 2003, Pages 143-148

  Fukushi, Jun Ichi ^a   Inatani, Masaru ^a   Yamaguchi, Yu ^a   Stallcup, William B ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Alkaline phosphatase; Endochondral ossification; Hypertrophic chondrocyte; Intramembranous ossification; NG2 proteoglycan; Osteoblast; Periosteum; Primary ossification; Tenascin C

Indexed keywords

ALKALINE PHOSPHATASE; NG2 PROTEOGLYCAN; PROTEOGLYCAN; TENASCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE MATRIX; CARTILAGE; DOWN REGULATION; EMBRYO; ENCHONDRAL OSSIFICATION; EPIPHYSIS; IMMUNOHISTOCHEMISTRY; LIMB; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PUBERTY; TIBIA; UPREGULATION;

ALKALINE PHOSPHATASE; ANIMALS; ANTIGENS; BONE AND BONES; BONE DEVELOPMENT; CELL DIFFERENTIATION; CHONDROCYTES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, INBRED C57BL; OSTEOBLASTS; PROTEOGLYCANS; TENASCIN; TIBIA; TIME FACTORS;

EID: 0042859898     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10359     Document Type: Article

References (30)

1. Aubin JE, Liu F, Malaval L, Gupta AK. 1995. Osteoblast and chondroblast differentiation. Bone 17:77S-83S.
2. Burg MA, Tillet E, Timpl R, Stallcup WB. 1996. Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. J Biol Chem 271:26110-26116.
3. Burg MA, Nishiyama A, Stallcup WB. 1997. A central segment of the NG2 proteoglycan is critical for the ability of glioma cells to bind and migrate toward type VI collagen. Exp Cell Res 235:254-264.
4. Burg MA, Grako KA, Stallcup WB. 1998. Expression of the NG2 proteoglycan enhances the growth and metastatic properties of melanoma cells. J Cell Physiol 177:299-312.
5. Daniels K, Solursh M. 1991. Modulation of chondrogenesis by the cytoskeleton and extracellular matrix. J Cell Sci 100:249-254.
6. Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J. 1999. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Nat Cell Biol 1:507-513.
7. Fang X, Burg MA, Barritt D, Dahlin-Huppe K, Nishiyama A, Stallcup WB. 1999. Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration. Mol Biol Cell 10:3373-3387.
8. Goretzki L, Burg MA, Grako KA, Stallcup WB. 1999. High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. J Biol. Chem 274:16831-16837.
9. Grako KA, Stallcup WB. 1995. Participation of the NG2 proteoglycan in rat aortic smooth muscle cell responses to platelet-derived growth factor. Exp Cell Res 221:231-240.
10. Grako KA, Ochiya T, Barritt D, Nishiyama A, Stallcup WB. 1999. PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci 112:905-915.
11. Habuchi H, Conrad HE, Glaser JH. 1985. Coordinate regulation of collagen and alkaline phosphatase levels in chick embryo chondrocytes. J Biol Chem 260:13029-13034.
12. Hall BK. 1997. Bone, embryonic development. In: Dulbecco R, editor. Encyclopedia of human biology. 2nd ed. New York: Academic Press.
13. Hall BK, Miyake T. 1995. Divide, accumulate, differentiate: cell condensation in skeletal development revisited. Int J Dev Biol 39:881-893.
14. Iida J, Meijne AM, Spiro RC, Roos E, Furcht LT, McCarthy JB. 1995. Spreading and focal contact formation of human melanoma cells in response to the stimulation of both melanoma-associated proteoglycan (NG2) and alpha 4 beta 1 integrin. Cancer Res 55:2177-2185.
15. Levine JM, Stallcup WB. 1987. Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen. J Neurosci 7:2721-2731.
16. Liu YH, Tang Z, Kundu RK, Wu L, Luo W, Zhu D, Sangiorgi F, Snead ML, Maxson RE. 1999. Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: a possible mechanism for MSX2-mediated craniosynostosis in humans. Dev Biol 205:260-274.
17. Mackie EJ, Ramsey S. 1996, Modulation of osteoblast behavior by tenascin. J Cell Sci 109:1597-1604.
18. Mackie EJ, Thesleff I, Chiquet-Ehrismann R. 1987. Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro. J Cell Biol 105:2569-2579.
19. Majumdar M, Vuori K, Stallcup WB. 2002. Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Cell Signal 15:79-84.
20. Midwood KS, Salter DM. 1998. Expression of NG2/human melanoma proteoglycan in human adult articular chondrocytes. Osteoarthritis Cartilage 6:297-305.
21. Nishiyama A, Dahlin KJ, Stallcup WB. 1991. The expression of NG2 proteoglycan in the developing rat limb. Development 111:933-944.
22. Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB. 1996a. Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res 43:299-314.
23. Nishiyama A, Lin XH, Giese N, Heldin CH, Stallcup WB. 1996b. Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF. J Neurosci Res 43:315-330.
24. Opperman LA. 2000. Cranial sutures as intramembranous bone growth sites. Dev Dyn 219:472-485.
25. Ozerdem U, Grako KA, Dahlin-Huppe K, Monosov E, Stallcup WB. 2001. NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Dev Dyn 222:218-227.
26. Reichenberger E, Aigner T, von der Mark K, Stoss H, Bertling W. 1991. In situ hybridization studies on the expression of type X collagen in fetal human cartilage. Dev Biol 148:562-572.
27. Stallcup WB, Beasley L. 1987. Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. J Neurosci 7:2737-2744.
28. Stallcup WB, Dahlin-Huppe K. 2001. Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization. J Cell Sci 114:2315-2325.
29. Tillet E, Gential B, Garrone R, Stallcup WB. 2002. NG2 proteoglycan mediates betal integrin-independent cell adhesion and spreading on collagen VI. J Cell Biochem 86:726-736.
30. Watanabe K, Yamada H, Yamaguchi Y. 1995. K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol 130:1207-1218.