Human herpes virus 6 and multiple sclerosis: A Finnish twin study

Multiple Sclerosis

Volumn 14, Issue 1, 2008, Pages 54-58

  Kuusisto, Hanna ^a   Hyoty H ^a,b   Kares, S ^a,b   Kinnunen, E ^c   Elovaara, I ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c HYVINKÄÄ HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS ANTIBODY; VIRUS DNA;

ANTIBODY DETECTION; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DIZYGOTIC TWINS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FINLAND; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MONOZYGOTIC TWINS; MULTIPLE SCLEROSIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; REMISSION; SEROLOGY; SIBLING; VIRUS REACTIVATION; BLOOD; CEREBROSPINAL FLUID; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; TWINS; VIROLOGY; VIRUS INFECTION;

ANTIBODIES, VIRAL; COHORT STUDIES; DNA, VIRAL; FEMALE; FINLAND; HERPESVIRUS 6, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MULTIPLE SCLEROSIS; ROSEOLOVIRUS INFECTIONS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 42149143583     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507080063     Document Type: Article

References (38)

1. Ebers GC, Bulman DE, Sadovnick AD, Paty DW, Warren S, Hader W et al. A population based study of multiple sclerosis in twins. New Engl J Med 1986; 315: 1638-42.
2. Mumford CJ, Wood NW, Kellar-Wood HF, Thorpe J, Miller D, Compston DA. The British Isles survey of multiple sclerosis in twins. Neurology 1994; 44: 11-15.
3. Andersen O, Lygner P-E, Bergstöm T, Andresson M, Vahlne A. Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study. J Neurol 1993; 249: 417-22.
4. Hunter SF, Hafler DA. Ubiquitous pathogens. Links between infection and autoimmunity in MS? Neurology 2000; 55: 164-65.
5. Wolfson C. Multiple sclerosis and antecedent infections. Epidemiology 2001; 12: 301.
6. Vastag B. Not so fast: Research on infectious links to MS questioned. JAMA 2001; 285: 279-81.
7. Compston DA, Vakarelis BN, Paul E, McDonald WI, Batchelor JR, Mims CA. Viral infection in patients with multiple sclerosis and HLA-DR matched controls. Brain 1986; 109: 32-44.
8. Clark D. Human herpes virus type 6 and multiple sclerosis. Herpes 2004; 11(Suppl 2): 112-19.
9. Höllsberg P, Kusk M, Bech E, Hansen HJ, Jakobsen J, Haahr S. Presence of Epstein-Barr virus and human herpes virus 6B DNA in multiple sclerosis patients: association with disease activity. Acta Neurol Scand 2005; 112: 395-402.
10. Knox KK, Brewer JH, Henry JM, Harrington DJ, Carrigan DR. Human herpesvirus 6 and multiple sclerosis: systemic active infections in patients with early disease. Clin Infect Dis 2000; 31: 894-903.
11. Soldan SS, Berti R, Salem N, Secchiero P, Flamand L, Calabresi PA et al. Association of human herpes vierus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 1997; 3: 1394-97.
12. Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D et al. Multiple sclerosis and Epstein-Barr virus. JAMA 2003; 289: 1533-36.
13. Sriram S, Stratton CV, Yao S, Thrap A, Ding L, Banna JD et al. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol 1999; 461: 6-14.
14. Sriram S. Failure to detect chlamydia pneumoniae in the central nervous system of patients with MS. Neurology 2000; 55: 1423-24.
15. Alvarez-Lafuente R, De Las Heras V, Bartolome M, Garcia-Montojo M, Arroyo R. Human herpes virus 6 and multiple sclerosis: a one-year follow-up study. Brain Pathol 2006; 16: 20-27.
16. Alvarez-Lafuente R, De las Heras V, Bartolome M, Picazo J, Arroyo R. Relapsing-remitting multiple sclerosis and human herpes virus 6 active infection. Arch Neurol 2004; 61: 1523-27.
17. Yoshikawa T, Asano, Y. Central nervous system complications in human herpes virus-6 infection. Brain Dev 2000; 22: 307-14.
18. Berardelli P. Herpes virus linked to multiple sclerosis. Science 1997; 278: 1710.
19. Moore FG, Wolfson C. Human herpes virus 6 and multiple sclerosis. Acta Neurol Scand 2002; 106: 63-83.
20. Swanborg RH, Whittum-Hudson JA. Human herpes virus 6 and chlamydia pneumoniae as etiologic agents in multiple sclerosis - a critical review. Microbes Infect 2002; 4: 1327-33.
21. Swanborg FH, Whittum-Hudson JA, Hudson PA. Infectious agents and multiple sclerosis - are chlamydia pneumoniae and human herpes virus 6 involved? J Neuroimmunol 2003; 136: 1-8.
22. Fotheringham J, Jacobson S. Human herpes virus 6 and multiple sclerosis: potential mechanism for virus-induced disease. Herpes 2005; 12: 4-9.
23. Berti R, Brennan MB, Soldan SS, Ohayon JM, Casareto L, McFarland HF et al. Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression. J Neurovirol 2002; 8: 250-56.
24. Chapenko S, Millers A, Nora Z, Logina I, Kukaine R, Murovska R. Correlation between HHV-6 reactivation and multiple sclerosis disease activity. J Med Virol 2003; 69: 111-17.
25. Kinnunen E, Valle M, Piirainen L, Kleemola M, Kantanen ML, Juntunen J et al. Viral antibodies in multiple sclerosis. A nationwide co-twin study. Arch Neurol 1990; 47: 743-46.
26. Poser CD, Paty DW, Scheinberg L, McDonald W, Davis FA, Ebers GC et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227-31.
27. Isaacson E, Glaser C, Forghani B, Amad Z, Wallace M, Armstrong R et al. Clin Infect Dis 2005; 40: 890-93.
28. Meinl E. Concepts of viral pathogenesis of multiple sclerosis. Curr Opin Neurol 1999; 12: 303-307.
29. Stohlman SA, Hinton DR. Viral induced demyelination. Brain Pathol 2001; 11: 92-106.
30. Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann Neurol 2003; 53: 189-97.
31. Stüve O, Racke M, Hemmer B. Viral pathogens in multiple sclerosis. Arch Neurol 2005; 1500-502.
32. Ongradi J, Rajda C, Marodi CL, Csiszar A, Vecsei L. A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients. J Neurovirol 1999; 5: 529-32.
33. Ablashi DV, Lapps W, Kaplan M, Whitman JE, Richert JR, Pearson GR. Human herpes virus-6 (HHV6) infection in multiple sclerosis: a preliminary report. Mult Scler 1998; 4: 490-96.
34. Nielsen L, Larsen AM, Munk M, Vestergaard BF. Human herpes virus-6 immunoglobulin G antibodies in patients with multiple sclerosis. Acta Neurol Scand 1997; 169: 76-78.
35. Prat A, Antel J. Pathogenesis of multiple sclerosis. Curr Opin Neurol 2005; 18: 225-30.
36. Enbom M, Wang F-Z, Fredriksson S, Martin C, Dahl H, Linde A. Similar humoral and cellular immunological reactivities to human herpes virus 6 in patients with multiple sclerosis and controls. Clin Diagn Lab Immunol 1999; 4: 545-49.
37. Secchiero P, Carrigan DR, Asano Y, Benedetti L, Crowley RW, Komaroff AL et al. Detection of human Herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Inf Dis 1995; 171: 273-80.
38. Kuusisto H, Hyöty H, Kares S, Kinnunen E, Saarelainen M, Elovaara I. Enteroviruses and the risk of MS in the Finnish Twin Cohort. Eur J Neurol 2005; 12: 707-709.