Purine substrate recognition by the nucleobase-ascorbate transporter signature motif in the YgfO xanthine permease ASN-325 binds and ALA-323 senses substrate

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19422-19433

  Georgopoulou, Ekaterini ^a   Mermelekas, George ^a   Karena, Ekaterini ^a   Frillingos, Stathis ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; CONFORMATIONAL SHIFTS; HIGH AFFINITY BINDING; HIGHLY SENSITIVE; INNER CAVITIES; LIGAND RECOGNITION; METHANETHIOSULFONATE; MOTIF SEQUENCE; NUCLEOBASES; SIMILAR PATTERN; SUBSTRATE RECOGNITION; WILD TYPES;

ALKYLATION; AMINO ACIDS; BINDING ENERGY; ESCHERICHIA COLI; FACE RECOGNITION; HYDROCARBONS; ORGANIC ACIDS;

SUBSTRATES;

2 SULFONATOETHYL METHANETHIOSULFONATE; N ETHYLMALEIMIDE; NUCLEOBASE ASCORBATE TRANSPORTER; NUCLEOBASE TRANSPORTER; PERMEASE; SOLVENT; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; YGFO XANTHINE PERMEASE;

ALKYLATION; ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; ENZYME INACTIVATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; IC 50; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ASCORBIC ACID; ASPARAGINE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHYLMALEIMIDE; INHIBITORY CONCENTRATION 50; KINETICS; MESYLATES; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACIDS; NUCLEOBASE TRANSPORT PROTEINS; PROTEIN STRUCTURE, SECONDARY; PURINES; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 77953482526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.120543     Document Type: Article

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