Efficacy of combination gene therapy with multiple growth factor cDNAs to enhance skin flap survival in a rat model

DNA and Cell Biology

Volumn 24, Issue 11, 2005, Pages 751-757

  Liu, Paul Y ^a,b   Liu, Kan ^b   Wang, Xiao Tian ^a,b   Badiavas, Evangelos ^a   Rieger Christ, Kimberly M ^b   Tang, Jin Bo ^a   Summerhayes, Ian C ^b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COMPLEMENTARY DNA; GROWTH FACTOR; LIPOFECTIN; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN; VASCULOTROPIN 165;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFER; DRUG EFFICACY; FEMALE; GENE THERAPY; GENE TRANSFER; GRAFT SURVIVAL; IMMUNOHISTOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN FLAP; TRANSGENE;

ANIMALS; CELL SURVIVAL; COMBINED MODALITY THERAPY; DNA, COMPLEMENTARY; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE THERAPY; NEOVASCULARIZATION, PHYSIOLOGIC; PLASMIDS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SURGICAL FLAPS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

ANIMALIA;

EID: 28444434476     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2005.24.751     Document Type: Article

References (36)

1. BENN, S.I., WHITSITT, J.S., BROADLEY, K.N., NANNEY, L.B., PERKINS, D., HE, L., PATEL, M., MORGAN, J.R., SWAIN, W.F., and DAVIDSON, J.M. (1996). Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. J. Clin. Invest. 98, 2894-2902.
2. BORNFELDT, K.E., RAINES, E.W., GRAVES, L.M., SKINNER, M.P., KREBS, E.G., and ROSS, R. (1995). Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann. N. Y. Acad. Sci. 766, 416-430.
3. BROWN, D.M., HONG, S.P., FARRELL, C.L., PIERCE, G.F., and KHOURI, R.K. (1995). Platelet-derived growth factor BB induces functional vascular anastomoses in vitro. Proc. Natl. Acad. Sci. USA 92, 5920-5924.
4. BROWN, R.L., BREEDEN, M.P., and GREENHALGH, D.G. (1994). PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J. Surg. Res. 56, 562-570.
5. CASTELLON, R., HAMDI, H.K., SACERIO, I., AOKI, A.M., KENNEY, M.C., and LJUBIMOV, A.V. (2002). Effects of angiogenic growth factor combinations on retinal endothelial cells. Exp. Eye. Res. 74, 523-535.
6. CAMPBELL, C., HULTMAN, S., CAIRNS, B., DeSERRES, S., and MEYER, A. (2003). Green fluorescent protein-adnoviral construct as a model for transient gene therapy for human cultured keratinocytes in an athymic mouse model. J. Trauma. 54, 72-79.
7. CLEAVER, O., and MELTON, D.A. (2003). Endothelial signaling during development. Nat. Med. 9, 661-668.
8. DE MARCHIS, F., RIBATTI, D., GIAMPIETRI, C., LENTINI, A., FARAONE, D., SCOCCIANTI, M., CAPOGROSSI, M.C., and FACCHIANO, A.A. (2002). Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor. Blood 99, 2045-2053.
9. ELLIS. I., GREY, A.M., SCHOR, A.M., and SCHOR, S.L. (1992). Antagonistic effects of TGF-beta 1 and MSF on fibroblast migration and hyaluronic acid synthesis. Possible implications for dermal wound healing. J. Cell. Sci. 102, 447-456.
10. HIJJAWI, J., MOGFORD, J.E., CHANDLER, L.A., CROSS, K.J., SAID, H., SOSNOWSKI, B.A., and MUSTOE, T.A. (2004). Platelet-derived growth factor B, but not fibroblast growth factor 2, plasmid DNA improves survival of ischemic myocutaneous flaps. Arch. Surg. 139, 142-147.
11. HOELLER, D., PETRIE, N., YAO, F., and ERIKSSON, E. (2002). Gene therapy in soft tissue reconstruction. Cells Tissues Organs 172, 118-125.
12. HOSNUTER, M., BABUCCU, O., KARGI, E., and ALTINYAZAR, C. (2003). Dual preconditioning: effects of pharmacological plus ischemic preconditioning on skin flap survival. Ann. Plast. Surg. 50, 398-402.
13. JESCHKE, M.G., BARROW, R.E., HAWKINS, H.K., CHRYSOPOULO, M.T., PEREZ-POLO, J.R., and HERNDON, D.N. (1999a). Effect of multiple gene transfers of insulin-like growth factor I complementary DNA gene constructs in rats after thermal injury. Arch. Surg. 134, 1137-1141.
14. JESCHKE, M.G., BARROW, R.E., HAWKINS, H.K., YANG, K., HAYES, R.L., LICHTENBELT, B.J., PEREZ-POLO, J.R., and HERNDON, D.N. (1999b). IGF-I gene transfer in thermally injured rats. Gene Ther. 6, 1015-1020.
15. JESCHKE, M.G., RICHTER, G., HOFSTADTER, F., HERNDON, D.N., PEREZ-POLO, J.R., and JAUCH, K.W. (2002). Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors. Gene Ther. 9, 1065-1074.
16. JYUNG, R.W., MUSTOE, J.A., BUSBY, W.H., and CLEMMONS, D.R. (1994). Increased wound-breaking strength induced by insulin-like growth factor I in combination with insulin-like growth factor binding protein-1. Surgery 115, 233-239.
17. KAVEN, C.W., SPRAUL, C.W., ZAVAZAVA, N.K., LANG, G.K., and LANG, G.E. (2000). Growth factor combinations modulate human retinal pigment epithelial cell proliferation. Curr. Eye Res. 20, 480-487.
18. KIRCHBERG, K., LANGE, T.S., KLEIN, E.C., JUNGTAUBL, H., HEINEN. G., MEYER-INGOLD, W., and SCHARFFETTER-KOCHANEK, K. (1995). Induction of beta 1 integrin synthesis by recombinant platelet-derived growth factor (PDGF-AB) correlates with an enhanced migratory response of human dermal fibroblasts to various extracellular matrix proteins. Exp. Cell Res. 220, 29-135.
19. KONDOH, K., KOYAMA, H., MIYATA, T., TAKATO, T., HAMADA, H., and SHIGEMATSU, H. (2004). Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor. Cardiovas. Res. 61, 132-142.
20. KUNKE, D., GRIMM, D., DENGER, S., KREUZER, J., DELIUS, H., KOMITOWSKI, D., and KLEINSCHMIDT, J.A. (2000). Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors. Cancer. Gene Ther. 7, 766-777.
21. LANDGREN, E., ERIKSSON, A., WENNSTROM, S., KANDA, S., and CLAESSON-WELSH, L. (1996). Induction of fibroblast growth factor receptor-1 mRNA and protein by platelet-derived growth factor BB. Exp. Cell Res. 223, 405-411.
22. LIU, P.Y., TONG, W., LIU, K., HAN, S.H., WANG, X.T., BADIAVAS, E., RIEGER-CHRIST, K., and SUMMERHAYES, I. (2004). Liposome-mediated transfer of vascular endothelial growth factor cDNA augments survival of random-pattern skin flaps in the rat. Wound. Repair Regen. 12, 80-85.
23. LOSER, P., HUSER, A., HILLGENBERG, M., KUMIN, D., BOTH, G.W., and HOFMANN, C. (2002). Advances in the development of non-human viral DNA-vectors for gene therapy. Curr Gene Ther. 2, 161-171.
24. MEYER, F., and FINER M. (2001). Gene therapy: Progress and challenges. Cell. Mol. Biol. 47, 1277-1294.
25. PANG, Y., LINEAWEAVER, W.C., LEI, M.P., OSWALD, T., SHAMBURGER, S., CAI, Z., and ZHANG, F. (2003). Evaluation of the mechanism of vascular endothelial growth factor improvement of ischemic flap survival in rats. Plast. Reconstr. Surg. 112, 556-564.
26. PARUMS, D.V., CORDELL, J.L., MICKLEM, K., HERYET, A.R., GATTER, K.C., and MASON, D.Y. (1990). JC70: A new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J. Clin. Pathol. 43, 752-757.
27. PETRIE, N.C., YAO, F., and ERIKSSON, E. (2003). Gene therapy in wound healing. Surg. Clin. North. Am. 83, 597-616.
28. RICHARD, L., VELASCO, P., and DETMAR, M. (1998). A simple immunomagnetic protocol for the selective isolation and long-term culture of human dermal microvascular endothelial cells. Exp. Cell Res. 240, 1-6.
29. SIM, E.K., ZHANG, L., SHIM, W.S., LIM, Y.L., and GE, R. (2002). Therapeutic angiogenesis for coronary artery disease. J. Card. Surg. 17, 350-354.
30. TAUB, P.J., MARMUR, J.D., ZHANG, W.X., SENDEROFF, D., NHAT, P.D., PHELPS, R., URKEN, M.L., SILVER, L, and WEINBERG, H. ( 1998a). Locally administered vascular endothelial growth factor cDNA increases survival of ischemic experimental skin flaps. Plast. Reconstr. Surg. 102, 2033-2039.
31. TAUB, P.J., MARMUR, J.D., ZHANG, W.X., SENDEROFF, D., URKEN, M.L., SILVER, L., and WEINBERG, H. (1998b). Effect of time on the viability of ischemic skin flaps treated with vascular endothelial growth factor (VEGF) cDNA. J. Reconstr. Microsurg. 14, 387-390.
32. WANG, X.T., LIU, P.Y., and TANG, J.B. (2004). Tendon healing in vitro: genetic modification of tenocytes with exogenous PDGF gene and promotion of collagen gene expression. J. Hand. Surg. (Am). 29, 884-890.
33. WANG, X.T., LIU, P.Y., and TANG, J.B. (2005). Tendon healing in vitro: Modification of tenocytes with exogenous vascular endothelial growth factor gene increases expression of transforming growth factor beta but minimally affects expression of collagen genes. J. Hand. Surg. (Am). 30, 222-229.
34. XIN, K.Q., OOKI, T., JOUNAI, N., MIZUKAMI, H., HAMAJIMA, K., KOJIMA, Y., OHBA, K., TODA, Y., HIRAI, S., KLINMAN, D.M., et al. (2003). A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV. J. Gene Med. 5, 438-445.
35. ZHANG, H., VUTSKITS, L., PEPPER, M.S., and KISS, J.Z. (2003). VEGF is a chemoattractant for FGF-2-stimulated neural progenitors. J. Cell Biol. 163, 1375-1384.
36. ZHU, W.H., IURLARO, M., MacINTYRE, A., FOGEL, E., and NICOSIA, R.F. (2003). The mouse aorta model: Influence of genetic background and aging on bFGF- and VEGF-induced angiogenic sprouting. Angiogenesis 6, 193-199.