A review of the research on the risks and harms associated to the use of marijuana

Journal of Global Drug Policy and Practice

Volumn 3, Issue 2, 2009, Pages

  Diplock, Jordan ^a   Cohen, Irwin ^a   Plecas, Darryl ^a  

^a UNIVERSITY OF THE FRASER VALLEY   (Canada)

Author keywords

Academic performance; Gateway; Harms; Health; Impairment; Marijuana; Mental health; Risks

Indexed keywords

CANNABIS; CARCINOGEN; TETRAHYDROCANNABINOL;

ACADEMIC ACHIEVEMENT; ANXIETY; BRAIN DYSFUNCTION; CANCER RISK; CANNABIS ADDICTION; CARDIOVASCULAR SYSTEM; COGNITION; COGNITIVE DEFECT; DEPRESSION; DRUG INDUCED DISEASE; DRUG USE; ELECTROENCEPHALOGRAPHY; IMMUNE SYSTEM; INTELLIGENCE; INTELLIGENCE QUOTIENT; MEDICAL RESEARCH; MEMORY DISORDER; MENTAL HEALTH; MOTOR PERFORMANCE; NONHUMAN; PREGNANCY; PSYCHOSIS; REPRODUCTION; RESPIRATORY TRACT DISEASE; REVIEW; RISK ASSESSMENT; SCHIZOPHRENIA; SOCIAL EVOLUTION; TASK PERFORMANCE; TRAFFIC ACCIDENT; WITHDRAWAL SYNDROME;

EID: 77953474082     PISSN: None     EISSN: 19344708     Source Type: Journal    
DOI: None     Document Type: Review

References (95)

1. Owen, J. Cannabis: An apology. The Independent. 2007 Mar 18 [cited 2008 Mar 19]. Available from http://news.independent.co.uk/health/article2368994.ece
2. ElSohly MA, Ross SA, Mehmedic Z, Arafat R, Yi B, Banahan BF. Potency trends of 9-THC and other cannabinoids in confiscated marijuana from 1980 - 1997. J Forensic Sci. 2000;45(1):24-30.
3. Newell, CJ. Potency of cannabis seized in central Florida during June 2002. Microgram Journal. 2003 [cited 2007 Nov 20];1:37-39. Available from http://www.usdoj.gov/dea/index.htm
4. Royal Canadian Mounted Police. Drug situation in Canada - 2006 [Internet]. Ottawa: RCMP; 2007 [cited 2009 May 26]. Available from http://www.rcmp-grc.gc.ca/drugs-drogues/drg-2006-eng.htm
5. King LA, Carpentier C, Griffiths, P. Cannabis potency in Europe. Addiction. 2005;100(7):884-886.
6. ElSohly MA, Slade, D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 2005;78:539-548. (Pubitemid 41653504)
7. United Nations Office on Drugs and Crime. World Drug Report. 2007 [cited 2008 Feb 21]. Available from http://www.unodc.org/unodc/en/data-and-analysis/ WDR-2007.html
8. Copeland J, Gerber S, Swift W. Evidence-based answers to cannabis questions: a review of the literature. Canberra: Australian National Council on Drugs; 2007.
9. Voth EA. Marijuana and cannabinoid research: current status and future potential. The Journal of Global Drug Policy And Practice. 2006[cited 2008 May 1];1(1):[about 5 p.]. Available from http://www.globaldrugpolicy.org/previous. php
10. Palys T S. Research Decisions: Quantitative and Qualitative Perspectives, 2nd ed. Toronto: Harcourt Brace & Company; 1997.
11. Howard RC, Menkes DB. Changes in brain function during acute cannabis intoxication: preliminary findings suggest a mechanism for cannabis-induced violence. Crim Behav and Ment Health. 2007;17:113-117.
12. Ilan AB, Smith ME, Gevins A. Effects of marijuana on neurophysiological signals of working and episodic memory. Psychopharmacology . 2004;176:214-222. (Pubitemid 39517951)
13. Kanayama G, Rogowska J, Pope HG, Gruber SA, Yurgelun-Todd DA. Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology. 2004;176:239-247. (Pubitemid 40012729)
14. O'Leary DS, Block RI, Koeppel JA, Schultz SK, Magnotta VA, Laura BP, et al. Effects of smoking marijuana on focal attention and brain blood flow. Human Psychopharmacology: Clinical and Experimental. 2007;22:135-148
15. Ramaekers JG, Kauert G, Van Ruitenbeek P, Theunissen EL, Schneider E, Moeller MR. High-potency marijuana impairs executive function and inhibitory motor control. Neuropsychopharmacology. 2006;31:2296-2303. (Pubitemid 44413210)
16. Bedard M, Dubois S, Weaver B. The impact of cannabis on driving. Can J Public Health: 2007;98(1):6-11.
17. Blows S, Ivers RQ, Connor J, Ameratunga S, Woodward M, Norton R. Marijuana use and car crash injury. Addiction. 2005l;100:605-611.
18. Kalant H. Adverse effects of cannabis on health: an update of the literature since 1996. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:849-863.
19. Khiabani HZ, Bramness JG, Bjornboe A, Morland J. Relationship between THC concentration in blood impairment in apprehended drivers. Traffic Inj Prev. 2006;7(2):111-116.
20. Laumon B, Gadegbeku B, Martin J, Biecheler M. Cannabis intoxication and fatal road crashes in France : population based case-control study. Br Med J. 2005;331:1371-1376. (Pubitemid 43773488)
21. Papafotiou K, Carter JD, Stough C. An evaluation of the sensitivity of the Standardised Field Sobriety Tests (SFST) to detect impairment due to marijuana intoxication. Psychopharmacology. 2005;180:107-114. (Pubitemid 40897077)
22. Ramaekers JG, Robbe HWJ, O'Hanlon JF. Marijuana, alcohol and actual driving performance. Hum Psychopharmacol: Clin Exp. 2000;15:551-558.
23. Pope HG, Gruber AJ, Hudson JI, Cohane G, Huestis MA, Yurgelun-Todd D. Early-onset cannabis use and cognitive deficits: What is the nature of the association? Drug Alcohol Depend. 2003;69:303-310.
24. Tapert SF, Schweinsburg AD, Drummond SPA, Paulus MP, Brown SA, Yang TT, et al. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Pyschopharmacology. 2007;194:173-183.
25. Pope, HG, Gruber, AJ, Hudson, JI, Huestis, MA, & Yurgelun-Todd, D. Neuropsychological performance in long-term cannabis users. Arch Gen Psychiatry. 2001;58:909-915. (Pubitemid 32937912)
26. Schneider JT, Pope HG, Silveri MM, Simpson NS, Gruber SA, Yurgelun-Todd, DA. Altered regional blood volume in chronic cannabis smokers. Exp Clin Psychopharmacol. 2006;14:422-428.
27. Bovet P, Viswanathan B, Faeh D, Warren W. Comparison of smoking, drinking, and marijuana use between students present or absent on the day of a school-based survey. J Sch Health. 2006;76(4):133-137.
28. Lynskey M, Hall W. The effects of adolescent cannabis use on educational attainment: a review. Addiction. 2000;95:1621-1630.
29. Fried P, Watkinson B, James D, Gray R. Current and former marijuana use: preliminary findings of a longitudinal study of effects on IQ in young adults. Can Med Assoc J. 2002;166:887-891. (Pubitemid 34275508)
30. Diego MA, Field TM, Sanders CE. Academic performance, popularity, and depression predict adolescent substance use. Adolescence. 2003;38:37-42.
31. Jeynes WH. The relation between the consumption of various drugs by adolescents and their academic achievement. Am J Drug Alcohol Abuse. 2002;28(1):15-35.
32. Eisen SA, Chantarujikapong S, Xian H, Lyons MJ, Toomey R, True WR, et al. Does marijuana use have residual adverse effects on self-reported health measures, socio-demographics and quality of life? a monozygotic co-twin control study in men. Addiction. 2001;97:1137-1144. (Pubitemid 35041805)
33. Green KM, Ensminger ME. Adult social behavioural effects of heavy adolescent marijuana use among African Americans. Dev Psychol. 2006;42:1168-1178.
34. Schuster C, O'Malley PM, Bachman JG, Johnston LD, Schulenberg J. Adolescent marijuana use and adult occupational attainment: A longitudinal study from age 18 - 28. Subst Use Misuse. 2001;36:997-1014. (Pubitemid 32730111)
35. Aldington S, Williams M, Nowitz M, Weatherall M, Pritchard A, McNaughton, A, et al. Effects of cannabis on pulmonary structure, function and symptoms. Thorax. 2007;62:1058-1063. (Pubitemid 350206197)
36. Earleywine M, Barnwell SS. Decreased respiratory symptoms in cannabis users who vaporize. Harm Reduct J. 2007[2007 Nov 21];4(11):[about 4 p.]. Available from http://www.harmreductionjournal.com/
37. Hazekamp A, Ruhaak R, Zuurman L, Van Gerven J, Verpoorte R. Evaluation of a vaporizing devince (Volcano) for the pulmonary administration of tetrahydrocannabinol. J Pharm Sci. 2006;95:1308-1317. (Pubitemid 43874444)
38. Moore BA, Augustson EM, Moser RP, Budney AJ. Respiratory effects of marijuana and tobacco use in a U.S. sample. J Gen Intern Med. 2004;20:33-37.
39. Sarafian TA, Habib N, Mao JT, Tsu I, Yamamoto ML, Hsu E, et al. Gene expression changes in human small airway epithelial cells exposed to 9-tetrahydrocannabinol. Toxicol Lett. 2005;158:95-107. (Pubitemid 41019347)
40. Sarafian TA, Habib N, Oldham M, Seeram N, Lee R, Lin L, et al. Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo. American Am J Physiol Lung Cell Mol Physiol. 2006;290:1202-1209. (Pubitemid 43830865)
41. Tashkin DR, Baldwin GC, Sarafian T, Dubinett S, Roth MD. Respiratory and immunological consequences of marijuana smoking. J Clin Pharmacol. 2002;42:71-81. (Pubitemid 35205049)
42. Taylor DR, Hall W. Respiratory health effects of cannabis: position statement of the Thoracic Society of Austra 95:1669-1677.
43. Tetrault JM, Crothers K, Moore BA, Mehra R, Concato J, Fiellin DA. Effects of marijuana smoking on pulmonary function and respiratory complications. Arch Intern Med. 2003;167:221-228.
44. Aryana A, Williams MA. Marijuana as a trigger for cardiovascular events: Speculation or scientific certainty? Int J Cardiol. 2007;118:141-144.
45. Caldicott DGE, Holmes J, Roberts-Thomas KC, Mahar L. Keep of the grass: Marijuana use and acute cardiovascular events. Eur J Emerg Med. 2005;12:238-244.
46. Lindsay AC, Foale RA, Warren O, Henry JA. Cannabis as a precipitant of cardiovascular emergencies. Int J Cardiol. 2005;104:230-232.
47. Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. Triggering myocardial infarction by marijuana. Circulation. 2001;103:2805-2809.
48. Rezkalla SH, Sharma P, Kloner RA. Coronary no-flow and ventricular tachycardia associated with habitual marijuana use. Ann Emerg Med. 2003;42:365-369. (Pubitemid 37052011)
49. Day NL, Goldschmidt L, Thomas CA. Prenatal marijuana exposure contributes to the prediction of marijuana use at age 14. Addiction. 2006;101:1313-1322. (Pubitemid 44199523)
50. Fried PA, Smith AM. A literature review of the consequences of prenatal marihuana exposure: an emerging theme of deficiency in aspects of executive function. Neurotoxicol Teratol. 2001;23:1-11.
51. Jukic AMZ, Weinberg CR, Baird DD, Wilcox AJ. Lifestyle and reproductive factors associated with follicular phase length. J Womens Health. 2007;16:1340-1347. (Pubitemid 350125864)
52. Kuczkowski KM. The effects of drug abuse on pregnancy. Curr Opin Obstet Gynecol. 2007;19:578-585.
53. Lee SY, Oh SM, Chung KH. Estrogenic effects of marijuana smoke condensate and cannabinoid compounds. Toxicol Appl Pharmacol. 2006;214:270-278.
54. Schuel H, Burkman LJ, Lippes J, Crickard K, Mahony MC, Giuffrida A, et al. Evidence that anandamide-signalling regulates human sperm functions required for fertilization. Mol Reprod Dev. 2002;63:376-387.
55. Wang X, Dow-Edwards D, Anderson V, Minkoff H, Hurd, YL. Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use. Pharmacogenomics J. 2006;6:255-264. (Pubitemid 44137952)
56. Whan LB, West MCL, McClure N, Lewis SEM. Effects of delta-9- tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro. Fertil Steril. 2006;85: 653-660. (Pubitemid 43261558)
57. Shay AH, Choi R, Whittaker K, Salehi K, Kitchen CMR, Tashkin DP, et al. Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine. J Infect Dis. 2003;187:700-704. (Pubitemid 36250038)
58. Aldington, S, Harwood, M, Cox, B, Weatherall, M, Beckert, L, Hansell, A, et al. Cannabis use and cancer of the head and neck: case-control study. Otolaryngol Head Neck Surg. 2008;138:374-380. (Pubitemid 351288442)
59. Cho CM, Hirsch R, Johnstone S. General and oral implications of cannabis use. Aust Dent J. 2005;50:70-74. (Pubitemid 40935097)
60. Hashibe M, Ford, DE, Zhang, ZF. Marijuana smoking and head and neck cancer. J Clin Pharmacol. 2002;42:103-107. (Pubitemid 35205053)
61. Hashibe M, Morgenstern H, Cui Y, Tashkin DP, Zhang Z, Cozen W, et al. Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2006;15:1829-1834. (Pubitemid 44664256)
62. Mehra R, Moore BA, Crothers K, Tetrault J, Fiellin DA. The association between marijuana smoking and lung cancer: a systematic review. Arch Intern Med. 2006;166:1359-1367. (Pubitemid 44036347)
63. Rosenblatt KA, Daling JR, Chen C, Sherman KJ, Schwartz SM. Marijuana use and risk of oral squamous cell carcinoma. Cancer Res. 2004;64:4049-4054. (Pubitemid 38697321)
64. Trivers KF, Mertens AC, Ross JA, Steinbuch M, Olshan AF, Robison LL. Parental marijuana use and risk of childhood acute myeloid leukaemia: a report from the Children's Cancer Group (United States and Canada). Paediatr Perinat Epidemiol. 2006;20:110-118.
65. Zhang ZF, Morgenstern H, Spitz MR, Tashkin DP, Yu GP, Marshall, JR, Hsu TC, Schantz SP. Marijuana use and increased risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev. 1999;8:1071-1078. (Pubitemid 30004904)
66. Copersino ML, Boyd SJ, Tashkin DP, Huestis MA, Heishman SJ, Dermand, J. C., Simmons, et al. Cannabis withdrawal among non-treatment-seeking adult cannabis users. Am J Addict. 2006;15:8-14.
67. Looby A, Earleywine M. Negative consequences associated with dependence in daily cannabis users. Subst Abuse Treat Prev Policy. 2007[cited 21 Nov 21];2(3): [about 7 p.]. Available from http://www.substanceabusepolicy.com/ content/2/1/3
68. Hall WD. Cannabis use and the mental health of young people. Aust N Z J Psychiatry. 2006;40:106-119.
69. Leshner, AI. The essence of drug addiction [Internet]. Bethessda, MD: National Institute on Drug Abuse; 2001 [updated 2008 Sept 30; cited 2009 May 26]. Available from http://www.nida.nih.gov/Published-Articles/Essence.html
70. Arseneault L, Cannon M, Witton J, Murray RM. Causal association between cannabis and psychosis: Examination of the evidence. Br J Psychiatry. 2004;184:110-117. (Pubitemid 38186851)
71. Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, et al. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in catechol-o-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry. 2005;57:1117-1127. (Pubitemid 40615773)
72. Degenhardt L, Hall W. Is cannabis use a contributory cause of psychosis? Can J Psychiatry. 2006;51:556-565.
73. Ferdinand RF, Van Der Ende J, Bongers I, Selten J, Huizink A, Verhulst FC. Cannabis - psychosis pathway independent of other types of psychopathology. Schizophr Res. 2005;79:289-295. (Pubitemid 41457269)
74. Linszen D, Van Amelsvoort T. Cannabis and psychosis: An update on course and biological plausible mechanisms. Curr Opin Psychiatry. 2007;20:116-120. (Pubitemid 46215416)
75. Arendt M. Rosenberg R, Foldager L, Perto G, Munk-Jorgensen P. Cannabis-induce psychosis and subsequent schizophreniaspectrum disorders: follow-up study of 535 incident cases. Br J Psychiatry. 2005;187:510-515. (Pubitemid 41752739)
76. Solowij N, Michie PT. Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia. J Psychiatry Neurosci. 2007;32(1):30-52. (Pubitemid 46269684)
77. Grech A, Van Os J, Jones PB, Lewin SW, Murray RM.. Cannabis use and outcome of recent onset psychosis. Eur Psychiatry. 2005;20:349-353. (Pubitemid 40978562)
78. Degenhardt L, Hall W, Lynskey M. Testing hypotheses about the relationship between cannabis and psychosis. Drug Alcohol Depend. 2002;71:37-48. (Pubitemid 36734857)
79. Hall W, Degenhardt L. Cannabis use and psychosis: a review of clinical and epidemiological evidence. Aust NZ J Psychiatry. 2000;34:26-34. (Pubitemid 34692842)
80. Smit F, Bolier L, Cuijpers P. Cannabis use and the risk of later schizophrenia: A review. Addiction. 2004;99:425-430. (Pubitemid 38496658)
81. Harder VS, Morral AR, Arkes J. Marijuana use and depression among adult: testing for causal associations. Addiction. 2006; 101:1463-1472. (Pubitemid 44337771)
82. Bonn-Miller MO, Zvolensky MJ, Leen-Feldner EW, Feldner MT, Yartz AR. Marijuana use among daily tobacco smokers: relationship to anxiety-related factors. J Psychopathol Behav Assess. 2005;27:279-289. (Pubitemid 40956553)
83. Fergusson DM, Horwood LJ. Does cannabis use encourage other forms of illicit drug use? Addiction. 2000;95:505-520.
84. Morral AR, McCaffrey DF, Paddock, SM. Reassessing the marijuana gateway effect. Addiction. 2002;97:1493-1504.
85. Fergusson DM, Boden JM, Horwood JL. Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. Addiction. 2006;101:556-569. (Pubitemid 43375619)
86. Lessem JM, Hopfer CJ, Haberstick BC, Timberlake D, Ehringer MA, Smolen A, et al. Relationship between adolescent marijuana use and young adult illicit drug use. Behav Genet, 36, 498-506.
87. Lynskey MT, Vink JM, Boomsma DI. Early onset cannabis use and progression to other drug use in a sample of Dutch twins. Behav Genet. 2006;36:195-200.
88. Although there are many possible explanations for the finding that marijuana-related impairment is associated with much fewer vehicle crashes than alcohol-related impairment, such as the lack in North America of a standardised and accepted roadside test instrument for marijuana impairment, this is still an important finding.
89. Absent students received the survey within the four weeks following the administration of the original survey.
90. When considering the relationship between cocaine use and standardized test scores, the inclusion of alcohol and cigarettes in the analysis had a similar effect as reported for marijuana.
91. Marijuana use and GPA had a partial correlation of -.400, while the correlations for alcohol use and GPA and cigarette smoking and GPA were -.355 and -.221 respectively.
92. High prestige included professionals with or without doctoral degrees.
93. Of the 3882 patients in this study, 124 reported marijuana use in the prior year, 37 reported using marijuana with 24 hours, and 9 reported using marijuana 1 hour prior to myocardial infarction symptoms.
94. It should be noted that this result is substantial, but far lower than that related to cocaine use.
95. Similar associations were found for cigarettes and alcohol.