Endophenotypes in schizophrenia;Endofenotypy w schizofrenii

Postepy Psychiatrii i Neurologii

Volumn 17, Issue 3, 2008, Pages 213-217

  Tylec, Aneta ^a   Kucharska Pietura, Katarzyna ^b   Stryjecka Zimmer, Marta ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b DIANA PRINCESS OF WALES HOSPITAL   (United Kingdom)

Author keywords

Endophenotypes; Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; PROTEIN KINASE FYN;

CLINICAL FEATURE; COGNITION; DISEASE CLASSIFICATION; DISEASE MARKER; ELECTRODERMAL RESPONSE; HETEROZYGOTE; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHENOTYPE; REVIEW; SCHIZOPHRENIA; SYMPTOMATOLOGY; VISUAL MASKING; WISCONSIN CARD SORTING TEST;

EID: 77953473807     PISSN: 12302813     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Gottesman I. Psychopathology through a life span-genetic prism. Am Psychol. 2001; 56: 867-878.
2. Petronis A, Gottesman I, Crow T, DeLisi L, Klar A, Macciardi F, McInnis M, McMahon F, Paterson A, Skuse D, Sutherland G. Psychiatric epigenetics: a new focus for the new century. Mol Psychiatry. 2000; 5: 342-346.
3. Opgen-Rhein C, Neuhaus A, Urbanek C, Dettling M. New strategies in schizophrenia: impact of endophentotypes. Psychiatr prax. 2004; 31; 2: 194-9.
4. Andreasen N. Fascynujacy mózg. Walka z chorobami psychicznymi w epoce genomu. Lublin: Czelej; 2003.
5. Gottesman I, Gould T. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry. 2003; 160: 636-645.
6. Cannon T, Keller M. Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol. 2006; 2: 267-90.
7. Prathikanti S, Weinberger D. Psychiatric genetics- the new era: genetic research and some clinical implications. British Medical Bulletin. 2005; 73: 107-122.
8. Shih R, Belmonte P, Zandi P. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry. 2004; 16 (4): 260-83.
9. Gottesman I. Schizophrenia genesis: the origins of madness. W: H. Freeman and Co., New York 1991.
10. Gottesman II, Shields J. Genetic theorizing and schizophrenia. Br J Psychiatry. 1973; 122: 15-30.
11. Zobel A, Maier W. Endophenotype - a new concept for biological characterization of psychiatric disorders. Nervenarzt. 2004; 75 (3): 205-14.
12. Pulver A, Pearlson G, McGrath J, Lasseter V, Swarts K, Papadimitriou G. Schizophrenia, in The Genetic Basis of Common Diseases. W: King RA, Rotter JI, Motulsky AG. New York: Oxford University Press; 2002.
13. Braff D, Light G. The use of neurophysiological endopheno-types to understand the genetic basis of schizophrenia. Dialogues Clin Neurosci. 2005; 7 (2): 125-35.
14. Watanabe A, Toyota T, Owada Y, Hayashi T, Iwavama Y, Matsumata M, Ishitsuka Y, Nakava A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol. 2007; 5 (11): 2469-2483.
15. Turetsky B, Calkin M, Light G, Olincy A, Radant A, Swerdlow N. Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures Schizophrenia Bulletin. 2007; 33, 1: 69-94.
16. Martin L, Hall M, Ross R, Zerbe G, Freedman R, Olincy A, Physiology of Schizophrenia, Bipolar Disorder, and Schizo-affective Disorder. Am J Psychiatry. 2007; 164: 1900-1906.
17. Freedman R, Leonard S, Gault J, Hopkins J, Cloninger C, Kaufmann C, Tsuang M, Farone S, Malaspina D, Svrakic D, Sanders A, Gejman P. Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet. 2001; 8, 105 (1): 20-2.
18. Bramon E, Dempster E, Frangou S, McDonald C, Schoenberg P, MacCabe J, Walshe M, Sham P, Collier D, Murray R. Is there an association between the COMT gene and P300 endophenotypes? Eur Psychiatry. 2006; 21(1): 70-3.
19. Yeap S, Kelly S, Sehatpour P, Magno E, Javitt D, Garavan H, Thakore J, Foxe J. Early Visual Sensory Deficits as Endophenotypes for Schizophrenia High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives. Arch Gen Psychiatry. 2006; 63: 1180-1188.
20. Butler P, Zemon V, Schechter I, Saperstein A, Hoptman M, Lim K, Revheim N, Silipo G, Javitt D. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry. 2005; 62: 495-504.
21. Schechter I, Butler P, Zemon V, Revheim N, Saperstein A, Jalbrzikowski M, Pasternak R, Silipo G, Javitt D. Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophrenia. Clin Neurophysiol. 2005; 116: 2204-2215.
22. Rybakowski J, Borkowska A, Czerski P, Dmitrzak-Weglarz M, Hauser J. The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker. Neuropsychobiology. 2003; 47 (3): 115-9.
23. Holzman PS. Eye movements and the search for the essence of schizophrenia. Brain Res Rev. 2000; 31 (2-3): 350-6.
24. Rybakowski J, Borkowska A, Czerski P, Hauser J. Dopamine D3 receptor (DRD3) gene polymorphism is associated with the intensity of eye movement disturbances in schizophrenic patients and healthy subjects. Mol Psychiatry. 2001; 6 (6): 718-24.
25. Hong L, Turano K, O'Neill H, Hao L, Wonodi I, McMahon R, Elliot A, Thaker G. Refining the predictive pursuit endophenotype in schizophrenia. Biol Psychiatry. 2008; 1, 63 (5): 458-64.
26. Toulopoulou T, Quraishi S, McDonald C, Murray RM. The Maudsley Family Study: premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia. J Clin Exp Neuropsychol. 2006; 28 (2): 243-259.
27. Gur R, Calkins M, Gur R, Horan W, Nuechterlein K, Seidman L, Stone W. The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes. Schizophr Bull. 2007; 33 (1): 49-68.
28. Toulopoulou T, Picchioni M, Rijsdijk F, Hua-Hall M, Ettinger U, Sham P, Murray R. Substantial Genetic Overlap Between Neurocognition and Schizophrenia Genetic Modeling in Twin Samples Timothea. Arch Gen Psychiatry. 2007; 64 (12): 1348-1355.
29. Rybakowski J, Borkowska A. Eye movement and neuropsychological studies in first-degree relatives of schizophrenic patients. Schizophr Res. 2002; 1, 54 (1-2): 105-10.
30. Rybakowski J, Borkowska A, Czerski P, Kapelski P, Dmitrzak-Weglarz M, Hauser J. An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia. J Neural Transm. 2005; 112 (11): 1575-82.
31. Rybakowski J, Borkowska A, Czerski P, Dmitrzak-Weglarz M, Skibinska M, Kapelski P, Hauser J. Performance on the Wisconsin Card Sorting Test in schizophrenia and genes of dopaminergic inactivation (COMT, DAT, NET). Psychiatry Res. 2006; 30, 143 (1): 13-9.
32. Rybakowski JK, Borkowska A, Skibinska M, Hauser J. Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia. Psychiatr Genet. 2007; 17 (3): 201-4.
33. Rybakowski JK, Borkowska A, Skibinska M, Szczepankiewicz A, Kapelski P, Leszczynska-Rodziewicz A, Czerski PM, Hauser J. Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin Neurosci. 2006; 60 (1): 70-6.
34. Egan M, Goldberg T, Kolachana B, Callicott J, Mazzanti C, Straub R, Goldman D, Wienberger D. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci. 2001; 5, 98 (12): 6917-22.
35. Bilder R, Volavka J, Czobor P, Malhotra A, Kennedy J, Ni X, Goldman R, Hoptman M, Sheitman B, Lindenmayer J, Citrome L, McEvoy J, Kunz M, Chakos M, Cooper T, Lieberman J. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry. 2002; 1, 52 (7): 701-7.
36. Callicott J, Straub R, Pezawas L, Egan M, Mattay V, Hariri A, Verchinski B, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg T, Weinberger D. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci. 2005; 14, 102 (24): 8627-32.
37. Goldberg T, Straub R, Callicott J, Hariri A, Mattay V, Bigelow L, Coppola R, Egan M, Weinberger D. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology. 2006; 31 (9): 2022-32.
38. Egan M, Kojima M, Callicott J, Goldberg T, Kolachana B, Bertolino A, Zaitsev E, Golb B, Goldman D, Dean M, Lu B, Weinberger D. The BDNF va166met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003; 24, 112 (2): 257-69.
39. Bedwell J, Kamath V, Baksh E. Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia. Schizophr Res. 2006; 88: 36-46.
40. Rybakowski J, Borkowska A. Eye movement and neuropsychological studies in first-degree relatives of schizophrenic patients. Schizophr Res. 2002; 1, 54 (1-2): 105-10.
41. Rybakowski J, Hauser J. Genetyka molekurna w schizofrenii. Kraków: Komitet Redakcyjno-Wydawniczy PTP; 2002.
42. Leppänen J, Niehaus D, Koen L, Du Toit E, Schoeman R, Emsley R. Deficits in facial affect recognition in unaffected siblings of Xhosa schizophrenia patients: Evidence for a neurocognitive endophenotype. Schizophrenia Res. 2007; 99 (1-3): 270-273.
43. Brewer W, Wood S, Pantelis C, Berger G, Copolov D, McGorry P. Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour. Psych Res. 2007; 15, 149 (1-3): 97-104.
44. Brewer W, Wood S, McGorry P, Francey S, Phillips L, Yung A, Anderson V, Copolov D, Singh B, Velakoulis D, Pantelis C. Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J Psychiatry. 2003; 160 (10): 1790-4.
45. Harrison P, Weinberger D. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psych. 2005; 10 (1): 40-68.
46. Callicott J. An expanded role for functional neuroimaging in schizophrenia. Current Opinion in Neurobiology. 2003; 13 (2): 256-260.
47. Szulc A, Czernikiewicz A. Pre-psychotic states - contemporary diagnostic and therapeutic issues. Part II. The biological markers of the risk of schizophrenia. Therapy of pre-psychotic states. Psychiatr Pol. 2007; 41 (1): 17-27.
48. Marcelisa M, Sucklingb J, Woodruff P, Hofmane P, Bullmoref E, van Os J. Searching for a structural endophenotype in psychosis using computational morphometry Psychiatry Research Neuroimaging. 2003; 122: 153-167.
49. Fan Y, Gur R, Gur R, Wu X, Shen D, Calkins M, Davatzikos C. Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification study. Biol Psychiatry. 2008; 63 (1): 118-24.
50. Zipparo L, Whitford T, Redoblado Hodge M, Lucas S, Farrow T, Brennan J, Gomes L, Williams L, Harris A. Investigating the neuropsychological and neuroanatomical changes that occur over the first 2-3 years of illness in patients with first-episode schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32 (2): 531-8.
51. Smesnya S, Klemmb S, Stockebrandb M, Grunwaldb S, Grunwald S, Gerhard U, Rosburg T, Sauer H, Blanz B. Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in Schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2007; 77: 79-85.
52. Nilsson B, Hultman C, Wiesel F. Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls. Prostaglandins Leukot Essent Fatty Acids. 2006; 74 (5): 339-46.
53. Tylec A, Jarzab A, Stryjecka-Zimmer M, Wójcicka A. Stres oksydacyjny w schizofrenii. Pol Merk Lek. 2007; 23 (133): 74-77.
54. Prabakaran S, Wengenroth M, Lockstone H, Lilley K, Leweke F, Bahn S. 2-D DIGE Analysis of Liver and Red Blood Cells Provides Further Evidence for Oxidative Stress in schizophrenia. J Proteome Res. 2007; 6 (1): 141-149.
55. Sham P. Genetic epidemiology. Br Med Bull. 1996; 52 (3): 408-33.
56. Squires-Wheeler E, Skodol A, Bassett A, Erlenmeyer-Kimling L. DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents. J Psychiatr Res. 1989; 23 (3-4): 229-39.
57. Parnas J, Cannon T, Jacobsen B, Schulsinger H, Mednick S. Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Results from the Copenhagen High-Risk Study. Arch Gen Psych. 1993; 50 (9): 707-14.
58. Kendler K, McGuire M, Gruenberg A, O'Hare A, Spellman M, Walsh D. The Roscommon Family Study. III. Schizophrenia-related personality disorders in relatives. Arch Gen Psychiatry. 1993; 50 (10): 781-8.
59. Thaker G. Schizophrenia endophenotypes as treatment targets. Expert Opin Ther Targets. 2007; 11 (9): 1189-206.
60. Czernikiewicz A, Szulc A. Pre-psychotic states - contemporary diagnostic and therapeutic issues. Part I. Clinical identification of pre-psychotic states. Psychiatr Pol. 2007; 41 (1): 5-15.