Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour

Psychiatry Research

Volumn 149, Issue 1-3, 2007, Pages 97-104

  Brewer, Warrick J ^a   Wood, Stephen J ^b,d   Pantelis, Christos ^b   Berger, Gregor E ^a   Copolov, David L ^c   McGorry, Patrick D ^a  

^a ORYGEN RESEARCH CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

Biological marker; Hexenoic acid; Metabolism

Indexed keywords

3 METHYL 2 HEXENOIC ACID; ALKANOIC ACID; ANDROSTERONE DERIVATIVE; BUTANOL; ESTRONE SULFATE; PHEROMONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; COHORT ANALYSIS; FEMALE; HABITUATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; ODOR; OLFACTORY SYSTEM; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA;

1-BUTANOL; ADOLESCENT; ADULT; AFFECT; ANDROSTATRIENES; ANDROSTENOLS; CHRONIC DISEASE; DEMOGRAPHY; DIFFERENTIAL THRESHOLD; ESTRONE; FEMALE; HEXANOIC ACIDS; HUMANS; MALE; MIDDLE AGED; ODORS; OLFACTION DISORDERS; PHEROMONES, HUMAN; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX;

EID: 33846255787     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2006.03.005     Document Type: Article

References (48)

1. Adams R., and Victor M. Principles of Neurology (1985), McGraw Hill, New York
2. Albone E.S., and Shirley S.G. Mammalian Semiochemistry. The Investigation of Chemical Signals Between Mammals (1984), John Wiley, New York
3. Bird S., and Gower D.B. Axillary 5-alpha-androst-16-en-3-one, cholesterol and squalene in men: preliminary evidence for 5-alpha-androst-16-en-3-one being a product of bacterial action. Journal of Steroidal Biochemistry 17 (1982) 517-522
4. Bradley E.A. Olfactory acuity to a pheromonal substance and psychotic illness. Biological Psychiatry 19 (1984) 899-905
5. Brewer W.J., Edwards J., Anderson V., Robinson T., and Pantelis C. Neuropsychological, olfactory, and hygiene deficits in men with negative symptom schizophrenia. Biological Psychiatry 40 (1996) 1021-1031
6. Brewer W.J., Wood S.J., McGorry P.D., Francey S.M., Phillips L.J., Yung, et al. Olfactory identification ability is impaired in individuals at ultra high-risk for psychosis who later develop schizophrenia. American Journal of Psychiatry 160 (2003) 1790-1794
7. Brooksbank B.W.L., and Pryse-Phillips W. Urinary alpha-16-androsten-3alpha-ol, 17-oxosteroids and mental illness. British Medical Journal 20 (1964) 1602-1606
8. Clark, T.O., Ball, R., 1987. Sensitivities to five putative human pheromones in a population of young male service recruits. Mimeograph. From Pharmabulletin 80, Health Commission of Victoria: Publisher.
9. Dalton P., Doolittle N., and Breslin P.A. Gender-specific induction of enhanced sensitivity to odors. Nature Neuroscience 5 (2002) 199-200
10. Doty R.L., Brugger W.E., Jurs P.C., et al. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal individuals. Physiological Behavior 20 (1978) 175-185
11. Doty R., Shaman P., and Dann W. Development of the University of Pennsylvania Smell Test: standardised micro-encapsulated test of olfactory function. Physiological Behavior 32 (1984) 489-502
12. Doty R.L., McKeown D.A., Lee W.W., and Shaman P. A study of the test-retest reliability of ten olfactory tests. Chemical Senses 20 (1995) 645-656
13. Fennig S., Kovasznay B., Rich C., Ram R., Pato C., Miller A., Rubinstein J., Carlson G., Schwartz J.E., and Phelan J. Six-month stability of psychiatric diagnoses in first-admission patients with psychosis. American Journal of Psychiatry 151 8 (1994) 1200-1208
14. Geddes J., Huws R., and Pratt P. Olfactory acuity in the positive and negative symptoms of schizophrenia. Biological Psychiatry 29 (1991) 774-778
15. Gordon S.G., Smith K., Rabinowitz J.L., and Vagelos P.R. Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans. Journal of Lipid Research 14 (1973) 495-503
16. Gower D.B., Bird P.S., and House F.R. Axillary 5-alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. Experientia 41 (1985) 1134-1136
17. Hubert H.B., Fabsitz R.R., Feinlab M., and Brown K.S. Science 208 (1980) 608-609
18. Hubert H.B., Fabsitz R.R., Brown K.S., and Feinlab M. In: Gedda L., Parise P., and Nance W.E. (Eds). Twin Research 3: Epidemiological and Clinical Studies (1981), Liss, New York 97-103
19. Jones-Gotman M., and Zatorre R.J. Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 26 (1988) 387-400
20. Kloek J. The smell of some steroid sex-hormones and their metabolites. Psychiatry, Neurology and Neurochemistry 64 (1961) 309-344
21. Koelega H.S., and Koster E.P. Some experiments on sex differences in odor perception. Annals of the New York Academy of Sciences 237 (1974) 234-246
22. Kopala L., Clark C., and Hurwitz T.A. Sex differences in olfactory function in schizophrenia. American Journal of Psychiatry 146 (1989) 1320-1322
23. Kopala L., Clark C., and Hurwitz T. Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophrenia Research 8 (1992) 245-250
24. Kopala L.C., Good K.P., Koczapski A.B., and Honer W.G. Olfactory deficits in patients with schizophrenia and severe polydipsia. Biological Psychiatry 43 (1998) 497-502
25. Krawiecka M., Goldberg D., and Vaughan M. A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatrica Scandinavica 55 (1977) 299-308
26. Liddell K. Smell as a diagnostic marker. Postgraduate Medical Journal 52 (1976) 136-138
27. Mackay-Sim A., and Doty R.L. The University of Pennsylvania Smell Identification Test: normative adjustment for Australian norms. Australian Journal of Otolaryngology 4 3 (2001) 174-177
28. Malnic B., Godfrey P.A., and Buck L.B. The human olfactory receptor gene family. Proceedings of the National Academy of Sciences 101 (2004) 2584-2589
29. Martzke J.S., Kopala L.C., and Good K.P. Olfactory dysfunction in neuropsychiatric disorders: review and methodological considerations. Biological Psychiatry 42 (1997) 721-732
30. McGorry P.D., Dosseter C.R., Kaplan I., McKenzie D., Van Riel R.J., Singh B.S., et al. Royal Park Multidiagnostic Instrument for Psychosis (RPMIPS) (1989), NH&MRC Schizophrenia Research Unit, Parkville, Australia
31. Moberg P.J., Agrin R., Gur R.E., Gur R.C., Turetsky B.I., and Doty R.L. Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21 (1999) 325-340
32. Nelson H.E., and O'Connell A. Dementia: the estimation of pre-morbid intelligence levels using the new adult reading test. Cortex 14 (1978) 234-244
33. Perry T.J., Melancon S.B., Lesk D., and Hansen S. Failure to detect trans-3-methyl-2-hexenoic acid in the sweat of schizophrenic patients. Clinical Chimica Acta 30 (1970) 721-725
34. Potter H., and Butters N. An assessment of olfactory deficits in patients with damage to prefrontal cortex. Neuropsychologia 18 (1980) 621-628
35. Purdon S.E., Klein S., and Flor-Henry P. Menstrual effects on asymmetrical olfactory acuity. Journal of the International Neuropsychological Society 7 (2001) 703-709
36. Roberts M.A. Some possible pathways for the synthesis of trans-3-methyl-2 hexenoic acid. Orthomolecular Psychiatry 9 2 (1980) 129-134
37. Sirota P., Davidson B., Mosheva T., Benhatov R., Zohar J., and Gross-Isseroff R. Increased olfactory sensitivity in first episode psychosis and the effect of neuroleptic treatment on olfactory sensitivity in schizophrenia. Psychiatry Research 86 (1999) 143-153
38. Smith R.V., and Leong A. Methods for the preparation of trans-3-methyl-2-hexenoic acid, the malodorous component of schizophrenics' sweat. Journal of Pharmaceutical Sciences 61 (1972) 316-317
39. Smith K., and Sines J.O. Demonstration of a peculiar odour in the sweat of schizophrenic patients. Archives of General Psychiatry 2 (1960) 184-188
40. Smith K., Thompson G.F., and Koster H.D. Sweat in schizophrenic patients: identification of odorous substance. Science 166 (1969) 398-399
41. Spitzer R.L., Williams J.B.W., and Gibbons M. Structured Clinical Interview for DSM-III-R (SCID-R) (1988), New York State Psychiatric Institute, Biometrics Research, New York
42. Stoddart D.M. Mammalian Odours and Pheromones (1976), Camelot Press, Southampton
43. Wiener H. External chemical messengers. I. Emission and reception in man. New York State Journal of Medicine (1966) 3153-3171 (Dec 15)
44. Wiener H. External chemical messengers, II. Natural history of schizophrenia. New York State Journal of Medicine (1967) 1144-1151 (May 1)
45. Willshire D., Kinsella G., and Prior M. Estimating WAIS-R IQ from the National Adult Reading Test: a cross-validation. Journal of Clinical and Experimental Neuropsychology 13 2 (1990) 204-216
46. Wu J., Buschbaum M.S., Moy K., Denlea N., Kesslak P., Tseng H., Plosnaj D., Hetu M., Potkin S., Bracha S., and Cotman C. Olfactory memory in unmedicated schizophrenics. Schizophrenia Research 9 (1993) 41-47
47. Wysocki C.J., and Beauchamp G.K. Ability to smell androstenone is genetically determined. Proceedings of the National Academy of Sciences 81 (1984) 4899-4902
48. Wysocki C.J., and Gilbert A.N. National Geographic Smell Survey: effects of age are heterogeneous. Annals of the New York Academy of Sciences 561 (1989) 12-48