Formulation and in-vitro evaluation of microbially triggered ibuprofen delivery for colon targetting

International Journal of PharmTech Research

Volumn 1, Issue 2, 2009, Pages 328-333

  Bhosale, A V ^a   Hardikar, S R ^a   Patil, Naresh ^a   Patel, Umang ^a   Sumbe, Yogesh ^a   Jagtap, Rajesh ^a  

^a PDEA's Seth Govind Raghunath Sable College of Pharmacy   (India)

Author keywords

Colon targeting; Compression coating; Enzyme activated; Guar gum; HPMC K4M; Microbially triggered system; Site specific drug delivery

Indexed keywords

EID: 77953451103     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ashford M, and Fell J. T, Colonic delivery of drugs, Current status on targeted drug delivery to the gastrointestinal tract. Short Hills (NJ). Capsugel, Symposia Series, 1993, 133-142.
2. Niwa K, Takaya T, Morimoto T, Takada K, Preparation and evaluation of a time-controlled release capsule made of ethyl cellulose for colon delivery of drugs. J Drug Target, 1995, 53: 83-89.
3. Chavan MS, Sant VP, Nagarsenker MS, Azo-containing urethane analogues for colonic drug delivery: synthesis, characterization and in-vitro evaluation. J Pharm Pharmacol 2001, 5: 895-900,
4. Symn C, Kala W, Van den Mooter G, Kinget R, Synthesis and in vitro biodegradation of poly (ether-ester) azo polymers designed for colon targeting. Int J Pharm, 2001,121: 211-216,
5. Ueda T, Yamaoka M, Miyamoto M, Kimura Y, Bacterial reduction of azo compounds as a model reaction for the degradation of azo-containing polyurethane by the action of intestinal flora. Bull Chem Soc Jpn, 1996,69: 1139-1142
6. Yamaoka T, Makita Y, Sasatani H, Kim SI, Kimura Y. Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behaviour, and utilization for drug formulation. J Control Rel, 2000 ,66: 187-197 (Pubitemid 30160856)
7. Ashford M, Fell JT, Attwood D, Sharma H, Woodhead P. Studies on pectin formulations for colonic drug delivery. J Control Rel, 1994,30:225-232
8. Milojevic S, Newton JM, Cummings JH, Gibson GR, Botham RL, Ring SC, Stockham M, Allwood MC. Amylose as a coating for drug delivery the colon: preparation and in vitro evaluation using glucose pellets. J Control Rel, vol 1996,38: 85-94.
9. Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S. Chitosan capsules for colon specific drug delivery: improvement of insulin absorption from the rat colon. J Pharm Sci, 1997, 86: 1016-1021 (Pubitemid 27382903)
10. Rubinstein A, Nakar D, Sintov A Chondroitin sulphate: a potential biodegradable carrier for colon-specific drug delivery. Int J Pharm. 1992,84: 141-150
11. Gliko-Kabir I, Yagen B, Penhasi A, Rubinstein A. Low swelling, cross linked guar and its potential use as colon-specific drug carrier. Pharm Res, 1998,15: 1019-1025 (Pubitemid 28356917)
12. Gliko-Kabir I, Yagen B, Baluom M, Rubinstein a Phosphated cross linked guar for colon-specific drug delivery. II. In vitro and in vivo evaluation. J Control Rel, 2000, vol 63:129-134.
13. Krishnaiah YSR, Seetha Devi A, Nageswara Rao L, Bhaskar Reddy PR, Karthikeyan RS, Satyanarayana V. Guar gum as a carrier for colon specific delivery; influence of metronidazole and tinidazole on in vitro release of albendazole from guar gum matrix tablets. J Pharm Pharmaceutics Sci, 2001,4: 235-243. (Pubitemid 34305599)
14. Krishnaiah YSR, Satyanarayana S, Rama Prasad YV, Narasimha Rao S. Gamma scintigraphic studies on guar gum matrix tablets for colonic drug delivery in healthy subjects. J Control Rel, 1998,55: 245-252. (Pubitemid 28477615)
15. Munira M, Punarikakshudu K. Studies on the development and optimization of oral colon targeted drug delivery system for sennoside in the treatment of constipation. Drug Deliv Technol, 2004, 6: 54-61.
16. Rama Prasad YV, Krishnaiah YSR, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J Control Rel, vol 51: 281-287(1998).
17. Wilson C. G., Washington N., Greaves J. L., Kamali F., Rees J. A., Sempik A. K. and Lampard J. F. Bimodal release of ibuprofen in a sustained-release formulation: a scintigraphic and pharmacokinetic open study in healthy volunteers under different conditions of food intake. Int. J. Pharm, 1989, 50:155-161.
18. Rittschell W. A. Handbook of Basic Pharmacokinetics, 4th ed., Drug Intelligence Publications, Hamilton Press, Illinois1992.
19. Ritschell W. A., Menon A. and Sakr A. Biopharmaceutical evaluation of furosemide as a potential candidate for a modified release peroral dosage form. Meth. Find Exp. Clin. Pharmacol, 1991, 13: 629-636.
20. Bolton S, editor. Pharmaceutical statistics. 3rd Ed. New York: Marcel Dekker, p 326, 1997.
21. Wong, D., Larrabeo, S., Clifford, K., Tremblay, J., Friend, D.R., USP dissolution Apparatus III (reciprocating cylinder) for screening of guarbased colonic delivery formulation. J. Control. Release 1997,47: 173-179. (Pubitemid 27212344)
22. Sinha VR, Mittal BR, Bhutani KK, Kumria R. Colonic drug delivery of 5-fluorouracil: an in vitro evaluation. Int J Pharm, 2004, 269: 101-108. (Pubitemid 38032827)
23. United States Pharmacopoeia Convention (USP). 1999. USP 24- NF-19, Rockville, USA.
24. Colombo, P., Bettini, R., Santi, P., Peppas, N.A., Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanism and optimal performance. Pharm. Sci. Tech. Today 2000, 3:198-204.
25. Vilivalam, V.D., Illum, L., Iqbal, K., Starch capsules: an alternative system for oral drug delivery. Pharm. Sci. Tech. Today 2000, 3: 64-69.