Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: Its properties, degradation behavior, and utilization for drug formulation

Journal of Controlled Release

Volumn 66, Issue 2-3, 2000, Pages 187-197

  Yamaoka, Tetsuji ^a   Makita, Yoshiya ^a   Sasatani, Haruhide ^b   Kim, Soon Ih ^b   Kimura, Yoshiharu ^a  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Azo reductase; Colon specific delivery; Segmented polyurethane; Targeting

Indexed keywords

15 CYCLOPENTYL 14 OXO 13 AZA 16,17,18,19,20 PENTANORPINANE THROMBOXANE A2; 3,3' DI(HYDROXYMETHYL)AZOBENZENE; AZO COMPOUND; AZO REDUCTASE; AZOBENZENE DERIVATIVE; CARBOXYMETHYLCELLULOSE; ETHYL CELLULOSE; ISOPHORONE; ISOPHORONE DIISOCYANATE; MACROGOL; OZAGREL; POLYMER; POLYURETHAN; PROPYLENE GLYCOL; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COLON; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEGRADATION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; ENERGY; FECES MICROFLORA; FILM; HYDROPHILICITY; INTESTINE FLORA; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

COLON; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINES; MAGNETIC RESONANCE SPECTROSCOPY; METHACRYLATES; MODELS, CHEMICAL; POLYMERS; POLYURETHANES; SPECTROPHOTOMETRY, ULTRAVIOLET; THROMBOXANE A2;

EID: 0034657032     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00270-9     Document Type: Article

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