Low swelling, crosslinked guar and its potential use as colon-specific drug carrier

Pharmaceutical Research

Volumn 15, Issue 7, 1998, Pages 1019-1025

  Gliko Kabir, Irit ^a   Yagen, Boris ^a   Penhasi, Adel ^b   Rubinstein, Abraham ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b Perio Products Ltd   (Israel)

Author keywords

Budesonide; Colon; Colonic delivery; Crosslinking; Glutaraldehyde; Guar gum; Hydrogel; Indomethacin; Sodium salicylate

Indexed keywords

BUDESONIDE; DRUG CARRIER; GUAR GUM; INDOMETACIN; SALICYLATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROGEL; IN VITRO STUDY; INTESTINE FLUID; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; STOMACH JUICE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUDESONIDE; CARBOHYDRATE SEQUENCE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; COLON; CROSS-LINKING REAGENTS; DRUG CARRIERS; GALACTANS; GLUTARAL; INDOMETHACIN; KINETICS; MANNANS; MOLECULAR SEQUENCE DATA; PLANT GUMS; RATS; SENSITIVITY AND SPECIFICITY; SODIUM SALICYLATE; STOMACH;

EID: 0031870290     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011921925745     Document Type: Article

References (30)

1. G. Hawksworth, B. S. Drasar, and M. J. Hill. Intestinal bacteria and the hydrolysis of glycosidic bonds. J. Med. Microbiol. 4:451-459 (1971).
2. M. Ashford, J. T. Fell, D. Attwood, H. Sharma, and P. J. Woodhead. An in vivo investigation into the suitability of pH dependent polymers for colonic targeting. Int. J. Pharm. 95:193-199 (1993).
3. J. Conchie and D. C. Macdonald. Glycosidases in the mammalian alimentary canal. Nature 184:1233 (1959).
4. H. N. Englyst, S. Hay, and G. T. Macfarlane. Polysaccharide breakdown by mixed populations of human fecal bacteria. FEMS Microbiol. Ecol. 95:163-171 (1987).
5. A. Rubinstein. Approaches and opportunities in colon-specific drug delivery. Crit. Rev. Ther. Drug Carr. Sys. 12:101-149 (1995).
6. A. Rubinstein and I. Gliko-Kabir. Synthesis and swelling dependent enzymatic degradation of borax modified guar gum for colonic delivery purposes, s.t.p. Pharm. Sci. 5:41-46 (1995).
7. H. Neukom. Galactomannans: properties and applications. Lebensm.-Wiss. u.-Technol. 22:41-45 (1993).
8. A. A. Lawrence. Natural Gums For Edible Purposes, Noyes Data Corporation, N.J., 1976, pp. 17-55.
9. S. K. Baveja, K. V. R. Ranga Rao, J. Arora, N. K. Mathur, and V. K. Vinayak. Chemical investigation of some galactomannan gums as matrix tablets for sustained drug delivery. Ind. J. Chem. 30:133-137 (1991).
10. A. W. Sarlikiotis and K. H. Bauer. Synthese und untersuchung von polyurethanen mit galactomannan-segmenten als hilfsstoffe zur freisetzung von peptid-arzneistoffen im dickdarm. Pharm. Ind. 54:873-880 (1992).
11. K. O. R. Lehmann and K. D. Dreher. Methacrylate-galactomannan coating for colon-specific drug delivery. Proceed. Int. Symp. Contr. Rel. Bioact. Mater. 18:331-332 (1991).
12. J. Tomlin, N. W. Read, C. A. Edwards, and B. I. Duerden. The degradation of guar gum by a faecal incubation system. Br. J. Nutr. 55:481-486 (1986).
13. G. T. Macfarlane, S. Hay, S. Macfarlane, and G. R. Gibson. Effect of different carbohydrates on growth, polysaccharidase and glycosidaseproduction by Bacteroides ovatus, in batch and continuous culture. J. App. Bacterial. 68:179-187 (1990).
14. C. T. Reinhart and N. A. Peppas. Solute diffusion in swollen membranes. Part II. Influence of crosslinking on diffusive properties. J. Membrane Sci. 18:227-239 (1984).
15. B. C. Thanoo, M. C. Sunny, and A. Jayakrishnan. Controlled release of oral drugs from cross-linked polyvinyl alcohol microspheres. J. Pharm. Pharmacol. 45:16-20 (1993).
16. C.-J. Kim and P. I. Lee. Composite poly(vinyl alcohol) heads for controlled drug delivery. Pharm. Res. 9:10-16 (1992).
17. M. Grimm, M. Grabenwoger, E. Eybl, A. Moritz, P. Bock, M. M. Muller, and E. Wolner. Improved biocompetability of biprosthetic heart valves by L-glutamic treatment. J. Card. Surg. 7:58-64 (1992).
18. J. Kawahara, T. Ohmori, T. Ohkubo, S. Hattori, and M. Kawamura. The structure of glutaraldehyde in aqueous solution determined by ultraviolet absorption and light scattering. Anal. Biochem. 201:94-98 (1992).
19. A. Ya. Sorokin, V. A. Kuznetsova, F. O. Pozdnyakova, L. E. Mal'tseva. M. M. Onopleva, N. A. Domnicheva, and N. O. Shemyakina. Effect of the quality of glutaraldehyde on the properties of crosslinked polyvinyl alcohol. Zhurnal Prikladnoi Khimii, 62:665-669 (1989).
20. U.S.P. XXIII, United States Pharmacopeial Convention (1995) Rockville, MD, pp. 2053.
21. N. A. Peppas and E. W. Merrill. Development of semicrystallinepoly (vinyl alcohol) hydrogels for biomedical applications. J. Biomed. Mater. Res. 11:423-434 (1977).
22. W. R. Sharman, E. L. Richards, and G. N. Malcolm. Hydrodynamic properties of aqueous solutions of galactomannans. Biopolymers 17:2817-2833 (1978).
23. P. Munk. Introduction to Macromolecular Science, New York, John Wiley & Sons, Chapter 4, 67-98 (1989).
24. J. E. Mark. Experimental determinations of crosslink densities. Rubber Chem. Tech. 55:762-768 (1982).
25. J. Kopecek, P. Kopeckova, H. Brondsted, R. Rathr, R. Rihova, P-Y. Yeh, and K. Ikesue. Polymers for colon-specific drug delivery. J. Contr. Rel. 19:121-130 (1992).
26. R. W. Korsmeyer and N. A. Peppas. Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs. J. Memb. Sci. 9:211-227 (1981).
27. J. C. Bray and E. W. Merrill. Poly(vinyl alcohol) hydrogels. Formation by electron beam irradiation of aqueous solutions and subsequent crystallization. J. Appl. Polymer Sci. 17:3779-3794 (1973).
28. P. J. Flory. Principles of Polymer Chemistry, Cornell University Press, Ithaca, N. Y., Chapters 11 and 13, 347-398, 541-593 (1953).
29. B. V. McCleary, E. Nurthen, F. R. Taravel, and J. -P. Joseleau. Characterization of the oligosaccharides produced on hydrolysis of galactomannan with β-D-mannanase. Carbohydr. Res. 118:91-109 (1983).
30. D. Wong, S. Larabee, K. Clifford, J. Tremblay, and D. R. Friend. USP dissolution appartus III (reciprocating cylinder) for screening of guar-based colonic delivery formulations. J. Contr. Rel. 47:173-179 (1997).