메뉴 건너뛰기




Volumn 1, Issue 3, 2009, Pages 321-327

IL-13 receptor-α2: A novel target for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; PROTEIN KINASE TYK2; STAT6 PROTEIN;

EID: 77953443734     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.09.8     Document Type: Editorial
Times cited : (18)

References (78)
  • 1
    • 0029839018 scopus 로고    scopus 로고
    • Receptor for interleukin (IL)13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells
    • Debinski W, Miner R, Leland P, Obiri NI, Puri RK: Receptor for interleukin (IL)13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells. J. Biol. Chem. 271, 22428-22433 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 22428-22433
    • Debinski, W.1    Miner, R.2    Leland, P.3    Obiri, N.I.4    Puri, R.K.5
  • 2
    • 0034210937 scopus 로고    scopus 로고
    • Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft
    • Husain SR, Puri RK: Interleukin-13 fusion cytotoxin as a potent targeted agent for AIDS-Kaposi's sarcoma xenograft. Blood 95, 3506-3513 (2000).
    • (2000) Blood , vol.95 , pp. 3506-3513
    • Husain, S.R.1    Puri, R.K.2
  • 3
    • 0036284481 scopus 로고    scopus 로고
    • Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: Differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin
    • Joshi BH, Kawakami K, Leland P, Puri RK: Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin. Clin. Cancer Res. 8, 1948-1956 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1948-1956
    • Joshi, B.H.1    Kawakami, K.2    Leland, P.3    Puri, R.K.4
  • 4
    • 0034162718 scopus 로고    scopus 로고
    • Interleukin-13 receptor α chain: A novel tumor-associated transmembrane protein in primary expiants of human malignant gliomas
    • Joshi BH, Plautz GE, Puri RK: Interleukin-13 receptor α chain: a novel tumor-associated transmembrane protein in primary expiants of human malignant gliomas. Cancer Res. 60, 1168-1172 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1168-1172
    • Joshi, B.H.1    Plautz, G.E.2    Puri, R.K.3
  • 5
    • 0034212488 scopus 로고    scopus 로고
    • Structure, function, and targeting of interleukin 4 receptors on human head and neck cancer cells
    • Kawakami K, Leland P, Puri RK: Structure, function, and targeting of interleukin 4 receptors on human head and neck cancer cells. Cancer Res. 60, 2981-2987 (2000). (Pubitemid 30395824)
    • (2000) Cancer Research , vol.60 , Issue.11 , pp. 2981-2987
    • Kawakami, K.1    Leland, P.2    Puri, R.K.3
  • 6
    • 33749005099 scopus 로고    scopus 로고
    • Interleukin-13 receptor α2 chain: A potential biomarker and molecular target for ovarian cancer therapy
    • DOI 10.1002/cncr.22134
    • Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK: Interleukin-13 receptor α2 chain: a potential biomarker and molecular target for ovarian cancer therapy. Cancer 107, 1407-1418 (2006). (Pubitemid 44452792)
    • (2006) Cancer , vol.107 , Issue.6 , pp. 1407-1418
    • Kioi, M.1    Kawakami, M.2    Shimamura, T.3    Husain, S.R.4    Puri, R.K.5
  • 7
    • 0028917463 scopus 로고
    • Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common γ chain shared by receptors for interleukins 2, 4, 7, 9, and 15
    • Obiri NI, Debinski W, Leonard WJ, Puri RK: Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common γ chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J. Biol. Chem. 270, 8797-8804 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 8797-8804
    • Obiri, N.I.1    Debinski, W.2    Leonard, W.J.3    Puri, R.K.4
  • 8
    • 33947723884 scopus 로고    scopus 로고
    • Role of interleukin-13 in cancer, pulmonary fibrosis, and other Th2-type diseases
    • Joshi BH, Hogaboam C, Dover P, Husain SR, Puri RK: Role of interleukin-13 in cancer, pulmonary fibrosis, and other Th2-type diseases. Vitam. Horm. 74, 479-504 (2006).
    • (2006) Vitam. Horm. , vol.74 , pp. 479-504
    • Joshi, B.H.1    Hogaboam, C.2    Dover, P.3    Husain, S.R.4    Puri, R.K.5
  • 9
    • 0031559793 scopus 로고    scopus 로고
    • Structure of IL-13 receptor: Analysis of subunit composition in cancer and immune cells
    • Murata T, Obiri NI, Debinski W, Puri RK: Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells. Biochem. Biophys. Res. Commun. 238, 90-94 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 90-94
    • Murata, T.1    Obiri, N.I.2    Debinski, W.3    Puri, R.K.4
  • 10
    • 0031568012 scopus 로고    scopus 로고
    • The IL-13 Receptor Structure Differs on Various Cell Types and May Share More Than One Component with IL-4 Receptor
    • Obiri NI, Leland P, Murata T, Debinski W, Puri RK: The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor. J. Immunol. 158, 756-764 (1997). (Pubitemid 127492652)
    • (1997) Journal of Immunology , vol.158 , Issue.2 , pp. 756-764
    • Obiri, N.I.1    Leland, P.2    Murata, T.3    Debinski, W.4    Puri, R.K.5
  • 11
    • 0030743489 scopus 로고    scopus 로고
    • Modulation of interleukin (IL)-13 binding and signaling by the γ c chain of the IL-2 receptor
    • Obiri NI, Murata T, Debinski W, Puri RK: Modulation of interleukin (IL)-13 binding and signaling by the γ c chain of the IL-2 receptor. J. Biol. Chem. 272, 20251-20258 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 20251-20258
    • Obiri, N.I.1    Murata, T.2    Debinski, W.3    Puri, R.K.4
  • 12
    • 58149143039 scopus 로고    scopus 로고
    • Tuning sensitivity to IL-4 and IL-13: Differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity
    • Junttila IS, Mizukami K, Dickensheets H et al.: Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity. J. Exp. Med. 205, 2595-2608 (2008)
    • (2008) J. Exp. Med. , vol.205 , pp. 2595-2608
    • Junttila, I.S.1    Mizukami, K.2    Dickensheets, H.3
  • 13
    • 0035353154 scopus 로고    scopus 로고
    • The interleukin-13 receptor α2 chain: An essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway
    • Kawakami K, Taguchi J, Murata T, Puri RK: The interleukin-13 receptor α2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway. Blood 97, 2673-2679 (2001).
    • (2001) Blood , vol.97 , pp. 2673-2679
    • Kawakami, K.1    Taguchi, J.2    Murata, T.3    Puri, R.K.4
  • 14
    • 0030584699 scopus 로고    scopus 로고
    • IL-13 induces phosphorylation and activation of JAK2 janus kinase in human colon carcinoma cell lines: Similarities between IL-4 and IL-13 signaling
    • Murata T, Noguchi PD, Puri RK: IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. J. Immunol. 156, 2972-2978 (1996). (Pubitemid 126660646)
    • (1996) Journal of Immunology , vol.156 , Issue.8 , pp. 2972-2978
    • Murata, T.1    Noguchi, P.D.2    Puri, R.K.3
  • 15
    • 0031036961 scopus 로고    scopus 로고
    • Human ovarian-carcinoma cell lines express IL-4 and IL-13 receptors: Comparison between IL-4- And IL-13-induced signal transduction
    • DOI 10.1002/(SICI)1097-0215(19970117)70:2<230::AID-IJC15>3.0.CO;2-M
    • Murata T, Obiri NI, Puri RK: Human ovarian-carcinoma cell lines express IL-4 and IL-13 receptors: comparison between IL-4-and IL-13-induced signal transduction. Int. J. Cancer 70, 230-240 (1997). (Pubitemid 27107422)
    • (1997) International Journal of Cancer , vol.70 , Issue.2 , pp. 230-240
    • Murata, T.1    Obiri, N.I.2    Puri, R.K.3
  • 16
    • 0032009864 scopus 로고    scopus 로고
    • Structure of and signal transduction through interleukin-4 and interleukin-13 receptors
    • review
    • Murata T, Obiri NI, Puri RK: Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review). Int. J. Mol. Med. 1, 551-557 (1998).
    • (1998) Int. J. Mol. Med. , vol.1 , pp. 551-557
    • Murata, T.1    Obiri, N.I.2    Puri, R.K.3
  • 17
    • 0031561791 scopus 로고    scopus 로고
    • Comparison of IL-13- and IL-4-induced signaling in EBV-immortalized human B cells
    • Murata T, Puri RK: Comparison of IL-13- and IL-4-induced signaling in EBV- immortalized human B cells. Cell. Immunol. 175, 33-40 (1997).
    • (1997) Cell. Immunol. , vol.175 , pp. 33-40
    • Murata, T.1    Puri, R.K.2
  • 18
    • 0032525073 scopus 로고    scopus 로고
    • Interleukin-13 receptor α' but not α chain: A functional component of interleukin-4 receptors
    • Murata T, Taguchi J Puri RK: Interleukin-13 receptor α′ but not a chain: a functional component of interleukin-4 receptors. Blood 91, 3884-3891 (1998). (Pubitemid 28225757)
    • (1998) Blood , vol.91 , Issue.10 , pp. 3884-3891
    • Murata, T.1    Taguchi, J.2    Puri, R.K.3
  • 19
    • 0032600012 scopus 로고    scopus 로고
    • Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system
    • Murata T, Taguchi J, Puri RK, Mohri H: Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system. Int. J. Hematol. 69, 13-20 (1999).
    • (1999) Int. J. Hematol. , vol.69 , pp. 13-20
    • Murata, T.1    Taguchi, J.2    Puri, R.K.3    Mohri, H.4
  • 20
    • 0029557497 scopus 로고
    • Receptors for interleukin (IL)-4 do not associate with the common γ chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells
    • Murata T, Noguchi PD, Puri RK: Receptors for interleukin (IL)-4 do not associate with the common γ chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. J. Biol. Chem. 270, 30829-30836 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 30829-30836
    • Murata, T.1    Noguchi, P.D.2    Puri, R.K.3
  • 21
    • 0028341465 scopus 로고
    • Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-γ-induced nuclear binding factor
    • DOI 10.1016/0014-5793(94)00438-2
    • Kohler I, Alliger P, Minty A et al.: Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-γ-induced nuclear binding factor. FEBS Lett. 345, 187-192 (1994). (Pubitemid 24188922)
    • (1994) FEBS Letters , vol.345 , Issue.2-3 , pp. 187-192
    • Kohler, I.1
  • 22
    • 0031903791 scopus 로고    scopus 로고
    • Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway
    • Murata T, Husain SR, Mohri H, Puri RK: Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway. Int. Immunol. 10, 1103-1110 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 1103-1110
    • Murata, T.1    Husain, S.R.2    Mohri, H.3    Puri, R.K.4
  • 23
    • 0029316775 scopus 로고
    • Activation of gene transcription by IL-4, IL-13 and IFN-γ through a shared DNA binding motif
    • Kohler I, Alliger P, Rieber EP: Activation of gene transcription by IL-4, IL-13 and IFN-γ through a shared DNA binding motif. Behring Inst. Mitt. 78-86 (1995).
    • (1995) Behring Inst. Mitt. , pp. 78-86
    • Kohler, I.1    Alliger, P.2    Rieber, E.P.3
  • 24
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin JX, Migone TS, Tsang M et al.: The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2, 331-339 (1995).
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.X.1    Migone, T.S.2    Tsang, M.3
  • 25
    • 0034544609 scopus 로고    scopus 로고
    • Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma
    • Ostrand-Rosenberg S, Grusby MJ, Clements VK: Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J. Immunol. 165, 6015-6019 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 6015-6019
    • Ostrand-Rosenberg, S.1    Grusby, M.J.2    Clements, V.K.3
  • 26
    • 0036174529 scopus 로고    scopus 로고
    • Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma
    • Blease K, Schuh JM, Jakubzick C et al.: Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am. J. Pathol. 160, 481-490 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 481-490
    • Blease, K.1    Schuh, J.M.2    Jakubzick, C.3
  • 27
    • 0032167603 scopus 로고    scopus 로고
    • The murine IL-13 receptor α 2: Molecular cloning, characterization, and comparison with murine IL-13 receptor α 1
    • Donaldson DD, Whitters MJ, Fitz LJ et al.: The murine IL-13 receptor α 2: molecular cloning, characterization, and comparison with murine IL-13 receptor α 1. J. Immunol. 161, 2317-2324 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 2317-2324
    • Donaldson, D.D.1    Whitters, M.J.2    Fitz, L.J.3
  • 29
    • 9644268915 scopus 로고    scopus 로고
    • Opposing roles for IL-13 and IL-13 receptor α 2 in health and disease
    • Mentink-Kane MM, Wynn TA: Opposing roles for IL-13 and IL-13 receptor α 2 in health and disease. Immunol. Rev. 202, 191-202 (2004).
    • (2004) Immunol. Rev. , vol.202 , pp. 191-202
    • Mentink-Kane, M.M.1    Wynn, T.A.2
  • 30
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn TA: IL-13 effector functions. Annu. Rev. Immunol. 21, 425-456 (2003).
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 31
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the Th1/Th2 paradigm
    • Wynn TA: Fibrotic disease and the Th1/Th2 paradigm. Nat. Rev. Immunol. 4, 583-594 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 32
    • 0030975719 scopus 로고    scopus 로고
    • Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor α-chains
    • Zhang JG, Hilton DJ, Willson TA et al.: Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor α-chains. J. Biol. Chem. 272, 9474-9480 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 9474-9480
    • Zhang, J.G.1    Hilton, D.J.2    Willson, T.A.3
  • 34
    • 0034585303 scopus 로고    scopus 로고
    • Mutation and functional analysis of IL-13 receptors in human malignant glioma cells
    • Kawakami M, Leland P, Kawakami K, Puri RK: Mutation and functional analysis of IL-13 receptors in human malignant glioma cells. Oncol. Res. 12, 459-467 (2000).
    • (2000) Oncol. Res. , vol.12 , pp. 459-467
    • Kawakami, M.1    Leland, P.2    Kawakami, K.3    Puri, R.K.4
  • 35
    • 34447103212 scopus 로고    scopus 로고
    • Endogenous metalloprotease solubilizes IL-13 receptor α2 in airway epithelial cells
    • Matsumura M, Inoue H, Matsumoto T et al.: Endogenous metalloprotease solubilizes IL-13 receptor α2 in airway epithelial cells. Biochem. Biophys. Res. Commun. 360, 464-469 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.360 , pp. 464-469
    • Matsumura, M.1    Inoue, H.2    Matsumoto, T.3
  • 36
    • 50649091566 scopus 로고    scopus 로고
    • Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor α2 in vivo
    • Chen W, Tabata Y, Gibson AM et al.: Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor α2 in vivo. J. Allergy Clin. Immunol. 122, 625-632 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.122 , pp. 625-632
    • Chen, W.1    Tabata, Y.2    Gibson, A.M.3
  • 37
    • 0034923170 scopus 로고    scopus 로고
    • Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    • Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA: Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34, 273-282 (2001).
    • (2001) Hepatology , vol.34 , pp. 273-282
    • Chiaramonte, M.G.1    Cheever, A.W.2    Malley, J.D.3    Donaldson, D.D.4    Wynn, T.A.5
  • 38
    • 9144219618 scopus 로고    scopus 로고
    • IL-13 receptor α 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis
    • Mentink-Kane MM, Cheever AW, Thompson RW et al.: IL-13 receptor α 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc. Natl Acad. Sci. USA 101, 586-590 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 586-590
    • Mentink-Kane, M.M.1    Cheever, A.W.2    Thompson, R.W.3
  • 39
    • 49849106612 scopus 로고    scopus 로고
    • Targeting IL-13Rα2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin
    • Kioi M, Seetharam S, Puri RK: Targeting IL-13Rα2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin. Mol. Cancer Ther. 7, 1579-1587 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1579-1587
    • Kioi, M.1    Seetharam, S.2    Puri, R.K.3
  • 40
    • 33845608432 scopus 로고    scopus 로고
    • N-linked glycosylation of IL-13Rα2 is essential for optimal IL-13 inhibitory activity
    • DOI 10.1096/fj.06-5995fje
    • Kioi M, Seetharam S, Puri RK: N-linked glycosylation of IL-13R α2 is essential for optimal IL-13 inhibitory activity. FASEB J. 20, 2378-2380 (2006). (Pubitemid 44953833)
    • (2006) FASEB Journal , vol.20 , Issue.13
    • Kioi, M.1    Seetharam, S.2    Puri, R.K.3
  • 41
    • 0036168305 scopus 로고    scopus 로고
    • IL-13Rα2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells
    • Rahaman SO, Sharma P, Harbor PC, Aman MJ, Vogelbaum MA, Haque SJ: IL-13Rα2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res. 62, 1103-1109 (2002). (Pubitemid 34160294)
    • (2002) Cancer Research , vol.62 , Issue.4 , pp. 1103-1109
    • Rahaman, S.O.1    Sharma, P.2    Harbor, P.C.3    Aman, M.J.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 42
    • 16844373256 scopus 로고    scopus 로고
    • Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: Involvement of IL-13Rα2
    • Rahaman SO, Vogelbaum MA, Haque SJ: Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Rα2. Cancer Res. 65, 2956-2963 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 2956-2963
    • Rahaman, S.O.1    Vogelbaum, M.A.2    Haque, S.J.3
  • 43
    • 0344091551 scopus 로고    scopus 로고
    • Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor α 2
    • Wood N, Whitters MJ, Jacobson BA et al.: Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor α 2. J. Exp. Med. 197, 703-709 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 703-709
    • Wood, N.1    Whitters, M.J.2    Jacobson, B.A.3
  • 44
    • 0035816669 scopus 로고    scopus 로고
    • Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor α 2 chain
    • Kawakami K, Takeshita F, Puri RK: Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor α 2 chain. J. Biol. Chem. 276, 25114-25120 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 25114-25120
    • Kawakami, K.1    Takeshita, F.2    Puri, R.K.3
  • 45
    • 30044449492 scopus 로고    scopus 로고
    • IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis
    • Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A: IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis. Nat. Med. 12, 99-106 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 99-106
    • Fichtner-Feigl, S.1    Strober, W.2    Kawakami, K.3    Puri, R.K.4    Kitani, A.5
  • 46
    • 33646263592 scopus 로고    scopus 로고
    • Characterization of a novel human tumor antigen interleukin-13 receptor α2 chain
    • Kawakami K, Terabe M, Kawakami M, Berzofsky JA, Puri RK: Characterization of a novel human tumor antigen interleukin-13 receptor α2 chain. Cancer Res. 66, 4434-4442 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 4434-4442
    • Kawakami, K.1    Terabe, M.2    Kawakami, M.3    Berzofsky, J.A.4    Puri, R.K.5
  • 48
    • 39549084707 scopus 로고    scopus 로고
    • Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma
    • Ueda R, Low KL, Zhu X et al.: Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma. J. Transl. Med. 5, 68 (2007).
    • (2007) J. Transl. Med. , vol.5 , pp. 68
    • Ueda, R.1    Low, K.L.2    Zhu, X.3
  • 51
    • 10844296758 scopus 로고    scopus 로고
    • Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
    • DOI 10.1158/0008-5472.CAN-04-0454
    • Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC: Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells. Cancer Res. 64, 9160-9166 (2004). (Pubitemid 39665531)
    • (2004) Cancer Research , vol.64 , Issue.24 , pp. 9160-9166
    • Kahlon, K.S.1    Brown, C.2    Cooper, L.J.N.3    Raubitschek, A.4    Forman, S.J.5    Jensen, M.C.6
  • 52
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM et al.: Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005).
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 53
    • 0035905491 scopus 로고    scopus 로고
    • In vivo overexpression of IL-13 receptor α2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice
    • Kawakami K, Kawakami M, Snoy PJ, Husain SR, Puri RK: In vivo overexpression of IL-13 receptor α2 chain inhibits tumorigenicity of human breast and pancreatic tumors in immunodeficient mice. J. Exp. Med. 194, 1743-1754 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1743-1754
    • Kawakami, K.1    Kawakami, M.2    Snoy, P.J.3    Husain, S.R.4    Puri, R.K.5
  • 54
    • 0034569025 scopus 로고    scopus 로고
    • NKT cell-mediated rexpression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
    • Terabe M, Matsui S, Noben-Trauth N et al.: NKT cell-mediated rexpression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1, 515-520 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 515-520
    • Terabe, M.1    Matsui, S.2    Noben-Trauth, N.3
  • 55
    • 50649087259 scopus 로고    scopus 로고
    • A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity
    • Berzofsky JA, Terabe M: A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity. Cancer Immunol. Immunother. 57, 1679-1683 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 1679-1683
    • Berzofsky, J.A.1    Terabe, M.2
  • 56
    • 11844306593 scopus 로고    scopus 로고
    • Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli
    • Joshi BH, Puri RK: Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli. Protein Expr. Purif. 39, 189-198 (2005).
    • (2005) Protein Expr. Purif. , vol.39 , pp. 189-198
    • Joshi, B.H.1    Puri, R.K.2
  • 57
    • 0029934957 scopus 로고    scopus 로고
    • Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin a (PE38QQR)
    • Puri RK, Leland P, Obiri NI et al.: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR). Blood 87, 4333-4339 (1996). (Pubitemid 26155030)
    • (1996) Blood , vol.87 , Issue.10 , pp. 4333-4339
    • Puri, R.K.1    Leland, P.2    Obiri, N.I.3    Husain, S.R.4    Kreitman, R.J.5    Haas, G.P.6    Pastan, I.7    Debinski, W.8
  • 58
    • 0035871986 scopus 로고    scopus 로고
    • Interleukin-13 receptor as a unique target for anti-glioblastoma therapy
    • Husain SR, Joshi BH, Puri RK: Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. Int. J. Cancer 92, 168-175 (2001).
    • (2001) Int. J. Cancer , vol.92 , pp. 168-175
    • Husain, S.R.1    Joshi, B.H.2    Puri, R.K.3
  • 59
    • 0031029303 scopus 로고    scopus 로고
    • Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein
    • Husain SR, Obiri NI, Gill P et al.: Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein. Clin. Cancer Res. 3, 151-156 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 151-156
    • Husain, S.R.1    Obiri, N.I.2    Gill, P.3
  • 60
    • 0035191656 scopus 로고    scopus 로고
    • Gene transfer of interleukin 13 receptor α2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts
    • DOI 10.1038/sj.cgt.7700373
    • Kawakami K, Husain SR, Bright RK, Puri RK: Gene transfer of interleukin 13 receptor α2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts. Cancer Gene Ther. 8, 861-868 (2001). (Pubitemid 33086533)
    • (2001) Cancer Gene Therapy , vol.8 , Issue.11 , pp. 861-868
    • Kawakami, K.1    Husain, S.R.2    Bright, R.K.3    Puri, R.K.4
  • 61
    • 0036705806 scopus 로고    scopus 로고
    • Improved anti-tumor activity and safety of interleukin-13 receptor targeted cytotoxin by systemic continuous administration in head and neck cancer xenograft model
    • Kawakami K, Husain SR, Kawakami M, Puri RK: Improved anti-tumor activity and safety of interleukin-13 receptor targeted cytotoxin by systemic continuous administration in head and neck cancer xenograft model. Mol. Med. 8, 487-494 (2002).
    • (2002) Mol. Med. , vol.8 , pp. 487-494
    • Kawakami, K.1    Husain, S.R.2    Kawakami, M.3    Puri, R.K.4
  • 62
    • 0035709278 scopus 로고    scopus 로고
    • Apoptotic pathways of cell death induced by an interleukin-13 receptor-targeted recombinant cytotoxin in head and neck cancer cells
    • Kawakami M, Kawakami K, Puri RK: Apoptotic pathways of cell death induced by an interleukin-13 receptor-targeted recombinant cytotoxin in head and neck cancer cells. Cancer Immunol. Immunother. 50, 691-700 (2002).
    • (2002) Cancer Immunol. Immunother. , vol.50 , pp. 691-700
    • Kawakami, M.1    Kawakami, K.2    Puri, R.K.3
  • 63
    • 0036667936 scopus 로고    scopus 로고
    • Cytokine receptor as a sensitizer for targeted cancer therapy
    • DOI 10.1097/00001813-200208000-00003
    • Kawakami K, Kawakami M, Puri RK: Cytokine receptor as a sensitizer for targeted cancer therapy. Anticancer Drugs 13, 693-699 (2002). (Pubitemid 34899207)
    • (2002) Anti-Cancer Drugs , vol.13 , Issue.7 , pp. 693-699
    • Kawakami, K.1    Kawakami, M.2    Puri, R.K.3
  • 64
    • 0038805154 scopus 로고    scopus 로고
    • Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts
    • Kawakami M, Kawakami K, Puri RK: Intratumor administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts. Mol. Cancer Ther. 1, 999-1007 (2002).
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 999-1007
    • Kawakami, M.1    Kawakami, K.2    Puri, R.K.3
  • 65
    • 0037114188 scopus 로고    scopus 로고
    • IL-13 receptor-targeted cytotoxin cancer therapy leads to complete eradication of tumors with the aid of phagocytic cells in nude mice model of human cancer
    • Kawakami K, Kawakami M, Puri RK: IL-13 receptor-targeted cytotoxin cancer therapy leads to complete eradication of tumors with the aid of phagocytic cells in nude mice model of human cancer. J. Immunol. 169, 7119-7126 (2002). (Pubitemid 36899301)
    • (2002) Journal of Immunology , vol.169 , Issue.12 , pp. 7119-7126
    • Kawakami, K.1    Kawakami, M.2    Puri, R.K.3
  • 66
    • 0035881289 scopus 로고    scopus 로고
    • Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer
    • Kawakami K, Kawakami M, Joshi BH, Puri RK: Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer. Cancer Res. 61, 6194-6200 (2001). (Pubitemid 32762557)
    • (2001) Cancer Research , vol.61 , Issue.16 , pp. 6194-6200
    • Kawakami, K.1    Kawakami, M.2    Joshi, B.H.3    Puri, R.K.4
  • 67
    • 0036157405 scopus 로고    scopus 로고
    • Internalization property of interleukin-4 receptor α chain increases cytotoxic effect of interleukin-4 receptor-targeted cytotoxin in cancer cells
    • Kawakami K, Kawakami M, Leland P, Puri RK: Internalization property of interleukin-4 receptor α chain increases cytotoxic effect of interleukin-4 receptor-targeted cytotoxin in cancer cells. Clin. Cancer Res. 8, 258-266 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 258-266
    • Kawakami, K.1    Kawakami, M.2    Leland, P.3    Puri, R.K.4
  • 68
    • 33748051727 scopus 로고    scopus 로고
    • Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Rα2-expressing contralateral tumors
    • Kawakami K, Terabe M, Kioi M, Berzofsky JA, Puri RK: Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Rα2-expressing contralateral tumors. Clin. Cancer Res. 12, 4678-4686 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4678-4686
    • Kawakami, K.1    Terabe, M.2    Kioi, M.3    Berzofsky, J.A.4    Puri, R.K.5
  • 69
    • 77952461038 scopus 로고    scopus 로고
    • Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: Presentation of interim findings from ongoing Phase 1 studies
    • Kunwar S. Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing Phase 1 studies. Acta Neurochir. (Suppl. 88), 105-111 (2003).
    • (2003) Acta Neurochir. , Issue.SUPPL. 88 , pp. 105-111
    • Kunwar, S.1
  • 70
    • 33747163632 scopus 로고    scopus 로고
    • Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies
    • Kunwar S, Chang SM, Prados MD et al.: Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies. Neurosurg. Focus 20, E15 (2006).
    • (2006) Neurosurg. Focus , vol.20
    • Kunwar, S.1    Chang, S.M.2    Prados, M.D.3
  • 71
    • 33947547455 scopus 로고    scopus 로고
    • Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: A report by the Cintredekin Besudotox Intraparenchymal Study Group
    • Kunwar S, Prados MD, Chang SM et al.: Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. J. Clin. Oncol. 25, 837-844 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , pp. 837-844
    • Kunwar, S.1    Prados, M.D.2    Chang, S.M.3
  • 73
    • 37349110365 scopus 로고    scopus 로고
    • Convection-enhanced delivery of cintredekin besudotox (interleukin-13- PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: Phase 1 study of final safety results
    • DOI 10.1227/01.neu.0000303199.77370.9e, PII 0000612320071100000017
    • Vogelbaum MA, Sampson JH, Kunwar S et al.: Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: Phase 1 study of final safety results. Neurosurgery 61, 1031-1037; discussion 1037-1038 (2007). (Pubitemid 350306946)
    • (2007) Neurosurgery , vol.61 , Issue.5 , pp. 1031-1037
    • Vogelbaum, M.A.1    Sampson, J.H.2    Kunwar, S.3    Chang, S.M.4    Shaffrey, M.5    Asher, A.L.6    Lang, F.F.7    Croteau, D.8    Parker, K.9    Grahn, A.Y.10    Sherman, J.W.11    Husain, S.R.12    Puri, R.K.13
  • 74
    • 28844462115 scopus 로고    scopus 로고
    • Final results of Phase I/II studies of IL-13PE38QQR administered intratumorally (IT) and/or peritumorally (PT) via convection-enhanceddelivery (CED) in patients undergoing tumor resection for recurrent malignant glioma
    • Prados M, Kunwar S, Lang F et al.: Final results of Phase I/II studies of IL-13PE38QQR administered intratumorally (IT) and/or peritumorally (PT) via convection-enhanceddelivery (CED) in patients undergoing tumor resection for recurrent malignant glioma. J. Clin. Oncol. 23, 115S (2005).
    • (2005) J. Clin. Oncol. , vol.23
    • Prados, M.1    Kunwar, S.2    Lang, F.3
  • 76
    • 0041849833 scopus 로고    scopus 로고
    • Convection-Enhanced Delivery (CED) by positive pressure infusion for intra-tumoral and peri-tumoral administration of IL-13PE38QQR a recombinant tumor-targeted cytotoxin in recurrent malignant glioma
    • Prados M, Lang F, Sherman J et al.: Convection-Enhanced Delivery (CED) by positive pressure infusion for intra-tumoral and peri-tumoral administration of IL-13PE38QQR a recombinant tumor-targeted cytotoxin in recurrent malignant glioma. J. Neurooncol. 4, S78 (2002).
    • (2002) J. Neurooncol. , vol.4
    • Prados, M.1    Lang, F.2    Sherman, J.3
  • 77
    • 77953439236 scopus 로고    scopus 로고
    • Intrtumoral and intracerebral microinfusion of Il13-PE38QQR cytotoxin: Phase I/II study of pre- and post-resection infusions in recurrent resectable malignant glioma
    • Prados M, Lang F, Strauss L et al.: Intrtumoral and intracerebral microinfusion of Il13-PE38QQR cytotoxin: Phase I/II study of pre- and post-resection infusions in recurrent resectable malignant glioma. J. Clin. Oncol. (2002).
    • (2002) J. Clin. Oncol.
    • Prados, M.1    Lang, F.2    Strauss, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.