Preparation and characterization of bovine serum albumin alginate/chitosan microspheres for oral administration

Asian Journal of Pharmaceutical Sciences

Volumn 4, Issue 4, 2009, Pages 215-220

  Jin, Meixia ^a   Zheng, Yanping ^a   Hu, Qiaohong ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alginate; Bovine serum albumin; Chitosan; Microspheres

Indexed keywords

ALGINIC ACID; BOVINE SERUM ALBUMIN; CALCIUM CHLORIDE; CHITOSAN; CHLORIDE; MICROSPHERE; PHOSPHATE BUFFERED SALINE;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SYNTHESIS; EMULSION; GELATINIZATION; IN VITRO STUDY; MICROENCAPSULATION; PARAMETER; PARTICLE SIZE; PH;

EID: 77953440626     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. M. Yang, S. Velaga, H. Yamamoto, et al. Characterization of salmon calcitonin in spray-dried powder for inhalation- effect of chitosan. Int. J. Pharm., 2007, 331: 176-181.
2. H. O. Alpar, S. Somavarapu, K. N. Atuah, et al. Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery. Adv. Drug Deliv. Rev., 2005, 57: 411-430.
3. C. Damgé, P. Maincent, N. Ubrich. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Release, 2007, 117: 163-170.
4. S. Martins, B. Sarmento, E. B. Souto, et al. Insulin-loaded alginate microspheres for oral delivery-Effect of poly-saccharide reinforcement on physicochemical properties and release profile. Carbohydr. Polym., 2007, 69: 725-731.
5. K. Won, S. Kima, K. J. Kim. Optimization of lipase entrapment in Ca-alginate gel beads. Process Biochemistry, 2005, 40: 2149-2154.
6. S. De, D. Robinson. Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. J. Control. Release, 2003, 89: 101-112.
7. Y. Pan, Y. Li, H. Zhao, et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm., 2002, 249: 139-147.
8. W. T. Kim, H. Chung, S. Shin. Characterization of calcium alginate and chitosan-treated calcium alginate gel beads entrapping alkyl isothiocyanate. Carbohydr. Polym., 2008, 71: 566-573.
9. S. C. Maja, G. D. Marija, G. Katerina. Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa. Eur. J. Pharm. Biopharm., 2008, 68: 565-578.
10. S. Wittaya-areekul, J. Kruenate, C. Prahsarn. Preparation and in vitro evaluation of mucoadhesive properties of alginate/ chitosan microparticles containing prednisolone. Int. J. Pharm., 2006, 312: 113-118.
11. J. H. Eldridge, C. J. Hammond, J. A. Meulbroek. Orally administered biodegradable microspheres target the Peyer's patches. J. Control. Release, 1990, 11: 205-214.
12. C. H. Zheng, J. Q. Gao, Y. P. Zhang, et al. A protein delivery system: biodegradable alginate-chitosan-poly (lactic-co-glycolic acid) composite microspheres. Biochem. Biophy. Res. Commun., 2004, 323: 1321-1327.
13. G. T. Grant, E. R. Morris, D. A. Rees, et al. Biological interactions between polysaccharides and divalent cations: the egg box model. FEBS Lett., 1973, 32: 195-198.
14. L. W. Chan, Y. Jin, P. W. S. Heng. Cross-linking mechanisms of calcium and zinc in production of alginate microspheres. Int. J. Pharm., 2002, 242: 255-258.
15. Y. C. Yu, Y. Q. Yao, Y. Q. Zhang, et al. Preparation and release behavior of chitosan/calcium-alginate nanoparticles encapsulating bovine serum albumin. Journal of Functional Polymers, 2005, 18: 598-601.
16. P. George, B. Nikolaos. Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate- chitosan beads. Int. J. Pharm., 2006, 323: 34-42.
17. K. M. Sanjay, C. Shruti, T. Sushma, et al. Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Formulation, optimization and in vitro characterization. Eur. J. Pharm. Biopharm., 2008, 68: 513-525.