Biological and clinical significance of GSK-3β in mantle cell lymphoma-an immunohistochemical study

International Journal of Clinical and Experimental Pathology

Volumn 3, Issue 3, 2010, Pages 244-253

  Chung, Randy ^a   Peters, Anthea C ^a   Armanious, Hanan ^a   Anand, Mona ^a   Gelebart, Pascal ^a   Lai, Raymond ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

GSK 3 ; immunohistochemistry; Mantle cell lymphoma

Indexed keywords

BETA CATENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ADULT; AGED; ARTICLE; FEMALE; HUMAN; MALE; MANTLE CELL LYMPHOMA; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CYCLIN D1; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LYMPHOMA, MANTLE-CELL; MALE; MIDDLE AGED; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 77953426686     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Karim, R., Tse, G., Putti, T., Scolyer, R., and Lee, S. (2004) The significance of the Wnt pathway in the pathology of human cancers. Pathology 36, 120-128
2. Jope, R. S., and Johnson, G. V. (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29, 95-102
3. Jope, R. S., Yuskaitis, C. J., and Beurel, E. (2007) Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32, 577-595
4. Kim, L., and Kimmel, A. R. (2000) GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr Opin Genet Dev 10, 508-514
5. Joshi, M. B., Ivanov, D., Philippova, M., Erne, P., and Resink, T. J. (2007) Integrin-linked kinase is an essential mediator for T-cadherin-dependent signaling via Akt and GSK3beta in endothelial cells. Faseb J 21, 3083-3095
6. Failor, K. L., Desyatnikov, Y., Finger, L. A., and Firestone, G. L. (2007) Glucocorticoid-induced degradation of glycogen synthase kinase-3 protein is triggered by serum- and glucocorticoidinduced protein kinase and Akt signaling and controls beta-catenin dynamics and tight junction formation in mammary epithelial tumor cells. Mol Endocrinol 21, 2403-2415
7. Manoukian, A. S., and Woodgett, J. R. (2002) Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways. Adv Cancer Res 84, 203-229
8. Diehl, J. A., Cheng, M., Roussel, M. F., and Sherr, C. J. (1998) Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12, 3499-3511
9. Takahashi-Yanaga, F., and Sasaguri, T. (2008) GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy. Cell Signal 20, 581-589
10. Swerdlow, S. H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Vardiman, J.W. (2008) Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fourth Edition. WHO Classification of Tumours, Volume 2 IARC 2, p229-232
11. Diehl, J. A. (2002) Cycling to cancer with cyclin D1. Cancer Biol Ther 1, 226-231
12. Jares, P., Colomer, D., and Campo, E. (2007) Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 7, 750-762
13. Gelebart, P., Anand, M., Armanious, H., Peters, A. C., Dien Bard, J., Amin, H. M., and Lai, R. (2008) Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112, 5171-5179
14. Dal Col, J., and Dolcetti, R. (2008) GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma. Cell Cycle 7, 2813-2816
15. Hui, D., Reiman, T., Hanson, J., Linford, R., Wong, W., Belch, A., and Lai, R. (2005) Immunohistochemical detection of cdc2 is useful in predicting survival in patients with mantle cell lymphoma. Mod Pathol 18, 1223-1231
16. Staal, F. J., and Clevers, H. C. (2005) WNT signalling and haematopoiesis: a WNT-WNT situation. Nat Rev Immunol 5, 21-30
17. Ortega-Paino, E., Fransson, J., Ek, S., and Borrebaeck, C. A. (2008) Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference. Blood 111, 1617-1624
18. Rizzatti, E. G., Falcao, R. P., Panepucci, R. A., Proto-Siqueira, R., Anselmo-Lima, W. T., Okamoto, O. K., and Zago, M. A. (2005) Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Br J Haematol 130, 516-526
19. Rudelius, M., Pittaluga, S., Nishizuka, S., Pham, T. H., Fend, F., Jaffe, E. S., Quintanilla-Martinez, L., and Raffeld, M. (2006) Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 108, 1668-1676
20. Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., Friend, S., and Linsley, P. S. (2006) Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A 103, 2794-2799
21. Jamieson, C. H., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., Sawyers, C. L., and Weissman, I. L. (2004) Granulocytemacrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351, 657-667
22. Clevers, H. (2006) Wnt/beta-catenin signaling in development and disease. Cell 127, 469-480
23. Marzec, M., Kasprzycka, M., Lai, R., Gladden, A. B., Wlodarski, P., Tomczak, E., Nowell, P., Deprimo, S. E., Sadis, S., Eck, S., Schuster, S. J., Diehl, J. A., and Wasik, M. A. (2006) Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. Blood 108, 1744-1750
24. Etienne-Manneville, S., and Hall, A. (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756
25. Bianchi, M., De Lucchini, S., Marin, O., Turner, D. L., Hanks, S. K., and Villa-Moruzzi, E. (2005) Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J 391, 359-370
26. Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., and Hung, M. C. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6, 931-940
27. Yatabe, Y., Suzuki, R., Tobinai, K., Matsuno, Y., Ichinohasama, R., Okamoto, M., Yamaguchi, M.,Tamaru, J., Uike, N., Hashimoto, Y., Morishima, Y., Suchi, T., Seto, M., and Nakamura, S. (2000) Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma. Blood 95, 2253-2261
28. Rosenwald, A., Wright, G., Wiestner, A., Chan, W. C., Connors, J. M., Campo, E., Gascoyne, R. D., Grogan, T. M., Muller-Hermelink, H. K., Smeland, E. B., Chiorazzi, M., Giltnane, J. M., Hurt, E. M., Zhao, H., Averett, L., Henrickson, S., Yang, L., Powell, J., Wilson, W. H., Jaffe, E. S., Simon, R., Klausner, R. D., Montserrat, E., Bosch, F., Greiner, T. C., Weisenburger, D. D., Sanger, W. G., Dave, B. J., Lynch, J. C., Vose, J., Armitage, J. O., Fisher, R. I., Miller, T. P., LeBlanc, M., Ott, G., Kvaloy, S., Holte, H., Delabie, J., and Staudt, L. M. (2003) The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 3, 185-197