Mapping of human autoantibody binding sites on the calcium-sensing receptor

Journal of Bone and Mineral Research

Volumn 25, Issue 1, 2010, Pages 132-140

  Kemp, E Helen ^a   Gavalas, Nikos G ^a   Akhtar, Samia ^a   Krohn, Kai J E ^b   Pallais, J Carl ^c   Brown, Edward M ^d   Watson, Philip F ^a   Weetman, Anthony P ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Autoantibody; Autoimmune polyendocrine syndrome type 1; Calcium sensing receptor; Hypoparathyroidism; Parathyroid

Indexed keywords

AMINO ACID DERIVATIVE; AUTOANTIBODY; CALCIUM SENSING RECEPTOR ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIBODY TITER; ARTICLE; AUTOIMMUNE HYPOCALCIURIC HYPERCALCEMIA; AUTOIMMUNE POLYENDOCRINOPATHY CANDIDIASIS ECTODERMAL DYSTROPHY; CHILD; CLINICAL ARTICLE; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPERCALCEMIA; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MALE; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN LOCALIZATION; SCHOOL CHILD;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; AUTOANTIBODIES; BINDING SITES; CASE-CONTROL STUDIES; CHILD; CONSENSUS SEQUENCE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; POLYENDOCRINOPATHIES, AUTOIMMUNE; PROTEIN INTERACTION MAPPING; RECEPTORS, CALCIUM-SENSING; YOUNG ADULT;

EID: 77953416752     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.090703     Document Type: Article

References (34)

1. Bringhurst FR, Demay MB, Kronenberg HM. Hormones and disorders of mineral metabolism. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams Text Book of Endocrinology. 10th ed. Philadelphia: Saunders, 2003:1303-1371.
2. 2+-sensing receptor from bovine parathyroid. Nature. 1993;366:575-580.
3. Perheentupa J. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2006;91:2843-2850.
4. Nagamine K, Peterson P, Scott HS, et al. Positional cloning of the APECED gene. Nat Genet. 1997;17:393-398.
5. The Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet. 1997;17:399-403.
6. Neufeld M, Maclaren N, Blizzard R. Autoimmune polyglandular syndromes. Pediatr Ann. 1980;9:154-162.
7. Uibo R, Aavik E, Peterson P, et al. Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. J Clin Endocrinol Metab. 1994;78:323-328.
8. Winqvist O, Karlsson FA, Kampe O. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet. 1992;339:1559-1562.
9. Krohn K, Uibo R, Aavik E, Peterson P, Savilahti K. Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase. Lancet. 1992;339:770-773.
10. Tuomi T, Bjorses P, Falorni A, et al. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab. 1996;81:1488-1494. (Pubitemid 26118581)
11. Gylling M, Tuomi T, Bjorses P, et al. β-Cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Clin Endocrinol Metab. 2000;85:4434-4440.
12. Posillico JT, Wortsman J, Srikanta S, Eisenbarth GS, Mallette LE, Brown EM. Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells. J Bone Miner Res. 1986;1:475-483.
13. Brandi ML, Aurbach GD, Fattorossi A, Quarto R, Marx SJ, Fitzpatrick LA. Antibodies to bovine parathyroid cells in autoimmune hypoparathyroidism. Proc Natl Acad Sci USA. 1986;83:8366-8369.
14. Li Y, Song YH, Rais N, et al. Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism. J Clin Invest 1996;97:910-914.
15. Mayer A, Ploix C, Orgiazzi J, et al. Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism. J Clin Endocrinol Metab. 2004;89:4484-4488. (Pubitemid 39244459)
16. Gavalas NG, Kemp EH, Krohn KJE, Brown EM, Watson PF, Weetman AP. The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab. 2007;92:2107-2114. (Pubitemid 46997107)
17. Goswami R, Brown EM, Kochupillai N, et al. Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol. 2004;150:9-18. (Pubitemid 38159736)
18. Kifor O, McElduff A, Leboff MS, et al. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab. 2004;89:548-556. (Pubitemid 38269856)
19. Kifor O, Moore FD, Delaney M, et al. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab. 2003;88:60-72. (Pubitemid 36115144)
20. Pallais JC, Kifor O, Chen Y-B, Slovik D, Brown EM. Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Eng J Med 2004;351:362-369. (Pubitemid 38944405)
21. Makita N, Sato J, Manaka K, et al. An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations. Proc Natl Acad Sci USA. 2007;104:5443-5448. (Pubitemid 47175699)
22. Barbas CF, Kang AS, Lerner RA, Benkovic SJ. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc Natl Acad Sci USA. 1991;88:7978-7982.
23. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
24. Kemp EH, Waterman EA, Hawes BE, et al. The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo. J Clin Invest. 2002;109:923-930.
25. Dromey JA, Weenink SM, Peters GH, et al. Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modelling: overlap of antibody and T cell determinants. J Immunol 2004;172:4084-4090.
26. Myers MA, Davies JM, Tong JC, et al. Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling. J Immunol 2000;165:3830-3838.
27. Al-Bukhari TA, Radford PM, Bouras G, et al. Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65-kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis. Clin Exp Immunol. 2002;130:131-139.
28. Hu J, Spiegel AM. Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. J Cell Mol Med. 2007;11:908-922.
29. Reyes-Cruz G, Hu J, Goldsmith PK, Steinbach PJ, Spiegel AM. Human Ca2+ receptor extracellular domain: analysis of function of lobe 1 loop deletion mutants. J Biol Chem. 2001;276:32145-32151. (Pubitemid 37384876)
30. 2+-binding pocket within the venus flytrap module of the human calcium-sensing receptor. J Biol Chem 2005;280:37917-37923.
31. 2+-sensing receptor. J Biol Chem. 2007;282:19000-19010.
32. Zhang Z, Qiu W, Quinn SJ, Conigrave AD, Brown EM, Bai M. Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem. 2002;277:33727-33735.
33. Syren K, Lindsay L, Stoehrer B, et al. Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase. J Immunol. 1996;157:5208-5214. (Pubitemid 126449606)
34. Hu J, Reyes-Cruz G, Goldsmith PK, Gantt NM, Miller JL, Spiegel AM. Functional effects of monoclonal antibodies to the purified aminoterminal extracellular domain of the human Ca2+ receptor. J Bone Miner Res. 2007;22:601-608. (Pubitemid 47457437)