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Volumn 81, Issue 4, 1996, Pages 1488-1494

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUTAMATE DECARBOXYLASE; HLA ANTIGEN; INSULIN; MONOCLONAL ANTIBODY;

EID: 0029988330     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.4.1488     Document Type: Article
Times cited : (124)

References (48)
  • 1
    • 0027933734 scopus 로고
    • A genome-wide search for human type 1 diabetes susceptibility genes
    • Davies JL, Kawaguchi Y, Bennett ST, et al. 1994 A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 371:130-136.
    • (1994) Nature , vol.371 , pp. 130-136
    • Davies, J.L.1    Kawaguchi, Y.2    Bennett, S.T.3
  • 2
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes mellitus as the GABA-synthesizing enzyme glutamic acid decarboxylase
    • Baekkeskov S, Aanstoot H, Christgau S, et al. 1990 Identification of the 64K autoantigen in insulin-dependent diabetes mellitus as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 347:151-156.
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.2    Christgau, S.3
  • 3
    • 0002637628 scopus 로고
    • Autoimmunity and prediction of insulin dependent diabetes mellitus
    • Marshall SM, Home PD, eds. Amsterdam: Elsevier
    • Greenbaum CJ, Brooks-Worrell BM, Palmer JP, Lernmark Å. 1994 Autoimmunity and prediction of insulin dependent diabetes mellitus. In: Marshall SM, Home PD, eds. The diabetes annual. Amsterdam: Elsevier; vol 8:21-52.
    • (1994) The Diabetes Annual , vol.8 , pp. 21-52
    • Greenbaum, C.J.1    Brooks-Worrell, B.M.2    Palmer, J.P.3    Lernmark, Å.4
  • 4
    • 0026500437 scopus 로고
    • Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes
    • Atkinson MA, Kaufman DL, Campbell L, et al. 1992 Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet. 339:458-459.
    • (1992) Lancet , vol.339 , pp. 458-459
    • Atkinson, M.A.1    Kaufman, D.L.2    Campbell, L.3
  • 5
    • 0027368141 scopus 로고
    • Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • Kaufman DL, Clare-Salzler M, Tian J, et al. 1993 Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 366:69-71.
    • (1993) Nature , vol.366 , pp. 69-71
    • Kaufman, D.L.1    Clare-Salzler, M.2    Tian, J.3
  • 6
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang X, Singer SM, Liblau RS, Fugger L, McDewitt HO. 1993 Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 366:72-75.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDewitt, H.O.6
  • 7
    • 0025878365 scopus 로고
    • Progression to type 1 diabetes in autoimmune endocrine patients with islet cell antibodies
    • Bosi E, Becker F, Bonifacio E, et al. 1991 Progression to type 1 diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes. 40:977-984.
    • (1991) Diabetes , vol.40 , pp. 977-984
    • Bosi, E.1    Becker, F.2    Bonifacio, E.3
  • 8
    • 0041097188 scopus 로고
    • Cytoplasmic islet cell antibodies in patients with autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED)
    • Copenh.
    • Ahonen P, Miettinen A, Perheentupa J. 1985 Cytoplasmic islet cell antibodies in patients with autoimmune polyendocrinopathy-candidosis-ectodermal dystrophy (APECED) [Abstract]. Acta Endocrinol (Copenh). 109(Suppl 270): 78.
    • (1985) Acta Endocrinol , vol.109 , Issue.270 SUPPL. , pp. 78
    • Ahonen, P.1    Miettinen, A.2    Perheentupa, J.3
  • 9
    • 0025362089 scopus 로고
    • Autoantibodies to GABA-ergic neurons and pancreatic beta cells in Stiff-Man syndrome
    • Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. 1990 Autoantibodies to GABA-ergic neurons and pancreatic beta cells in Stiff-Man syndrome. N Engl J Med. 322:1555-1560.
    • (1990) N Engl J Med , vol.322 , pp. 1555-1560
    • Solimena, M.1    Folli, F.2    Aparisi, R.3    Pozza, G.4    De Camilli, P.5
  • 11
    • 0028852633 scopus 로고
    • Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity
    • Wheelman AP. 1995 Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity. Clin Endocrinol Metab. 9:157-174.
    • (1995) Clin Endocrinol Metab , vol.9 , pp. 157-174
    • Wheelman, A.P.1
  • 12
    • 0025295238 scopus 로고
    • Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients
    • Ahonen P, Myllärniemi S, Sipilä I, Perheentupa J. 1990 Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med. 322:1829-1836.
    • (1990) N Engl J Med , vol.322 , pp. 1829-1836
    • Ahonen, P.1    Myllärniemi, S.2    Sipilä, I.3    Perheentupa, J.4
  • 13
    • 0028064998 scopus 로고
    • An autosomal locus causing autoimmune disease: Autoimmune polyglandular disease type I assigned to chromosome 21
    • Aaltonen J, Björses P, Sandkijl L, Perheentupa J, Peltonen L. 1994 An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21. Nature Genet. 8:83-88.
    • (1994) Nature Genet , vol.8 , pp. 83-88
    • Aaltonen, J.1    Björses, P.2    Sandkijl, L.3    Perheentupa, J.4    Peltonen, L.5
  • 14
    • 0028258006 scopus 로고
    • A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM
    • Grubin E, Daniels T, Toivola B, et al. 1994 A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia. 37:344-350.
    • (1994) Diabetologia , vol.37 , pp. 344-350
    • Grubin, E.1    Daniels, T.2    Toivola, B.3
  • 16
    • 0026046093 scopus 로고
    • Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
    • Karlsen AE, Hagopian WA, Grubin CE, et al. 1991 Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci USA. 88:8337-8841.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8337-8841
    • Karlsen, A.E.1    Hagopian, W.A.2    Grubin, C.E.3
  • 17
    • 0025936419 scopus 로고
    • Cloning, characterization and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus (IDDM)
    • Michelsen B, Petersen JS, Boel E, Møldrup A, Dyrberg T, Madsen OD. 1991 Cloning, characterization and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus (IDDM). Proc Natl Acad Sci USA. 88:8754-8758.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8754-8758
    • Michelsen, B.1    Petersen, J.S.2    Boel, E.3    Møldrup, A.4    Dyrberg, T.5    Madsen, O.D.6
  • 18
    • 0028855244 scopus 로고
    • Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies
    • Li L, Jiang J, Hagopian WA, et al. 1995 Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies. J Histochem Cytochem. 43:53-59.
    • (1995) J Histochem Cytochem , vol.43 , pp. 53-59
    • Li, L.1    Jiang, J.2    Hagopian, W.A.3
  • 19
    • 0028092704 scopus 로고
    • High level of concordance between assays for glutamic acid decarboxylase antibodies. First International Glutamic Acid Decarboxylase Antibody Workshop
    • Schmidli RS, Colman P, Bonifacio E, Bottazzo GF, Harrison LC. 1994 High level of concordance between assays for glutamic acid decarboxylase antibodies. First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes. 43:1005-1009.
    • (1994) Diabetes , vol.43 , pp. 1005-1009
    • Schmidli, R.S.1    Colman, P.2    Bonifacio, E.3    Bottazzo, G.F.4    Harrison, L.C.5
  • 20
    • 0028658449 scopus 로고
    • Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes
    • Falorni A, Grubin CE, Takei I, et al. 1994 Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes. Autoimmunity. 19: 113-125.
    • (1994) Autoimmunity , vol.19 , pp. 113-125
    • Falorni, A.1    Grubin, C.E.2    Takei, I.3
  • 22
    • 0025862373 scopus 로고
    • Modified PCR-RFLP method for HLA-DPB1 and -DQA1 genotyping
    • Ota M, Seki T, Nomura N, et al. 1991 Modified PCR-RFLP method for HLA-DPB1 and -DQA1 genotyping. Tissue Antigens. 38:60-71.
    • (1991) Tissue Antigens , vol.38 , pp. 60-71
    • Ota, M.1    Seki, T.2    Nomura, N.3
  • 23
    • 0001545277 scopus 로고
    • Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique
    • Sasazuki T, ed. Oxford: Oxford University Press
    • Kimura A, Sasazuki T. 1992 Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In: Sasazuki T, ed. HLA 1991. Oxford: Oxford University Press; vol 1:397-425.
    • (1992) HLA 1991 , vol.1 , pp. 397-425
    • Kimura, A.1    Sasazuki, T.2
  • 24
    • 0027417171 scopus 로고
    • An HLA-DR typing protocol using group-specific PCR-amplification followed by restriction enzyme digests
    • Westman P, Kuismin T, Partanen J, Koskimies S. 1993 An HLA-DR typing protocol using group-specific PCR-amplification followed by restriction enzyme digests. Eur J Immunogen. 20:103-109.
    • (1993) Eur J Immunogen , vol.20 , pp. 103-109
    • Westman, P.1    Kuismin, T.2    Partanen, J.3    Koskimies, S.4
  • 25
    • 0018602014 scopus 로고
    • Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
    • National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
    • (1979) Diabetes , vol.28 , pp. 1039-1057
  • 26
    • 0027195529 scopus 로고
    • Heterogeneity of autoantibodies in stiff-man syndrome
    • Grimaldi LME, Martino G, Braghi S, et al. 1993 Heterogeneity of autoantibodies in stiff-man syndrome. Ann Neurol. 34:57-64.
    • (1993) Ann Neurol , vol.34 , pp. 57-64
    • Grimaldi, L.M.E.1    Martino, G.2    Braghi, S.3
  • 28
    • 9244236115 scopus 로고
    • Association between antibodies to the MR 67,000 isoform of glutamate decarboxylase (GAD) and type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune polyendocrine syndrome type II
    • In press
    • Seissler J, Bieg S, Yassin N, et al. 1995 Association between antibodies to the MR 67,000 isoform of glutamate decarboxylase (GAD) and type 1 (insulin-dependent) diabetes mellitus with coexisting autoimmune polyendocrine syndrome type II. Autoimmunity. In press.
    • (1995) Autoimmunity
    • Seissler, J.1    Bieg, S.2    Yassin, N.3
  • 29
    • 0028157414 scopus 로고
    • Autoantibodies against a novel 52-KDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type 1
    • Velloso A, Winqvist O, Gustafsson J, Kämpe O, Karlsson FA. 1994 Autoantibodies against a novel 52-KDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type 1. Diabetologia. 37: 61-69.
    • (1994) Diabetologia , vol.37 , pp. 61-69
    • Velloso, A.1    Winqvist, O.2    Gustafsson, J.3    Kämpe, O.4    Karlsson, F.A.5
  • 30
    • 0025141413 scopus 로고
    • Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes
    • Bonifacio EP, Bingley PJ, Shattock M, et al. 1990 Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet. 335:147-149.
    • (1990) Lancet , vol.335 , pp. 147-149
    • Bonifacio, E.P.1    Bingley, P.J.2    Shattock, M.3
  • 31
    • 0025011787 scopus 로고
    • A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes
    • Riley WJ, MacLaren NK, Krischer J, et al. 1990 A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med. 323:1167-1172.
    • (1990) N Engl J Med , vol.323 , pp. 1167-1172
    • Riley, W.J.1    MacLaren, N.K.2    Krischer, J.3
  • 32
    • 0028172563 scopus 로고
    • GAD65 Autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus
    • Schott M, Schatz D, Atkinson M, et al. 1994 GAD65 Autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus. J Autoimmun. 7:865-872.
    • (1994) J Autoimmun , vol.7 , pp. 865-872
    • Schott, M.1    Schatz, D.2    Atkinson, M.3
  • 33
    • 0027942922 scopus 로고
    • Do glutamic acid decarboxylase antibodies improve the prediction of IDDM in first-degree relatives at risk for IDDM?
    • Schmidli RS, Colman PG, Harrison LC. 1994 Do glutamic acid decarboxylase antibodies improve the prediction of IDDM in first-degree relatives at risk for IDDM?. J Autoimmun. 7:873-879.
    • (1994) J Autoimmun , vol.7 , pp. 873-879
    • Schmidli, R.S.1    Colman, P.G.2    Harrison, L.C.3
  • 34
    • 0028113695 scopus 로고
    • A universal model of antibody prediction (MAP) of type 1 diabetes in children
    • Elliott RB, Pilcher CC. 1994 A universal model of antibody prediction (MAP) of type 1 diabetes in children. J Autoimmun. 7:881-888.
    • (1994) J Autoimmun , vol.7 , pp. 881-888
    • Elliott, R.B.1    Pilcher, C.C.2
  • 35
    • 0024556867 scopus 로고
    • Ten-year follow-up study of islet-cell antibodies diabetes mellitus
    • Bruining GJ, Grobbee DE, Scheffer GJ, et al. 1989 Ten-year follow-up study of islet-cell antibodies diabetes mellitus. Lancet. 1:1100-1103.
    • (1989) Lancet , vol.1 , pp. 1100-1103
    • Bruining, G.J.1    Grobbee, D.E.2    Scheffer, G.J.3
  • 36
    • 0028169720 scopus 로고
    • Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population
    • Aanstoot H-J, Sigurdsson E, Jaffe M, et al. 1994 Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population. Diabetologia. 37:917-924.
    • (1994) Diabetologia , vol.37 , pp. 917-924
    • Aanstoot, H.-J.1    Sigurdsson, E.2    Jaffe, M.3
  • 37
    • 0027500697 scopus 로고
    • Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin dependent onset of disease
    • Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles WJ, Mackay IR. 1993 Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin dependent onset of disease. Diabetes. 42:359-362.
    • (1993) Diabetes , vol.42 , pp. 359-362
    • Tuomi, T.1    Groop, L.C.2    Zimmet, P.Z.3    Rowley, M.J.4    Knowles, W.J.5    Mackay, I.R.6
  • 38
    • 0027391608 scopus 로고
    • Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody positivity at onset predicts diabetes type
    • Hagopian WA, Karlsen AE, Gottsäter A, et al. 1993 Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD-64) showed 64K autoantibody positivity at onset predicts diabetes type. J Clin Invest. 91:368-374.
    • (1993) J Clin Invest , vol.91 , pp. 368-374
    • Hagopian, W.A.1    Karlsen, A.E.2    Gottsäter, A.3
  • 39
    • 0023184612 scopus 로고
    • Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study
    • Betterle C, Presotto F, Pedini B, et al. 1987 Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study. Diabetologia. 30:292-297.
    • (1987) Diabetologia , vol.30 , pp. 292-297
    • Betterle, C.1    Presotto, F.2    Pedini, B.3
  • 40
    • 0028008978 scopus 로고
    • GAD autoantibodies in IDDM, stiff-man syndrome and autoimmune polyendocrine syndrome type 1 recognize different epitopes
    • Björk E, Velloso LA, Kämpe O, Karlson FA. 1993 GAD autoantibodies in IDDM, stiff-man syndrome and autoimmune polyendocrine syndrome type 1 recognize different epitopes. Diabetes. 43:161-165.
    • (1993) Diabetes , vol.43 , pp. 161-165
    • Björk, E.1    Velloso, L.A.2    Kämpe, O.3    Karlson, F.A.4
  • 41
    • 0028267290 scopus 로고
    • Autoantigenic properties of native and denatured glutamic acid decarboxylase: Evidence for a conformational epitope
    • Tuomi T, Rowley MJ, Knowles WJ, et al. 1994 Autoantigenic properties of native and denatured glutamic acid decarboxylase: evidence for a conformational epitope. Clin Immunol Immunopathol. 71:53-59.
    • (1994) Clin Immunol Immunopathol , vol.71 , pp. 53-59
    • Tuomi, T.1    Rowley, M.J.2    Knowles, W.J.3
  • 42
    • 0027366956 scopus 로고
    • Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease
    • Winqvist O, Gustafsson J, Rorsman F, Karlsson FA, Kämpe O. 1993 Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. J Clin Invest. 92:2377-2385.
    • (1993) J Clin Invest , vol.92 , pp. 2377-2385
    • Winqvist, O.1    Gustafsson, J.2    Rorsman, F.3    Karlsson, F.A.4    Kämpe, O.5
  • 43
    • 84995870568 scopus 로고
    • Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease
    • Uibo R, Aaik E, Peterson P, et al. 1994 Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. J Clin Endocrinol Metab. 78:323-328.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 323-328
    • Uibo, R.1    Aaik, E.2    Peterson, P.3
  • 44
    • 0023138282 scopus 로고
    • Adrenal and steroidal cell antibodies in patients with autoimmune polyglandular disease type I (APG type I) and risk of adrenocortical ovarian failure
    • Ahonen P, Miettinen A, Perheentupa J. 1987 Adrenal and steroidal cell antibodies in patients with autoimmune polyglandular disease type I (APG type I) and risk of adrenocortical ovarian failure. J Clin Endocrinol Metab. 64:494-500.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 494-500
    • Ahonen, P.1    Miettinen, A.2    Perheentupa, J.3
  • 45
    • 0028283078 scopus 로고
    • Lack of immunohistochemical changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-selective GAD-specific islet cell antibodies
    • Wagner R, McNally JM, Bonifazio E, et al. 1994 Lack of immunohistochemical changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-selective GAD-specific islet cell antibodies. Diabetes. 43:851-856.
    • (1994) Diabetes , vol.43 , pp. 851-856
    • Wagner, R.1    McNally, J.M.2    Bonifazio, E.3
  • 46
    • 0028072061 scopus 로고
    • Major histocompatibility complex class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility
    • Partanen J, Peterson P, Westman P, Aranko S, Krohn K. 1994 Major histocompatibility complex class II and III in Addison's disease. MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility. Hum Immunol. 41:135-140.
    • (1994) Hum Immunol , vol.41 , pp. 135-140
    • Partanen, J.1    Peterson, P.2    Westman, P.3    Aranko, S.4    Krohn, K.5
  • 47
    • 0028211968 scopus 로고
    • Thymic hypoplasia and T-cell deficiency in ectodermal dysplasia: Case report and review of the literature
    • Brooks EG, Klimpel GR, Vaidya S, et al. 1994 Thymic hypoplasia and T-cell deficiency in ectodermal dysplasia: case report and review of the literature. Clin Immunol Immunopathol. 71:44-52.
    • (1994) Clin Immunol Immunopathol , vol.71 , pp. 44-52
    • Brooks, E.G.1    Klimpel, G.R.2    Vaidya, S.3
  • 48
    • 0024270615 scopus 로고
    • Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus
    • Thomson G, Robinson WP, Kuhner MK, et al. 1988 Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet. 43:799-816.
    • (1988) Am J Hum Genet , vol.43 , pp. 799-816
    • Thomson, G.1    Robinson, W.P.2    Kuhner, M.K.3


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