KGF promotes paracrine activation of the SCF/c-KIT axis from human keratinocytes to melanoma cells

Translational Oncology

Volumn 3, Issue 2, 2010, Pages 80-90

  Belleudi, Francesca ^a   Cardinali, Giorgia ^b   Kovacs, Daniela ^b   Picardo, Mauro ^b   Torrisi, Maria Rosaria ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; STEM CELL FACTOR RECEPTOR;

ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE MICROSCOPY; KERATINOCYTE; MELANOMA CELL; NUCLEOTIDE SEQUENCE; PARACRINE SIGNALING; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT;

EID: 77953398159     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.09196     Document Type: Article

References (37)

1. Chin L, Garraway LA, and Fisher DE (2006). Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 20, 2149-2182.
2. Zaidi MR, Day CP, and Merlino G (2008). From UV to metastases: modeling melanoma initiation and progression in the mouse. J Invest Dermatol 128, 2381-2391.
3. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, et al. (2005). Distinct sets of genetic alterations in melanoma. N Engl J Med 353, 2135-2147.
4. Goel VK, Lazar AJ, Warneke CL, Redston MS, and Haluska FG (2006). Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol 126, 154-160.
5. Muthusamy V, Hobbs C, Nogueira C, Cordon-Cardo C, McKee PH, Chin L, and Bosenberg MW (2006). Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosomes Cancer 45, 447-454.
6. Curtin JA, Pinkel D, and Bastian B (2006). Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24, 4340-4346.
7. Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH, Tsujigiwa H, Tamamura R, Han KN, and Nagai N (2008). c-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 452, 27-32.
8. Ashida A, Tarata M, Murata H, Kido K, and Saida T (2009). Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas. Int J Cancer 124, 862-868.
9. Smalley KSM, Contractor R, Nguyen TK, Xiao M, Edwards R, Muthusamy V, Kng AJ, Flaherty KT, Bosenberg M, Herlyn M, et al. (2008). Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. Cancer Res 68, 5743-5752.
10. Willmore-Payne C, Golden JA, Hirschowitz S, and Layfield LJ (2006). BRAF and c-kit gene copy number in mutation-positive malignant melanoma. Hum Pathol 37, 520-527.
11. Smalley KSM, Sondak VK, and Weber J (2009). c-KIT signaling as the driving oncogenic event in sub-groups of melanomas. Histol Histopathol 24, 643-650.
12. Lennartsson J, Jelacic T, Linnekin D, and Shivakrupa R (2005). Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 23, 16-43.
13. Smalley KS (2003). A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 104, 527-532.
14. Smalley KS (2010). Understanding melanoma signaling networks as the basis for molecular targeted therapy. J Invest Dermatol 130, 28-37.
15. Ugurel S, Hildenbrand R, Zimpfer A, La Rosée P, Paschka P, Sucker A, Keikavoussi P, Becker JC, Rittgen W, Hochhaus A, et al. (2005). Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer 92, 1398-1405.
16. Hodi FS, Friedlander P, Corless CL, Heinrich MC, Mac Rae S, Kruse A, Jagannathan J, Van den Abbeele AD, Velazquez EF, Demetri GD, et al. (2008). Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 26, 2046-2051.
17. Lutzky J, Bauer J, and Bastian BC (2008). Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res 21, 492-493.
18. Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH, Papadopoulos NE, Bedikian AY, Camacho LH, Ross MI, et al. (2008). Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer 99, 734-740.
19. Lee JT and Herlyn M (2007). Microenvironmental influences in melanoma progression. J Cell Biochem 101, 862-872.
20. Finch PW, Rubin JS, Miki T, Ron D, and Aaronson SA (1989). Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245, 752-755.
21. Marchese C, Rubin J, Ron D, Faggioni A, Torrisi MR, Messina A, Frati L, and Aaronson SA (1990). Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol 144, 326-332.
22. Hines MD and Allen-Hoffmann BL (1996). Keratinocyte growth factor inhibits cross-linked envelope formation and nucleosomal fragmentation in cultured human keratinocytes. J Biol Chem 271, 6245-6251.
23. auf dem Keller U, Krampert M, Kumin A, Braun S, and Werner S (2004). Keratinocyte growth factor: effects on keratinocytes and mechanisms of action. Eur J Cell Biol 83, 607-612.
24. Braun S, Krampert M, Bodó E, Kumin A, Born-Berclaz C, Paus R, and Werner S (2006). Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents. J Cell Sci 119, 4841-4849.
25. Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi MR, and Mancini P (2007). Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes. Exp Cell Res 313, 1758-1777.
26. Miki T, Fleming TP, Bottaro DP, Rubin JS, Ron D, and Aaronson SA (1991). Expression DNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 251, 72-75.
27. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM, and Aaronson SA (1992). Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 89, 246-250.
28. Cardinali G, Ceccarelli S, Kovacs D, Aspite N, Lotti LV, Torrisi MR, and Picardo M (2005). Keratinocyte growth factor promotes melanosome transfer to keratinocytes. J Invest Dermatol 125, 1190-1199.
29. Cardinali G, Bolasco G, Aspite N, Lucania G, Lotti LV, Torrisi MR, and Picardo M (2008). Melanosome transfer promoted by keratinocyte growth factor in light and dark skin-derived keratinocytes. J Invest Dermatol 128, 558-567.
30. Lugini L, Matarrese P, Tinari A, Lozupone F, Federici C, Iessi E, Gentile M, Luciani F, Parmiani G, Rivoltini L, et al. (2006). Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells. Cancer Res 66, 3629-3638.
31. Bartolovic K, Balabanov S, Hartmann U, Komor M, Boehmler AM, Bühring HJ, Möhle R, Hoelzer D, Kanz L, Hofmann WK, et al. (2004). Inhibitory effect of imatinib on normal progenitor cells in vitro. Blood 103, 523-529.
32. Imokawa G (2004). Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res 17, 96-110.
33. Grabbe J, Welker P, Rosenbach T, Nürnberg W, Krüger-Krasagakes S, Artuc M, Fiebiger E, and Henz BM (1996). Release of stem cell factor from human keratinocyte line, HaCaT, is increased in differentiating versus proliferating cells. J Invest Dermatol 107, 219-224.
34. Mildner M, Mlitz V, Gruber F, Wojta J, and Tschachler E (2007). Hepatocyte growth factor establishes autocrine and paracrine feedback loops for the protection of skin cells after UV irradiation. J Invest Dermatol 127, 2637-2644.
35. Otsuka T, Takayama H, Sharp R, Celli G, LaRochelle WJ, Bottaro DP, Ellmore N, Vieira W, Owens JW, Anver M, et al. (1998). c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 58, 5157-5167.
36. Albino AP, Davis BM, and Nanus DM (1991). Induction of growth RNA expression in human malignant melanoma: markers of transformation. Cancer Res 51, 4815-4820.
37. Marchese C, Felici A, Visco V, Lucania G, Igarashi M, Picardo M, Frati L, and Torrisi MR (2001). Fibroblast growth factor 10 induces proliferation and differentiation of human primary cultured keratinocytes. J Invest Dermatol 116, 623-628.