A novel AMPK activator from Chinese herb medicine and ischemia phosphorylate the cardiac transcription factor FOXO3

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 1, Issue 2, 2009, Pages 116-126

  Wang, Jingying ^a   Ma, Heng ^a   Zhang, Xiaoyu ^b   He, Leilei ^a   Wu, Jianming ^c   Gao, Xiaoping ^c   Ren, Jun ^a   Li, Ji ^a  

^a UNIVERSITY OF WYOMING   (United States)

^b North West Normal University   (China)

^c Department of Research and Development   (China)

Author keywords

AMP activated protein kinase (AMPK); Forkhead transcription factor 3 (FOXO3); Ischemia; Oleanolic acid (OA)

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FORKHEAD TRANSCRIPTION FACTOR 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OLEANOLIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHINESE HERB; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLUORESCENCE ANALYSIS; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HERBAL MEDICINE; IN VIVO STUDY; ISCHEMIC HEART DISEASE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 77953392525     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ferdinand P, Schulz R and Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 2007; 59: 418-458.
2. Young LH, Li J, Baron SJ and Russell RR. AMP-activated protein kinase: a key stress signaling pathway in the heart. Trends Cardiovasc Med 2005; 15: 110-118.
3. Zou MH, Hou XY, Shi CM, Kirkpatick S, Liu F, Goldman MH and Cohen RA. Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol Chem 2003; 278: 34003-34010.
4. Russell RR, 3rd, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ and Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004; 114: 495-503.
5. Coven DL, Hu X, Cong L, Bergeron R, Shulman GI, Hardie DG and Young LH. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. Am J Physiol Endocrinol Metab 2003; 285: E629-636.
6. Kudo N, Gillespie JG, Kung L, Witters LA, Schulz R, Clanachan AS and Lopaschuk GD. Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia. Biochim Biophys Acta 1996; 1301: 67-75.
7. Li J, Hu X, Selvakumar P, Russell RR, 3rd, Cushman SW, Holman GD and Young LH. Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol Endocrinol Metab 2004; 287: E834-841.
8. Russell RR, 3rd, Bergeron R, Shulman GI and Young LH. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am J Physiol 1999; 277: H643-649.
9. Jorgensen SB, Nielsen JN, Birk JB, Olsen GS, Viollet B, Andreelli F, Schjerling P, Vaulont S, Hardie DG, Hansen BF, Richter EA and Wojtaszewski JF. The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. Diabetes 2004; 53: 3074-3081.
10. Hardie DG and Carling D. The AMP-activated protein kinase - fuel gauge of the mammalian cell? Eur J Biochem 1997; 246: 259-273.
11. Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP and Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007; 282: 30107-30119.
12. Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP and Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 2007; 17: 1646-1656.
13. Price KR, Johnson IT and Fenwick GR. The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr 1987; 26: 27-135.
14. Kim KA, Lee JS, Park HJ, Kim JW, Kim CJ, Shim IS, Kim NJ, Han SM and Lim S. Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci 2004; 74: 2769-2779.
15. Niikawa M, Hayashi H, Sato T, Nagase H and Kito H. Isolation of substances from glossy privet (Ligustrum lucidum Ait.) inhibiting the mutagenicity of benzo[a]pyrene in bacteria. Mutat Res 1993; 319: 1-9.
16. Gao D, Li Q, Li Y, Liu Z, Liu Z, Fan Y, Han Z, Li J and Li K. Antidiabetic potential of oleanolic acid from Ligustrum lucidum Ait. Can J Physiol Pharmacol 2007; 85: 1076-1083.
17. Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR, 3rd and Young LH. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res 2005; 97: 872-879.
18. Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R and Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008; 451: 578-582.
19. Dong F, Zhang X, Yang X, Esberg LB, Yang H, Zhang Z, Culver B and Ren J. Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. J Endocrinol 2006; 188: 25-36.
20. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, Steele GD, Jr. and Chen LB. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A 1991; 88: 3671-3675.
21. Konrad D, Rudich A, Bilan PJ, Patel N, Richardson C, Witters LA and Klip A. Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells. Diabetologia 2005; 48: 954-966.
22. Zhao P, Xiao X, Kim AS, Leite MF, Xu J, Zhu X, Ren J and Li J. c-Jun Inhibits Thapsigargin-Induced ER Stress Through Up-Regulation of DSCR1/Adapt78. Exp Biol Med (Maywood) 2008; 233: 1289-1300.
23. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW and Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015.
24. Li Q, Ceylan-Isik AF, Li J and Ren J. Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction. Rejuvenation Res 2008; 11: 725-733.
25. Mammucari C, Schiaffino S and Sandri M. Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy 2008; 4: 524-526.
26. Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON an Fruman DA. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood 2004; 103: 4268-4275.
27. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995; 49: 57-68.
28. Kashiwada Y, Wang HK, Nagao T, Kitanaka S, Yasuda I, Fujioka T, Consentino LM, Kozuka M, Okabe H, Ikeshiro Y, Hu CQ, Yeh E and Lee KH. Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids. J Nat Prod 1998; 61: 1090-1095.
29. Talmor D, Applebaum A, Rudich A, Shapira Y and Tirosh A. Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass. Circ Res 2000; 86: 1004-1007.
30. Sun HX, Zheng QF and Tu J. Induction of apoptosis in HeLa cells by 3beta-hydroxy-12-oleanen-27-oic acid from the rhizomes of Astilbe chinensis. Bioorg Med Chem 2006; 14: 1189-1198.
31. Baron SJ, Li J, Russell RR, 3rd, Neumann D, Miller EJ, Tuerk R, Wallimann T, Hurley RL, Witters LA and Young LH. Dual mechanisms regulating AMPK kinase action in the ischemic heart. Circ Res 2005; 96: 337-345.
32. Du Y and Ko KM. Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats. Planta Med 2006; 72: 222-227.
33. Senthil S, Sridevi M and Pugalendi KV. Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats. Toxicol Pathol 2007; 35: 418-423.