Ethnopharmacological use of herbal remedies for the treatment of malaria in the Dangme West District of Ghana

Journal of Ethnopharmacology

Volumn 129, Issue 3, 2010, Pages 367-376

  Asase, Alex ^a   Akwetey, George A ^a   Achel, Daniel G ^b  

^a UNIVERSITY OF GHANA   (Ghana)

^b Ghana Atomic Energy Commission   (Ghana)

Author keywords

Antisplasmodial activity; Ghana; Malaria; Medicinal plants; Phytochemical constituents

Indexed keywords

ACANTHOSPERMUN HISPIDUS EXTRACT; ANANAS COMOSUS EXTRACT; AZADIRACHTA INDICA EXTRACT; BAMBUSA VULGARIS EXTRACT; CARICA PAPAYA EXTRACT; CITRUS AURANTIFOLIA EXTRACT; COCOS NUCIFERA EXTRACT; DEINBOLLIA PINNATA EXTRACT; ELAEIS GUINEENSIS EXTRACT; GREENWAYODENDRON EXTRACT; GUAVA EXTRACT; HERBACEOUS AGENT; KHAYA SENEGALENSIS EXTRACT; MANGIFERA INDICA EXTRACT; MORINDA LUCIDA EXTRACT; MORINGA OLEIFERA EXTRACT; MUSA PARADISIACA EXTRACT; NAUCLEA LATIFOLIA EXTRACT; OCIMUM GRATISSIMUM EXTRACT; PHYLLANTHUS AMARUS EXTRACT; PLANT EXTRACT; SACCHARUM OFFICINARUM EXTRACT; SECURINEGA VIROSA EXTRACT; SENNA ALATA EXTRACT; SENNA OCCIDENTALIS EXTRACT; SENNA SIAMEA EXTRACT; SOLANUM TORVUM EXTRACT; THEOBROMA CACAO EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERNONIA AMYGDALINA EXTRACT;

ACANTHOSPERMUN HISPIDUS; ANANAS COMOSUS; ANTIMALARIAL ACTIVITY; ARTICLE; BAMBUSA VULGARIS; CACAO; COCONUT; COMMUNITY; COST EFFECTIVENESS ANALYSIS; DEINBOLLIA PINNATA; DRUG USE; ELAEIS GUINEENSIS; ETHNOPHARMACOLOGY; GHANA; GREENWAYODENDRON; HERBAL MEDICINE; HOUSEHOLD; HUMAN; KHAYA SENEGALENSIS; KNOWLEDGE; LIME (FRUIT); MALARIA; MEDICINAL PLANT; MORINDA LUCIDA; MUSA PARADISIACA; NONHUMAN; PLANT LEAF; PLASMODIUM; PRESCRIPTION; QUESTIONNAIRE; SECURINEGA VIROSA; SENNA ALATA; SENNA OCCIDENTALIS; SENNA SIAMEA; SOLANUM TORVUM; SUGARCANE;

ADOLESCENT; ADULT; ANTIMALARIALS; ETHNOPHARMACOLOGY; FEMALE; GHANA; HUMANS; MALARIA; MALE; MEDICINE, AFRICAN TRADITIONAL; MIDDLE AGED; PLANT PREPARATIONS; PLANTS, MEDICINAL; QUESTIONNAIRES; YOUNG ADULT;

ANNONACEAE; ARECACEAE; BAMBUSA VULGARIS; DEINBOLLIA; ELAEIS GUINEENSIS; GREENWAYODENDRON; POACEAE; SAPINDACEAE; SOLANACEAE; SOLANUM TORVUM;

EID: 77953363300     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.04.001     Document Type: Article

References (78)

1. Abbiw D.K. Useful Plants of Ghana 1990, Intermediate Technology Publications. London Publications Department, Royal Botanic Gardens, Kew, 337 pp.
2. Abebe W. Traditional pharmaceutical practice in Gondar region, Northwestern Ethiopia. Journal of Ethnopharmacology 1984, 11:33-47.
3. Abegaz B.M., Keige A.W., Diaz J.D., Herz W. Sesquiterpene lactones and other constituents of Vernonia species from Ethiopia. Phytochemistry 1994, 37:191-196.
4. Addae-Kyereme J., Crof S.L., Kendrick H., Wright C.W. Antiplasmodial activities of some Ghanaian plants traditionally used for fever/malaria treatment and some of the alkaloids from Pleiocarpa mutica; in vivo antimalarial activity of pleiocarpine. Journal of Ethnopharmacology 2001, 76:99-103.
5. Afari E.A., Appawu M., Dunyo S., Baffoe-Wilmot A., Krumah F.F. Malaria infection, morbidity and transmission in two ecological zones in southern Ghana. African Journal of Health Science 1995, 2:312-316.
6. Agyepong I.A. Malaria: ethnomedical perceptions and practice in an Adangbe farming community and implications for control. Social Science and Medicine 1992, 35:131-137.
7. Akihisa T., Uchiyama E., Kikuchi T., Tokuda H., Suzuki T., Kimura Y. Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos. Journal of Natural Products 2009, 7:1786-1792.
8. Asase A., Kokubun T., Garyer R.J., Kite G., Simmonds M.S.J., Oteng-Yeboah A.A., Odamtten G.T., Simmonds M.S.J. Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia seiberiana, Haemastostaphis barteri, Mitragyna inermis and Pseudocedrela kotchyi. Phytotherapy Research 2008, 22:1013-1016.
9. Asase A., Oppong-Mensah G. Traditional antimalarial phytotherapy remedies in herbal markets in southern Ghana. Journal of Ethnopharmacology 2009, 126:492-499.
10. Asase A., Oteng-Yeboah A.A., Odamtten G.T., Simmonds M.S.J. Ethnobotanical study of some Ghanaian anti-malarial plants. Journal of Ethnopharmacology 2005, 99:273-279.
11. Ashihara H., Sano H., Crozier A. Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry 2008, 69:841-856.
12. Barreto J.C., Trevisan M.T., Hull W.E., Erben G., de Brito E.S., Pfundstein B., Würtele G., Spiegelhalder B., Owen R.W. Characterization and quantification of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agriculture and Food Chemistry 2008, 56:5599-5610.
13. Berhow M.A., Bennett R.D., Poling S.M., Vannier S., Hidaka T., Omura M. Acylated flavonoids in callus cultures of Citrus aurantifolia. Phytochemistry 1994, 36:1225-1227.
14. Bero J., Ganfon H., Jonville M.C., Frédérich M., Gbaguidi F., DeMol P., Moudachirou M., Quetin-Leclercq J. In vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria. Journal of Ethnopharmacology 2009, 122:439-444.
15. Bhat G.P., Surolia N. In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. American Journal of Tropical Medicine and Hygiene 2001, 65:304-308.
16. Branch L.C., Silva M.F. Folk medicine of alter Do Chão, Pará, Brazil. Acta Amazônica 1983, 13:737-797.
17. Bryce T.A., Martin-Smith M., Osske G., Schreiber K., Subramanian G. Sterols and triterpenoids-XI: isolation of arundoin and sawamilletin from Cuban sugar cane wax. Tetrahedron 1967, 23:1283-1296.
18. Canini A., Alesiani D., D'Arcangelo G., Tagliatesta P. Gas chromatography-mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf. Journal of Food Composition and Analysis 2007, 20:584-590.
19. Colombo R., Lanças F.M., Yariwake J.H. Determination of flavonoids in cultivated sugarcane leaves, bagasse, juice and in transgenic sugarcane by liquid chromatography-UV detection. Journal of Chromatography A 2006, 1103:118-124.
20. Dangme-West Assembly, 1996. Five Year Development Plan 1996. Dodowa.
21. Deshmane S.S., Dev S. Higher isoprenoids-II: triterpenoids and steroids of Saccharum officinarum Linn. Tetrahedron 1971, 27:1109-1118.
22. Erasto P., Grierson D.S., Afolayan A.J. Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina. Journal of Ethnopharmacology 2006, 106:117-120.
23. Figueirinha A., Paranhos A., Pérez-Alonso J.J., Santos-Buelga C., Batista M.T. Cymbopogon citratus leaves: characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols. Food Chemistry 2008, 110:718-728.
24. Fredros O.O., Bart G.J., Knols U.F. Larvicidal effects of a neem (Azadirachta indica) oil formulation on the malaria vector Anopheles gambiae. Malaria Journal 2007, 6:63.
25. Gbeassor M., Koumaglo H.K., Awang D.V.C., Durst J., Mackinnon S., Arnason J.T. Development of ethical phytomedicines for Togo, West Africa. Chemistry, Biological and Pharmacological Properties of African Medicinal Plants 1996, 211-219. University of Zimbabwe Publications. K. Hostettman, M. Chinyanganya, M. Mai, J.-L. Wolfender (Eds.).
26. Gessler M.C., Msuya D.E., Nkunya M.H.H., Mwasumbi L.B., Schär A., Heinrich M., Tanner M. Traditonal healers in Tanzania: the treatment of malaria with plant remedies. Journal of Ethnopharmacology 1995, 48:131-144.
27. Ghana Health Service, 2007. Annual Report of the Ghana Health Service, 75 pp.
28. Ghana Statistical Service, 2005. Report on 2000 Population and Housing Census. Ghana Statistical Service, Accra.
29. Grayer R.J., Veitch N.C., Kite G.C., Price A.M., Kokubun T. Distribution of 8-oxygenated leaf-surface flavones in the genus Ocimum. Phytochemistry 2001, 56:559-567.
30. Gutiérrez R.M.P., Mitchell S., Solis R.V. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology 2008, 117:1-27.
31. Hatano, T., Miyatake, H., Osakabe, N., T akizawa T., Ito, H., Yoshida, T., 2002. Procanthocyanidin glycosides and related polyphenols from Cacao liquor and their antioxidant effects. Phytochemistry 59, 749-758.
32. Heinrich M., Edwards S., Moerman D.E., Leonti M. Ethnopharmacological field studies; a critical assessment of their conceptual basis and methods. Journal of Ethnopharmacology 2009, 124:1-17.
33. Houghton P.J., Woldemanam T.Z., O'Shea S., Thyagarajan S.P. Two Securinega-type alkaloids from Phyllanthus amarus. Phytochemistry 1996, 43:715-717.
34. Iwu M.M. African Medicinal Plants in the Search for New Drugs Based on Ethnobotanical Leads. Ethnobotany and Search for New Drugs 1994, Wiley, Chichester, pp. 116-129.
35. Jisaka M., Ohigashi H., Takegawa K., Hirota M., Lrie R., Huffman M.A., Koshimi{ogonek}zu K. Steroid glucosides from Vernonia amygdalina, a possible chimpanzee medicinal plant. Phytochemistry 1993, 43:409-413.
36. Juan Hernández Cano., So: J.H., Volpato G. Herbal mixtures in the traditional medicine of Eastern Cuba. Journal of Ethnopharmacology 2004, 90:293-316.
37. Kaou A.M., Mahiou-Leddet V., Hutter S., Aïnouddine S., Hassani S., Yahaya I., Azas N., Ollivier E. Antimalarial activity of crude extracts from nine African medicinal plants. Journal of Ethnopharmacology 2008, 116:74-83.
38. Kilama W.L. Ethnical perspective on malaria research for Africa. Acta Tropica 2005, 95:276-284.
39. Kirira P.G., Rukunga G.M., Wanyonyi A.W., Muregi F.M., Gathirwa J.W., Muthaura C.N., Omar S.A., Tolo F., Mungai G.M., Ndiege I.O. Antiplasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in Meru and Kilifi districts of Kenya. Journal of Ethnopharmacology 2006, 106:403-407.
40. Klayman D.L. Qinghaosu (artemisinin): an antimalarial from China. Science 1985, 31:1049-1055.
41. Lu Y., Luo J., Xu D., Huang X., Kong L. Characterization of spirostanol saponins in Solanum torvum by high-performance liquid chromatography/evaporative light scattering detector/electrospray ionization with multi-stage tandem mass spectrometry. Magnetic Resonance Chemistry 2008, 47:808-812.
42. Ma C., Xiao S.-v., Li Z.-g., Wang W., Du L.-J. Characterization of active phenolic components in the ethanolic extract of Ananas comosus L. leaves using high-performance liquid chromatography with diode array detection and tandem mass spectrometry. Journal of Chromatography 2007, 1165:39-44.
43. Macías F.A., Lacret R., Varela R.M., Nogueiras C., Molinillo J.M. Bioactive apocarotenoids from Tectona grandis. Phytochemistry 2008, 69:2708-2715.
44. Mbatchi S.F., Mbatchi B., Banzouzi J.T., Bansimba T., Nsonde Ntandou G.F., Ouamba J.-M., Berry A., Benoit-Vical F. In vitro antiplasmodial activity of 18 plants used in Congo Brazzaville traditional medicine. Journal of Ethnopharmacology 2006, 104:168-174.
45. Mshana, R.N., Abbiw, D.K., Addae-Mensah, I., Adjanouhoun, E., Ahyi, M.R.A., Ekpere, J.A., Enow-Rock, E.G., Gbile, Z.O., Noamesi, G.K., Odei, M.A., Odunlami, H., Oteng-Yeboah, A.A., Sarpong, K., Sofowora, A., Tackie, A.N., 2001. Traditional Medicine and Pharmacopoeia: Contribution to the Revision of Ethnobotanical and Floristic Studies in Ghana. Institute for Scientific and Technological Information, Accra, 919 pp.
46. Muthaura C.N., Rukunga G.M., Chhabra S.C., Mungai G.M., Njagi E.N.M. Traditional antimalarial phytotherapy remedies used by the Kwale community of the Keyan Coast. Journal of Ethnopharmacology 2007, 144:377-386.
47. Mwangi J.W., Addae-Mensah I., Muriuki G., Munavu R., Lwande W., Hassanali A. Essential oils of Lippia species in Kenya IV. Maize weevil (Stiophilus zeamis) repellency and larvicidal activity. International Journal of Crude Drug 1991, 30:9-17.
48. Nguta J.M., Mbaria J.M., Gakuya D.W., Gathumbi P.K., Kiama S.G. Antimalarial herbal remedies of Msambweni, Kenya. Journal of Ethnopharmacology 2010, 128:424-432.
49. Odugbemi O.T., Akinsulire O.R., Aibinu I.E., Fabeku P.O. Medicinal plants useful for malaria therapy in Okeigbo Ondo State, South Western Nigeria. African Journal of Traditional, Complementary and Alternative Medicines 2007, 4:191-198.
50. Ola S.S., Catia G., Marzia I., Francesco V.F., Afolabi A.A., Nadia M. HPLC/DAD/MS characterization and analysis of flavonoids and cynnamoil derivates in four Nigerian green-leafy vegetable. Food Chemistry 2009, 155:1568-1574.
51. Piccinelli A.L., García, Mesa M., Armenteros D.M., Alfonso M.A., Arevalo A.C., Campone L., Rastrelli LHPLC-PDA-MS and NMR characterization of C-glycosyl flavones in a hydroalcoholic extract of Citrus aurantifolia leaves with antiplatelet activity. Journal of Agriculture and Food Chemistry 2008, 56:574-581.
52. Pieroni A. Medicinal plants and food medicines in the folk traditions of the Upper Lucca Province, Italy. Journal of Ethnopharmacology 2000, 70:235-273.
53. Prance G.T. Introduction. Ethnobotany and the Search for New Drugs. Ciba Foundation Symposium 185 1994, 57-90. G.T. Prance, D.J. Chadwick, J. Marsh (Eds.).
54. Sanon S., Ollivier E., Azas N., Mahiou V., Gasquet M., Ouattara C.T., Nebie I., Traore A.S., Esposito F., Balansard G., Timon-David P., Fumoux F. Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso. Journal of Ethnopharmacology 2003, 86:143-147.
55. Shepard G. A sensory ecology of medicinal therapy in two Amazonian societies. American Anthropologist 2004, 106:252-266.
56. Siddiqui B.S., Afshan F., Gulzar T., Hanif M. Tetracyclic triterpenoids from the leaves of Azadirachta indica. Phytochemistry 2004, 65:2363-2367.
57. Siddiqui B.S., Ali S.K., Naqvi S.N., Tariq R.M. Variation of major limonoids in Azadirachta indica fruits at different ripening stages and toxicity against Aedes aegypti. Natural Products Communication 2009, 4:473-476.
58. Sittie A.A., Lemmich E., Olsen C.E., Hviid L., Kharazmi A., Nkrumah F.K., Christensen S.B. Structure-activity studies: In vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida. Planta Medica 1999, 65:259-261.
59. Sofowora A. Medicinal Plants and Traditional Medicine in Africa 1993, Spectrum Book Ltd., Ibadan, Nigeria, 289 pp. 2nd Edition.
60. Srisilam, K., Veersham, C., 2003. Antimalarialsof plant origin. In: Nishan, I., Khanu, A. (Eds.), Role of Biotechnology in Medicinal and Aromatic Plants, Vol. VII, pp. 17-47.
61. Sultana B., Anwar F. Flavonols (kaempferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chemistry 2008, 108:879-884.
62. Sumthong P., Damveld R.A., Choi Y.H., Arentshorst M., Ram A.F., van den Hondel C.A., Verpoorte R. Activity of quinones from teak (Tectona grandis) on fungal cell wall stress. Planta Medica 2006, 72:943-944.
63. Tabuti J.R.S. Herbal medicines used in the treatment of malaria in Budiope County, Uganda. Journal of Ethnopharmacology 2008, 116:33-42.
64. Tona L., Cimanga R.K., Mesia K., Musuamba C.T., De Bruyne T., Apers S., Hernans N., Miert S.V., Pieters L., Totté J., Vlietinck A.J. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. Journal of Ethnopharmacology 2004, 93:27-32.
65. Tona L., Ngimbi N.P., Tsakala M., Mesia K., Cimanga K., Apers S., De Bruyne T., Pieters L., Totté J., Vlietinck A.J. Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo. Journal of Ethnopharmacology 1999, 68:193-203.
66. Valentin A., Pélioier Y., Benoi Y., Marion C., Kone D., Millie M., Bastide J.-M. Composition and antimalarial activity in vitro of volatile components of Lippia multiflora. Phytochemistry 1995, 4:1439-1442.
67. Van Wyk B.-E., Van Oudshoorne B., Gericke N. Medicinal Plants of South Africa 2002, Briza Publications, Pretoria, South Africa, 336 pp.
68. Van Wyk B.-E., Wink M. Medicinal Plants of the World: An Illustrated Scientific Guide to Important Medicinal Plants and their Uses 2004, Timber Press, Portland, Oregon, USA, 480 pp.
69. Vigneron M., Deparis X., Deharo E., Bourdy G. Antimalarial remedies in French Guiana: acknowledge attitudes and practices study. Journal of Ethnopharmacology 2005, 98:351-360.
70. Vijayakumar S., Presannakumar G., Vijayalakshmi N.R. Antioxidant activity of banana flavonoids. Fitoterapia 2008, 79:279-282.
71. Waako P.J., Gumede B., Smith P., Folb P.I. The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. et Thonn. Journal of Ethnopharmacology 2005, 99:137-143.
72. White N.J. Antimalarial drug resistance. Journal of Clinical Investigation 2004, 113:1084-1092.
73. WHO, 2001. Promoting the Role of Traditional Medicine in Health Systems: A Strategy for the African Region. WHO Regional Office for Africa, Harare, p. 17.
74. WHO, 2005. World Malaria Report 2005, 294 pp.
75. Yeap Foo L. Amariinic acid and related ellagitannins from Phyllanthus amarus. Phytochemistry 1995, 39:217-244.
76. Yoo H.D., Cremin P.A., Zeng L., Garo E., Williams C.T., Lee C.M., Goering M.G., O'Neil-Johnson M., Eldridge G.R., Hu J.F. Suaveolindole, a new mass-limited antibacterial indolosesquiterpene from Greenwayodendron suaveolens obtained via high-throughput natural products chemistry methods. Journal of Natural Products 2005, 68:122-124.
77. Yuan T., Yang S.P., Zhang C.R., Zhang S., Yue J.M. Two limonoids, khayalenoids A and B with an unprecedented 8-oxa-tricyclo [4.3.2.0(2, 7)] undecane motif from Khaya senegalensis. Organic Letters 2009, 11:617-620.
78. Zirihi G.N., Mambu L., Guóedóe-Guina F., Bodo B., Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology 2005, 98:281-285.