Assessment of cross-sectional lung ventilation-perfusion imbalance in primary and passive pulmonary hypertension with automated V/Q SPECT

Nuclear Medicine Communications

Volumn 31, Issue 7, 2010, Pages 673-681

  Suga, Kazuyoshi ^a   Tokuda, Osamu ^b   Okada, Munemasa ^b   Koike, Masahiro ^b   Iwanaga, Hideyuki ^b   Matsunaga, Naofumi ^b  

^a St Hill Hospital   (Japan)

^b YAMAGUCHI UNIVERSITY   (Japan)

Author keywords

Lung; Perfusion; Pulmonary hypertension; Single photon emission computed tomography; Ventilation

Indexed keywords

PERTECHNETIC ACID TC 99M;

ADULT; AGED; ARTERIAL OXYGEN TENSION; ARTERY DILATATION; ARTICLE; AUTOMATION; BRONCHUS OBSTRUCTION; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; HEART LEFT VENTRICLE FAILURE; HUMAN; HYPOXIC VASOCONSTRICTION REFLEX; LUNG ARTERY PRESSURE; LUNG VENTILATION PERFUSION RATIO; MALE; PULMONARY HYPERTENSION; REFLEX; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; ALBUMINS; AUTOMATION; CASE-CONTROL STUDIES; FEMALE; HUMANS; HYPERTENSION, PULMONARY; LUNG; MALE; MIDDLE AGED; SODIUM PERTECHNETATE TC 99M; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; VENTILATION-PERFUSION RATIO; YOUNG ADULT;

EID: 77953361634     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e328339ea9b     Document Type: Article

References (42)

1. Chemla D, Castelain V, Herve P, Lecarpentier Y, Brimioulle S. Haemodynamic evaluation of pulmonary hypertension. Eur Respir J 2002; 20:1314-1331.
2. Pietra GG, Edwards WD, Kay JM, Rich S, Kernis J, Schloo B, et al. Histopathology of primary pulmonary hypertension. Circulation 1989; 80:1198-1206.
3. Burke AP, Farb A, Virmani A. The pathology of primary pulmonary hypertension. Mod Pathol 1991; 4:269-282.
4. Rich S, Pietra GG, Kieras K, Hart K, Brundage B. Primary pulmonary hypertension: radiographic and scintigraphic patterns of histologic sub-types. Ann Intern Med 1986; 105:499-502.
5. Schannwell CM, Steiner S, Strauer BE. Diagnostics in pulmonary hypertension. J Physiol Pharmacol 2007; 58:591-602.
6. Voelkel NF, Tuder RM, Weir EK. Pathophysiology of primary pulmonary hypertension: from physiology to molecular mechanisms. In: Rubin LJ, Rich S, editors. Primary pulmonary hypertension. New York, NY: Marcel Dekker; 1997. pp. 83-133.
7. Palevsky HI, Schloo BL, Pietra GG,Weber KT, Janicki JS, Rubin E, Fishman AP. Primary pulmonary hypertension: vascular structure, morphometry, and responsiveness to vasodilator agents. Circulation 1989; 80:1207-1221.
8. Engeler CE, Kuni CC, Tashjian JH, Engeler CM, du Cret RP. Regional alterations in lung ventilation in end-sage primary pulmonary hypertension: correlation between CT and scintigraphy. Am J Roentgenol 1995; 164:831-835.
9. Worsley DF, Palevsky HI, Alavi A. Ventilation-perfusion lung scanning in the evaluation of pulmonary hypertension. J Nucl Med 1994; 35:793-796.
10. Powe JE, Palevsky HI, McCarthy KE, Alavi A. Pulmonary arterial hypertension: value of perfusion scintigraphy. Radiology 1987; 164: 727-730.
11. Scott JA. Pulmonary perfusion patterns and pulmonary arterial pressure. Radiology 2002; 224:513-518.
12. Fukuchi K, Hayashida K, Nakanishi N, Inubushi M, Kyotani S, Nagaya N, Ishida Y. Quantitative analysis of lung perfusion in patients with primary pulmonary hypertension. J Nucl Med 2002; 43:757-761.
13. Bartalena T, Oboldi D, Guidalotti PL, Rinaldi MF, Bertaccini P, Napoli G, Gavelli G. Lung perfusion in patients with pulmonary hypertension: comparison between MDCT pulmonary angiography with minIP reconstructions and 99mTc-MAA perfusion scan. Invest Radiol 2008; 43:368-373.
14. Sanchez O, Revel MP, Couchon S, Meyer G. Imaging of pulmonary arterial hypertension. Perfusion techniques for pulmonary thromboendarterectomy under deep hypothermia circulatory arrest: a case series. Rev Mal Respir 2007; 24:155-169.
15. Ohno Y, Hatabu H, Murase K, Higashino T, Nogami M, Yoshikawa T, Sugimura K. Primary pulmonary hypertension: 3D dynamic perfusion MRI for quantitative analysis of regional pulmonary perfusion. Am J Roentgenol 2007; 188:48-56.
16. Revel M-P, Faivre J-B, Remy-Jardin M, Delannoy-Deken V, Duhamel A, Remy J. Pulmonary hypertension: ECG-gated 64-section CT angiographic evaluation of new functional parameters as diagnostic criteria. Radiology 2009; 250:558-566.
17. Jones AT, Hansell DM, Evans TW. Quantifying pulmonary perfusion in primary pulmonary hypertension using electron-beam computed tomography. Eur Respir J 2004; 23:202-207.
18. Laffon E, Laurent FO, Bernard V, de Boucaud L, Ducassou D, Marthan R. Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method. J Appl Physiol 2001; 90:2197-2202.
19. Bratel T, Lagerstrand L, Brodin L-Å , Nowak J, Randma I. Ventilation-perfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment. Respir Physiol Neurobiol 2007; 158:59-69.
20. Petersson J, Sánchez-Crespo A, Rohdin M, Montmerle S, Nyre S. Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion. J Appl Physiol 2004; 96:1127-1136.
21. Petersson J, Sánchez-Crespo A, Larsson SA. Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol 2007; 102:468-476.
22. Meignan MA. Lung ventilation/perfusion SPECT: the right technique for hard times. J Nucl Med 2002; 43:648-651.
23. Sando Y, Inoue T, Nagai R, Endo K. Ventilation/perfusion ratios and simultaneous dual-radionuclide single-photon emission tomography with krypton-81m and technetium-99m macroaggregated albumin. Eur J Nucl Med 1997; 24:1237-1244.
24. Itti E, Nguyen S, Robin F, Desarnaud S, Rosso J, Harf A, Meignan M. Distribution of ventilation/perfusion ratios in pulmonary embolism: an adjunct to the interpretation of ventilation/perfusion lung scans. J Nucl Med 2002; 43:1596-1602.
25. Harris B, Bailey D, Miles S, Bailey E, Bailey E, Rogers K, et al. Objective analysis of tomographic ventilation-perfusion scintigraphy in pulmonary embolism. Am J Respir Crit Care Med 2007; 175:1173-1180.
26. Benumof JL,Wahrenbrock EA. Blunted hypoxic pulmonary vasoconstriction by increased lung vascular pressures. J Appl Physiol 1975; 38:846-850.
27. Jian MY, King JA, Al-Mehdi AB, Liedtke W, Townsley MI. High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol 2008; 38:386-392.
28. Bratel T, Lagerstrand L, Brodin LA, Nowak J, Randmaa I. Ventilationperfusion relationships in pulmonary arterial hypertension: effect of intravenous and inhaled prostacyclin treatment. Respir Physiol Neurobiol 2007; 158:59-69.
29. Ward JP, McMurtry IF. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr Opin Pharmacol 2009; 9:287-296.
30. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol 2005; 98:390-403.
31. A Mark E. Hypoxic pulmonary vasoconstriction. Essays Biochem 2007; 43:61-76.
32. Wartski M, Zerbib E, Regnard J-F, Herve P. Reverse ventilation-perfusion mismatch in lung cancer suggests intrapulmonary functional shunting. J Nucl Med 1998; 39:1986-1989.
33. Pezzulli F, Posner D, Mask K. Reverse V/P mismatch in radiation pneumonitis. Australas Radiol 1994; 38:135-137.
34. Zucker I, Heyman S, Ozdemir S. Reversed ventilation-perfusion mismatch involving a pediatric patient in congestive heart failure. J Nucl Med 1997; 38:1681-1683.
35. Ravin CE, Greenspan RH, McLoud TC, Lange RC, Langou RA, Putman CE. Redistribution of pulmonary blood flow secondary to pulmonary arterial hypertension. Invest Radiol 1980; 15:29-33.
36. Van der Lee I, Zanen P, Grutters JC, Snijder RJ, van den Bosch JM. Diffusing capacity for nitric oxide and carbon monoxide in patients with diffuse parenchymal lung disease and pulmonary arterial hypertension. Chest 2006; 129:378-383.
37. Champion HC, Michelakis ED, Hassoun PM. Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit state of the art and clinical and research implications. Circulation 2009; 120:992-1007.
38. Resten A, Maitre S, Humbert M, Rabiller A, Sitbon O, Capron F, et al. Pulmonary hypertension: CT of the chest in pulmonary venoocclusive disease. Am J Roentgenol 2004; 183:65-70.
39. Suga K, Kawakami Y, Iwanaga H, Hayashi N, Seto A, Matsunaga N. Comprehensive assessment of lung CT attenuation alteration at perfusion defects of acute pulmonary thromboembolism with breath-hold SPECT-CT fusion images. J Comput Assist Tomogr 2006; 30:83-91.
40. Sherrick AD, Swensen SJ, Hartman TE. Mosaic pattern of lung attenuation on CT scans: frequency among patients with pulmonary artery hypertension of different causes. Am J Roentgenol 1997; 169:79-82.
41. Worthy SA, Muller NL, Hartman TE, Swensen SJ, Padley SP, Hansell DM. Mosaic attenuation pattern on thin-section CT scans of the ling: differentiation among infiltrative lung, airway, and vascular diseases as a cause. Radiology 1997; 205:465-470.
42. Whiteley JP, Gavaghan DJ, Hahn CE. A mathematical evaluation of the multiple breath nitrogen washout (MBNW) technique and the multiple inert gas elimination technique (MIGET). J Theor Biol 1998; 194:517-539.