Ventilation-perfusion relationships in pulmonary arterial hypertension: Effect of intravenous and inhaled prostacyclin treatment

Respiratory Physiology and Neurobiology

Volumn 158, Issue 1, 2007, Pages 59-69

  Bratel, Tomas ^a   Lagerstrand, Lars ^a   Brodin, Lars Åke ^a   Nowak, Jacek ^a   Randmaa, Ivar ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Epoprostenol; Hypoxaemia; Inhaled iloprost; Mixed venous oxygenation; Multiple inert gas elimination technique; over(V, )A over(Q, ) Ratios; Pulmonary arterial hypertension; Shunt

Indexed keywords

ANTICOAGULANT AGENT; DIURETIC AGENT; FUROSEMIDE; ILOPROST; LOW MOLECULAR WEIGHT HEPARIN; OXYGEN; PROSTACYCLIN; VASODILATOR AGENT;

ADULT; AGED; ARTERIAL OXYGEN TENSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG EFFECT; FEMALE; HEART CATHETERIZATION; HEART OUTPUT; HEMODYNAMICS; HUMAN; LUNG VASCULAR RESISTANCE; LUNG VENTILATION PERFUSION RATIO; LUNG VOLUME; MALE; NEBULIZER; OXYGEN THERAPY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SHUNT INFECTION; TREATMENT DURATION; TREATMENT OUTCOME; VENOUS OXYGEN TENSION;

ADMINISTRATION, ORAL; AGED; BLOOD PRESSURE; ECHOCARDIOGRAPHY; EPOPROSTENOL; EXERCISE TEST; FEMALE; FORCED EXPIRATORY VOLUME; HEART CATHETERIZATION; HUMANS; HYPERTENSION, PULMONARY; INHALATION; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; QUALITY OF LIFE; SYSTOLE; VASCULAR RESISTANCE; VITAL CAPACITY;

EID: 34250667115     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.03.003     Document Type: Article

References (45)

1. Agustí A.G.N., Roca J., Gea J., Wagner P.D., Xaubet A., and Rodriguez-Roisin R. Mechanisms of gas-exchange impairment in primary pulmonary fibrosis. Am. Rev. Respir. Dis. 143 (1991) 219-225
2. Aerosolized Iloprost Randomized Study Group. Inhaled iloprost for severe pulmonary hypertension. N. Engl. J. Med. 347 (2002) 322-329
3. Barberà J.A., Riverola A., Roca J., Ramirez J., Wagner P.D., Ros D., Wiggs B., and Rodriguez-Roisin R. Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive lung disease. Am. J. Respir. Crit. Care Med. 149 (1994) 423-429
4. Barberà J.A., Roger N., Roca J., Rovira I., Higgenbottam T.W., and Rodriguez-Roisin R. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347 (1996) 436-440
5. Brimioulle S., LeJeune P., and Naeije R. Effects of hypoxic vasoconstriction on pulmonary gas exchange. J. Appl. Physiol. 81 4 (1996) 1535-1543
6. Cardús J., Burgos F., Diaz O., Roca J., Barberà J.A., Marrades R.M., Rodriguez-Roisin R., and Wagner P.D. Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals. Am. J. Respir. Crit. Care Med. 156 (1997) 648-653
7. Cotes J. Measurement of transfer factor (diffusing capacity) and its subdivisions. Lungfunction-Assessment on Application in Medicine. fifth ed. (1993), Blackwell Publishers, Oxford 299-324
8. Currie P.J., Seward J.B., Chan K.-L., Fyfe D.A., Hagler D.J., Mair D.D., Reeder G.S., Nishimura R.A., and Tajik A.J. Continuous wave Doppler determination of right ventricular pressure: a simultaneous Doppler-catheterization study in 127 patients. J. Am. Coll. Cardiol. 6 (1985) 750-756
9. Dantzker D.R., and Bower J.S. Mechanisms of gas exchange abnormality in patients with chronic obliterative pulmonary vascular disease. J. Clin. Invest. 64 (1979) 1050-1055
10. Dantzker D.R., Lynch J.P., and Weg J.G. Depression of cardiac output is a mechanism of shunt reduction in the therapy of acute respiratory failure. Chest 77 (1980) 636-642
11. A / over(Q, ̇) matching in oblierative pulmonary hypertension. J. Appl. Physiol. 51 (1981) 607-613
12. Dantzker D.R., D'Alonzo G.E., Bower J.S., Popat K., and Crevey J. Pulmonary gas exchange during exercise in patients with chronic obliterative pulmonary hypertension. Am. Rev. Respir. Dis. 130 (1984) 412-416
13. Gale G.A., Torre-Bueno J.R., Moon R.E., Saltzman H.A., and Wagner P.D. Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J. Appl. Physiol. 58 3 (1985) 978-988
14. Güell R., Resqueti V., Sangenis M., Morante F., Martorell B., Casan P., and Guyatt P.H. Impact of pulmonary rehabilitation on psychosocial morbidity in patients with severe COPD. Chest 129 (2006) 899-904
15. Guyatt G.H., Berman L.B., Townsend M., Pugsley S.O., and Camber L.W. A measure of quality of life for clinical trials in chronic lung disease. Thorax 42 (1987) 773-778
16. Hardy C.C., Bradding P., Robinson C., and Holgate S.T. Bronchoconstrictor and antibronchoconstrictor response of inhaled prostacyclin in asthma. J. Appl. Physiol. 64 4 (1988) 1567-1574
17. Hermle G., Shütte H., Walmrath D., Geiger K., Seeger W., and Grimminger F. Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide. Am. J. Respir. Crit. Care Med. 160 (1999) 1179-1187
18. Hoeper M.M., Schwarze M., Ehlerding S., Sadler-Schuermeyer A., Spiekerkoetter E., Niedermeyer J., Hamm M., and Fabel H. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N. Engl. J. Med. 342 (2000) 1866-1870
19. Kapitan K.S., Buchbinder M., Wagner P.D., and Moser K.M. Mechanisms of hypoxemia in chronic thromboembolic pulmonary hypertension. Am. Rev. Respir Dis. 139 (1989) 1149-1154
20. Lang I., Gomez-Sanchez M., Kneussl M., Naeije R., Escribano P., Skoro-Sajer N., and Vachiery J.-L. Efficacy of long-term subcutaneous trepostinil sodium therapy in pulmonary hypertension. Chest 129 (2006) 1636-1643
21. Manier G., and Castaing Y. Influence of cardiac output on the oxygen exchange in acute pulmonary embolism. Am. Rev. Respir. Dis. 145 (1992) 130-136
22. Melot C., Naeije R., Mols P., Vandenbossche J.L., and Denolin H. Effects of nifedipine on ventilation/perfusion matching in primary pulmonary hypertension. Chest 83 (1983) 203-207
23. Melot C., Hallemans R., Naeije R., Mols P., and Lejeune P. Deleterious effect of nifedipine on pulmonary gas exchange in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 130 (1984) 612-616
24. Olschewski H., Walmrath D., Schermuly R., Ghofrani A., Grimminger F., and Seeger W. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann. Intern. Med. 124 9 (1996) 820-824
25. Opitz C.F., Wensel R., Bettmann M., Schaffarczyk R., Linscheid M., Hetzer R., and Ewert R. Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation. Eur. Heart. J. 24 (2003) 356-365
26. Opitz C.F., Wensel R., Winkler J., Halank M., Bruch L., Kleber F.-X., Höffken G., Anker S.D., Negassa A., Felix S.B., Hetzer R., and Ewert R. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with primary pulmonary arterial hypertension. Eur. Heart. J. 26 (2005) 1895-1902
27. Oswald-Mammosser M., Weitzenblum E., Moser G., Chaouat A., Charpentier C., and Kessler R. Prognostic factors in COPD patients receiving long-term oxygen therapy. Chest 107 (1995) 1193-1198
28. Otto C.M. Textbook of Clinical Echocardiography. second ed. (2000), WB Saunders pp. 123-126
29. Otulana B., and Higenbottam T.W. The role physiological deadspace and shunt in the gas exchange of patients with pulmonary hypertension: a study of exercise and prostacyclin infusion. Eur. Respir. J. 1 8 (1988) 732-737
30. Pettersson J., Sanchez-Crespo A., Rohdin M., Montmerle S., Nyren S., Jacobsson H., Larsson S.A., Lindahl S.G., Linnarsson D., Glenny R.W., and Mure M. Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion. J. Appl. Physiol. 96 3 (2004) 1127-1136
31. Pietra G.G., Capron F., Stewart S., Leone O., Humbert M., Robbins I.M., Reid L.M., and Tuder R.M. Pathologic assessment of vasculopathies in pulmonary hypertension. J. Am. Coll. Cardiol. 43 (2004) 25S-32S
32. Primary Pulmonary Hypertension Study Group. A comparison of continuous intravenous epoprostanol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N. Engl. J. Med. 334 (1996) 296-302
33. Quanjer, P.H. (Ed.), 1983. Standardised lung function testing. Bull. Europ. Physiopath. Respir. 9 (Suppl. 5), 45-51.
34. Rafanan A.L., Golish J.A., Dinner D.S., Hague L.K., and Arroliga A.C. Nocturnal hypoxemia is common in primary pulmonary hypertension. Chest 120 (2001) 894-899
35. Ries A.L., and Moser K.M. Predicting treadmill/walking speed from cycle ergometry exercise in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 126 (1982) 924-927
36. Romano A.M., Tomaselli S., Gualtieri G., Zoia M.C., Fanfullah F., Berrayah L., and Cerveri I. Respiratory function in precapillary pulmonary hypertension. Monaldi Arch. Chest Dis. 48 3 (1993) 201-204
37. Sandek K., Bratel T., Hellström G., and Lagerstrand L. Ventilation-perfusion inequality and carbon dioxide sensitivity in hypoxaemic chronic obstructive pulmonary disease (COPD) and effects of 6 months of long-term oxygen treatment (LTOT). Clin. Physiol. 21 5 (2001) 584-593
38. Sitbon O., Humbert M., Jagot J.-L., Taravella O., Fartoukh M., Parent F., Herve P., and Simonneau G. Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension. Eur. Respir. J. 12 (1998) 265-270
39. Tamhane R.M., Johnson R.L., and Hsia C.C. Pulmonary membrane diffusing capacity and capillary blood volume measured during exercise from nitric oxide uptake. Chest 120 (2001) 1850-1856
40. Wagner P.D., Saltzman H.A., and West J.B. Measurement of continuous distributions ventilation-perfusion ratios: theory. J. Appl. Physiol. 36 (1974) 588-599
41. Wagner P.D., Nauman P.F., and Lavaruso R.B. Simultaneous measurement of eight foreign gases in blood by gas chromatography. J. Appl. Physiol. 36 (1974) 600-605
42. 2. J. Clin. Invest. 54 (1974) 54-68
43. Wagner P.D., Hedenstierna G., Bylin G., and Lagertsrand L. Reproducibility of the multiple inert gas elimination technique. J. Appl. Physiol. 62 (1987) 1740-1746
44. West J.B., and Wagner P.D. Pulmonary gas exchange. In: West J.B. (Ed). Bioengeneering Aspects of the Lung (1977), Marcel Dekker, New York 361-364
45. Yi E.S., Kim H., Ahn H., Strother J., Morris T., Masliah E., Hansen L.A., Park K., and Friedman P.J. Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 162 (2000) 1577-1586