Th1/Th2 cytokines' expression and production by propolis-treated mice

Journal of Ethnopharmacology

Volumn 129, Issue 3, 2010, Pages 314-318

  Orsatti, Cláudio Lera ^a   Missima, Fabiane ^a   Pagliarone, Ana Carolina ^a   Sforcin, José Maurício ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Cytokine; Immunomodulation; Propolis; Real time PCR

Indexed keywords

AROMATIC CARBOXYLIC ACID; BENZOPYRAN DERIVATIVE; COMPLEMENTARY DNA; CONCANAVALIN A; CYTOKINE; DITERPENE; ESSENTIAL OIL; FLAVONOID; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; PARA COUMARIC ACID; PROPOLIS; RNA; TRITERPENE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GAS CHROMATOGRAPHY; IMMUNOMODULATION; INHIBITION KINETICS; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SPLEEN CELL; SPLENECTOMY; SUPERNATANT; TH1 CELL; TH2 CELL; THIN LAYER CHROMATOGRAPHY; TREATMENT DURATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; PROPOLIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; TH1 CELLS; TH2 CELLS;

MUS;

EID: 77953357506     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.03.030     Document Type: Article

References (34)

1. Ansorge S., Reinhold D., Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta 1 production of human immune cells. Zeitschrift fur Naturforschung 2003, 58c:580-589.
2. Bankova V. Recent trends and important developments in propolis research. Evidence-based Complementary and Alternative Medicine 2005, 2:29-32.
3. Bankova V., Boudourova-Krasteva G., Popov S., Sforcin J.M., Funari S.R.C. Seasonal variations of the chemical composition of Brazilian propolis. Apidologie 1998, 29:361-367.
4. Bankova V., Boudourova-Krasteva G., Sforcin J.M., Frete X., Kujumgiev A., Maimoni-Rodella R., Popov S. Phytochemical evidence for the plant origin of Brazilian propolis from Sao Paulo state. Zeitschrift fur Naturforschung 1999, 54c:401-405.
5. Burdock G.A. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology 1998, 36:347-363.
6. Choi P., Reiser H. IL-4: role in disease and regulation of production. Clinical and Experimental Immunology 1998, 113:317-319.
7. Das J., Chen C.H., Yang L., Cohn L., Ray P., Ray A. A critical role for NF-kappaB in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nature Immunology 2001, 2:45-50.
8. Freitas S.F., Shinohara L., Sforcin J.M., Guimaraes S. In vitro effects of propolis on Giardia duodenalis trophozoites. Phytomedicine 2006, 13:170-175.
9. Girgin G., Baydar T., Ledochowski M., Schennach H., Bolukbasi D.N., Sorkun K., Salih B., Sahin G., Fuchs D. Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation. Immunobiology 2009, 214:129-134.
10. Hodge G., Hodge S., Han P. Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry 2002, 48:209-215.
11. Hu F., Hepburn H.R., Li Y., Chen M., Radloff S.E., Daya S. Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models. Journal of Ethnopharmacology 2005, 100:276-283.
12. Huang C.F., Lin S.S., Liao P.H., Young S.C., Yang C.C. The immunopharmaceutical effects and mechanisms of herb medicine. Cellular & Molecular Immunology 2008, 5:23-31.
13. Marquez N., Sancho R., Macho A., Calzado M.A., Fiebich B.L., Munoz E. Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. Journal of Pharmacology and Experimental Therapeutics 2004, 308:993-1001.
14. Missima, F., Pagliarone, A.C., Orsatti, C.L., Araújo Jr., J.P., Sforcin, J.M., in press. Propolis effect on Th1/Th2 cytokines' expression and production by melanoma-bearing mice submitted to stress. Phytotherapy Research.
15. Murad J.M., Calvi S.A., Soares A.M., Bankova V., Sforcin J.M. Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis. Journal of Ethnopharmacology 2002, 79:331-334.
16. Oppenheim J.J. Cytokines: past, present, and future. International Journal of Hematology 2001, 74:3-8.
17. Orsatti, C.L., Missima, F., Pagliarone, A.C., Bachiega, T.F., Búfalo, M.C., Araújo, Jr., J.P., Sforcin, J.M., in press. Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytotherapy Research.
18. Orsi R.O., Sforcin J.M., Funari S.R., Bankova V. Effects of Brazilian and Bulgarian propolis on bactericidal activity of macrophages against Salmonella typhimurium. International Immunopharmacology 2005, 5:359-368.
19. Pagliarone A.C., Missima F., Orsatti C.L., Bachiega T.F., Sforcin J.M. Propolis effect on Th1/Th2 cytokines production by acutely stressed mice. Journal of Ethnopharmacology 2009, 125:230-233.
20. Romagnani S. Regulation of the T cell response. Clinical and Experimental Allergy 2006, 36:1357-1366.
21. Sá-Nunes A., Faccioli L.H., Sforcin J.M. Propolis: lymphocyte proliferation and IFN-g production. Journal of Ethnopharmacology 2003, 87:93-97.
22. Schinkel C. The role of IFN-gamma in surgical patients. Journal of Interferon & Cytokine Research 2003, 23:341-349.
23. Scumpia P.O., Moldawer L.L. Biology of interleukin-10 and its regulatory roles in sepsis syndromes. Critical Care Medicine 2005, 33:S468-471.
24. Sforcin J.M. Propolis and the immune system: a review. Journal of Ethnopharmacology 2007, 113:1-14.
25. Sforcin J.M., Orsi R.O., Bankova V. Effect of propolis, some isolated compounds and its source plant on antibody production. Journal of Ethnopharmacology 2005, 98:301-305.
26. Skapenko A, Niedobitek G.U., Kalden J.R., Lipsky P.E., Schulze-Koops H. Generation and regulation of human Th1-based immune responses in vivo: a critical role for IL-4 and IL-10. Journal of Immunology 2004, 172:6427-6434.
27. Spelman K., Burns J., Nichols D., Winters N., Ottersberg S., Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative Medicine Review 2006, 11:128-150.
28. Sy L.B., Wu Y.L., Chiang B.L., Wang Y.H., Wu W.M. Propolis extracts exhibit an immunoregulatory activity in an OVA-sensitized airway inflammatory animal model. International Immunopharmacology 2006, 6:1053-1060.
29. Szabo S.J., Sullivan B.M., Peng S.L., Glimcher L.H. Molecular mechanisms regulating Th1 immune responses. Annual Review of Immunology 2003, 21:713-758.
30. Tan E.L., Selvaratnam G., Kananathan R., Sam C.K. Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-beta1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma. BMC Cancer 2006, 6:227.
31. Wan Y.Y., Flavell R.A. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunological Reviews 2006, 212:114-130.
32. Yang E.V., Glaser R. Stress-induced immunomodulation and the implications for health. International Immunopharmacology 2002, 2:315-324.
33. You K.M., Son K.H., Chang H.W., Kang S.S., Kim H.P. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. Planta Medica 1998, 64:546-550.
34. Zhou L., Chong M.M., Littman D.R. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009, 30:646-655.