Propolis: Lymphocyte proliferation and IFN-γ production

Journal of Ethnopharmacology

Volumn 87, Issue 1, 2003, Pages 93-97

  Sa Nunes A ^a   Faccioli, L H ^a   Sforcin, J M ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

IFN ; Lymphocyte activation; Mitogen induced proliferation; Propolis

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; MITOGENIC AGENT; PROPOLIS;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; SPLEEN CELL; SUPERNATANT;

EID: 17444444328     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(03)00121-1     Document Type: Article

References (31)

1. Bankova V., Boudourova-Krasteva G., Popov S., Sforcin J.M., Funari S.R.C. Seasonal variations in essential oil from Brazilian propolis. Journal of Essential Oil Research. 10:1998a;693-696.
2. Bankova V., Boudourova-Krasteva G., Popov S., Sforcin J.M., Funari S.R.C. Seasonal variations of the chemical composition of Brazilian propolis. Apidologie. 29:1998b;361-367.
3. Bankova V., Boudourova-Krasteva G., Sforcin J.M., Frete X., Kujumgiev A., Maimoni-Rodella R., Popov S. Phytochemical evidence for the plant origin of Brazilian propolis from São Paulo State. Zeitschrift für Naturforschung. 54c:1999;401-405.
4. Banskota A.H., Nagaoka T., Sumioka L.Y., Tezuka Y., Awale S., Midorikawa K., Matsushige K., Kadota S. Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines. Journal of Ethnopharmacology. 80:2002;67-73.
5. Bazo A.P., Rodrigues M.A.M., Sforcin J.M., Camargo J.L.V., Ribeiro L.R., Salvadori D.M.F. Protective action of propolis on the rat colon carcinogenesis. Teratogenesis, Carcinogenesis and Mutagenesis. 22:2002;183-194.
6. Bocca A.L., Hayashi E.E., Pinheiro A.G., Furlanetto A.B., Campanelli A.P., Cunha F.Q., Figueiredo F. Treatment of Paracoccidioides brasiliensis-infected mice with a nitric oxide inhibitor prevents the failure of cell-mediated immune response. Journal of Immunology. 161:1998;3056-3063.
7. Boudourova-Krasteva G., Bankova V., Sforcin J.M., Nikolova N., Popov S. Phenolics from Brazilian propolis. Zeitschrift für Naturforschung. 52c:1997;676-679.
8. Burdock G.A. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology. 36:1998;347-363.
9. Curry R.C., Kiener P.A., Spitalny G.L. A sensitive immunochemical assay for biologically active MuIFN-γ Journal of Immunological Methods. 104:1987;137-142.
10. Ding A.H., Nathan C.F., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. Journal of Immunology. 141:1988;2407-2412.
11. Drapier J.C., Hibbs J.B. Jr. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. Journal of Clinical Investigations. 78:1986;790-797.
12. Gazzinelli R.T., Hieny S., Wynn T.A., Wolf S., Sher A. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proceedings of the National Academy of Sciences of U.S.A. 90:1993;6115-6119.
13. Green S.J., Crawford R.M., Hockmeyer J.T., Meltzer M.S., Nacy C.A. Leishmania major amastigotesinitiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α Journal of Immunology. 145:1990;4290-4297.
14. Hirano T., Oka K., Kawashima E., Akiba M. Effects of synthetic and naturally occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes. Life Sciences. 45:1989;1407-1411.
15. Hoffman R.A., Langrehr J.M., Billiar T.R., Curran R.D., Simmons R.L. Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. Journal of Immunology. 145:1990;2220-2226.
16. Ivanovska N., Neychev H., Stefanova Z., Bankova V., Popov S. Influence of cinnamic acid on lymphocyte proliferation, cytokine release and Klebsiella infection in mice. Apidologie. 26:1995;73-81.
17. Khayyal M.T., el-Ghazaly M.A., el-Khatib A.S. Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Experimental and Clinical Research. 19:1993;197-203.
18. Kwon N.S., Stuehr D.J., Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. Journal of Experimental Medicine. 174:1991;761-767.
19. Mellouk S., Green S.J., Nacy C.A., Hoffman S.L. IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism. Journal of Immunology. 146:1991;3971-3976.
20. Mookerjee B.K., Lee T.P., Logue G.P., Lippes H.A., Middleton E. The effects of flavonoids on human lymphocyte proliferative responses. Progress in Clinical and Biological Research. 213:1986;511-520.
21. Murad J.M., Calvi S.A., Soares A.M.V.C., Bankova V., Sforcin J.M. Effects of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides brasiliensis. Journal of Ethnopharmacology. 79:2002;331-334.
22. Namgoong S.Y., Son K.H., Chang H.W., Kang S.S., Kim H.P. Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture. Life Sciences. 54:1994;313-320.
23. Orsi R.O., Funari S.R.C., Soares A.M.V.C., Calvi S.A., Oliveira S.L., Sforcin J.M., Bankova V. Immunomodulatory action of propolis on macrophage activation. The Journal of Venomous Animals and Toxins. 6:2000;205-219.
24. Pervin S., Singh R., Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proceedings of the National Academy of Sciences of U.S.A. 98:2001;3583-3588.
25. Scheller S., Gazda G., Pietsz G., Gabrys J., Szumlas J., Eckert L., Shani J. The ability of ethanol extract of propolis to stimulate plaque formation in immunized mouse spleen cells. Pharmacological Research Communications. 20:1988;323-328.
26. Sforcin J.M., Fernandes A. Jr., Lopes C.A., Bankova V., Funari S.R. Seasonal effect on Brazilian propolis antibacterial activity. Journal of Ethnopharmacology. 73:2000;243-249.
27. Sforcin J.M., Kaneno R., Funari S.R.C. Absence of seasonal effect on the immunomodulatory action of Brazilian propolis on natural killer activity. The Journal of Venomous Animals and Toxins. 8:2002;19-29.
28. Vynograd N., Vynograd I., Sosnowski Z. A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine. 7:2000;1-6.
29. You K.M., Son K.H., Chang H.W., Kang S.S., Kim H.P. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. Planta Medica. 64:1998;546-550.
30. Zar, J.H., 1984. Biostatistical Analysis, 2nd ed. Prentice-Hall, Englewood Cliffs, NJ, 718 pp.
31. Zhou P., Sieve M.C., Bennett J., Kwon-Chung K.J., Tewari R.P., Gazzinelli R.T., Sher A., Seder R.A. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ Journal of Immunology. 155:1995;785-795.