A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1803, Issue 7, 2010, Pages 858-864

  Child, Emma S ^a   Hendrychová, Tereza ^b   McCague, Karen ^a   Futreal, Andy ^c   Otyepka, Michal ^b   Mann, David J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Cdc28; Cdk; Cyclin dependent kinase; P21Cip1; P27Kip1; PSTAIRE

Indexed keywords

CYCLIN DEPENDENT KINASE 2; LEUCINE; PROLINE;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME BINDING; GLIOBLASTOMA; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF; REGULATORY MECHANISM;

ANIMALS; CELL LINE; CIRCULAR DICHROISM; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; ONCOGENE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA;

EID: 77953356348     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.04.004     Document Type: Article

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