Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4300-4309

  Pak, Valeriy V ^a   Koo, Minseon ^b   Kwon, Dae Young ^b   Shakhidoyatov, Khusnutdin M ^a   Yun, Lyubov ^a  

^a S Yu Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences   (Uzbekistan)

^b Korea Food Research Institute   (South Korea)

Author keywords

Turn conformation; Circular dichroism; Design; HMG CoA reductase; Inhibitors; Peptides

Indexed keywords

ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PEPTIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; BETA TURN; CONTROLLED STUDY; ENZYME INHIBITION; FRAGMENTATION REACTION; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; SOYBEAN; STRUCTURE ACTIVITY RELATION; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DRUG DESIGN; KINETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CIRCULAR DICHROISM; DRUG DESIGN; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; MODELS, MOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCINE MAX;

EID: 77953324564     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.090     Document Type: Article

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