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Volumn 18, Issue 12, 2010, Pages 4317-4327
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Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases
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Author keywords
Chemical array based approach; Inhibition; Quinazolin 4(3H) one structure analogues; Thermolysin
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Indexed keywords
2 (4 METHYLPHENYL) 3 (1,3 THIAZOL 2 YL)QUINAZOLIN 4;
2 AMINOBENZOYLE N[3 (4 OXO 2 PHENYLQUINAZOLIN 3 YL)PROPYL]BENZAMIDE;
2 CHLORO N(2 METHYL 4 OXOQUINAZOLIN 3 YL)ACETAMIDE;
2 PHENYL 3 (1,3 THIAZOL 2 YL)QUINAZOLIN 4 ONE;
2 PHENYL 3 [(E) PHENYLDIAZENYL] 1,23,4 TETRAHYDRO 10H(1,2,4)TRIAZINO(6,1B)QUINAZOLIN 10 ONE;
3 (2 HYDROXYETHYL) 2 METHYLQUINAZOLIN 4 ONE;
3 (2 HYDROXYETHYL)QUINAZOLIN 4 ONE;
3 (3 AMINOETHYL) 2 (4 METHYLPHENYL)QUINAZOLIN 4 ONE;
3 (3 AMINOPROPYL) 2 (4 METHYLPHENYL)QUINAZOLIN 4 ONE;
3 (4 IODOPHENYL) 2 PHENYLQUINAZOLIN 4 ONE;
3 [[(2 HYDROXYNAPHTHALEN 1 YL)METHYLENE]AMINO] 2 PHENYLQUINAZOLIN 4 ONE;
3 [[(3 CHLOROPHENYL)METHYLENE]AMINO] 2 PHENYL QUINAZOLIN 4 ONE;
3 [[[4 (DIMETHYLAMINO)PHENYL]METHYLENE]AMINO] 2 METHYLQUINAZOLIN 4 ONE;
3 [[[4 (DIMETHYLAMINO)PHENYL]METHYLENE]AMINO] 2 PHENYLQUINAZOLIN 4 ONE;
3 AMINO 2 (4 CHLOROPHENYL)QUINAZOLIN 4 ONE;
3 AMINO 2 (4 NITROPHENYL)QUINAZOLIN 4 ONE;
3 AMINO 2 (HYDRAZINOMETHYL)QUINAZOLIN 4 ONE;
3 AMINO 2 (TRIFLUOROMETHYL)QUINAZOLIN 4 ONE;
3 AMINO 2 METHYLQUINAZOLIN 4 ONE;
3 AMINO 2 PHENYLQUINAZOLIN 4 ONE;
3 MESITYL 2 PHENYLQUINAZOLIN 4 ONE;
3 PHENYL 2 (TRIFLUOROMETHYL)QUINAZOLIN 4 ONE;
4 METHYL N(2 METHYL 4 OXOQUINAZOLIN 3 YL)BENZ;
METALLOPROTEINASE INHIBITOR;
METHYL 2 [(TRIFLUOROACETYL)AMINO]BENZOATE;
N(2 METHYL 4 OXOQUINAZOLIN 3 YL)ACETAMIDE;
N(2 METHYL 4 OXOQUINAZOLIN 3 YL)BENZAMIDE;
N(2 PHENYL 4 OXOQUINAZOLIN 3 YL)ACETAMIDE;
QUINAZOLINE DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
3-(ISOPROPYLIDENEAMINO)-2,2-DIMETHYL-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE;
3-PHENYL-2-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE;
PROTEINASE INHIBITOR;
QUINAZOLINONE DERIVATIVE;
THERMOLYSIN;
ARTICLE;
CARBON NUCLEAR MAGNETIC RESONANCE;
DRUG IDENTIFICATION;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ELECTROSPRAY;
ENZYME KINETICS;
IC 50;
INFRARED SPECTROSCOPY;
MOLECULAR DOCKING;
PROTEINASE INHIBITION;
PROTON NUCLEAR MAGNETIC RESONANCE;
ANTAGONISTS AND INHIBITORS;
BINDING SITE;
CHEMISTRY;
COMPUTER SIMULATION;
CONFORMATION;
METABOLISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
BINDING SITES;
COMPUTER SIMULATION;
MOLECULAR CONFORMATION;
PROTEASE INHIBITORS;
QUINAZOLINES;
QUINAZOLINONES;
STRUCTURE-ACTIVITY RELATIONSHIP;
THERMOLYSIN;
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EID: 77953321861
PISSN: 09680896
EISSN: None
Source Type: Journal
DOI: 10.1016/j.bmc.2010.04.083 Document Type: Article |
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Times cited : (31)
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References (52)
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