Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages

Journal of Toxicological Sciences

Volumn 35, Issue 3, 2010, Pages 327-334

  Tanaka, Satoru ^a   Tsutsui, Masaru ^a   Kishida, Tomoyuki ^a   Souma, Shinji ^a   Kuroda, Junji ^a   Yoshida, Takemi ^b  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

IL 6; iNOS; LPS; Salbutamol; TNF

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SALBUTAMOL; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PROTEIN INDUCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

RATTUS;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CELLS, CULTURED; HEME OXYGENASE-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 77953320416     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.327     Document Type: Article

References (37)

1. Abramson, N.G., Drummond, G.S., Lutton, J.D. and Kappas, A. (1996): The biological significance and physiological role of heme oxygenase. Cell Physiol. Biochem., 6, 129-168.
2. Abramson, S.N., Martin, M.W., Hughes, A.R., Harden, T.K., Neve, K.A., Barrett, D.A. and Molinoff, P.B. (1988): Interaction of β-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. Biochem. Pharmacol., 37, 4289-4297.
3. Brodde, O.E., Zerkowski, H.R., Schranz, D., Broede-Sitz, A., Michel-Reher, M., Schäfer-Beisenbusch, E., Piotrowski, J.A. and Oelert, H. (1995): Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium. J. Cardiovasc. Pharmacol., 26, 20-26.
4. Cavicchi, M., Gibbs, L. and Whittle, B.J.R. (2000): Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors. Gut, 47, 771-778.
5. Chen, K. and Maines, M.D. (2000): Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell. Mol. Biol., 46, 609-617.
6. Chen, J., Kuhlencordt, P., Urano, F., Ichinose, H., Astern, J. and Huang, P.L. (2003): Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice. Arterioscler. Thromb. Vasc. Biol., 23, 97-103.
7. 2-adrenergic receptors on cardiac myocytes apoptosis. Role of pertussis toxin-sensitive G protein. Circulation, 100, 2210-2212.
8. 2-adrenergic receptor to different G proteins by protein kinase A. Nature, 390, 88-91.
9. Grisham, M.B., Jourd'Heuil, D. and Wink, D.A. (1999): Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am. J. Physiol., 276, G315-321.
10. Hamid, Q., Springall, D.R., Riveros-Moreno, V., Chanez, P., Howarth, P., Redington, A., Bousquet, J., Godard, P., Holgate, S. and Polak, J.M. (1993): Induction of nitric oxide synthase in asthma. Lancet, 342, 1510-1513. (Pubitemid 23362167)
11. Horváth, I., Donnelly, L.E., Kiss, A., Paredi, P., Kharitonov, S.A. and Barnes, P.J. (1998): Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax, 53, 668-672. (Pubitemid 28378481)
12. Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A. and Shirato, K. (2000): Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am. J. Respir. Crit. Care Med., 162, 701-706.
13. Izeboud, C.A., Monshouwer, M., van Miert, A.S. and Witkamp, R.F. (1999): The β-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-α and IL-6 in vitro and in vivo. Inflamm. Res., 48, 497-502. (Pubitemid 29451841)
14. Jeffery, P.K., Venge, P., Gizycki, M.J., Egerod, I., Dahl, R. and Faurschou, P. (2002): Effects of salmeterol on mucosal inflammation in asthma: a placebo-controlled study. Eur. Respir. J., 20, 1378-1385.
15. 2-Adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i). Circ. Res., 87, 705-709.
16. Kim, S.H., Kim, J. and Sharma, R.P. (2004): Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Pharmacol. Res., 49, 433-439.
17. Kim, Y.M., Bombeck, C.A. and Billiar, T.R. (1999): Nitric oxide as a bifunctional regulator of apoptosis. Circ. Res., 84, 253-256.
18. Koprowski, H., Zheng, Y.M., Heber-Kalz, E., Fraser, N., Rorke, L., Fu, Z.F., Hanlon, C. and Dietzschold, B. (1993): In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. PNAS, 90, 3024-3027.
19. Liaw, W.J., Tzao, C., Wu, J.Y., Chen, S.J., Wang, J.H. and Wu, C.C. (2003): Inhibition by terbutaline of nitric oxide and superoxide anion levels of endotoxin-induced organs injury in the anesthetized rat. Shock, 19, 281-288.
20. Lorsbach, R.B., Murphy, W.J., Lowenstein, C.J., Snyder, S.H. and Russell, S.W. (1993): Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J. Biol. Chem., 268, 1908-1913.
21. 2-adrenergic agonist salbutamol is a potent suppressor of established collagen- induced arthritis: mechanisms of action. J. Immunol., 162, 6278-6283.
22. Ohta, K., Kikuchi, T., Arai, S., Yoshida, N., Sato, A. and Yoshimura, N. (2003): Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats. Exp. Eye Res., 77, 665-673.
23. Oguro, T., Takahashi, Y., Ashino, T., Takaki, A., Shioda, S., Horai, R., Asano, M., Iwakura, Y. and Yoshida, T. (2002): Involvement of tumor necrosis factor α, rather than interleukin-1α/β or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver. FEBS Lett., 516, 63-66. (Pubitemid 34311934)
24. Parratt, J.R. (1998): Nitric oxide in sepsis and endotoxaemia. J. Antimicrob. Chemother., 41, Suppl. A, 31-39.
25. Poss, K.D. and Tonegawa, S. (1997): Reduced stress defense in heme oxygenase 1-deficient cells. PNAS, 94, 10925-10930.
26. Ricciardol, F.L.M., Caramori, G., Ito, K., Capelli, A., Brun, P., Abatangelo, G., Papi, A., Chung, K.F., Adcock, I., Barnes, P.J., Donner, C.F., Rossi, A. and Di Stefano, A. (2005): Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 116, 1028-1035.
27. Rocha, M.F.G., Maia, M.E.T., Bezerra, L.R.P.S., Lyerly, D.M., Guerrant, R.L., Ribeiro, R.A. and Lima, A.A.M. (1997): Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1β, tumor necrosis factor alpha, and leukotrienes. Infect. Immun., 65, 2740-2746.
28. Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N. and Ames, B.N. (1987): Bilirubin is an antioxidant of possible physiological importance. Science, 235, 1043-1046. (Pubitemid 17049750)
29. Suh, S.J., Chung, T.W., Son, M.J., Kim, S.H., Moon, T.C., Son, K.H., Kim, H.P., Chang, H.W. and Kim, C.H. (2006): The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-κB regulation, in RAW264.7 cells. Arch. Biochem. Biophys., 447, 136-146.
30. Ulmer, A.J., Rietschel, E.Th., Zähringer, U. and Heine, H. (2002): Structure, bioactivity, receptors, and signal transduction. Trends Glycosci. Glycotechnol., 14, 53-68.
31. 2- adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-α in vitro and in vivo. J. Vet. Pharmacol. Ther., 28, 531-537.
32. Waldeck, B. (2002): β-Adrenoceptor agonists and asthma-100 years of development. Eur. J. Pharmacol., 445, 1-12.
33. 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol. Pharmacol., 47, 322-329.
34. 2-adrenoceptor to Gi proteins and its physicalogical relevance in murine cardiac myocytes. Circ. Res., 84, 43-52.
35. Xie, Q.W., Cho, H.J., Calaycay, J., Mumford, R.A., Swiderek, K.M., Lee, T.D., Ding, A., Troso, T. and Nathan, C. (1992): Cloning and characterization of inducible nitric oxide synthase gene from mouse macrophages. Science, 256, 225-228.
36. Xu, W., Liu, L. and Charles, I.G. (2002): Microencapsulated iNOS-expressing cells cause tumor suppression in mice. FASEB J., 16, 213-215.
37. Yamasaki, K., Edington, H.D., McClosky, C., Tzeng, E., Lizonova, A., Kovesdi, I., Steed, D.L. and Billiar, T.R. (1998): Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J. Clin. Invest., 101, 967-971. (Pubitemid 28125274)