Interaction of organic cation transporter 3 (SLC22A3) and amphetamine

Journal of Neurochemistry

Volumn 114, Issue 1, 2010, Pages 142-149

  Zhu, Hao Jie ^a   Appel, David I ^a   Gründemann, Dirk ^b   Markowitz, John S ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Amphetamine; Inhibitor; Monoamine neurotransmitters; Organic cation transporter 3; Substrate

Indexed keywords

AMPHETAMINE; DEXAMPHETAMINE; DOPAMINE; NORADRENALIN; ORGANIC CATION TRANSPORTER 3; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; GENOTYPE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; CELL LINE; CENTRAL NERVOUS SYSTEM STIMULANTS; DEXTROAMPHETAMINE; DOPAMINE; FEMALE; HUMANS; MALE; MICE; MICE, KNOCKOUT; NOREPINEPHRINE; ORGANIC CATION TRANSPORT PROTEINS; SEROTONIN; TISSUE DISTRIBUTION; TRANSFECTION;

ANIMALIA; MUS;

EID: 77953316286     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06738.x     Document Type: Article

References (30)

1. Amphoux A., Vialou V., Drescher E. et al. (2006) Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology 50, 941 952.
2. Aoyama N., Takahashi N., Kitaichi K. et al. (2006) Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. Alcohol. Clin. Exp. Res. 30, 1644 1649.
3. Baganz N. L., Horton R. E., Calderon A. S. et al. (2008) Organic cation transporter 3: keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc. Natl Acad. Sci. USA 105, 18976 18981.
4. Cui M., Aras R., Christian W. V. et al. (2009) The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc. Natl Acad. Sci. USA 106, 8043 8048.
5. Feng N., Mo B., Johnson P. L., Orchinik M., Lowry C. A. Renner K. J. (2005) Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus. Brain Res. 1063, 69 76.
6. Feng N., Telefont M., Kelly K. J., Orchinik M., Forster G. L., Renner K. J. Lowry C. A. (2009) Local perfusion of corticosterone in the rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations. Horm. Behav. 56, 149 157.
7. Gasser P. J., Lowry C. A. Orchinik M. (2006) Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J. Neurosci. 26, 8758 8766.
8. Gorboulev V., Ulzheimer J. C., Akhoundova A. et al. (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16, 871 881. (Pubitemid 27332696)
9. Grundemann D., Schechinger B., Rappold G. A. Schomig E. (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat. Neurosci. 1, 349 351.
10. Grundemann D., Liebich G., Kiefer N., Koster S. Schomig E. (1999) Selective substrates for non-neuronal monoamine transporters. Mol. Pharmacol. 56, 1 10.
11. Haag C., Berkels R., Grundemann D., Lazar A., Taubert D. Schomig E. (2004) The localisation of the extraneuronal monoamine transporter (EMT) in rat brain. J. Neurochem. 88, 291 297.
12. Kitaichi K., Fukuda M., Nakayama H., Aoyama N., Ito Y., Fujimoto Y., Takagi K. Hasegawa T. (2005) Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice. Neurosci. Lett. 382, 195 200.
13. Klaassen C. D. Aleksunes L. M. (2010) Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol. Rev. 62, 1 96.
14. Koepsell H. (2004) Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol. Sci. 25, 375 381.
15. Koepsell H., Schmitt B. M. Gorboulev V. (2003) Organic cation transporters. Rev. Physiol. Biochem. Pharmacol. 150, 36 90.
16. Koepsell H., Lips K. Volk C. (2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm. Res. 24, 1227 1251.
17. Martel F., Vetter T., Russ H., Grundemann D., Azevedo I., Koepsell H. Schomig E. (1996) Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch. Pharmacol. 354, 320 326.
18. Nakayama H., Kitaichi K., Ito Y., Hashimoto K., Takagi K., Yokoi T., Ozaki N., Yamamoto T. Hasegawa T. (2007) The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res. 1184, 260 269.
19. Naoi M., Takahashi T. Nagatsu T. (1987) A fluorometric determination of N-methyl-4-phenylpyridinium ion, using high-performance liquid chromatography. Anal. Biochem. 162, 540 545.
20. Okuda M., Saito H., Urakami Y., Takano M. Inui K. (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun. 224, 500 507.
21. Rytting E., Bryan J., Southard M. Audus K. L. (2007) Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino) styryl)-N- methylpyridinium iodide (4-Di-1-ASP) in BeWo cells. Biochem. Pharmacol. 73, 891 900.
22. Schmitt A., Mossner R., Gossmann A., Fischer I. G., Gorboulev V., Murphy D. L., Koepsell H. Lesch K. P. (2003) Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J. Neurosci. Res. 71, 701 709.
23. Sulzer D., Sonders M. S., Poulsen N. W. Galli A. (2005) Mechanisms of neurotransmitter release by amphetamines: a review. Prog. Neurobiol. 75, 406 433.
24. Vialou V., Amphoux A., Zwart R., Giros B. Gautron S. (2004) Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J. Neurosci. 24, 2846 2851.
25. Vialou V., Balasse L., Callebert J., Launay J. M., Giros B. Gautron S. (2008) Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice. J. Neurochem. 106, 1471 1482.
26. Volz T. J., Fleckenstein A. E. Hanson G. R. (2007) Methamphetamine- induced alterations in monoamine transport: implications for neurotoxicity, neuroprotection and treatment. Addiction 102 (Suppl. 1 44 48.
27. Wu X., Kekuda R., Huang W., Fei Y. J., Leibach F. H., Chen J., Conway S. J. Ganapathy V. (1998) Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J. Biol. Chem. 273, 32776 32786.
28. Wultsch T., Grimberg G., Schmitt A. et al. (2009) Decreased anxiety in mice lacking the organic cation transporter 3. J. Neural. Transm. 116, 689 697.
29. Zhu H. J., Wang J. S., DeVane C. L., Williard R. L., Donovan J. L., Middaugh L. D., Gibson B. B., Patrick K. S. Markowitz J. S. (2006) The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine. Drug Metab. Dispos. 34, 1116 1121.
30. Zwart R., Verhaagh S., Buitelaar M., Popp-Snijders C. Barlow D. P. (2001) Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol. Cell. Biol. 21, 4188 4196.