EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma

European Journal of Immunology

Volumn 40, Issue 6, 2010, Pages 1590-1602

  Tsuchiya, Kimitake ^a   Jo, Taisuke ^a   Takeda, Naoya ^a   Al Heialy, Saba ^a   Siddiqui, Sana ^a   Shalaby, Karim Hamdy ^a   Risse, Paul André ^a   Maghni, Karim ^b   Martin, James G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

Asthma; CD4+ T cells; EGF receptors; IL 6

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CHEMOKINE; CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; OVALBUMIN;

AIRWAY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN NORWAY RAT; CD4+ T LYMPHOCYTE; CHEMOTAXIS; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EOSINOPHIL; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE MIGRATION; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIZATION; T LYMPHOCYTE;

ALLERGENS; ANIMALS; ASTHMA; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CELL SEPARATION; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FLOW CYTOMETRY; INTERLEUKIN-6; LUNG; OVALBUMIN; RATS; RATS, INBRED BN; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TYRPHOSTINS;

EID: 77953313173     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939907     Document Type: Article

References (45)

1. Kalmes, A., Daum, G. and Clowes, A. W., EGFR transactivation in the regulation of SMC function. Ann. N. Y. Acad. Sci. 2001. 947: 42-54; discussion 54-45.
2. Baselga, J. and Arteaga, C. L., Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J. Clin. Oncol. 2005. 23: 2445-2459.
3. Burgel, P. R. and Nadel, J. A., Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 2004. 59: 992-996.
4. Tamaoka, M., Hassan, M., McGovern, T., Ramos-Barbon, D., Jo, T., Yoshizawa, Y., Tolloczko, B. et al., The epidermal growth factor receptor mediates allergic airway remodeling in the rat. Eur. Respir. J. 2008. 32: 1213-1223.
5. Amishima, M., Munakata, M., Nasuhara, Y., Sato, A., Takahashi, T., Homma, Y. and Kawakami, Y., Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am. J. Respir. Crit. Care Med. 1998. 157: 1907-1912.
6. Takeyama, K., Dabbagh, K., Lee, H. M., Agusti, C., Lausier, J. A., Ueki, I. F., Grattan, K. M. and Nadel, J. A., Epidermal growth factor system regulates mucin production in airways. Proc. Natl. Acad. Sci. USA 1999. 96: 3081-3086.
7. Puddicombe, S. M., Polosa, R., Richter, A., Krishna, M. T., Howarth, P. H., Holgate, S. T. and Davies, D. E., Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 2000. 14: 1362-1374. (Pubitemid 30439745)
8. Wong, W. S., Inhibitors of the tyrosine kinase signaling cascade for asthma. Curr. Opin. Pharmacol. 2005. 5: 264-271.
9. Levitzki, A., Tyrosine kinases as targets for cancer therapy. Eur. J. Cancer 2002,. 38: S11-S18.
10. Ishii, Y., Fujimoto, S. and Fukuda, T., Gefitinib prevents bleomycin-induced lung fibrosis in mice. Am. J. Respir. Crit. Care Med. 2006. 174: 550-556.
11. Rice, A. B., Moomaw, C. R., Morgan, D. L. and Bonner, J. C., Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats. Am. J. Pathol. 1999. 155: 213-221.
12. Vargaftig, B. B. and Singer, M., Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. Am. J. Physiol. Lung Cell Mol. Physiol. 2003. 285: L808-L818.
13. Abdullah, N. A., Torres, B. A., Basu, M. and Johnson, H. M., Differential effects of epidermal growth factor, transforming growth factor-alpha, and vaccinia virus growth factor in the positive regulation of IFN-gamma production. J. Immunol. 1989. 143: 113-117.
14. Feistritzer, C., Mosheimer, B. A., Sturn, D. H., Riewald, M., Patsch, J. R. and Wiedermann, C. J., Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor. J. Immunol. 2006. 176: 1019-1025. (Pubitemid 43099702)
15. Zaiss, D. M., Yang, L., Shah, P. R., Kobie, J. J., Urban, J. F. and Mosmann, T. R., Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science 2006. 314: 1746. (Pubitemid 44969079)
16. Dery, R. E., Ulanova, M., Puttagunta, L., Stenton, G. R., James, D., Merani, S., Mathison, R. et al., Frontline: Inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro-endocrine pathway. Eur. J. Immunol. 2004. 34: 3315-3325.
17. Murphey, S. M., Brown, S., Miklos, N. and Fireman, P., Reagin synthesis in inbred strains of rats. Immunology 1974. 27: 245-253.
18. Zosky, G. R. and Sly, P. D., Animal models of asthma. Clin. Exp. Allergy 2007. 37: 973-988.
19. Takaishi, K., Ohtsuka, T., Tsuneyoshi, S., Maehara, N., Harada, M., Yoshida, H., Watanabe, K. and Tsurufuji, S., Inhibition of the production of rat cytokine-induced neutrophil chemoattractant (CINC)-1, a member of the interleukin-8 family, by adenovirus-mediated overexpression of IkappaBalpha. J. Biochem. 2000. 127: 511-516.
20. Sheikh, N., Tron, K., Dudas, J. and Ramadori, G., Cytokine-induced neutrophil chemoattractant-1 is released by the noninjured liver in a rat acute-phase model. Lab Invest. 2006. 86: 800-814.
21. Shim, J. J., Dabbagh, K., Ueki, I. F., Dao-Pick, T., Burgel, P. R., Takeyama, K., Tam, D. C. and Nadel, J. A., IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am. J. Physiol. Lung Cell Mol. Physiol. 2001. 280: L134-L140.
22. Lamb, D. J., Modjtahedi, H., Plant, N. J. and Ferns, G. A., EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques. Atherosclerosis 2004. 176: 21-26.
23. Chung, K. F., Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. Suppl. 2001. 34: 50s-59s.
24. Deng, H., Mason, S. N. and Auten, R. L., Jr., Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Am. J. Respir. Crit. Care Med. 2000. 162: 2316-2323.
25. Ponath, P. D., Qin, S., Ringler, D. J., Clark-Lewis, I., Wang, J., Kassam, N., Smith, H. et al., Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J. Clin. Invest. 1996. 97: 604-612.
26. Biswas, D. K. and Iglehart, J. D., Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer. J. Cell Physiol. 2006. 209: 645-652.
27. Nichols, D., Chmiel, J. and Berger, M., Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clin. Rev. Allergy Immunol. 2008. 34: 146-162.
28. Sugita, A., Ogawa, H., Azuma, M., Muto, S., Honjo, A., Yanagawa, H., Nishioka, Y. et al., Antiallergic and anti-inflammatory effects of a novel IkappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation. Int. Arch. Allergy Immunol. 2008. 148: 186-198.
29. Poynter, M. E., Cloots, R., van Woerkom, T., Butnor, K. J., Vacek, P., Taatjes, D. J., Irvin, C. G. and Janssen-Heininger, Y. M., NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness. J. Immunol. 2004. 173: 7003-7009.
30. Chu, E. K., Foley, J. S., Cheng, J., Patel, A. S., Drazen, J. M. and Tschumperlin, D. J., Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am. J. Respir. Cell Mol. Biol. 2005. 32: 373-380.
31. Varley, C., Hill, G., Pellegrin, S., Shaw, N. J., Selby, P. J., Trejdosiewicz, L. K. and Southgate, J., Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro. Exp. Cell Res. 2005. 306: 216-229.
32. Zhuang, S., Yan, Y., Daubert, R. A. and Schnellmann, R. G., Epiregulin promotes proliferation and migration of renal proximal tubular cells. Am. J. Physiol. Renal Physiol. 2007. 293: F219-F226.
33. Willmarth, N. E. and Ethier, S. P., Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J. Biol. Chem. 2006. 281: 37728-37737.
34. Shao, M. X. and Nadel, J. A., Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J. Immunol. 2005. 175: 4009-4016.
35. Careau, E., Proulx, L. I., Pouliot, P., Spahr, A., Turmel, V. and Bissonnette, E. Y., Antigen sensitization modulates alveolar macrophage functions in an asthma model. Am. J. Physiol. Lung Cell Mol. Physiol. 2006. 290: L871-L879.
36. Lampinen, M., Carlson, M., Hakansson, L. D. and Venge, P., Cytokineregulated accumulation of eosinophils in inflammatory disease. Allergy 2004. 59: 793-805.
37. Tager, A. M., Dufour, J. H., Goodarzi, K., Bercury, S. D., von Andrian, U. H. and Luster, A. D., BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J. Exp. Med. 2000. 192: 439-446.
38. Yokoyama, A., Kohno, N., Fujino, S., Hamada, H., Inoue, Y., Fujioka, S., Ishida, S. and Hiwada, K., Circulating interleukin-6 levels in patientswith bronchial asthma. Am. J. Respir. Crit. Care Med. 1995. 151: 1354-1358.
39. Broide, D. H., Lotz, M., Cuomo, A. J., Coburn, D. A., Federman, E. C. and Wasserman, S. I., Cytokines in symptomatic asthma airways. J. Allergy Clin. Immunol. 1992. 89: 958-967.
40. Marini, M., Vittori, E., Hollemborg, J. and Mattoli, S., Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J. Allergy Clin. Immunol. 1992. 89: 1001-1009.
41. DiCosmo, B. F., Geba, G. P., Picarella, D., Elias, J. A., Rankin, J. A., Stripp, B. R., Whitsett, J. A. and Flavell, R. A., Airway epithelial cell expression of interleukin-6 in transgenicmice. Uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 1994. 94: 2028-2035.
42. Bacon, K., Gearing, A. and Camp, R., Induction of in vitro human lymphocyte migration by interleukin 3, interleukin 4, and interleukin 6. Cytokine 1990. 2: 100-105.
43. Weissenbach, M., Clahsen, T., Weber, C., Spitzer, D., Wirth, D., Vestweber, D., Heinrich, P. C. and Schaper, F., Interleukin-6 is a direct mediator of T cell migration. Eur. J. Immunol. 2004. 34: 2895-2906.
44. Lloyd, C. M., Delaney, T., Nguyen, T., Tian, J., Martinez, A. C., Coyle, A. J. and Gutierrez-Ramos, J. C., CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J. Exp. Med. 2000. 191: 265-274.
45. + T cells Journal of Immunology 2004 173 4 2231-2235 45 Takata, H., Tomiyama, H., Fujiwara, M., Kobayashi, N. and Takiguchi, M., Cutting edge: expression of chemokine receptor CXCR1 on human effector CD8+ T cells. J. Immunol. 2004. 173: 2231-2235. (Pubitemid 39063076)