Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: A longitudinal study

Kidney International

Volumn 70, Issue 2, 2006, Pages 351-357

  Melamed, M L ^a,b   Eustace, J A ^a,c   Plantinga, L ^a,b   Jaar, B G ^a,b,d   Fink, N E ^a,b,d   Coresh, J ^a,b,d   Klag, M J ^a,b,d   Powe, N R ^a,b,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c University College Cork and INFANT Centre   (Ireland)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Clinical epidemiology; Dialysis; Epidemiology and outcomes; Hospitalization; Mortality risk

Indexed keywords

CALCIUM; CALCIUM PHOSPHATE; PARATHYROID HORMONE; PHOSPHATE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ABNORMALLY LOW SUBSTRATE CONCENTRATION IN BLOOD; AGED; ARTICLE; BONE MINERAL; CALCIUM BLOOD LEVEL; COMORBIDITY; CONTROLLED STUDY; DEATH; DIALYSIS; FEMALE; FOLLOW UP; HAZARD ASSESSMENT; HEMODIALYSIS PATIENT; HUMAN; HYPERCALCEMIA; HYPERPHOSPHATEMIA; INFLAMMATION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MOLECULAR STABILITY; MORTALITY; PARAMETERS OF MEASUREMENT AND ANALYSIS; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RISK; RISK REDUCTION; STATISTICAL ANALYSIS;

ADULT; AFRICAN AMERICANS; AGED; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CALCITRIOL; CALCIUM; FEMALE; HUMANS; INCIDENCE; KIDNEY FAILURE, CHRONIC; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PARATHYROID HORMONE; PHOSPHATES; PREDICTIVE VALUE OF TESTS; RENAL DIALYSIS; RISK FACTORS; SEX DISTRIBUTION;

EID: 33746176065     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001542     Document Type: Article

References (30)

1. Foley RN, Parfrey PS, Sarnak MJ. Epidemiology of cardiovascular disease in chronic renal disease. J Am Soc Nephrol 1998; 9: S16-S23.
2. Longenecker JC, Coresh J, Powe NR et al. Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE Study. J Am Soc Nephrol 2002; 13: 1918-1927.
3. Sarnak MJ. Cardiovascular complications in chronic kidney disease. Am J Kidney Dis 2003; 41: 11-17.
4. Block GA, Hulbert-Shearon TE, Levin NW et al. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998; 31: 607-617.
5. Block GA, Klassen PS, Lazarus JM et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15: 2208-2218.
6. Ganesh SK, Stack AG, Levin NW et al. Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 2001; 12: 2131-2138.
7. Stevens LADO, Cardew S, Cameron EC, Levin A. Calcium, phosphate, and parathyroid hormone levels in combination and as a function of dialysis duration predict mortality: evidence for the complexity of the association between mineral metabolism and outcomes. J Am Soc Nephrol 2004; 15: 770.
8. Slinin Y, Foley RN, Collins AJ. Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: the USRDS waves 1, 3, and 4 study. J Am Soc Nephrol 2005; 16: 1788-1793.
9. Avram MM, Mittman N, Myint MM et al. Importance of low serum intact parathyroid hormone as a predictor of mortality in hemodialysis and peritoneal dialysis patients: 14 years of prospective observation. Am J Kidney Dis 2001; 38: 1351-1357.
10. Foley RN, Parfrey PS, Harnett JD et al. Hypocalcemia, morbidity, and mortality in end-stage renal disease. Am J Nephrol 1996; 16: 386-393.
11. Teng M, Wolf M, Ofsthun MN et al. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005; 16: 1115-1125.
12. DeSoi CA, Umans JG. Phosphate kinetics during high-flux hemodialysis. J Am Soc Nephrol 1993; 4: 1214-1218.
13. Chertow GM, Burke SK, Raggi P. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 2002; 62: 245-252.
14. Jono S, McKee MD, Murry CE et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000; 87: E10-E17.
15. Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004; 95: 560-567.
16. Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483.
17. Raggi P, Boulay A, Chasan-Taber S et al. Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002; 39: 695-701.
18. Guerin AP, London GM, Marchais SJ et al. Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol Dial Transplant 2000; 15: 1014-1021.
19. Blacher J, Guerin AP, Pannier B et al. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 2001; 38: 938-942.
20. Schluter KD, Piper HM. Left ventricular hypertrophy and parathyroid hormone: a causal connection? Cardiovasc Res 1998; 39: 523-524.
21. Saleh FN, Schirmer H, Sundsfjord J et al. Parathyroid hormone and left ventricular hypertrophy. Eur Heart J 2003; 24: 2054-2060.
22. London GM, Marty C, Marchais SJ et al. Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 2004; 15: 1943-1951.
23. Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis 2000; 36: 1115-1121.
24. Kestenbaum B, Andress DL, Schwartz SM et al. Survival following parathyroidectomy among United States dialysis patients. Kidney Int 2004; 66: 2010-2016.
25. Eknoyan G LA, Levin NW, National Kidney Foundation. Bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003; 42: 1-201.
26. USRDS. United States Renal Data System 1999 Annual Data Report. National Institutes of Health, NIDDK: Bethesda, MD, 1999.
27. Unruh ML, Evans IV, Fink NE et al. Skipped treatments, markers of nutritional nonadherence, and survival among incident hemodialysis patients. Am J Kidney Dis 2005; 46: 1107-1116.
28. Miskulin DC, Martin AA, Brown R et al. Predicting 1 year mortality in an outpatient haemodialysis population: a comparison of comorbidity instruments. Nephrol Dial Transplant 2004; 19: 413-420.
29. Athienites NV, Miskulin DC, Fernandez G et al. Comorbidity assessment in hemodialysis and peritoneal dialysis using the index of coexistent disease. Semin Dial 2000; 13: 320-326.
30. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol 1993; 4: 1205-1213.