Association of serum alkaline phosphatase with coronary artery calcification in maintenance hemodialysis patients

Clinical Journal of the American Society of Nephrology

Volumn 4, Issue 6, 2009, Pages 1106-1114

  Shantouf, Ronney ^a,b   Kovesdy, Csaba P ^e   Kim, Youngmee ^a   Ahmadi, Naser ^c   Luna, Amanda ^a   Luna, Claudia ^a   Rambod, Mehdi ^a   Nissenson, Allen R ^d   Budoff, Matthew J ^b   Kalantar Zadeh, Kamyar ^a,c  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d DAVITA INC   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTERY CALCIFICATION; ARTICLE; CALCIUM BLOOD LEVEL; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CORONARY ARTERY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; ELECTRON BEAM TOMOGRAPHY; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PREDICTION; AGED; BLOOD; CALCINOSIS; CHRONIC KIDNEY FAILURE; CORONARY ARTERY DISEASE; METABOLISM; MIDDLE AGED; PREDICTION AND FORECASTING; REGRESSION ANALYSIS; RENAL REPLACEMENT THERAPY; RISK FACTOR; STATISTICS;

ADULT; AGED; ALKALINE PHOSPHATASE; CALCINOSIS; CORONARY ARTERY DISEASE; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS; RENAL DIALYSIS; RISK FACTORS;

EID: 69249221643     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.06091108     Document Type: Article

References (48)

1. Braun J, Oldendorf M, Moshage W, Heidler R, Zeitler E, Luft FC: Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis 27: 394-401, 1996
2. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, Wang Y, Chung J, Emerick A, Greaser L, Elashoff RM, Salusky IB: Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342: 1478-1483, 2000
3. Shanahan CM: Mechanisms of vascular calcification in renal disease. Clin Nephrol 63: 146-157, 2005
4. Jeziorska M, McCollum C, Woolley DE: Calcification in atherosclerotic plaque of human carotid arteries: Associations with mast cells and macrophages. J Pathol 185: 10-17, 1998
5. Lomashvili KA, Cobbs S, Hennigar RA, Hardcastle KI, O'Neill WC: Phosphate-induced vascular calcification: Role of pyrophosphate and osteopontin. J Am Soc Nephrol 15: 1392-1401, 2004
6. Lomashvili K, Garg P, O'Neill WC: Chemical and hormonal determinants of vascular calcification in vitro. Kidney Int 69: 1464-1470, 2006
7. Lomashvili KA, Garg P, Narisawa S, Millan JL, O'Neill WC: Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification. Kidney Int 73: 1024-1030, 2008
8. Schoppet M, Shroff RC, Hofbauer LC, Shanahan CM: Exploring the biology of vascular calcification in chronic kidney disease: What's circulating? Kidney Int 73: 384-390, 2008
9. Caglar K, Yilmaz MI, Saglam M, Cakir E, Kilic S, Sonmez A, Eyileten T, Yenicesu M, Oguz Y, Tasar M, Vural A, Ikizler TA, Stenvinkel P, Lindholm B: Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease. Nephron Clin Pract 108: c233-c240, 2008
10. Regidor DL, Kovesdy CP, Mehrotra R, Rambod M, Jing J, McAllister CJ, Van Wyck D, Kopple JD, Kalantar-Zadeh K: Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients. J Am Soc Nephrol 19: 2193-2203, 2008
11. Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millan JL: Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification. J Bone Miner Res 22: 1700-1710, 2007
12. Kalantar-Zadeh K, Kopple JD, Kamranpour N, Fogelman AM, Navab M: HDL-inflammatory index correlates with poor outcome in hemodialysis patients. Kidney Int 72: 1149-1156, 2007
13. Colman S, Bross R, Benner D, Chow J, Braglia A, Arzaghi J, Dennis J, Martinez L, Baldo DB, Agarwal V, Trundnowski T, Zitterkoph J, Martinez B, Khawar OS, et al.: The Nutritional and Inflammatory Evaluation in Dialysis patients (NIED) study: Overview of the NIED study and the role of dietitians. J Ren Nutr 15: 231-243, 2005
14. Shantouf R, Budoff MJ, Ahmadi N, Tiano J, Flores F, Kalantar-Zadeh K: Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patients. Am J Nephrol 28: 275-279, 2008
15. Rambod M, Kovesdy CP, Bross R, Kopple JD, Kalantar-Zadeh K: Association of serum prealbumin and its changes over time with clinical outcomes and survival in patients receiving hemodialysis. Am J Clin Nutr 88: 1485-1494, 2008
16. Mehrotra R, Kermah D, Fried L, Kalantar-Zadeh K, Khawar O, Norris K, Nissenson A: Chronic peritoneal dialysis in the United States: Declining utilization despite improving outcomes. J Am Soc Nephrol 18: 2781-2788, 2007
17. Beddhu S, Bruns FJ, Saul M, Seddon P, Zeidel ML: A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients. Am J Med 108: 609-613, 2000
18. Budoff MJ, Shaw LJ, Liu ST, Weinstein SR, Mosler TP, Tseng PH, Flores FR, Callister TQ, Raggi P, Berman DS: Long-term prognosis associated with coronary calcification: Observations from a registry of 25,253 patients. J Am Coll Cardiol 49: 1860-1870, 2007
19. Nelson EE, Hong CD, Pesce AL, Singh S, Pollak VE: Anthropometric norms for the dialysis population. Am J Kidney Dis 16: 32-37, 1990
20. Basiotis PP, Welsh SO, Cronin FJ, Kelsay JL, Mertz W: Number of days of food intake records required to estimate individual and group nutrient intakes with defined confidence. J Nutr 117: 1638-1641, 1987
21. Kalantar-Zadeh K, Dunne E, Nixon K, Kahn K, Lee GH, Kleiner M, Luft FC: Near infra-red interactance for nutritional assessment of dialysis patients. Nephrol Dial Transplant 14: 169-175, 1999
22. Kalantar-Zadeh K, Kuwae N, Wu DY, Shantouf RS, Fouque D, Anker SD, Block G, Kopple JD: Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr 83: 202-210, 2006
23. Tornel PL, Ayuso E, Martinez P: Evaluation of the turn-around time of an integrated preanalytical and analytical automated modular system in a medium-sized laboratory. Clin Biochem 38: 548-551, 2005
24. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR: Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 347: 1557-1565, 2002 25. Erbagci AB, Tarakcioglu M, Aksoy M, Kocabas R, Nacak M, Aynacioglu AS, Sivrikoz C: Diagnostic value of CRP and Lp(a) in coronary heart disease. Acta Cardiol 57: 197-204, 2002
25. Pecoits-Filho R, Barany P, Lindholm B, Heimburger O, Stenvinkel P: Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol Dial Transplant 17: 1684-1688, 2002
26. Beutler B, Cerami A: The biology of cachectin/TNF: A primary mediator of host response. Annu Rev Immunol 7: 625-655, 1989
27. Durrleman S, Simon R: Flexible regression models with cubic splines. Stat Med 8: 551-561, 1989
28. O'Malley PG, Taylor AJ, Jackson JL, Doherty TM, Detrano RC: Prognostic value of coronary electron-beam computed tomography for coronary heart disease events in asymptomatic populations. Am J Cardiol 85: 945-948, 2000
29. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, et al.: Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358: 1336-1345, 2008
30. Budoff MJ, Yu D, Nasir K, Mehrotra R, Chen L, Takasu J, Agrawal N, Liu ST, Blumenthal RS: Diabetes and progression of coronary calcium under the influence of statin therapy. Am Heart J 149: 695-700, 2005
31. Qunibi WY: Dyslipidemia and progression of cardiovascular calcification (CVC) in patients with end-stage renal disease (ESRD). Kidney Int Suppl S43-S50, 2005
32. Stompor T, Pasowicz M, Sullowicz W, Dembinska-Kiec A, Janda K, Wojcik K, Tracz W, Zdzienicka A, Klimeczek P, Janusz-Grzybowska E: An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis. Am J Kidney Dis 41: 203-211, 2003
33. Al-Aly Z: Arterial calcification: A tumor necrosis factor-alpha mediated vascular Wnt-opathy. Transl Res 151: 233-239, 2008
34. Al-Aly Z: Medial vascular calcification in diabetes mellitus and chronic kidney disease: The role of inflammation. Cardiovasc Hematol Disord Drug Targets 7: 1-6, 2007
35. Rao AK, Djamali A, Korcarz CE, Aeschlimann SE, Wolff MR, Stein JH: Mitral annular calcification is associated with reduced left ventricular function and inflammation in patients with chronic kidney disease. J Am Soc Echocardiogr 21: 747-750, 2008
36. Tsirpanlis G: Is inflammation the link between atherosclerosis and vascular calcification in chronic kidney disease? Blood Purif 25: 179-182, 2007
37. Shroff RC, Shah V, Hiorns MP, Schoppet M, Hofbauer LC, Hawa G, Schurgers LJ, Singhal A, Merryweather I, Brogan P, Shanahan C, Deanfield J, Rees L: The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not Matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis. Nephrol Dial Transplant 23: 3263-3271, 2008
38. Westenfeld R, Jahnen-Dechent W, Ketteler M: Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med 17: 124-128, 2007
39. Hernandes FR, Barreto FC, Rocha LA, Draibe SA, Canziani ME, Carvalho AB: Evaluation of the role of severe hyperparathyroidism on coronary artery calcification in dialysis patients. Clin Nephrol 67: 89-95, 2007
40. Chertow GM, Burke SK, Raggi P: Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 62: 245-252, 2002
41. El-Abbadi M, Giachelli CM: Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: Current concepts at the bench. Curr Opin Nephrol Hypertens 14: 519-524, 2005
42. Mehrotra R, Budoff M, Christenson P, Ipp E, Takasu J, Gupta A, Norris K, Adler S: Determinants of coronary artery calcification in diabetics with and without nephropathy. Kidney Int 66: 2022-2031, 2004
43. Towler DA: Inorganic pyrophosphate: A paracrine regulator of vascular calcification and smooth muscle phenotype. Arterioscler Thromb Vasc Biol 25: 651-654, 2005
44. Avbersek-Luznik I, Balon BP, Rus I, Marc J: Increased bone resorption in HD patients: is it caused by elevated RANKL synthesis? Nephrol Dial Transplant 20: 566-570, 2005
45. Iba K, Takada J, Yamashita T: The serum level of bonespecific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients. J Bone Miner Metab 22: 594-596, 2004
46. Kalantar-Zadeh K, Kuwae N, Regidor DL, Kovesdy CP, Kilpatrick RD, Shinaberger CS, McAllister CJ, Budoff MJ, Salusky IB, Kopple JD: Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int 70: 771-780, 2006
47. Blayney MJ, Pisoni RL, Bragg-Gresham JL, Bommer J, Piera L, Saito A, Akiba T, Keen ML, Young EW, Port FK: High alkaline phosphatase levels in hemodialysis patients are associated with higher risk of hospitalization and death. Kidney Int 74: 655-663, 2008
48. Sánchez Navarro MR, Fernández-Conde ME, Blanco Martín S, Samaniego C: Alkaline phosphatase isoenzymes in the serum of patients with renal insufficiency. An Med Interna 19: 449-452, 2002