Preventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on DEN-induced hepatocarcinogenesis in rats

Biomedicine and Pharmacotherapy

Volumn 64, Issue 5, 2010, Pages 319-326

  Nagahara, Takakazu ^a   Okano, Jun ichi ^a   Fujise, Yuki ^a   Abe, Ryo ^a   Murawaki, Yoshikazu ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase 2; Diethylnitrosamine; Hepatocellular carcinoma

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOTIN; CYCLINE; CYCLOOXYGENASE 2 INHIBITOR; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P; PHOSPHATE BUFFERED SALINE; TILMACOXIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BENZENESULFONATES; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHEMOPREVENTION; CYCLOOXYGENASE 2 INHIBITORS; DIETHYLNITROSAMINE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE TRANSFERASE; IN SITU NICK-END LABELING; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXAZOLES; OXIDATIVE STRESS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; TIME FACTORS;

EID: 77953289963     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2009.09.023     Document Type: Article

References (22)

1. Bosch F.X., Ribes J., Borras J. Epidemiology of primary liver cancer. Semin Liver Dis 1999, 19:271-285.
2. Okuda H. Hepatocellular carcinoma development in cirrhosis. Best Pract Res Clin Gastroenterol 2007, 21:161-173.
3. Thomas M.B. Systemic therapy for hepatocellular carcinoma. Cancer J 2008, 14:123-127.
4. Shiota G., Okubo M., Noumi T., Noguchi N., Oyama K., Takano Y., et al. Cyclooxygenase-2 expression in hepatocellular carcinoma. Hepatogastroenterology 1999, 46:407-412.
5. Leng J., Han C., Demetris A.J., Michalopoulos G.K., Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 2003, 38:756-768.
6. Kern M.A., Haugg A.M., Koch A.F., Schilling T., Breuhahn K., Walczak H., et al. Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res 2006, 66:7059-7066.
7. Foderà D., D'Alessandro N., Cusimano A., Poma P., Notarbartolo M., Lampiasi N., et al. Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. Ann N Y Acad Sci 2004, 1028:440-449.
8. Li J., Chen X., Dong X., Xu Z., Jiang H., Sun X. Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells. J Gastroenterol Hepatol 2006, 21:1814-1820.
9. Rahman M.A., Dhar D.K., Masunaga R., Yamanoi A., Kohno H., Nagasue N. Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines. Cancer Res 2006, 60:2085-2089.
10. Marquez-Rosado L., Trejo-Solis M.C., Garcia-Cuellar C.M., Villa-Trevino S. Celecoxib, a cyclooxygenase-2 inhibitor, prevents induction of liver preneoplastic lesions in rats. J Hepatol 2005, 43:653-660.
11. Yoshiji H., Nakae D., Kinugasa T., Matsuzaki M., Denda A., Tsujii T., et al. Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital. Br J Cancer 1991, 64:839-842.
12. Sakai M., Muramatsu M. Regulation of glutathione transferase P: a tumor marker of hepatocarcinogenesis. Biochem Biophys Res Commun 2007, 357:575-578.
13. Squire R.A., Levitt M.H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 1975, 35:3214-3223.
14. Tessitore L. Apoptosis and cell proliferation are involved in the initiation of liver carcinogenesis by a subnecrogenic dose of diethylnitrosamine in refed rats. J Nutr 2000, 130:104-110.
15. Sundaresan S., Subramanian P. Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine. Mol Cell Biochem 2008, 310:209-214.
16. Shiota G., Maeta Y., Mukoyama T., Yanagidani A., Udagawa A., Oyama K., et al. Effects of Sho-Saiko-to on hepatocarcinogenesis and 8-hydroxy-2'-deoxyguanosine formation. Hepatology 2002, 35:1125-1133.
17. Yamamoto H., Kondo M., Nakamori S., Nagano H., Wakasa K., Sugita Y., et al. JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1. Gastroenterology 2003, 125:556-571.
18. Nagahara T., Okano J., Murawaki Y. Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. Oncol Rep 2007, 18:1281-1290.
19. Nishimura J., Dewa Y., Okamura T., Jin M., Saegusa Y., Kawai M., et al. Role of Nrf2 and oxidative stress on fenofibrate-induced hepatocarcinogenesis in rats. Toxicol Sci 2008, 106:339-349.
20. Munkarah A.R., Genhai Z., Morris R., Baker V.V., Deppe G., Diamond M.P., et al. Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. Gynecol Oncol 2003, 88:429-433.
21. Na H.K., Surh Y.J. Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis. Ann N Y Acad Sci 2002, 973:153-160.
22. Dajani E.Z., Islam K. Cardiovascular and gastrointestinal toxicity of selective cyclo-oxygenase-2 inhibitors in man. J Physiol Pharmacol 2008, 59:117-133.