Could a loss of memory T cells limit responses to hepatitis C virus (HCV) antigens in blood leucocytes from patients chronically infected with HCV before and during pegylated interferon-α and ribavirin therapy?

Clinical and Experimental Immunology

Volumn 161, Issue 1, 2010, Pages 118-126

  Lee, S ^a,b   Hammond, T ^b   Watson, M W ^a   Flexman, J P ^a   Cheng, W ^a   Fernandez, S ^b   Price, P ^a,b  

^a ROYAL PERTH HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

HCV; Interferon based therapy; PD 1; T cells

Indexed keywords

CD31 ANTIGEN; CD45RA ANTIGEN; CYTOMEGALOVIRUS ANTIGEN PP65; FAS ANTIGEN; GAMMA INTERFERON; HEPATITIS C ANTIGEN; PEGATRON; PEGINTERFERON ALPHA2A; PROGRAMMED DEATH 1 LIGAND 1; RIBAVIRIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LOSS; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIGENS, VIRAL; ANTIVIRAL AGENTS; APOPTOSIS REGULATORY PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; DRUG THERAPY, COMBINATION; FEMALE; HEPACIVIRUS; HEPATITIS C ANTIGENS; HEPATITIS C, CHRONIC; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON ALFA-2A; INTERFERON-GAMMA; LEUKOCYTES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RIBAVIRIN; RNA, VIRAL; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 77953283942     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04141.x     Document Type: Article

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