Microindentation for in vivo measurement of bone tissue mechanical properties in humans

Journal of Bone and Mineral Research

Volumn 25, Issue 8, 2010, Pages 1877-1885

  Diez Perez, Adolfo ^a,f   Güerri, Roberto ^a   Nogues, Xavier ^a,f   Cáceres, Enric ^a,f   Peñ, Maria Jesus ^a   Mellibovsky, Leonardo ^a,f   Randal, Connor ^a,b   Bridges, Daniel ^a,b   Weaver, James C ^b,c   Proctor, Alexander ^d   Brimer, Davis ^d   Koester, Kurt J ^e   Ritchie, Robert O ^e   Hansma, Paul K ^b,d  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Coastal Marine Biolabs ^*  (United States)

^d Active Life Technologies   (United States)

^e No 1760   (United States)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Bone; Bone quality; Clinical trials; Fracture; Instrument

Indexed keywords

ARTICLE; BIOMECHANICS; BONE GROWTH; BONE STRENGTH; BONE TISSUE; CADAVER; CLINICAL ARTICLE; FEMALE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; HUMAN TISSUE; OSTEOPOROSIS; PERIOSTEUM; REPRODUCIBILITY; SCANNING ELECTRON MICROSCOPY; TIBIA; VERTEBRA FRACTURE;

BIOMECHANICS; BONE AND BONES; CADAVER; FEMALE; FRACTURES, BONE; HUMANS; ORTHOPEDICS; OSTEOPOROSIS; ROC CURVE; TISSUE DONORS;

EID: 77953271840     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.73     Document Type: Article

References (47)

1. Ettinger MP. Aging bone and osteoporosis: strategies for preventing fractures in the elderly. Arch Intern Med. 2003;163:2237-2246.
2. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. JAMA. 2001;285:785-795.
3. Rivadeneira F, Zillikens MC, Laet CED, et al. Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res. 2007;22:1781-1790. (Pubitemid 351235145)
4. Yang L, Peel N, Clowes JA, McCloskey EV, Eastell R. Use of DXA-based structural engineering models of the proximal femur to discriminate hip fracture. J Bone Miner Res. 2009;24:33-42.
5. Cummings SR, Karpf DB, Harris F, et al. Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med. 2002;112:281-289.
6. Boutroy S, Rietbergen BV, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite Element Analysis Based on In Vivo HR-pQCT Images of the Distal Radius Is Associated With Wrist Fracture in Postmenopausal Women. J Bone Miner Res. 2008 23:392-399.
7. Garnero P S-RE, Claustrat B, Delmas PD. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study. J Bone Miner Res. 2000;15: 1526-1536. (Pubitemid 30484522)
8. Chavassieux P, Seeman E, Delmas PD. Insights into Material and Structural Basis of Bone Fragility from Diseases Associated with Fractures: How Determinants of the Biomechanical Properties of Bone Are Compromised by Disease. Endocrine Reviews. 2007;28: 151-164.
9. Vashishth D. Age-dependent biomechanical modifications in bone. Crit Rev Eukar Gene. 2005;15:343-357.
10. Currey JD. Changes in impact energy absorption with age. J Biomech. 1979;12:459-469.
11. Currey J. Incompatible mechanical properties in compact bone. J Theor Biol. 2004;231:569-580. (Pubitemid 39369989)
12. Turner CH. Biomechanics of bone: Determinants of skeletal fragility and bone quality. Osteoporosis Int. 2002;13:97-104.
13. Bouxsein ML. Bone quality: where do we go from here? Osteoporosis Int. 2003;14:S118-S127.
14. Jepsen KJ. The aging cortex: to crack or not to crack. Osteoporos Int. 2003;14 Suppl 5: S57-S62.
15. Seeman E, Delmas PD. Mechanisms of disease - Bone quality - The material and structural basis of bone strength and fragility. New Engl J Med. 2006;354:2250-2261.
16. Saito M, Marumo K. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus Osteoporosis Int. Available at: http:// www.springerlink.com. Accessed November 12, 2009.
17. Hansma PK, Yu H, Schultz D, et al. The tissue diagnostic instrument. Rev Sci Instrum. 2009;80:054303.
18. Hansma PK, Turner PJ, Fantner GE. Bone diagnostic instrument. Rev Sci Instrum. 2006;77:075105.
19. Hansma PK, Turner P, Drake B, et al. The bone diagnostic instrument II: Indentation distance increase. Rev Sci Instrum. 2008 79:064303.
20. Randall C, Mathews P, Yurtsev E, Sahar N, Kohn D, Hansma P. The bone diagnostic instrument III: testing mouse femora. Rev Sci Instrum. 2009;80:065108.
21. Habelitz S, Marshall GW, Balooch M, Marshall SJ. Nanoindentation and storage of teeth. J Biomech. 2002;35:995-998.
22. Koester KJ, Ager JW, Ritchie RO. The true toughness of human cortical bone measured with realistically short cracks. Nat Mater. 2008;7:672-677.
23. Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO. Mechanistic aspects of fracture and R-curve behavior of human cortical bone. Biomaterials. 2005;26:217-231. (Pubitemid 38789105)
24. Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: Concept of microcrack toughening. J Biomech. 1997;30:763-769.
25. The R Project for Statistical Computing. Available at: http://www. R-project.org. Accessed November 12, 2009.
26. Fawcett T. An introduction to ROC analysis. Pattern Recognition Letters. 2006;27:861-874.
27. Thurner PJ, Erickson B, Jungmann R, et al. High-speed photography of compressed human trabecular bone correlates whitening to microscopic damage. Engineering Fracture Mechanics. 2007;74: 1928-1941.
28. Thurner PJ, Erickson B, Turner P, et al. The Effect of NaF In Vitro on the Mechanical and Material Properties of Trabecular and Cortical Bone. Adv Mater. 2009;21:451-457.
29. Fratzl P, Gupta HS, Paschalis EP, Roschger P. Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem. 2004;14:2115-2123.
30. Taylor D, Hazenberg JG, Lee TC. Living with cracks: damage and repair in human bone. Nat Mater. 2007;6:263-268. (Pubitemid 46516815)
31. Burr D, Microdamage and bone strength. Osteoporos Int. 2003;14 Suppl 5: S67-S72.
32. Boskey A. Bone mineral crystal size. Osteoporosis Int. 2003;14:S16-S20.
33. Burr DB. The contribution of the organic matrix to bone's material properties. Bone. 2002;31:8-11.
34. Garnero P, Borel O, Gineyts E, et al. Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone. 2006;38:300-309.
35. Peterlik H, Roschger P, Klaushofer K, Fratzl P. From brittle to ductile fracture of bone. Nat Mater. 2006;5:52-55.
36. Carando S, Portigliatti Barbos M, Ascenzi A, Boyde A. Orientation of collagen in human tibial and fibular shaft and possible correlation with mechanical properties. Bone. 1989;10:139-142. (Pubitemid 19213556)
37. Ascenzi MG, Gill J, Lomovtsev A. Orientation of collagen at the osteocyte lacunae in human secondary osteons. J Biomech. 2008; 41:3426-3435.
38. Fantner GE, Hassenkam T, Kindt JH, et al. Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture. Nat Mater. 2005;4:612-616.
39. Gupta HS, Fratzl P, Kerschnitzki M, Benecke G, Wagermaier W, Kirchner HOK. Evidence for an elementary process in bone plasticity with an activation enthalpy of 1 eV. J R Soc Interface. 2007;4:277-282. (Pubitemid 46513058)
40. Fantner GE, Oroudjev E, Schitter G, et al. Sacrificial bonds and hidden length: Unraveling molecular mesostructures in tough materials. Biophys J. 2006;90:1411-1418.
41. Fantner GE, Rabinovych O, Schitter G, et al. Hierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales. Compos Sci Technol. 2006;66:1205-1211.
42. Thurner PJ, Erickson B, Schriock Z, et al. High-speed photography of the development of microdamage in trabecular bone during compression. J Mater Res. 2006;21:1093-1100.
43. Ritchie RO, Buehler MJ, Hansma P. Plasticity and toughness in bone. Phys Today. 2009;62:41-47.
44. Gupta HS, Wagermaier W, Zickler GA, et al. Nanoscale deformation mechanisms in bone. Nano Lett. 2005;5:2108-2111.
45. Thurner PJ, Muller R, Kindt J, et al. 2005 Novel Techniques for High-Resolution Functional Imaging of Trabecular Bone. Proceedings of SPIE - Medical Imaging 2005: Physiology, Function, and Structure from Medical Images; Amir A. Amini , Armando Manduca , Editors, 5746:515-526.
46. Thurner P. Atomic force microscopy and indentation force measurement of bone. Available at: www.wiley.com/wires/nanomed. Accessed November 12, 2009.
47. Hvid I, Linde F. Penetration Testing of Bone Using the Osteopenetrometer. In: An YH, Draughn RA, eds. Mechanical Testing of Bone and the Bone-Implant Interface. Boca Raton, FL: CRC Press; 2000:241-246.