Repeated-dose toxicity of HSP27-binding heptapeptide in mice

Drug and Chemical Toxicology

Volumn 33, Issue 3, 2010, Pages 284-290

  Lee, Hae June ^a   Lee, Yun Sil ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

Author keywords

Heptapeptide; HSP27; PCK ; Safety; Toxicology

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CREATININE; GLUCOSE; HEAT SHOCK PROTEIN 27; HEMOGLOBIN; HEPTAPEPTIDE; LACTATE DEHYDROGENASE; PHENYLALANYLGLUTAMYLGLUTAMINYLPHENYLALANYLLEUCYLASPARTYLISOLEUCINE; PROTEIN; PROTEIN KINASE C DELTA; UNCLASSIFIED DRUG; UREA; OLIGOPEPTIDE; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOPHIL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; BRAIN WEIGHT; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; EOSINOPHIL; ERYTHROCYTE COUNT; FEMALE; HEART; HEART WEIGHT; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; INFLAMMATION; KIDNEY MASS; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LIVER CELL; LIVER WEIGHT; LUNG INTERSTITIUM; LUNG WEIGHT; LYMPHOCYTE COUNT; MALE; MAXIMUM TOLERATED DOSE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONONUCLEAR CELL; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN BLOOD LEVEL; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SPLEEN WEIGHT; THROMBOCYTE COUNT; TOXICITY TESTING; UREA NITROGEN BLOOD LEVEL; ANIMAL; BLOOD ANALYSIS; BLOOD CELL COUNT; CYTOCHEMISTRY; DRUG EFFECTS; EATING; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; RANDOMIZATION;

ANIMALS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; EATING; FEMALE; HISTOCYTOCHEMISTRY; HSP27 HEAT-SHOCK PROTEINS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED ICR; OLIGOPEPTIDES; PROTEIN BINDING; RANDOM ALLOCATION;

MUS;

EID: 77953269378     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480540903483425     Document Type: Article

References (22)

1. Bruey, J. M., Ducasse, C., Bonniaud, P., Ravagnan, L., Susin, S. A., Diaz-Latoud, C., et al. (2000). Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2:645-652.
2. Charette, S. J., Landry, J. (2000). The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fasinduced apoptosis. Ann N Y Acad Sci 926:126-131.
3. Erkizan, O., Kirkali, G., Yörüko?lu, K., Kirkali, Z. (2004). Significance of heat shock protein-27 expression in patients with renal cell carcinoma. Urology 64:474-476.
4. Garrido, C., Ottavi, P., Fromentin, A., Hammann, A., Arrigo, A. P., Chauffert, B., et al. (1997). HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res 57:2661-2667.
5. Guay, J., Lambert, H., Gingras-Breton, G., Lavoie, J. N., Huot, J., Landry, J. (1997). Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci 110:357-368.
6. Huot, J., Houle, F., Marceau, F. (1997). Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res 80:383-392.
7. Kim, E. H., Lee, H. J., Lee, D. H., Bae, S., Soh, J. W., Jeoung, D., et al. (2007). Inhibition of heat shock protein 27-mediated resistance to DNA damaging agents by a novel PKCD-V5 heptapeptide. Cancer Res 67:6333-6341.
8. Lavoie, J. N., Hickey, E., Weber, L. A., Landry, J. (1993). Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J Biol Chem 268:24210-24214.
9. Lee, Y. J., Cho, H. N., Jeoung, D. I., Soh, J. W., Cho, C. K., Bae, S., et al. (2004). HSP25 overexpression attenuates oxidative stress-induced apoptosis: roles of ERK1/2 signaling and manganese superoxide dismutase. Free Radic Biol Med 36:429-444.
10. Lee, Y. J., Lee, D. H., Cho, C. K., Bae, S., Jhon, G. J., Lee, S. J., et al. (2005). HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction. J Biol Chem 280:18108-18119.
11. Mairesse, N., Horman, S., Mosselmans, R., Galand, P. (1996). Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells. Cell Biol Int 20:205-212.
12. Mehlen, P., Coronas, V., Ljubic-Thibal, V., Ducasse, C., Granger, L., Jourdan, F., et al. (1999). Small stress protein Hsp27 accumulation during dopamine-mediated differentiation of rat olfactory neurons counteracts apoptosis. Cell Death Differ 6:227-233.
13. Oesterreich, S., Weng, C. N., Qiu, M., Hilsenbeck, S. G., Osborne, C. K., Fugua, S. A. (1993). The small heat shock protein, HSP27, is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 53: 4443-4448.
14. Paul, C., Manero, F., Gonin, S., Kretz-Remy, C., Virot, S., Arrigo, A. P. (2002). Hsp27 as a negative regulator of cytochrome C release. Mol Cell Biol 22:816-834.
15. Ravel, D., Dubois, V., Quinonero, J., Meyer-Losic, F., Delord, J., Rochaix, P., et al. (2008). Preclinical toxicity, toxicokinetics, and antitumoral efficacy studies of DTS-201, a tumorselective peptidic prodrug of doxorubicin. Clin Caner Res 14:1258-11256
16. Richards, E. H., Hickey, E., Weber, L., Master, J. R. (1996). Effect of overexpression of the small heat shock protein, HSP27, on the heat and drug sensitivities of human testis tumor cells. Cancer Res 56:2446-2451.
17. Sileno, A. P., Brandt, G. C., Spann, B. M., Quay, S. C. (2006). Lower mean weight after 14 days intravenous administration peptide YY3-36 (PYY3-36) in rabbits. Int J Obes 30:68-72.
18. Storm, F. K., Mahvi, D. M., Gilchrist, K. W. (1996). Heat shock protein 27 overexpression in breast cancer lymph node metastasis. Ann Surg Oncol 3:570-573.
19. Sugerman, P. B, Savage, N. W., Xu, L. J., Walsh, L. J., Seymour, G. J. (1995). Heat shock protein expression in oral epithelial dysplasia and squamous cell carcinoma. Eur J Cancer Biol Oral Oncol 31B:63-67.
20. Thor, A., Benz, C., Moore, D., Goldman, E., Edgerton, S., Landry, J., et al. (1991). Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J Natl Cancer Inst 83: 170-178.
21. Woodburn, K. W., Schatz, P. J., Fong, K. L., Wilson, S. D., Ferrell, T., Spainhour, C. B., et al. (2008). Preclinical safety and pharmacology of Hematide, a peptidic erythropoiesisstimulating agent (ESA), in rats and monkeys. Drug Chem Toxicol 32:229-244.
22. Wagstaff, M. J., Collaco-Moraes, Y., Smith, J., de Belleroche, J. S., Coffin, R. S., Latchman, D. S. (1999). Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector. J Biol Chem 274:5061-5069.