Preclinical toxicity, toxicokinetics, and antitumoral efficacy studies of DTS-201, a tumor-selective peptidic prodrug of doxorubicin

Clinical Cancer Research

Volumn 14, Issue 4, 2008, Pages 1258-1265

  Ravel, Denis ^a   Dubois, Vincent ^a   Quinonero, Jérôme ^a   Meyer Losic, Florence ^a   Delord, Jean Pierre ^b   Rochaix, Philippe ^b   Nicolazzi, Céline ^a   Ribes, Fabien ^a   Mazerolles, Catherine ^c   Assouly, Elise ^a   Vialatte, Karine ^a   Hor, Inès ^a   Kearsey, Jonathan ^a   Trouet, André ^a  

^a Diatos SA   (France)

^b INSTITUT CLAUDIUS REGAUD   (France)

^c CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; CPI 0004NA; DOXORUBICIN; DOXORUBICIN DERIVATIVE; DTS 201; MEMBRANE METALLOENDOPEPTIDASE; N SUCCINYL BETA ALANYLLEUCYLALANYLLEUCYLDOXORUBICIN; PRODRUG; THIMET OLIGOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CARDIOTOXICITY; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG SELECTIVITY; FEMALE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; ISOTOPE LABELING; LUNG CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RAT; TOXICOKINETICS; TUMOR BIOPSY; TUMOR XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; DOGS; DOXORUBICIN; FEMALE; HUMANS; MALE; METALLOENDOPEPTIDASES; MICE; NEOPLASMS, EXPERIMENTAL; NEPRILYSIN; OLIGOPEPTIDES; PRODRUGS; PROSTATIC NEOPLASMS; RATS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 39749186005     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-1165     Document Type: Article

References (26)