Development of valsartan-loaded gelatin microcapsule without crystal change using hydroxypropylmethylcellulose as a stabilizer

Drug Delivery

Volumn 17, Issue 5, 2010, Pages 322-329

  Li, Dong Xun ^a,b   Yan, Yi Dong ^a   Oh, Dong Hoon ^a   Yang, Kwan Yeol ^a   Seo, Yoon Gi ^a   Kim, Jong Oh ^a   Kim, Yong Il ^a   Yong, Chul Soon ^a   Choi, Han Gon ^a  

^a Yeungnam University   (South Korea)

^b University of Traditional Chinese Medicine   (China)

Author keywords

Gelatin microcapsule; HPMC; No crystal change; Pharmacokinetics; Valsartan

Indexed keywords

GELATIN; HYDROXYPROPYLMETHYLCELLULOSE; VALSARTAN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROCAPSULE; NONHUMAN; POWDER; PRIORITY JOURNAL; RAT; SPRAY DRYING; THERMOSTABILITY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CAPSULES; CRYSTALLIZATION; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; GELATIN; MALE; METHYLCELLULOSE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TEMPERATURE; TETRAZOLES; VALINE;

EID: 77953240821     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717541003717031     Document Type: Article

References (31)

1. Anderberg, E.K., Bisrat, M., Nyström, C. (1988). Physicochemical aspects of drug release. VII. The effect of surfactant concentration and drug particle size on solubility and dissolution rate of felodipine, a sparingly soluble drug. Int J Pharm. 47:67-77.
2. Brunella, C., Cleelia, D.M., Maria, I., Agnese, M. (2006). Improvement of solubility and stability of valsartan by hydroxypropyl-β-cyclodextrin. J Incl Phenom Macro. 54:289-294
3. Castelli, F., Messina, C., Pignatello, R., Puglisi, G. (2001). Effect of pH on diclofenac release from Eudragit RS100® microparticles. A kinetic study by DSC. Drug Deliv. 8:173-177
4. Choi, H.G., Oh, Y.K., Kim, C.K. (1998). In-situ gelling and mucoadhesive liquid suppository containing acetaminophen, enhanced bioavailability. Int J Pharm. 165:23-32.
5. Comoglu, T., Gonul, N., Dogan, A., Basci, N. (2008). Development and in vitro evaluation of pantoprazole-loaded microspheres. Drug Deliv. 15:295-302.
6. Doherty, C., York, P. (1987). Mechanisms of dissolution of furosemide, PVP solid dispersions. Int J Pharm. 34:197-205.
7. Dressman, J.B., Reppas, C. (2008). In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur J Pharm Sci. 11:S73-80.
8. Flesch, G., Müller, P., Lloyd, P. (1997). Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man, Eur J Clin Pharmacol. 52:115-120
9. Gibaldi, M., Perrier, D. (1982). Pharmacokinetics. 2nd ed. New York: Marcel-Dekker.
10. Kim, C.K., Yoon, Y.S. (1995). Developement of digoxin dry elixir as a novel dosage form using a spray-drying technique. J Microencapsul. 12:547-556
11. Kim, C.K., Yoon, Y.S., Kong, J.Y. (1995). Preparation and evaluation of flurbiprofen dry elixir as a novel dosage form using a spraydrying technique. Int J Pharm. 120:21-31.
12. Li, D.X., Oh, Y.K., Lim, S.J., Kim, J.O., Yang, H.J., Sung, J.H., Yong, C.S., Choi, H.G. (2008). Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray drying technique. Int J Pharm. 355:277-284
13. Macek, J., Klíma, J., Ptácek, P. (2006). Rapid determination of valsartan in human plasma by protein precipitation and high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 832:169-172
14. Markham, A., Goa, K.L. (1997). A review of its pharmacology and therapeutic use in essential hypertension. Drugs. 54:299-311. (Pubitemid 27361837)
15. Marsac, P.J., Shamblin, S.L., Taylor, L.S. (2006). Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm Res. 23:2417-2426
16. Matsumoto, T., Zografi, G. (1999). Physical properties of solid molecular dispersions of Indomethacine with PVP and PVPVA in relation to Indomethacine recrystallization. Pharm Res. 16:1722-1728
17. Mbah, C.J. (2005). Physicochemical properties of valsartan and the effect of ethyl alcohol, propylene glycol and pH on its solubility. Pharmazie. 60:849-850
18. Mbah, C.J. (2006). Solubilization of valsartan by aqueous glycerol, polyethylene glycol and micellar solutions. Pharmazie. 61:322-324
19. Okimoto, K., Miyake, M., Ibuki, R., Yasumura, M., Ohnishi, N., Nakai, T. (1997). Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropylmethylcellulose. Int J Pharm. 159:85-93.
20. Piao, M.G., Yang, C.W., Li, D.X., Kim, J.O., Jang, K.Y., Yoo, B.K., Kim, J.A., Woo, J.S., Lyoo, W.S., Han, S.S., Lee, Y.B., Kim, D.D., Yong, C.S., Choi, H.G. (2008a). Preparation and in vivo evaluation of piroxicam-loaded gelatin microcapsule by spray drying technique. Biol Pharm Bull. 31:1284-1287
21. Piao, Z.Z., Lee, E.S., Tran, H.T., Lee, B.J. (2008b). Improved analytical validation and pharmacokinetics of valsartan using HPLC with UV detection. Arch Pharm Res. 31:1055-1059
22. Serajuddin, A.T.M. (1999). Solid dispersion of poorly water-soluble drugs, early promises, subsequent problems, and recent breakthroughs. J Pharm Sci. 88:1058-1066
23. Shrivastava, A.R., Ursekar, B., Kapadia, C.J. (2009). Design, optimization, preparation and evaluation of dispersion granules of valsartan and formulation into tablets. Curr Drug Deliv. 6:28-37.
24. Smal, J., Haapala, O., Marvola, M., Kuusela, S., Happonen, I. (1995). Prolonged-release hard gelatin capsules of furosemide for the treatment of dogs. J Vet Pharmacol Ther. 18:17-23.
25. Society of Toxicology (SOT). December (2008). Guiding principles in the use of animals in toxicology. Available online at: www.toxicology. org/AI/FA/guidingprinciples.pdf.
26. Vaidyanathan, S., Jarugula, V., Dieterich, H.A., Howard, D., Dole, W.P. (2008). Clinical pharmacokinetics and pharmacodynamics of aliskiren. Clin Pharmacokinet. 47:515-531
27. Veiga, M.D., Diaz, P.J., Ahsan, F. (1998). Interaction of griseofulvin with cyclodextrins in solid binary systems. J Pharm Sci. 87:891-900.
28. Venkateswarlu, V., Manjunath, K. (2004). Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Contr Rel. 95:627-638
29. Verreck, G., Chun, I., Peeters, J., Rosenblatt, J., Brewster, M.E. (2003). Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm Res. 20:810-817
30. Yokoi, Y., Etsuo, Y., Katsuhide, T. (2005). Effects of sugar ester and hydroxypropyl methylcellulose on the physicochemical stability of amorphous cefditoren pivoxil in aqueous suspension. Int J Pharm. 290:91-99
31. Yong, C.S., Li, D.X., Oh, D.H., Kim, J.A., Yoo, B.K., Woo, J.S., Rhee, J.D., Choi, H.G. (2006). Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde. Arch Pharm Res. 29:431-4.