CRTH2 expression on T cells in asthma

Clinical and Experimental Immunology

Volumn 161, Issue 1, 2010, Pages 34-40

  Mutalithas, K ^a   Guillen, C ^a   Day, C ^a   Brightling, C E ^a   Pavord, I D ^a   Wardlaw, A J ^a  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

Author keywords

Asthma; CRTH2; Lung T cell

Indexed keywords

CHEMOKINE RECEPTOR; CORTICOSTEROID; CRTH2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; PROSTAGLANDIN D2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTHMA; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG LAVAGE; LYMPHOCYTE MIGRATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

ADRENAL CORTEX HORMONES; ADULT; AGED; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; FEMALE; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PROSTAGLANDIN D2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; T-LYMPHOCYTE SUBSETS; TH2 CELLS; YOUNG ADULT;

EID: 77953238757     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04161.x     Document Type: Article

References (21)

1. Lewis RA, Soter NA, Diamond PT, Austen KF, Oates JA, Roberts LJ II. Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol 1982 129 : 1627 1631.
2. Gosset P, Pichavant M, Faveeuw C, Bureau F, Tonnel AB, Trottein F. Prostaglandin D2 affects the differentiation and functions of human dendritic cells: impact on the T cell response. Eur J Immunol 2005 35 : 1491 1500.
3. Pettipher R, Hansel TT, Armer R. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov 2007 6 : 313 325.
4. Hirai H, Tanaka K, Yoshie O et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001 193 : 255 261.
5. Gervais FG, Cruz RP, Chateauneuf A et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. J Allergy Clin Immunol 2001 108 : 982 988.
6. Shiraishi Y, Asano K, Nakajima T et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther 2005 312 : 954 960.
7. Pettipher R. The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol 2008 153 (Suppl. 1 S191 S199.
8. Gyles SL, Xue L, Townsend ER, Wettey F, Pettipher R. A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. Immunology 2006 119 : 362 368.
9. Nagata K, Hirai H. The second PGD(2) receptor CRTH2: Structure, properties, and functions in leukocytes. Prostaglandins Leukot Essent Fatty Acids 2003 69 : 169 177.
10. Nagata K, Hirai H, Tanaka K et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999 459 : 195 199.
11. Nagata K, Tanaka K, Ogawa K et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 1999 162 : 1278 1286.
12. Spik I, Brenuchon C, Angeli V et al. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. J Immunol 2005 174 : 3703 3708.
13. Sugimoto H, Shichijo M, Iino T et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther 2003 305 : 347 352.
14. Xue L, Gyles SL, Wettey FR et al. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol 2005 175 : 6531 6536.
15. Robinson DS. Th-2 cytokines in allergic disease. Br Med Bull 2000 56 : 956 968.
16. Cosmi L, Annunziato F, Galli MIG, Maggi RME, Nagata K, Romagnani S. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol 2000 30 : 2972 2979.
17. Huang JL, Gao PS, Mathias RA et al. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet 2004 13 : 2691 2697.
18. Aizawa H, Shigyo M, Nogami H, Hirose T, Hara N. BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmatics. Chest 1996 109 : 338 342.
19. Chevalier E, Stock J, Fisher T et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J Immunol 2005 175 : 2056 2060.
20. Brightling BE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ. Th2 cytokine expression in bronchoalveolar lavage T-lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 2002 110 : 899 905.
21. Morgan AJ, Symon FA, Berry MA, Pavord ID, Corrigan CJ, Wardlaw AJ. IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4. J Allergy Clin Immunol 2005 116 : 594 600.