Calcium-channel blockers do not affect iron transport mediated by divalent metal-ion transporter-1

Blood

Volumn 115, Issue 20, 2010, Pages 4148-4149

  Mackenzie, Bryan ^a   Shawki, Ali ^a   Ghio, Andrew J ^b   Stonehuerner, Jacqueline D ^b   Zhao, Lin ^c   Ghadersohi, Saied ^d   Garrick, Laura M ^d   Garrick, Michael D ^c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DOXYCYCLINE; IRON; IRON 59; MANGANESE; METAL ION; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NICARDIPINE; NIFEDIPINE; VERAPAMIL; DMRT1 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; CELL MEMBRANE TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON OVERLOAD; IRON TRANSPORT; LETTER; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS; ANIMAL; CYTOLOGY; ION TRANSPORT; METABOLISM; XENOPUS LAEVIS;

ANIMALS; CALCIUM CHANNEL BLOCKERS; HUMANS; ION TRANSPORT; IRON; NIFEDIPINE; OOCYTES; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

EID: 77953234851     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-274738     Document Type: Letter

References (10)

1. 2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med. 2007;13(4):448-454.
2. Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388(6641):482- 488.
3. Fleming MD, Trenor CC, Su MA, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16(4):383-386.
4. Garrick MD, Kuo HC, Vargas F, et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. Biochem J. 2006;398(3):539-546.
5. Mackenzie B, Takanaga H, Hubert N, Rolfs A, Hediger MA. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J. 2007;403(1):59-69.
6. Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99(19):12345-12350.
7. Savigni DL, Morgan EH. Mediation of iron uptake and release in erythroid cells by photodegradation products of nifedipine. Biochem Pharmacol. 1996;51(12):1701-1709.
8. Savigni DL, Wege D, Cliff GS, Meesters ML, Morgan EH. Iron and transition metal transport into erythrocytes mediated by nifedipine degradation products and related compounds. Biochem Pharmacol. 2003;65(8):1215-1226.
9. Gruen AB, Zhou J, Morton KA, Milstone LM. Photodegraded nifedipine stimulates uptake and retention of iron in human epidermal keratinocytes. J Invest Dermatol. 2001;116(5):774-777.
10. Mackenzie B, Shawki A, Ghio AJ, et al. A role for the divalent metal-ion transporter (DMT1) is doubtful in the mechanism by which calcium-channel blockers reverse iron overload [abstract]. FASEB J. 2008;22:1192.2.