Photodegraded nifedipine stimulates uptake and retention of iron in human epidermal keratinocytes

Journal of Investigative Dermatology

Volumn 116, Issue 5, 2001, Pages 774-777

  Gruen, Alison B ^a   Zhou, Jing ^a   Morton, Kathryn A ^b   Milstone, Leonard M ^a  

^a YALE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Desquamation; Hemochromatosis; Skin; Treatment

Indexed keywords

IRON; IRON BINDING PROTEIN; NIFEDIPINE; NITROSO DERIVATIVE; TRANSFERRIN;

ARTICLE; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; EPIDERMIS; HUMAN; HUMAN CELL; IRON TRANSPORT; KERATINOCYTE; PHOTODEGRADATION; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SUN EXPOSURE;

EID: 0035021121     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01318.x     Document Type: Article

References (14)

1. Apte SV, Venkatachalam PS: Factors influencing dermal loss of iron in human volunteers. Ind Med Res 50:817-822, 1962
2. Batey RG, Fong PLC, Shamir S, Sherlock S: A non-transferrin-bound serum iron in idiopathic hemochromatosis. Digest Dis Sci 25:340-346, 1980
3. Brissot P, Wright TL, Ma W-L, Weisiger RA: Efficient clearance of non-transferrin-bound iron by rat liver. J Clin Invest 76:1463-1470, 1985
4. Brune M, Magnusson B, Persson H, Hallberg L: Iron losses in sweat. Am J Clin Nutr 43:438-443, 1986
5. Friedlaender MM, Kaufman B, Rubinger D, Moreb J, Popovtzer MM, Goredetsky R: Noninvasive assessment of skin iron content in hemodialysis patients. An index of parenchymal tissue iron content? Am J Kidney Dis 12:18-25, 1988
6. Green R, Charlton R, Seftel H, et al: Body iron excretion in man. Am J Med 45:336-353, 1968
7. Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bomford A, Sadler PJ: Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. J Biol Chem 264:4417-4422, 1989
8. Gunshin H, Mackenzie B, Berger UV, et al: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488, 1997
9. Luttropp CA, Vu C, Morton KA: Photodegraded nifedipine promotes transferrin-independent gallium uptake by cultured tumor cells. J Nucl Med 40:159-165, 1999
10. Mitchell HH, Hamilton TS: The dermal excretion under controlled environmental conditions of nitrogen and minerals in human subjects, with particular reference to calcium and iron. J Biol Chem 178:345-360, 1949
11. Molin L, Wester PO: The estimated daily loss of trace elements from normal skin by desquamation, Scan J Clin Lab Invest 36:679-682, 1976
12. Reizenstein P, Skog E, Stigell P: Radio-iron content of epithelium and cell turnover in psoriasis. Acta Derm-Venereol 48:70-74, 1968
13. Savigni DL, Morgan EH: Mediation of iron uptake and release in erythroid cells by photodegradation products of nifedipine. Biochem Pharmacol 51:1701-1709, 1996
14. Zhou J, Haggerty JG, Milstone LM: Growth and differentiation regulate CD44 expression on human keratinocytes. In Vitro Cell Dev Biol 35:228-235, 1999