Expression of the hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: Postmortem study

Neurochemical Research

Volumn 35, Issue 7, 2010, Pages 994-1002

  Vrajová, Monika ^a   Šťastný, František ^b   Horáček, Jiří ^a   Lochman, Jan ^d   Šerý, Omar ^d   Peková, Soňa ^e   Klaschka, Jan ^c   Höschl, Cyril ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c INSTITUTE OF COMPUTER SCIENCE   (Czech Republic)

^d MASARYK UNIVERSITY   (Czech Republic)

^e NA HOMOLCE HOSPITAL   (Czech Republic)

Author keywords

GluN1 subunit of NMDA receptor; Hippocampus; Laterality; Schizophrenia; Splice variants

Indexed keywords

ISOPROTEIN; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN GLUN1; PROTEIN NR1 2B; PROTEIN NR1 4B; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LEFT HEMISPHERE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RIGHT HEMISPHERE; SCHIZOPHRENIA;

AGED; ALTERNATIVE SPLICING; FEMALE; HUMANS; MALE; PROTEIN ISOFORMS; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 77953231677     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0145-z     Document Type: Article

References (41)

1. NEM Van Haren W Cahn HE Hulshoff, et al. 2008 Schizophrenia as a progressive brain disease Eur Psychiatry 23 245 254 10.1016/j.eurpsy.2007.10.013 18513927
2. PJ Harrison DR Weinberger 2005 Schizophrenia genes, gene expression, and neurobiology: on the matter of their convergence Mol Psychiatry 10 40 68 10.1038/sj.mp.4001558 1:CAS:528:DC%2BD2cXhtFeisL3N 15263907 (Pubitemid 40139588)
3. S Cull-Candy S Brickley M Farrant 2001 NMDA receptor subunits: diversity, development and disease Curr Opin Neurobiol 11 327 335 10.1016/S0959-4388(00) 00215-4 1:CAS:528:DC%2BD3MXks1Oktbg%3D 11399431 (Pubitemid 32524098)
4. LV Kristiansen I Huerta M Beneyto, et al. 2007 NMDA receptors and schizophrenia Curr Opin Pharmacol 7 48 55 10.1016/j.coph.2006.08.013 1:CAS:528:DC%2BD2sXntlGiug%3D%3D 17097347
5. S Dracheva SAE Marras SL Elhakem, et al. 2001 N-Methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia Am J Psychiatry 158 1400 1410 10.1176/appi.ajp.158.9.1400 1:STN:280:DC%2BD3MvovFKrsw%3D%3D 11532724 (Pubitemid 32847238)
6. CR Scherzer GB Landwehrmeyer JA Kerner, et al. 1998 Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: hippocampus and cortex J Comp Neurol 390 75 90 10.1002/(SICI)1096-9861(19980105)390:1<75:AID- CNE7>3.0.CO;2-N 1:CAS:528:DyaK1cXhvVygtA%3D%3D 9456177
7. RL Foldes V Rampersad RK Kamboj 1993 Cloning and sequence analysis of cDNA encoding human hippocampal N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing Gene 131 293 298 10.1016/0378-1119(93)90309-Q 1:CAS:528:DyaK2cXhtVym 8406025
8. M Zimmer TM Fink Y Franke, et al. 1995 Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1) Gene 159 219 223 10.1016/0378-1119(95)00044-7 1:CAS:528:DyaK2MXnt1GqtLc%3D 7622053
9. WG Tingley KW Roche AK Thompson, et al. 1993 Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain Nature 364 70 73 10.1038/364070a0 1:CAS:528:DyaK3sXkvVKnsb4%3D 8316301 (Pubitemid 23233458)
10. T Kutsuwada N Kashiwabuchi H Mori, et al. 1992 Molecular diversity of the NMDA receptor channel Nature 358 6381 36 41 10.1038/358036a0 1:CAS:528:DyaK38Xks1elsrg%3D 1377365
11. L Chen LY Huang 1991 Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid Neuron 7 2 319 326 10.1016/0896-6273(91)90270-A 1678615
12. RS Zukin VL Bennett 1995 Alternatively spliced isoforms of the NMDAR1 receptor subunit Trends Neurosci 18 306 313 10.1016/0166-2236(95)93920-S 1:CAS:528:DyaK2MXmsFymt7g%3D 7571011
13. LV Kristiansen M Beneyto V Haroutunian, et al. 2006 Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia Mol Psychiatry 11 737 747 10.1038/sj.mp.4001844 1:CAS:528:DC%2BD28Xnt1yqtLY%3D 16702973 (Pubitemid 44141806)
14. S Le Corre CG Harper P Lopez, et al. 2000 Increased levels of expression of an NMDAR1 splice variant in the superior temporal gyrus in schizophrenia NeuroReport 11 983 986 10.1097/00001756-200004070-00017 10790868
15. X-M Gao K Sakai RC Roberts, et al. 2000 Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia Am J Psychiatry 157 1141 1149 10.1176/appi.ajp.157.7.1141 1:STN:280:DC%2BD3czjsVWgtg%3D%3D 10873924 (Pubitemid 30432497)
16. C Humphries A Mortimer S Hirsch, et al. 1996 NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia NeuroReport 7 2051 2055 10.1097/00001756-199608120-00040 1:CAS:528:DyaK28XmvFWltr0%3D 8905723
17. AJ Law JFW Deakin 2001 Asymetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses NeuroReport 12 2971 2974 10.1097/00001756-200109170-00043 1:CAS:528:DC%2BD3MXnsFSlt74%3D 11588613
18. C Toro JFW Deakin 2005 NMDA receptor subunit NR1 and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder Schizophr Res 80 323 330 10.1016/j.schres.2005.07.003 16140506 (Pubitemid 41713658)
19. PM Thompson S Egbufoama MP Vawter 2003 SNAP-25 reduction in the hippocampus of patients with schizophrenia Biol Psychiatry 39 919 928
20. CS Woolley NG Weiland BS McEwen, et al. 1997 Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density J Neurosci 17 1848 1859 1:CAS:528:DyaK2sXhtlOmsb8%3D 9030643
21. B McEwen 2002 Estrogen activations through the brain Recent Prog Horm Res 57 357 384 10.1210/rp.57.1.357 1:CAS:528:DC%2BD38Xjt1WqtLY%3D 12017552
22. TJ Huber M Borsutzky U Schneider, et al. 2004 Psychotic gonadal function: evidence supporting the oestrogen hypothesis Acta Psychiatr Scand 109 269 274 10.1046/j.1600-0447.2003.00251.x 1:CAS:528:DC%2BD2cXjsVansLo%3D 15008800 (Pubitemid 38406708)
23. AW Toga PM Thompson 2003 Mapping brain asymmetry Nat Neurosci 4 37 48 10.1038/nrn1009 1:CAS:528:DC%2BD3sXptlA%3D (Pubitemid 37271087)
24. LS Pilowsky RA Bressan JM Stone, et al. 2006 First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients Mol Psychiatry 11 118 119 10.1038/sj.mp.4001751 1:CAS:528:DC%2BD28XnsV2msg%3D%3D 16189506 (Pubitemid 43164609)
25. MR Hynd JM Lewohl HL Scott, et al. 2003 Biochemical and molecular studies using human brain tissue J Neurochem 85 543 562 1:CAS:528:DC%2BD3sXnslyrs7g%3D 12694381
26. Rozozen S, Skaletsky HJ (2000) Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana, Totowa, pp 365-386
27. J Bradley SR Carter VR Rao, et al. 2006 Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression J Neurosci 26 1065 1076 10.1523/JNEUROSCI.3347-05.2006 1:CAS:528:DC%2BD28XhsVSjsLs%3D 16436592 (Pubitemid 43237038)
28. M Beneyto LV Kristiansen A Oni-Orisan, et al. 2007 Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders Neuropsychopharmacology 32 1888 1902 10.1038/sj.npp.1301312 1:CAS:528:DC%2BD2sXptVWisrw%3D 17299517 (Pubitemid 47258508)
29. PJ Harrison AJ Law SL Eastwood 2003 Glutamate receptors and transporters in the hippocampus in schizophrenia Ann N Y Acad Sci 1003 94 101 10.1196/annals.1300.006 1:CAS:528:DC%2BD2cXptlGkuw%3D%3D 14684437 (Pubitemid 38083047)
30. Z Kryštofíková I Kozmiková P Hovorková, et al. 2008 Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia Neurochem Int 53 118 125 10.1016/j.neuint.2008.06.009
31. A Leung P Chue 2000 Sex differences in schizophrenia, a review of evidence Acta Psychiatr Scand 101 3 38 10.1111/j.0065-1591.2000.0ap25.x
32. S Akbarian NJ Sucher D Bradley, et al. 1996 Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics J Neurosci 16 19 30 1:CAS:528:DyaK28Xht1Sktg%3D%3D 8613785
33. DB Scott TA Blanpied GT Swanson, et al. 2001 An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing J Neurosci 21 3063 3072 1:CAS:528:DC%2BD3MXjtFyqurw%3D 11312291
34. WG Tingley MD Ehlers K Kameyama, et al. 1997 Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies J Biol Chem 272 5157 5166 10.1074/jbc.272.8.5157 1:CAS:528:DyaK2sXhsValu7s%3D 9030583 (Pubitemid 27090073)
35. AM Sánchez-Pérez V Felipo 2005 Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms Neurochem Int 47 84 91 10.1016/j.neuint.2005.04.011 15936117 (Pubitemid 40848697)
36. S Standley KW Roche J McCallum, et al. 2000 PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants Neuron 28 887 898 10.1016/S0896-6273(00)00161-6 1:CAS:528:DC%2BD3MXis1Kjuw%3D%3D 11163274 (Pubitemid 32038079)
37. AR Rutter FM Freman FA Stephenson 2002 Further characterization of the molecular interaction between PSD-95 and NMDA receptor: the effect of the NR1 splice variant and evidence of modulation of channel gating J Neurochem 81 1298 1307 10.1046/j.1471-4159.2002.00923.x 1:CAS:528:DC%2BD38XltVWks7g%3D 12068077 (Pubitemid 34809263)
38. H Toyoda R Takahata Y Inayama, et al. 1997 Effect of antipsychotic drugs on the gene expression of NMDA receptor subunits in rats Neurochem Res 22 249 252 10.1023/A:1022426402611 1:CAS:528:DyaK2sXhs1Glsrk%3D 9051657 (Pubitemid 27091811)
39. T Hanaoka H Toyada T Mizuna, et al. 2003 Alterations in NMDA receptor subunit levels in the brain regions of rats chronically administered typical or atypical antipsychotic drugs Neurochem Res 28 919 924 10.1023/A:1023231611616 1:CAS:528:DC%2BD3sXislyjtbw%3D 12718446 (Pubitemid 36438410)
40. A Schmitt M Zink B Muller, et al. 2003 Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits Neurochem Res 28 235 241 10.1023/A:1022325116309 1:CAS:528:DC%2BD3sXhtVems7k%3D 12608697 (Pubitemid 36207348)
41. MA Riva F Tascedda E Lovati, et al. 1997 Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs Brain Res Mol Brain Res 50 136 142 10.1016/S0169-328X(97)00175-7 1:CAS:528:DyaK2sXmtleiurw%3D 9406928 (Pubitemid 27488900)