Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma

Cancer Immunology, Immunotherapy

Volumn 59, Issue 8, 2010, Pages 1273-1284

  Kamphausen, Esther ^a   Kellert, Christiane ^a   Abbas, Tarish ^a   Akkad, Nadja ^b   Tenzer, Stefan ^b   Pawelec, Graham ^c   Schild, Hansjoerg ^b   Van Endert, Peter ^d,e   Seliger, Barbara ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d INSERM   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

ERAP; Immune escape; Regulation; Structural alterations; Tumour

Indexed keywords

AMINOPEPTIDASE; ENDOPLASMIC RETICULUM RESIDENT AMINOPEPTIDASE 1; ENDOPLASMIC RETICULUM RESIDENT AMINOPEPTIDASE 2; ESTROGEN RECEPTOR; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; MELANOMA; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; TUMOR ESCAPE;

5' UNTRANSLATED REGIONS; AMINOPEPTIDASES; ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CLONING, MOLECULAR; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HLA ANTIGENS; HUMANS; INTERFERON-GAMMA; MELANOMA; MUTAGENESIS, SITE-DIRECTED;

EID: 77953229217     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0856-7     Document Type: Article

References (32)

1. PE Jensen 2007 Recent advances in antigen processing and presentation Nat Immunol 8 1041 1048 10.1038/ni1516 1:CAS:528:DC%2BD2sXhtVCkurjF 17878914 (Pubitemid 47423752)
2. JW Yewdell 2005 The seven dirty little secrets of major histocompatibility complex class I antigen processing Immunol Rev 207 8 18 10.1111/j.0105-2896.2005.00309.x 1:CAS:528:DC%2BD2MXhtFOqt7fE 16181323 (Pubitemid 41415004)
3. GE Hammer T Kanaseki N Shastri 2007 The final touches make perfect the peptide-MHC class I repertoire Immunity 26 397 406 10.1016/j.immuni.2007.04.003 1:CAS:528:DC%2BD2sXltVKjsrw%3D 17459809 (Pubitemid 46603005)
4. AL Goldberg P Cascio T Saric KL Rock 2002 The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides Mol Immunol 39 147 164 10.1016/S0161-5890(02)00098-6 1:CAS:528:DC%2BD38XmsVWqtLc%3D 12200047 (Pubitemid 35013508)
5. L Saveanu O Carroll Y Hassainya P van Endert 2005 Complexity, contradictions, and conundrums: studying post-proteasomal proteolysis in HLA class I antigen presentation Immunol Rev 207 42 59 10.1111/j.0105-2896.2005. 00313.x 1:CAS:528:DC%2BD2MXhtFOqtL7N 16181326 (Pubitemid 41415007)
6. F Levy L Burri S Morel, et al. 2002 The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases J Immunol 169 4161 4171 1:CAS:528:DC%2BD38XnvFGntLo%3D 12370345
7. P Endert 2008 Role of tripeptidyl peptidase II in MHC class I antigen processing-the end of controversies Eur J Immunol 38 609 613 10.1002/eji.200838181 18286570
8. KL Rock IA York AL Goldberg 2004 Post-proteasomal antigen processing for major histocompatibility complex class I presentation Nat Immunol 5 670 677 10.1038/ni1089 1:CAS:528:DC%2BD2cXlt1Wmu70%3D 15224092 (Pubitemid 39023295)
9. L Stoltze M Schirle G Schwarz, et al. 2000 Two new proteases in the MHC class I processing pathway Nat Immunol 5 413 418 10.1038/80852
10. GE Hammer F Gonzalez E James H Nolla N Shastri 2007 In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides Nat Immunol 8 101 108 10.1038/ni1409 1:CAS:528: DC%2BD28Xhtlaqs7fF 17128277 (Pubitemid 46242364)
11. SC Chang F Momburg N Bhutani AL Goldberg 2006 The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism Proc Natl Acad Sci USA 102 17107 17112 10.1073/pnas.0500721102
12. GE Hammer F Gonzalez M Champsaur D Cado N Shastri 2006 The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules Nat Immunol 7 103 112 10.1038/ni1286 1:CAS:528:DC%2BD2MXhtlSqu7rM 16299505 (Pubitemid 41823874)
13. GP Dunn CM Koebel RD Schreiber 2006 Interferons, immunity and cancer immunoediting Nat Rev Immunol 6 836 848 10.1038/nri1961 1:CAS:528: DC%2BD28XhtFWns7fK 17063185 (Pubitemid 44631652)
14. T Cabrera I Maleno A Collado MA Lopez Nevot BD Tait F Garrido 2007 Analysis of HLA class I alterations in tumors: choosing a strategy based on known patterns of underlying molecular mechanisms Tissue Antigens 69 Suppl 1 264 268 10.1111/j.1399-0039.2006.00777.x 1:STN:280:DC%2BD2s3js1Oquw%3D%3D 17445216 (Pubitemid 46625898)
15. B Seliger U Ritz S Ferrone 2006 Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation Int J Cancer 118 129 138 10.1002/ijc.21312 1:CAS:528:DC%2BD2MXht1KgsrrN 16003759 (Pubitemid 41681589)
16. CC Chang S Ferrone 2007 Immune selective pressure and HLA class I antigen defects in malignant lesions Cancer Immunol Immunother 56 227 236 10.1007/s00262-006-0183-1 1:CAS:528:DC%2BD28Xht1Gnu7vE 16783578 (Pubitemid 44833096)
17. AM Mehta ES Jordanova GG Kenter S Ferrone GJ Fleuren 2008 Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma Cancer Immunol Immunother 57 197 206 10.1007/s00262-007-0362-8 1:CAS:528:DC%2BD2sXhtlaqt7vK 17622526 (Pubitemid 350159921)
18. D Fruci P Giacomini MR Nicotra, et al. 2008 Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues J Cell Physiol 216 742 749 10.1002/jcp.21454 1:CAS:528:DC%2BD1cXhtVSisrjI 18393273
19. D Fruci S Ferracuti MZ Limongi, et al. 2006 Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines J Immunol 176 4869 4879 1:CAS:528:DC%2BD28XjtV2gtr4%3D 16585582
20. A Varona L Blanco JI Lopez, et al. 2007 Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma Am J Physiol Renal Physiol 292 F780 F788 10.1152/ajprenal.00148.2006 1:CAS:528:DC%2BD2sXjt1Gmt7o%3D 16985214 (Pubitemid 46220546)
21. AM Mehta ES Jordanova T van Wezel, et al. 2007 Genetic variation of antigen processing machinery components and association with cervical carcinoma Genes Chromosomes Cancer 46 577 586 10.1002/gcc.20441 1:CAS:528: DC%2BD2sXkslGhtr8%3D 17366619 (Pubitemid 46649572)
22. MM Schatz B Peters N Akkad, et al. 2008 Characterizing the N-terminal processing motif of MHC class I ligands J Immunol 180 3210 3217 1:CAS:528:DC%2BD1cXit1OksLs%3D 18292545
23. E Reits J Neijssen C Herberts, et al. 2004 A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation Immunity 20 495 506 10.1016/S1074-7613(04)00074-3 1:CAS:528:DC%2BD2cXjs1Gksbc%3D 15084277 (Pubitemid 38482126)
24. X Cui FN Rouhani F Hawari SJ Levine 2003 Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding J Immunol 171 6814 6819 1:CAS:528:DC%2BD3sXpsV2rtbo%3D 14662887
25. T Akada T Yamazaki H Miyashita, et al. 2002 Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is involved in the activation of endothelial integrins J Cell Physiol 193 253 262 10.1002/jcp.10169 1:CAS:528:DC%2BD38Xns1Ohsrk%3D 12385003
26. F Shido T Ito S Nomura, et al. 2006 Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells Endocrinology 147 1780 1788 10.1210/en.2005-1449 1:CAS:528:DC%2BD28Xjt1Oht70%3D 16439450
27. AM Mehta ES Jordanova WE Corver, et al. 2009 Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma Genes Chromosomes Cancer 48 410 418 10.1002/gcc.20648 1:CAS:528:DC%2BD1MXktVaitLc%3D 19202550
28. D Jung C Hilmes A Knuth E Jaeger C Huber B Seliger 1999 Gene transfer of the co-stimulatory molecules B7-1 and B7-2 enhances the immunogenicity of human renal cell carcinoma to a different extent Scand J Immunol 50 242 249 10.1046/j.1365-3083.1999.00588.x 1:CAS:528:DyaK1MXlvF2gurk%3D 10447932 (Pubitemid 29399896)
29. F Herrmann J Trowsdale C Huber B Seliger 2003 Cloning and functional analyses of the mouse tapasin promoter Immunogenetics 55 379 388 10.1007/s00251-003-0597-2 1:CAS:528:DC%2BD3sXntlelu70%3D 12942211 (Pubitemid 37255489)
30. D Atkins S Ferrone GE Schmahl S Storkel B Seliger 2004 Downregulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma J Urol 171 885 889 10.1097/01.ju.0000094807.95420.fe 1:CAS:528:DC%2BD2cXisV2ltQ%3D%3D 14713847 (Pubitemid 38090527)
31. B Seliger U Ritz R Abele M Bock R Tampé G Sutter I Drexler, et al. 2001 Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway Cancer Res 61 8647 8650 1:CAS:528:DC%2BD38Xht1Ohuw%3D%3D 11751378
32. T Kanaseki N Blanchard GE Hammer F Gonzalez N Shastri 2006 ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulium Immunity 25 795 806 10.1016/j.immuni.2006.09.012 1:CAS:528:DC%2BD28Xht1Gnt7zE 17088086 (Pubitemid 46107289)