Telomerase inhibition as a novel therapy for pediatric ependymoma

Brain Pathology

Volumn 20, Issue 4, 2010, Pages 780-786

  Wong, Vincent C H ^a   Morrison, Andrew ^a   Tabori, Uri ^a   Hawkins, Cynthia E ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Ependymomas; Telomerase; Telomeres; Therapeutics

Indexed keywords

CASPASE 3; GLIAL FIBRILLARY ACIDIC PROTEIN; HISTONE H2AX; KI 67 ANTIGEN; MST 312; TELOMERASE; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER ADJUVANT THERAPY; CANCER INHIBITION; CELL COUNT; CELL PROLIFERATION; CELL VIABILITY; CHILDHOOD CANCER; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; EPENDYMOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; NITROBLUE TETRAZOLIUM TEST; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TELOMERE; TUMOR CELL; ANALYSIS OF VARIANCE; ANTAGONISTS AND INHIBITORS; BRAIN TUMOR; CELL CULTURE; CELL SURVIVAL; CHILD; DRUG EFFECTS; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM;

ANALYSIS OF VARIANCE; APOPTOSIS; BENZAMIDES; BRAIN NEOPLASMS; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHILD; DNA DAMAGE; EPENDYMOMA; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; TELOMERASE; TELOMERE;

EID: 77953223394     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2010.00372.x     Document Type: Article

References (23)

1. Agaoglu FY, Ayan I, Dizdar Y, Kebudi R, Gorgun O, Darendeliler E (2005) Ependymal tumors in childhood. Pediatr Blood Cancer 45 : 298 303.
2. Ahmed A, Tollefsbol T (2003) Telomeres, telomerase, and telomerase inhibition: clinical implications for cancer. J Am Geriatr Soc 51 : 116 122.
3. Carter M, Nicholson J, Ross F, Crolla J, Allibone R, Balaji V et al (2002) Genetic abnormalities detected in ependymomas by comparative genomic hybridisation. Br J Cancer 86 : 929 939.
4. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T et al (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 : 194 198.
5. Falchetti ML, Larocca LM, Pallini R (2002) Telomerase in brain tumors. Childs Nerv Syst 18 : 112 117.
6. Gellert GC, Dikmen ZG, Wright WE, Gryaznov S, Shay JW (2006) Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Res Treat 96 : 73 81.
7. Izbicka E, Wheelhouse RT, Raymond E, Davidson KK, Lawrence RA, Sun D et al (1999) Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res 59 : 639 644.
8. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266 : 2011 2015.
9. Kraemer K, Fuessel S, Schmidt U, Kotzsch M, Schwenzer B, Wirth MP, Meye A (2003) Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin Cancer Res 9 : 3794 3800.
10. Mathon NF, Lloyd AC (2001) Cell senescence and cancer. Nat Rev Cancer 1 : 203 213.
11. Merchant TE, Mulhern RK, Krasin MJ, Kun LE, Williams T, Li C et al (2004) Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22 : 3156 3162.
12. Mikami-Terao Y, Akiyama M, Yuza Y, Yanagisawa T, Yamada O, Yamada H (2008) Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells. Cancer Lett 261 : 226 234.
13. Salgaller ML, Liau LM (2006) Current status of clinical trials for glioblastoma. Rev Recent Clin Trials 1 : 265 281.
14. Seimiya H, Oh-hara T, Suzuki T, Naasani I, Shimazaki T, Tsuchiya K, Tsuruo T (2002) Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol Cancer Ther 1 : 657 665.
15. Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T et al (2003) Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther 2 : 825 833.
16. Shammas MA, Koley H, Batchu RB, Bertheau RC, Protopopov A, Munshi NC, Goyal RK (2005) Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. Mol Cancer 4 : 24.
17. Shay JW, Bacchetti S (1997) A survey of telomerase activity in human cancer. Eur J Cancer 33 : 787 791.
18. Tabori U, Ma J, Carter M, Zielenska M, Rutka J, Bouffet E et al (2006) Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma. J Clin Oncol 24 : 1522 1528.
19. Tabori U, Vukovic B, Zielenska M, Hawkins C, Braude I, Rutka J et al (2006) The role of telomere maintenance in the spontaneous growth arrest of pediatric low-grade gliomas. Neoplasia 8 : 136 142.
20. Tabori U, Wong V, Ma J, Shago M, Alon N, Rutka J et al (2008) Telomere maintenance and dysfunction predict recurrence in paediatric ependymoma. Br J Cancer 99 : 1129 1135.
21. Tihan T, Zhou T, Holmes E, Burger PC, Ozuysal S, Rushing EJ (2008) The prognostic value of histological grading of posterior fossa ependymomas in children: a Children's Oncology Group study and a review of prognostic factors. Mod Pathol 21 : 165 177.
22. Wiestler O, Schiffer D, Coons S, Prayson R, Rosenblum M (2000) Ependymal tumours. In : Pathology and Genetics of Tumours of the Nervous System. P Kleihues, W Cavenee (eds), pp. 71 82. IARC Press
23. Wong VC, Ma J, Hawkins CE (2009) Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas. Cancer Lett 274 : 151 159.