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Volumn 2009, Issue 11, 2009, Pages 22-30

2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin: Synthesis and evaluation of the affinity for Photinus pyralis luciferase

Author keywords

2,6 disubstituted benzothiazoles; D luciferin; Luciferase

Indexed keywords


EID: 77953189127     PISSN: 1551-7012     EISSN: 15517004     Source Type: Journal    
DOI: 10.3998/ark.5550190.0010.b03     Document Type: Article
Times cited : (5)

References (34)
  • 6
    • 0034760638 scopus 로고    scopus 로고
    • For luciferase-mediated gene imaging a dose of 125 mg/Kg of D-luciferin is required
    • For luciferase-mediated gene imaging a dose of 125 mg/Kg of D-luciferin is required: Wu, J. C.; Sundaresan, G.; Iyer, M.; Gambhir, S. S. Mol. Ther. 2001, 4, 297.
    • (2001) Mol. Ther. , vol.4 , pp. 297
    • Wu, J.C.1    Sundaresan, G.2    Iyer, M.3    Gambhir, S.S.4
  • 17
    • 85069247298 scopus 로고    scopus 로고
    • For instance, we have attempted to prepare 6'-O-methyl luciferin 1d from D-luciferin 1a. The methylation of compound 1a under a variety of experimental conditions afforded mixture of products, due to the instability of D-luciferin itself and also a few attempts of radiosynthesis failed. Starting from the methyl ester of D-luciferin, the corresponding 11C methyl ether has later been prepared by reaction with 11C-CH3OTf.7
    • For instance, we have attempted to prepare 6'-O-methyl luciferin 1d from D-luciferin (1a). The methylation of compound 1a under a variety of experimental conditions afforded mixture of products, due to the instability of D-luciferin itself and also a few attempts of radiosynthesis failed. Starting from the methyl ester of D-luciferin, the corresponding [11C] methyl ether has later been prepared by reaction with [11C]-CH3OTf.7
  • 23
    • 85069238703 scopus 로고    scopus 로고
    • We have also tried other reagents for the demethylation step such as BBr3 or trimethylsilyl iodide, but the nitrile moiety reacted as well and the yields of the transformation were considerably lowered
    • We have also tried other reagents for the demethylation step such as BBr3 or trimethylsilyl iodide, but the nitrile moiety reacted as well and the yields of the transformation were considerably lowered.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.